Article
Pathology
Tsuyoshi Mishiro, Kotaro Shibagaki, Chika Fukuyama, Masatoshi Kataoka, Takumi Notsu, Noritsugu Yamashita, Akihiko Oka, Mamiko Nagase, Asuka Araki, Kousaku Kawashima, Norihisa Ishimura, Riruke Maruyama, Yoshikazu Kinoshita, Shunji Ishihara
Summary: With the decrease in Helicobacter pylori-infected individuals, the occurrence of gastric neoplasms in H. pylori-naive patients, such as sporadic foveolar-type gastric adenoma (FGA), has been increasing. This study investigated the genomic features of sporadic FGA and identified a novel single-nucleotide variation (SNV) in the KLF4 gene that may contribute to the slow-growing properties of this neoplasm.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Kotaro Shibagaki, Norihisa Ishimura, Satoshi Kotani, Chika Fukuyama, Yusuke Takahashi, Kenichi Kishimoto, Tomotaka Yazaki, Masatoshi Kataoka, Taisuke Omachi, Yasuhito Kinoshita, Nobuaki Hasegawa, Akihiko Oka, Yoshiyuki Mishima, Tsuyoshi Mishiro, Naoki Oshima, Kousaku Kawashima, Mamiko Nagase, Asuka Araki, Kyuichi Kadota, Shunji Ishihara
Summary: This study aimed to establish an endoscopic diagnostic index to distinguish Foveolar-type gastric adenoma (FGA) and Helicobacter pylori-naive gastric hyperplastic polyp (HpN-GHP). It was found that FGAs more frequently exhibited bright-red color, peripheral hyperplasia, papillary/gyrus-like microstructure, visible capillaries, and demarcation line compared to HpN-GHPs. By satisfying four criteria, FGA could be accurately diagnosed with high sensitivity and specificity. The study suggests that the composite diagnostic index contributes to the reproducible, accurate, preoperative differential diagnosis of FGA and HpN-GHP.
Article
Oncology
Kentaro Imamura, Kenshi Yao, Satoshi Nimura, Hiroshi Tanabe, Takao Kanemitsu, Masaki Miyaoka
Summary: A man in his 60s had an upper gastrointestinal endoscopy that revealed a 30-mm elevated lesion in the upper stomach, multiple secondary lesions in the gastric fornix and body, and a histopathological examination confirmed gastric adenocarcinoma. The main lesion was removed using endoscopic submucosal dissection, revealing additional GA-FGM and GA-FG lesions. The patient declined further surgical treatment and has been followed up with regular endoscopy and computed tomography for five years without tumor growth or metastasis.
Article
Pathology
Kotaro Shibagaki, Tsuyoshi Mishiro, Chika Fukuyama, Yusuke Takahashi, Ayako Itawaki, Saya Nonomura, Noritsugu Yamashita, Satoshi Kotani, Hironobu Mikami, Daisuke Izumi, Kousaku Kawashima, Norihisa Ishimura, Mamiko Nagase, Asuka Araki, Noriyoshi Ishikawa, Riruke Maruyama, Ryoji Kushima, Shunji Ishihara
Summary: Sporadic foveolar-type gastric adenoma (FGA) is extremely rare and typically whitish and flatly elevated, but a recent study found that sporadic FGA with a raspberry-like appearance (FGA-RA) is not uncommon in H. pylori-naive gastric mucosa. This study examined 43 cases of FGA-RA in 34 patients and found that these lesions exhibit specific endoscopic and microscopic features, with most lesions showing low-grade dysplasia. The presence of fundic gland polyps in the background mucosa was significantly higher in multiple FGA-RA cases compared to solitary cases.
Article
Gastroenterology & Hepatology
Hiroya Ueyama, Takashi Yao, Yoichi Akazawa, Takuo Hayashi, Koichi Kurahara, Yumi Oshiro, Masaoshi Yamada, Ichiro Oda, Shin Fujioka, Chiaki Kusumoto, Masayoshi Fukuda, Kunihisa Uchita, Tomohiro Kadota, Yasuhiro Oono, Kazuhisa Okamoto, Kazunri Murakami, Yasumasa Matsuo, Motohiko Kato, Tadateru Maehata, Naohisa Yahagi, Yumiko Yasuhara, Tomoyuki Yada, Koji Uraushihara, Tetumi Yamane, Taiji Matsuo, Masanori Ito, Yasuhiko Maruyama, Ayumi Osako, Shoko Ono, Mototsugu Kato, Kazuyoshi Yagi, Takashi Hashimoto, Natsumi Tomita, Sho Tsuyama, Tsuyoshi Saito, Kohii Matsumoto, Kenshi Matsumoto, Sumio Watanabe, Naomi Uemura, Tsutomu Chiba, Akihiito Nagahara
Summary: This study established a new histopathological classification of GEN-FGML, including OGA, GA-FG, and GA-FGM, with distinct clinicopathological features for each type and subtype. The frequent presence of GNAS mutation in GEN-FGML was identified as a characteristic genetic feature.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Kentaro Imamura, Kenshi Yao, Satoshi Nimura, Hiroshi Tanabe, Takao Kanemitsu, Masaki Miyaoka, Yoichiro Ono, Toshiharu Ueki, Akinori Iwashita
Summary: The study found that endoscopic findings of GA-FGM showed specific features under dye-spraying method which were not observed in GA-FG lesions. Magnifying endoscopy revealed that GA-FGM lesions met the diagnostic criteria for cancer, while GA-FG lesions did not, suggesting the potential usefulness of magnifying endoscopy with NBI for diagnosing GA-FGM.
Article
Oncology
Ken Namikawa, Norio Tanaka, Yuki Ota, Manabu Takamatsu, Mayuko Kosugi, Yoshitaka Tokai, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Sayuri Amino, Rie Furuya, Osamu Gotoh, Tomoko Kaneyasu, Izuma Nakayama, Yu Imamura, Tetsuo Noda, Junko Fujisaki, Seiichi Mori
Summary: This study compared the genomic differences between HP-exposed and HP-naive diffuse-type gastric cancer (DGC) and found that they develop along different molecular pathways. This finding provides a basis for early detection strategies in high incidence settings.
JOURNAL OF PATHOLOGY
(2022)
Article
Gastroenterology & Hepatology
Masaya Iwamuro, Chiaki Kusumoto, Masahiro Nakagawa, Kazuhiro Matsueda, Sayo Kobayashi, Masao Yoshioka, Tomoki Inaba, Tatsuya Toyokawa, Chihiro Sakaguchi, Shouichi Tanaka, Takehiro Tanaka, Hiroyuki Okada
Summary: This study compared the endoscopic features of oxyntic gland adenoma and gastric adenocarcinoma of the fundic gland type between patients with and without Helicobacter pylori infection. The study found differences in these lesions between patients with and without H. pylori infection.
BMC GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Huan Zhang, Shuyan Wang, Yongping Zhang, Fusang Ye, Chunnian Wang
Summary: Gastric adenocarcinoma of the fundic gland type (GA-FG), a rare and unusual neoplasm, has been reported in China infrequently, necessitating further investigation of its clinicopathological characteristics. This study presents five cases of GA-FG and finds immunohistochemical results indicating differentiation between gastric adenocarcinoma and fundic glands. The tumor exhibits low proliferation and its pathogenesis is distinct from traditional intestinal and diffuse gastric carcinomas.
Article
Oncology
Keitaro Takahashi, Nobuhiro Ueno, Takahiro Sasaki, Yu Kobayashi, Yuya Sugiyama, Yuki Murakami, Takehito Kunogi, Katsuyoshi Ando, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Yuki Kamikokura, Sayaka Yuzawa, Mishie Tanino, Toshikatsu Okumura, Mikihiro Fujiya
Summary: This study reported a case of gastric adenocarcinoma of the fundic gland mucosa type (GA-FGM) with findings suggesting that the unaltered tumor size reflects low-grade malignancy and slow growth, and that the endoscopic morphology is influenced by Helicobacter pylori eradication.
JOURNAL OF GASTRIC CANCER
(2021)
Article
Medicine, General & Internal
Lifeng Liu, Lin Han, Qingzhu Ma, Jinliang Zhang
Summary: Gastric adenocarcinoma of fundic gland (chief cell predominant type) is a rare variant characterized by mild nuclear atypia and specific immunohistochemical markers, often coexisting with well-differentiated tubular adenocarcinoma. It presents in the deep mucosal layer and muscularis mucosa, undetectable by endoscopy but discernible in pathology with mild nuclear atypia and special biomarkers.
Article
Pathology
Kotaro Shibagaki, Ayako Itawaki, Yoichi Miyaoka, Kenichi Kishimoto, Yusuke Takahashi, Satoshi Kotani, Tsuyoshi Mishiro, Naoki Oshima, Kousaku Kawashima, Norihisa Ishimura, Hideyuki Onuma, Makoto Nagasaki, Mamiko Nagase, Asuka Araki, Kyuichi Kadota, Ryoji Kushima, Shunji Ishihara
Summary: Gastric dysplasia rarely occurs in Helicobacter pylori-naive patients, with distinctive clinicopathologic features. Most lesions are low-grade dysplasia, some progress to high-grade components, and one may advance to intramucosal carcinoma. Neoplastic cells express CDX2, MUC2, and CD10 immunohistochemically, showing an intestinal phenotype.
Article
Pathology
Adam L. Booth, Raul S. Gonzalez
Summary: The study evaluated the rate and significance of H. pylori in CPD, finding that routine examination for H. pylori in duodenal foveolar metaplasia samples may not be necessary, and had correlations with factors such as patient age, sex, and symptoms.
JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Oncology
Xuemei Liu, Xinglong Wu, Jiaxing Zhu, Kazuyoshi Yagi, Yoichi Ajioka, Shuji Terai, Kenichi Mizuno, Hongping Li, Biguang Tuo, Lianjun Di
Summary: This article describes a case of early gastric cancer without H. pylori infection, with characteristic magnifying narrow-band imaging and novel histological findings. The difficulty in accurate diagnosis and differential diagnosis is emphasized, aiming to provide more clinical experience for the diagnosis of H. pylori infection-negative gastric cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Lixin Wang, Gang Chen, Jingui Jiang
Summary: Gastric adenocarcinoma of the fundic gland type (GA-FG) is a new tissue type of gastric cancer with unique clinicopathological features, good prognosis, and no tendency to relapse.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2021)