Article
Oncology
Jijun Zhang, Xiaoya Luo, Qitao Huang, Yuhua Huang
Summary: Nasopharyngeal carcinoma in children and adolescents is rare, with most cases staged as Stage IVa disease. The majority of patients tested positive for EBV antibodies, with a significant difference in survival rates observed in patients with high plasma EBV DNA and positive serum EBV antibodies.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Medicine, Research & Experimental
Meichun Zeng, Qingjun Jia, Jingjing Chen, Liming Xu, Li Xie, Qinglin Cheng, Qingchun Li, Ming Xiao, Zijian Fang
Summary: The relationship between plasma EBV-DNA load (PEDL) and Epstein-Barr virus (EBV)-encoded small RNA (EBER) during the early treatment of lymphoma is not well-established. This study found that although EBER affects the levels of PEDL, there is poor concordance between EBER and qualitative analysis of PEDL (qPEDL).
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Oncology
Mandi Nohtani, Katerina Vrzalikova, Maha Ibrahim, Judith E. Powell, Eanna Fennell, Susan Morgan, Richard Grundy, Keith McCarthy, Sarah Dewberry, Jan Bouchal, Katerina Bouchalova, Pamela Kearns, Paul G. Murray
Summary: The Epstein-Barr virus (EBV) plays an important role in the development of classical Hodgkin lymphoma (cHL) and its impact on clinical outcomes varies with different age groups. Elderly patients with EBV-positive cHL have worse outcomes, while younger adults may benefit moderately from EBV positivity or show no effect. The effects of EBV on children and adolescents with cHL are conflicting.
Article
Virology
Julien Lupo, Mansour Tsougaev, Stephane Blachier, Guillaume Chovelon, Aurelie Truffot, Corentin Leroy, Joris Giai, Olivier Epaulard, Raphaele Germi, Patrice Morand
Summary: This study compared the performance of two immunoassays for detecting serological markers of EBV infection. The results showed a high agreement between the two methods, but differences were found in sensitivity and detection rates for early primary infection and past infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Mengjia Liu, Xinyu Wang, Linlin Zhang, Guoshuang Feng, Yueping Zeng, Ran Wang, Zhengde Xie
Summary: Epstein-Barr virus (EBV) is highly prevalent worldwide, causing infectious mononucleosis (IM). The disease burden of children hospitalized with IM in China has been rarely described. This study provides insights into the epidemiological characteristics and disease burden of hospitalized children with IM.
Article
Genetics & Heredity
Ruyue Chen, Qiang Lin, Yun Zhu, Yunyan Shen, Qinying Xu, Hanyun Tang, Ningxun Cui, Lu Jiang, Xiaomei Dai, Weiqing Chen, Xiaozhong Li
Summary: The article reports successful cases of using PD-1 inhibitor Sintilimab to treat CAEBV and EBV-HLH. Among the three patients, two had CAEBV and one had EBV-HLH. After treatment, the clinical symptoms of the patients improved significantly, and the EBV-DNA load decreased significantly. The study supports the efficacy of PD-1 targeted therapy in certain patients with CAEBV and EBV-HLH and suggests that Sintilimab may provide a cure without HSCT.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Review
Oncology
Yin Luo, Yitong Liu, Chengkun Wang, Runliang Gan
Summary: Epstein-Barr virus is closely associated with multiple human cancers, mainly lymphomas and carcinomas. The virus can induce oncogenesis through activating various signaling pathways in host cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Virology
Ting Shi, Linlin Huang, Zhengrong Chen, Jianmei Tian
Summary: This study investigated the characteristics of primary EBV infection and reactivation in children in Suzhou, China, finding that primary EBV infection was more common in children aged 36 to <72 months and often led to infectious mononucleosis. Reactivation of EBV mainly occurred in children aged 8 to <36 months and was identified as a risk factor for hemophagocytic lymphohistiocytosis (HLH). Among reactivated patients, HLH had a higher viral load compared to EBV infection and respiratory infection.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Oncology
Racha Bahri, Francois Boyer, Mohamad Adnan Halabi, Alain Chaunavel, Jean Feuillard, Arnaud Jaccard, Sylvie Ranger-Rogez
Summary: Angioimmunoblastic T cell lymphoma (AITL) is a peripheral T cell lymphoma with poor prognosis, and EBV virus is detected in most cases. This study analyzed the viral genomes in AITL and found two main strains associated with shorter post-diagnosis survival, supporting the role of EBV in AITL.
Article
Immunology
Fransenio Clark, Anna Gil, Ishwor Thapa, Nuray Aslan, Dario Ghersi, Liisa K. K. Selin
Summary: Older people have difficulty controlling infection with common viruses, and changes in T cell receptor (TCR) repertoires may contribute to waning immunity with age. There are differences in TCR usage between young and older individuals, particularly in the alpha and beta repertoires. Both young and older individuals have cross-reactive T cell responses to the common viruses, but the specific features of these responses differ.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Paula Alves, Marcella Larrate, Aruana Garcia-Costa, Paulo Rohan, Bianca Ervatti Gama, Eliana Abdelhay, Edson Delatorre, Rocio Hassan
Summary: In this study, the genetic diversity of Epstein-Barr virus (EBV) in Brazil was characterized. Four main EBV clades were identified, with the Raji/Argentine and Mediterranean clades being the most prevalent in South America. The Raji/Argentine clade showed associations with certain polymorphisms and high haplotype diversity.
Article
Oncology
Kelly J. Yu, Wan-Lun Hsu, Chun-Ju Chiang, Tseng-Cheng Chen, Zhiwei Liu, Pei-Jen Lou, Scott Diehl, Alisa M. Goldstein, Chien-Jen Chen, Cheng-Ping Wang, Allan Hildesheim
Summary: This study reassessed familial aggregation of cancer in high-risk Taiwanese multiplex families with NPC cases and found evidence of NPC coaggregation within families, but not a broader familial syndrome involving NPC and other tumors. The study also observed elevated rates of secondary cancers among NPC cases, mostly head and neck and hematopoietic cancers, suggesting radiation treatment effects on subsequent cancer risk.
Review
Oncology
Oswald Zhao Jian Lee, Noorjehan Omar, Joshua K. Tay, Victor Kwan Min Lee
Summary: This review provides a comprehensive overview of Epstein-Barr virus-associated mesenchymal tumors, including their clinical features, pathological characteristics, pathophysiology, prognostic factors, and current treatment approaches. Through an extensive literature search, three distinct EBV-associated mesenchymal tumors were identified: EBV-associated smooth muscle tumors, inflammatory pseudotumor-like follicular dendritic cell sarcomas, and EBV-associated osteosarcomas. Although there is still incomplete understanding of the underlying pathophysiology, this review aims to serve as a catalyst for further research to bridge the knowledge gap and contribute to future therapeutic approaches.
Review
Biotechnology & Applied Microbiology
Linlin Zhang, Ran Wang, Zhengde Xie
Summary: Epstein-Barr virus (EBV) is closely associated with several malignant and lymphoproliferative diseases. Aberrant methylation of viral DNA and the host genome plays a crucial role in EBV-associated diseases. EBV controls gene methylation by hijacking host epigenetic machinery, and its proteins interact with host epigenetic regulatory factors to mediate the methylation of important tumour suppressor gene promoters. Epigenetic modifications, particularly DNA methylation, can be targeted for epigenetic therapy against EBV-associated tumours. The methylation patterns in the host and EBV genomes may also have diagnostic and prognostic value.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Pediatrics
Salvatore Accomando, Giulia Angela Restivo, Simona Scalzo, Melania Guardino, Giovanni Corsello, Mario Giuffre
Summary: This study reports a rare case of pediatric EBV-associated acute pancreatitis. The patient was diagnosed with EBV-associated acute pancreatitis after laboratory and imaging investigations ruled out other causes. The patient recovered after conservative treatment.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
