Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes

Tissue-specific exosome biomarkers for noninvasively monitoring immunologic rejection of transplanted tissue

(2017) Prashanth Vallabhajosyula et al.   JOURNAL OF CLINICAL INVESTIGATION

A divergent population of autoantigen-responsive CD4 + T cells in infants prior to β cell autoimmunity

(2017) Anne-Kristin Heninger et al.   Science Translational Medicine

Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation

(2017) Masayuki Hatanaka et al.   Scientific Reports

Presence of diabetes autoantigens in extracellular vesicles derived from human islets

(2017) Craig P. Hasilo et al.   Scientific Reports

Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes

(2017) Marta Garcia-Contreras et al.   Scientific Reports

A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes

(2016) Anne M. Pesenacker et al.   DIABETES

Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity

(2016) Chiara Cianciaruso et al.   DIABETES

Extracellular vesicles: masters of intercellular communication and potential clinical interventions

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cells release subpopulations of exosomes with distinct molecular and biological properties

(2016) Eduard Willms et al.   Scientific Reports

Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study

(2016) Attila A. Seyhan et al.   Scientific Reports

Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells

(2015) Claudiane Guay et al.   Cell Communication and Signaling

Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes

(2015) Marisa M. Fisher et al.   DIABETES

Regulated delivery of molecular cargo to invasive tumour-derived microvesicles

(2015) James W. Clancy et al.   Nature Communications

Low-dose cytokine-induced neutral ceramidase secretion from INS-1 cells via exosomes and its anti-apoptotic effect

(2014) Qun Zhu et al.   FEBS Journal

Prevalence of Type 1 and Type 2 Diabetes Among Children and Adolescents From 2001 to 2009

(2014) Dana Dabelea et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Diabetes-Associated MicroRNAs in Pediatric Patients With Type 1 Diabetes Mellitus: A Cross-Sectional Cohort Study

(2014) Julia Osipova et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Development of a conditionally immortalized human pancreatic β cell line

(2014) Raphaël Scharfmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exosomes Released by Islet-Derived Mesenchymal Stem Cells Trigger Autoimmune Responses in NOD Mice

(2013) M. J. Rahman et al.   DIABETES

Circulating miR-375 as a Biomarker of β-Cell Death and Diabetes in Mice

(2013) Suheda Erener et al.   ENDOCRINOLOGY

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

Circulating miRNAs: cell–cell communication function?

(2013) A. Turchinovich et al.   Frontiers in Genetics

Microvesicles Derived from Endothelial Progenitor Cells Enhance Neoangiogenesis of Human Pancreatic Islets

(2012) Vincenzo Cantaluppi et al.   CELL TRANSPLANTATION

Changes in MicroRNA Expression Contribute to Pancreatic  -Cell Dysfunction in Prediabetic NOD Mice

(2012) E. Roggli et al.   DIABETES

Characterization of Membrane-shed Microvesicles from Cytokine-stimulated β-Cells Using Proteomics Strategies

(2012) Giuseppe Palmisano et al.   MOLECULAR & CELLULAR PROTEOMICS

Insulinoma-Released Exosomes or Microparticles Are Immunostimulatory and Can Activate Autoreactive T Cells Spontaneously Developed in Nonobese Diabetic Mice

(2011) H. Sheng et al.   JOURNAL OF IMMUNOLOGY

Detection of   cell death in diabetes using differentially methylated circulating DNA

(2011) E. M. Akirav et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic   cell death

(2011) Q. Ruan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of MicroRNAs in the Cytotoxic Effects Exerted by Proinflammatory Cytokines on Pancreatic  -Cells

(2010) E. Roggli et al.   DIABETES

Epidemiology of Type 1 Diabetes

(2010) David M. Maahs et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

miR-21: a small multi-faceted RNA

(2008) Anna M. Krichevsky et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE