Article
Immunology
Chao Yang, Fengyu Cao, Shuoyang Huang, Yongbin Zheng
Summary: This study identified crucial ECM-related genes responsible for LNM in CRC through multi-omics analysis, highlighting the impact of FSTL3 on LNM and prognosis in CRC, as well as its potential role in promoting an inhibitory immune microenvironment leading to chemoresistance but immunotherapy sensitivity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Hirosato Tamari, Yasuhiko Kitadai, Hidehiko Takigawa, Ryo Yuge, Yuji Urabe, Fumio Shimamoto, Shiro Oka
Summary: In colorectal cancer, tumor-infiltrating T cells are associated with lymph node metastasis and prognosis. This study investigated the relationship between T cells and lymph node metastasis in early-stage CRC and found that a higher number of Foxp3+ T cells and higher Foxp3/CD4 and Foxp3/CD8 ratios at the invasive front of the tumor were associated with lymph node metastasis. Tumor invasion was also positively correlated with the number of T cells in CRC.
Review
Cell Biology
Yen-Liang Li, Wen-Chun Hung
Summary: Lymphatic metastasis is a major cause of cancer-related deaths, and the molecular basis of this process is not well understood. Cancer cells invade the lymphatic system and enter the sentinel lymph node, where they modify the microenvironment and suppress anti-tumor immunity. Developing strategies to reverse these changes in the sentinel lymph node may reduce colonization and distant metastasis. Alternatively, nanotechnology-based approaches for targeted drug delivery to the lymph node could enhance the efficacy of cancer treatment by killing cancer cells on site and promoting antigen presentation for immune activation.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Yoshitaka Kiya, Yusuke Yoshioka, Yuichi Nagakawa, Takahiro Ochiya
Summary: Extracellular vesicles (EVs) are lipid bilayer particles secreted by various cells in the body. They interact with recipient cells and modulate biological functions by transporting cargoes such as nucleic acids and proteins. They play a role in tumor progression by stimulating signaling pathways, regulating immune system activation, and establishing premetastatic niches. EVs express immune checkpoint molecules, allowing tumor cells to evade immune cell attack and acquire resistance to immune checkpoint inhibitors. This review discusses the association between EVs and tumor progression through the immune system, as well as the clinical application of EVs as biomarkers and therapeutic agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jiangping Fu, Mengjie Tu, Yin Zhang, Yan Zhang, Jiasi Wang, Zhaoping Zeng, Jie Li, Fanxin Zeng
Summary: This study developed and validated a multiple tumor marker nomogram for predicting lymph node metastasis in colorectal cancer (CRC) patients. The nomogram showed good discrimination and performance in assessing lymph node metastasis, and demonstrated good calibration and clinical usefulness.
Article
Immunology
Liwei Jiang, Mine Yilmaz, Mayuko Uehara, Cecilia B. Cavazzoni, Vivek Kasinath, Jing Zhao, Said Movahedi Naini, Xiaofei Li, Naima Banouni, Paolo Fiorina, Su Ryon Shin, Stefan G. Tullius, Jonathan S. Bromberg, Peter T. Sage, Reza Abdi
Summary: Lymph node-resident stromal cells, particularly the leptin receptor-expressing cells, play a crucial role in immune response regulation. Leptin signaling through the JAK/STAT pathway supports the survival and anti-inflammatory properties of these stromal cells. Deficiency in leptin signaling leads to increased inflammatory responses and lymphatic abnormalities. Restoration of leptin signaling improves LN microarchitecture, reduces intra-LN inflammation, and corrects metabolic abnormalities.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Zhiyuan Zheng, Peng Li, Fangrong Shen, Yufang Shi, Changshun Shao
Summary: This article discusses the pathological role of mesenchymal stem/stromal cells (MSCs) in tumor initiation, progression, and metastasis, highlighting the importance of targeting MSCs in cancer therapy.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Oncology
Zhenghao Chen, Chuan Qin, Gang Wang, Donghao Shang, Ye Tian, Lushun Yuan, Rui Cao
Summary: This study developed a nomogram that included an StrLNM signature to predict the lymph node metastasis status in bladder cancer patients. The nomogram showed good performance in prediction and was validated in multiple independent cohorts.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Shiyong Xin, Xiang Liu, Ziyao Li, Xianchao Sun, Rong Wang, Zhenhua Zhang, Xinwei Feng, Liang Jin, Weiyi Li, Chaozhi Tang, Wangli Mei, Qiong Cao, Haojie Wang, Jianguo Zhang, Lijin Feng, Lin Ye
Summary: This study analyzed the heterogeneity of tumor microenvironment in prostate cancer using single-cell RNA sequencing, and explored the mechanism of lymph node metastasis. The results showed that only EEF2+ and FOLH1+ luminal subgroups were present in lymph node metastasis of prostate cancer, and MYC pathway played a role in this process.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Oncology
Ramakanth Chirravuri-Venkata, Vi Dam, Rama Krishna Nimmakayala, Zahraa Wajih Alsafwani, Namita Bhyravbhatla, Imayavaramban Lakshmanan, Moorthy P. Ponnusamy, Sushil Kumar, Maneesh Jain, Dario Ghersi, Surinder K. Batra
Summary: MUC16/CA125 is an important cancer biomarker still used in clinical practice. The regulation and role of MUC16 in tumor and stromal compartments were investigated, revealing its involvement in controlling CAF differentiation. The proportion of mesothelium-derivative stromal cells was found to be higher in invasive PDAC, especially in TP53 deficient tumors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Tianhang Li, Tianyao Liu, Zihan Zhao, Xinyan Xu, Shoubin Zhan, Shengkai Zhou, Ning Jiang, Wenjie Zhu, Rui Sun, Fayun Wei, Baofu Feng, Hongqian Guo, Rong Yang
Summary: Cancer metastasis is a malignant biological behavior that greatly contributes to cancer-related deaths. Recent evidence suggests that the interaction between tumor cells and the host organ microenvironment, as well as the epigenetic reprogramming of metastatic cancer cells, play important roles in the process of cancer metastasis. Lymph nodes serve as the initial metastatic niche for many types of cancer, and the presence of lymph node metastasis indicates poor prognosis. Various immune cells are involved in the formation of malignant properties of tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Tsunenori Yamamoto, Ryouichi Tsunedomi, Masao Nakajima, Nobuaki Suzuki, Shin Yoshida, Shinobu Tomochika, Ming Xu, Yuki Nakagami, Hiroto Matsui, Yukio Tokumitsu, Yoshitaro Shindo, Yusaku Watanabe, Michihisa Iida, Shigeru Takeda, Shoichi Hazama, Tsuyoshi Tanabe, Tatsuya Ioka, Yoshinobu Hoshii, Akifumi Kiyota, Hitoshi Takizawa, Yutaka Kawakami, Tomio Ueno, Hiroaki Nagano
Summary: This study investigated the relationship between an immunosuppressive state and patient prognosis in colorectal cancer (CRC) by evaluating the levels of interleukin (IL)-6 in both the systemic and tumor microenvironment. The results showed that elevated serum IL-6 levels were associated with elevated stromal IL-6 levels and a poor prognosis for CRC patients. In addition, tumor-infiltrating immune cells expressing IL-6 were primarily composed of myeloid cells and rarely lymphoid cells.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Zongmei Zheng, Xinxin Hou, Zhaoxiang Bian, Wei Jia, Ling Zhao
Summary: This review explores the crucial role of gut microbiota in the metastasis of colorectal cancer (CRC) and elucidates the molecular mechanisms through which gut microbiota contribute to the formation of a tumor-permissive microenvironment, as well as facilitate malignant transformation and dissemination of tumor cells, thus mediating CRC metastasis.
Article
Medicine, General & Internal
Fengxiang Zhang, Xianzhe Li, Huaxian Chen, Jianping Guo, Zhizhong Xiong, Shi Yin, Longyang Jin, Xijie Chen, Dandong Luo, Haijie Tang, Chaobin Mao, Lei Lian
Summary: This study found that MUC16 mutation status is associated with tumor mutational burden, microsatellite status, lymph node metastasis, and survival in patients with gastric cancer. These findings may provide new insights into prognostic predictions and immunotherapy guidance for patients with gastric cancer.
FRONTIERS IN MEDICINE
(2022)
Article
Cell Biology
Zhiyuan Zheng, Yazhang Xu, Yufang Shi, Changshun Shao
Summary: This review summarizes the role of neutrophils in tumorigenesis, with a focus on their interaction with mesenchymal stromal cells (MSCs).
CELLULAR IMMUNOLOGY
(2022)