期刊
DNA AND CELL BIOLOGY
卷 37, 期 3, 页码 154-159出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/dna.2017.4059
关键词
flavivirus; mosquitoes; sfRNA; innate immunity; Xrn1; transmission
资金
- National Medical Research Council of Singapore as an NIG [NMRC/ BNIG/2032/2015]
- National Medical Research Council of Singapore a CBRG [NMRC/CBRG/0074/2014]
- Ministry of Education [MOE2015-T3-1-003]
Mosquito-borne flaviviruses (MBFVs) are a global public health burden. MBFVs have several unique 3UTR structures that inhibit the host RNA decay machinery to produce subgenomic flaviviral RNAs (sfRNAs). Number of sfRNA species and their relative quantities are dependent on the 3UTR tertiary structures and can vary between tissues. Two recent in vivo studies demonstrated that sfRNA enhances mosquito transmission, resulting in increased infection rate of saliva. Transmission efficiency is determined by the immune response. First evidence points to sfRNA interference with the Toll and RNAi immune pathways. However, a more complex picture that includes flexibility in sfRNA production and interaction with immune-related proteins remains to be explored.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据