Article
Cardiac & Cardiovascular Systems
Kelly A. Stockelman, Anthony R. Bain, Caitlin A. Dow, Kyle J. Diehl, Jared J. Greiner, Brian L. Stauffer, Christopher A. DeSouza
Summary: Insufficient sleep is associated with endothelial dysfunction and increased cardiovascular risk, while regular aerobic exercise can improve endothelial function and reduce cardiovascular risk. In this study, aerobic exercise training was found to enhance endothelium-dependent vasodilation and reduce ET-1-mediated vasoconstriction in adults with habitual insufficient nightly sleep, regardless of changes in sleep duration. Regular aerobic exercise can potentially mitigate the cardiovascular risk associated with insufficient sleep-related endothelial dysfunction.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anna Bartakova, Marie Novakova
Summary: Cardiovascular diseases are a major cause of death globally, often involving endothelial dysfunction. Plants contain biologically active substances that can affect the endothelium, potentially contributing to the development of cardiovascular disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jing Li, Xue-Qi Liang, Yun-Feng Cui, Zi-Yue Ma, Ying-Tao Cui, Xian-Hui Dong, Hai -Jun Huang, Ting -Ting Tong, Ya-Mei Zhu, Ya-Dong Xue, Yong-Zhen Wang, Tao Ban, Rong Huo
Summary: PFI-3 exerts a relaxation effect on rat mesenteric arteries independent of endothelium. This vasodilatory effect is attributed to its inhibition of VDCCs and ROCCs on vascular smooth muscle cells.
Review
Cardiac & Cardiovascular Systems
Helen Christou, Raouf A. Khalil
Summary: Pulmonary hypertension is a serious disease characterized by vasoconstriction and remodeling of the pulmonary arterioles, leading to increased pulmonary vascular resistance and right ventricular hypertrophy. Current pharmacological therapies focus on pulmonary vasodilation but are not universally successful. Therefore, researchers are exploring novel approaches to reverse pulmonary vascular pathology and structural remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Physiology
Janee D. Terwoord, Matthew L. Racine, Christopher M. Hearon, Gary J. Luckasen, Frank A. Dinenno
Summary: The study demonstrates that endothelium-dependent agonists interact to induce vasodilation and limit α-adrenergic vasoconstriction in humans.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Peripheral Vascular Disease
Yifei Zhu, Yuan Chu, Sheng Wang, Junjian Tang, Hu Li, Lei Feng, Fan Yu, Xin Ma
Summary: Smooth muscle cell TRPV4 plays a significant role in vascular contraction and blood pressure regulation, and its expression level may be associated with obesity. The study found that TRPV4(SMC) has different effects on vasomotor tone regulation compared to endothelial TRPV4, and the loss of TRPV4(SMC) can protect obese mice from vasoconstriction and hypertension.
Article
Biochemistry & Molecular Biology
Naris Thengchaisri, Travis W. Hein, Yi Ren, Lih Kuo
Summary: Activation of PKC beta 2 may compromise NO-mediated vasodilation through Rho kinase-mediated JNK signaling and superoxide production from xanthine oxidase, independently of the activation of the smooth muscle contractile machinery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Ashley E. Walker, Jazmin A. Cole, Sahana Krishna Kumaran, Jonathan I. Kato, Xinhao Zhuang, Julia R. Wolf, Grant D. Henson, Belinda H. McCully
Summary: Obesity increases the risk of complications and mortality after trauma, which are associated with vascular damage. The impact of obesity on vascular dysfunction after traumatic hemorrhage is unclear. This study suggests that obesity may potentiate trauma-induced vascular inflammation and dysfunction.
Article
Physiology
Tomonori Nakata, Manabu Shibasaki, Yukihide Nishimura, Tokio Kinoshita, Takamasa Hashizaki, Yoshi-ichiro Kamijo, Ken Kouda, Yasunori Umemoto, Fumihiro Tajima
Summary: Control of cutaneous circulation is crucial for thermoregulation in CSCI individuals. The study found that the vasoconstrictor responsiveness and neural functions of the cutaneous vasoconstrictor system are maintained after CSCI, and dopamine is likely to induce cutaneous vasodilation in the skin.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kenneth R. Olson
Summary: This article discusses the mechanism of oxygen sensing, proposing the metabolism of hydrogen sulfide and polysulfides as a view on oxygen dependence, and compares it with the reactive oxygen species-mediated oxygen sensing mechanism.
Article
Neurosciences
Matthew R. Irwin, Carlos M. Curay, Shinbe Choi, Eugene A. Kiyatkin
Summary: The co-administration of ketamine and xylazine is commonly used for anesthesia in rodent surgical procedures. This mixture provides anesthesia and pain control, as well as potent analgesia. Our study shows that the ketamine-xylazine mixture induces modest brain hyperthermia, increases heat loss due to skin vasodilation, and slightly decreases brain oxygen levels. These effects differ from other general anesthetic drugs.
Article
Peripheral Vascular Disease
Lauren A. Biwer, Brigett V. Carvajal, Qing Lu, Joshua J. Man, Iris Z. Jaffe
Summary: The study showed that deletion of endothelial MR in obese female animals can improve vascular dilation, and endothelial ER alpha plays a positive role in increasing nitric oxide to rescue vasodilation. MR and ER alpha may compete for striatin binding within endothelial cells to regulate NO.
Article
Neurosciences
Sangwon Choi, Ju-Young Lee, Jong Seok Bae, Hong-Ki Song, Ju-Hun Lee, Yerim Kim
Summary: RCVS is a rare disease characterized by reversible multifocal stenosis of cerebral arteries, with unclear pathomechanisms. This reported case linked RCVS to the levonorgestrel-releasing IUS, causing thunderclap headache and multiple arterial stenosis. The potential role of levonorgestrel in vasoconstriction and endothelin-1 elevation may shed light on the mechanisms of RCVS.
Review
Biochemistry & Molecular Biology
Liangliang Liu, Mengting Guo, Xiaowang Lv, Zhiwei Wang, Jigang Yang, Yanting Li, Fan Yu, Xin Wen, Lei Feng, Tingting Zhou
Summary: TRPV4 channels play a crucial role in the vasculature, influencing various aspects such as vascular dilation and constriction, vascular permeability, vascular remodeling, and vascular damage.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Medicine, Research & Experimental
Lei Shen, Michael R. Dashwood, Carlo Casale, Nelson N. Orie, Ian M. Evans, Pratik Sufi, Rosaire Gray, Vidya Mohamed -Ali
Summary: In obese non-diabetic patients, omental adipose tissue (OAT) exhibits higher levels of norepinephrine (NE) concentration, tyrosine hydroxylase (TH) density, angiogenesis and maximal vasoconstriction compared to subcutaneous adipose tissue (SAT). However, OAT arterioles show lower sensitivity to NE and higher collagen deposition. In diabetic patients, NE sensitivity is reduced in SAT arterioles.
