Article
Endocrinology & Metabolism
Jingyi Lu, Chunfang Wang, Jinghao Cai, Yun Shen, Lei Chen, Lei Zhang, Wei Lu, Wei Zhu, Gang Hu, Tian Xia, Jian Zhou
Summary: The relationship between HbA1c and all-cause mortality among patients with type 2 diabetes varies depending on the degree of glycemic variability. In patients with high glycemic variability, HbA1c may not be a robust marker of mortality, suggesting the need for new metrics for better diabetes management in these individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Antonio Ceriello, Giuseppe Lucisano, Francesco Prattichizzo, Rosalba La Grotta, Stefan Franzen, Ann-Marie Svensson, Bjorn Eliasson, Antonio Nicolucci
Summary: HbA1c variability is associated with the development of cardiovascular complications, especially in people within the recommended HbA1c target range. The risk related to HbA1c variability is higher in individuals with a mean HbA1c <= 53 mmol/mol, even if HbA1c remains at the target level during follow-up.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Tzu-En Wu, Yu-Wen Su, Harn-Shen Chen
Summary: This study followed 1869 patients with type 2 diabetes for a median of 9.5 years and found that both mean HbA1c and HbA1c variability were associated with diabetes-related complications. Mean HbA1c was more effective at predicting retinopathy, while HbA1c variability was more effective at predicting deterioration of renal function and increased mortality.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Marcus Lind, Henrik Imberg, Ruth L. Coleman, Olle Nerman, Rury R. Holman
Summary: The glycemic legacy effects in type 2 diabetes are largely explained by historical HbA(1c) values having a greater impact than recent values on clinical outcomes. Early detection and intensive glucose control from the time of diagnosis are essential to maximize reduction of long-term glycemic complications.
Article
Public, Environmental & Occupational Health
Kosuke Inoue, Roch Nianogo, Donatello Telesca, Atsushi Goto, Vahe Khachadourian, Yusuke Tsugawa, Takehiro Sugiyama, Elizabeth Rose Mayeda, Beate Ritz
Summary: This study found that low HbA1c levels were associated with increased risk of all-cause mortality among individuals without diabetes, while not being associated with cardiovascular mortality risk. The research also indicated that diabetes patients had a higher risk of all-cause mortality.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Endocrinology & Metabolism
Regina Prigge, Sarah H. Wild, Caroline A. Jackson
Summary: This study investigated the mortality risks among participants with diabetes, depression, or both in a large cohort study in the UK. The results showed that individuals with both depression and diabetes had the highest risk of all-cause mortality, particularly from cancer and non-circulatory diseases.
Review
Nutrition & Dietetics
Faina Wehrli, Petek E. Taneri, Arjola Bano, Lia Bally, Lauren C. Blekkenhorst, Weston Bussler, Brandon Metzger, Beatrice Minder, Marija Glisic, Taulant Muka, Hua Kern
Summary: The consumption of oats may reduce the risk of type 2 diabetes and all-cause mortality. However, there is no significant association between oat consumption and cardiovascular disease. Future studies should focus on standardizing methods for assessing oat intake and investigating the dose-dependent response of oat products on cardiometabolic outcomes.
Article
Endocrinology & Metabolism
Yuan Zhang, Rongrong Yang, Yabing Hou, Yanchun Chen, Shu Li, Yaogang Wang, Hongxi Yang
Summary: This study assessed the impact of healthy cardiovascular health (CVH) on complications, mortality, and life expectancy in individuals with type 2 diabetes. It found that favorable CVH was associated with a reduced risk of complications and mortality, as well as a longer life expectancy. Inflammatory processes may mediate these associations.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Endocrinology & Metabolism
Jinghao Cai, Qing Yang, Jingyi Lu, Yun Shen, Chunfang Wang, Lei Chen, Lei Zhang, Wei Lu, Wei Zhu, Tian Xia, Jian Zhou
Summary: This study found that lower complexity of glucose time series is associated with an increased risk of all-cause mortality among well-controlled type 2 diabetes patients. The complexity of glucose time series index (CGI) may serve as a novel marker for assessing residual risk of death in these patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Cardiac & Cardiovascular Systems
Antonio Ceriello, Francesco Prattichizzo
Summary: Studies suggest that variability of risk factors such as blood pressure, plasma lipids, and weight may play a role in diabetes complications, with potential additive effects. While causality of variability is uncertain, monitoring risk factor variability in clinical practice could improve quality of care.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Endocrinology & Metabolism
Maria Giovanna Scarale, Mario Mastroianno, Cornelia Prehn, Massimiliano Copetti, Lucia Salvemini, Jerzy Adamski, Salvatore De Cosmo, Vincenzo Trischitta, Claudia Menzaghi
Summary: This study investigated the association between serum metabolites and all-cause mortality in type 2 diabetes. Hexanoylcarnitine, kynurenine, and tryptophan were found to be significantly associated with mortality. The kynurenine-to-tryptophan ratio (KTR) mediated the association between the antiatherogenic interleukin (IL) 13 and mortality. Adding these three metabolites improved the accuracy and classification of mortality prediction models.
Article
Nutrition & Dietetics
Shamima Akter, Tetsuya Mizoue, Akiko Nanri, Atsushi Goto, Mitsuhiko Noda, Norie Sawada, Taiki Yamaji, Motoki Iwasaki, Manami Inoue, Shoichiro Tsugane
Summary: The study found a U-shaped association between low-carbohydrate diet (LCD) score and total mortality among Asians, with high animal protein and fat in LCD associated with higher mortality risk. Conversely, a LCD high in plant-based sources of protein and fat was associated with a lower risk of total and cardiovascular mortality.
CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Chiu-Shong Liu, Chia-Ing Li, Mu-Cyun Wang, Sing-Yu Yang, Tsai-Chung Li, Cheng-Chieh Lin
Summary: The study developed and validated risk score systems for patients with type 2 diabetes by examining the effects of glycaemic and blood pressure variabilities on mortality. The prediction models showed good accuracy for both cardiovascular-specific and all-cause mortalities, indicating the importance of considering these variabilities in risk assessment.
DIABETES OBESITY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Jiao Wang, Yunliang Tang, Ying Liu, Wei Cai, Jixiong Xu
Summary: This study found a significant correlation between serum methylmalonic acid (MMA) levels and all-cause and cause-specific deaths in individuals with diabetes. Higher serum MMA levels were associated with higher all-cause, cardiovascular disease (CVD), and cancer mortality rates.
FRONTIERS IN NUTRITION
(2022)
Review
Nutrition & Dietetics
Shuting Li, Leying Hou, Siyu Zhu, Qian Yi, Wen Liu, Yang Zhao, Feitong Wu, Xue Li, An Pan, Peige Song
Summary: No consensus has been reached on the associations of lipid variability with cardiovascular diseases and all-cause mortality. This study found that variability in total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol is associated with an increased risk of cardiovascular diseases and all-cause mortality. The relationship between triglyceride variability and risk is inconclusive. These findings suggest that measuring and monitoring lipid variability could have important clinical implications for risk assessment of cardiovascular diseases and all-cause mortality.
Meeting Abstract
Endocrinology & Metabolism
Valeria Grancini, Laura L. Porcaro, Alessia Gaglio, Veronica Resi, Emanuela Orsi
Article
Medicine, General & Internal
Guido Bocci, Paola Orlandi, Maria Laura Manca, Chiara Rossi, Antonio Salvati, Maurizia Rossana Brunetto, Anna Solini
Summary: This study found that circulating biomarker profiles can predict the severity of chronic liver disease of NAFLD/NASH or HCV origin. In HCV patients, there was an inverse correlation between disease stage and circulating levels of BMP-9 and VEGF-A, while in NASH/NAFLD, direct correlations between stage and BMP-9 and VEGF-A circulating levels were observed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Luca Sacchetta, Martina Chiriaco, Lorenzo Nesti, Simone Leonetti, Giovanna Forotti, Andrea Natali, Anna Solini, Domenico Trico
Summary: This study demonstrates the long-term impact of diabetic microvascular complications (MVC) on all-cause mortality in diabetes patients and reveals the varying effects of different combinations of MVC on mortality risk.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Emanuela Orsi, Anna Solini, Giuseppe Penno, Enzo Bonora, Cecilia Fondelli, Roberto Trevisan, Monica Vedovato, Franco Cavalot, Olga Lamacchia, Jonida Haxhi, Antonio Nicolucci, Giuseppe Pugliese
Summary: This study investigated the relationship between BMI and central adiposity surrogate measures with all-cause mortality in individuals with type 2 diabetes. The results showed that mildly and moderately obese individuals had a lower risk of mortality compared to normal-weight individuals, while severely obese individuals had a higher risk. The relationship between BMI and mortality did not change after adjusting for smoking, physical activity, and comorbidities. Additionally, central adiposity measures such as waist circumference, waist-to-height ratio, and A Body Shape Index were found to be associated with mortality risk.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Enzo Bonora
Summary: A large number of meta-analyses and reviews are published in scientific journals, which may be due to the preferences of editors and publishers for these types of papers that are frequently cited and can increase the impact factor of their journals. However, relying too heavily on meta-analyses and reviews can have a negative impact on the intellectual growth of investigators, particularly early career researchers, who may neglect original research in favor of these types of papers. While meta-analyses and reviews are valuable for emphasizing data and disseminating concepts, progress in science requires original ideas, experiments, and papers. 'Analysts' and 'novelists' are welcome, but 'scientists' are indispensable.
Article
Endocrinology & Metabolism
E. Biancalana, G. Petralli, F. Raggi, Mr Distaso, G. Piazza, C. Rossi, D. Trico, A. Solini
Summary: This study examined the role of patient phenotype prior to treatment in determining the kidney response to SGLT2 inhibitors and GLP1 receptor agonists in type 2 diabetes patients. The results showed that patients with a faster decline in eGFR were more likely to benefit from treatment with SGLT2 inhibitors.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Emanuela Orsi, Anna Solini, Enzo Bonora, Martina Vitale, Monia Garofolo, Cecilia Fondelli, Roberto Trevisan, Monica Vedovato, Franco Cavalot, Gianpaolo Zerbini, Antonio Nicolucci, Giuseppe Pugliese
Summary: The presence and grade of diabetic retinopathy (DR) can predict all-cause mortality in individuals with type 2 diabetes mellitus, independent of cardiovascular disease (CVD) and other complications. The risk of death is higher in patients with advanced DR, especially proliferative DR. However, the impact of DR is more significant in patients without diabetic kidney disease (DKD) or CVD.
DIABETES & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Diego Moriconi, Luca Sacchetta, Martina Chiriaco, Lorenzo Nesti, Giovanna Forotti, Andrea Natali, Anna Solini, Domenico Trico
Summary: This study evaluated the prognostic value of glomerular hyperfiltration in predicting long-term kidney-related outcomes and mortality in patients with diabetes. The analysis of 21-year longitudinal data showed that glomerular hyperfiltration is associated with worse kidney function and increased risk of mortality from cardiovascular or renal causes. Active screening of these patients is recommended for better risk stratification and treatment of subclinical kidney disease.
Letter
Endocrinology & Metabolism
Enzo Bonora
Article
Endocrinology & Metabolism
Edoardo Biancalana, Chiara Rossi, Francesco Raggi, Mariarosaria Distaso, Domenico Trico, Simona Baldi, Ele Ferrannini, Anna Solini
Summary: This study aimed to investigate the involvement of NHE3 in modulating the response to sodium glucose co-transporter-2 inhibitors in humans. The results showed that empagliflozin acutely increased urinary pH and induced a substrate shift toward lipid utilization and ketogenesis in healthy young male volunteers, without significant changes in renal NHE3 protein expression.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Cristina Bianchi, Olga Vaccaro, Mariarosaria Distaso, Laura Franzini, Francesco Raggi, Anna Solini
Summary: MG53 is not associated with cardiovascular risk profile or long-term mortality in Caucasian individuals with T2D.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Giovanni Petralli, Antonio Salvati, Domenico Trico, Gabriele Ricco, Piero Colombatto, Maurizia Rossana Brunetto, Anna Solini
Summary: Insulin resistance is independently associated with non-invasive markers of MAFLD severity in overweight/obese individuals, and this relationship is largely mediated by hyperinsulinemia.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Endocrinology & Metabolism
Anna Solini, Domenico Trico, Stefano Del Prato
Summary: Major cardiovascular outcome trials and real-life observations have shown that GLP-1 receptor agonists (GLP-1RAs) provide clinically relevant cardiovascular protection regardless of GLP-1 homology. GLP-1RAs offer cardioprotective benefits through various mechanisms, including improved insulin secretion and action, weight loss, reduced blood pressure, improved lipid profile, as well as direct effects on the heart and vasculature. The available evidence has led professional and medical societies to recommend GLP-1RAs for reducing cardiovascular risk in people with type 2 diabetes.
Review
Medicine, General & Internal
Johanna Paivarinta, Ioanna A. A. Anastasiou, Niina Koivuviita, Kanishka Sharma, Pirjo Nuutila, Ele Ferrannini, Anna Solini, Eleni Rebelos
Summary: Thanks to medical imaging technology, the study of renal anatomy and physiology has advanced. However, difficulties in studying the metabolism and vasculature of the human kidney have limited research in these areas. This review provides an overview of recent findings on renal perfusion, oxygenation, and substrate uptake. The use of PET and fMRI has allowed for the evaluation of renal perfusion and the effects of therapeutic agents on kidney hemodynamics. Despite limited studies, these imaging modalities offer promising prospects for understanding renal pathophysiology in various diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sara Dule, Ilaria Barchetta, Flavia Agata Cimini, Giulia Passarella, Arianna Dellanno, Tiziana Filardi, Vittorio Venditti, Enrico Bleve, Diego Bailetti, Elisabetta Romagnoli, Susanna Morano, Marco Giorgio Baroni, Maria Gisella Cavallo
Summary: Type 2 diabetes mellitus is associated with increased fracture risk. This study aimed to explore differences in bone alterations between women with type 2 diabetes and controls, and to identify clinical predictors of bone impairment in type 2 diabetes. The results showed that type 2 diabetes patients had a lower normal bone category and their bone status was correlated with high-density lipoprotein cholesterol and vitamin D levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
