Article
Endocrinology & Metabolism
Kohei Kaku, Takashi Kadowaki, Yutaka Seino, Taro Okamoto, Masayoshi Shirakawa, Asako Sato, Edward A. O'Neill, Samuel S. Engel, Keith D. Kaufman
Summary: Adding ipragliflozin 50 mg once daily to sitagliptin 50 mg once daily monotherapy significantly improved glycemic control and was generally well tolerated in Japanese patients with type 2 diabetes.
DIABETES OBESITY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Raffaele Marfella, Celestino Sardu, Nunzia D'Onofrio, Francesco Prattichizzo, Lucia Scisciola, Vincenzo Messina, Rosalba La Grotta, Maria Luisa Balestrieri, Paolo Maggi, Claudio Napoli, Antonio Ceriello, Giuseppe Paolisso
Summary: This study finds that patients with poorly controlled type 2 diabetes have a weakened response to the COVID-19 vaccine and are more susceptible to breakthrough infections. In addition to glycemic control, smoking and gender are also associated with the risk of infection.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Roderick C. Slieker, Louise A. Donnelly, Elina Akalestou, Livia Lopez-Noriega, Rana Melhem, Aysim Gunes, Frederic Abou Azar, Alexander Efanov, Eleni Georgiadou, Hermine Muniangi-Muhitu, Mahsa Sheikh, Giuseppe N. Giordano, Mikael Akerlund, Emma Ahlqvist, Ashfaq Ali, Karina Banasik, Soren Brunak, Marko Barovic, Gerard A. Bouland, Frederic Burdet, Mickael Canouil, Iulian Dragan, Petra J. M. Elders, Celine Fernandez, Andreas Festa, Hugo Fitipaldi, Phillippe Froguel, Valborg Gudmundsdottir, Vilmundur Gudnason, Mathias J. Gerl, Amber A. van der Heijden, Lori L. Jennings, Michael K. Hansen, Min Kim, Isabelle Leclerc, Christian Klose, Dmitry Kuznetsov, Dina Mansour Aly, Florence Mehl, Diana Marek, Olle Melander, Anne Niknejad, Filip Ottosson, Imre Pavo, Kevin Duffin, Samreen K. Syed, Janice L. Shaw, Over Cabrera, Timothy J. Pullen, Kai Simons, Michele Solimena, Tommi Suvitaival, Asger Wretlind, Peter Rossing, Valeriya Lyssenko, Cristina Legido Quigley, Leif Groop, Bernard Thorens, Paul W. Franks, Gareth E. Lim, Jennifer Estall, Mark Ibberson, Joline W. J. Beulens, Leen M't Hart, Ewan R. Pearson, Guy A. Rutter
Summary: We identified biomarkers for disease progression in type 2 diabetes cohorts, including metabolites, lipids, and proteins. Various substances such as homocitrulline, isoleucine, 2-aminoadipic acid, triacylglycerol species, and sphingomyelin 42:2;2 levels were found to predict faster progression towards insulin requirement. Proteins like GDF15/MIC-1, IL-18Ra, CRELD1, NogoR, FAS, and ENPP7 were associated with faster progression, while others like SMAC/DIABLO, SPOCK1, and HEMK2 predicted slower progression rates. The findings also suggested possible disease mechanisms and potential therapeutic avenues to slow diabetes progression.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Yutaka Seino, Kohei Kaku, Takashi Kadowaki, Taro Okamoto, Asako Sato, Masayoshi Shirakawa, Edward A. O'Neill, Samuel S. Engel, Keith D. Kaufman
Summary: In Japanese patients with type 2 diabetes, adding sitagliptin to ipragliflozin monotherapy provided significant improvement in glycemic control and was generally well tolerated.
DIABETES OBESITY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Anca Balintescu, Marcus Lind, Mikael Andersson Franko, Anders Oldner, Maria Cronhjort, Bjorn Eliasson, Christer Svensen, Johan Martensson
Summary: This study found an association between glycated haemoglobin (HbA1c) and sepsis in adults with type 1 diabetes, and explored the relationship between HbA1c and mortality among individuals who developed sepsis. It revealed a J-shaped relationship between HbA1c and sepsis risk, with the lowest risk observed at HbA1c levels about 53 mmol/mol (7.0%). HbA1c was not associated with mortality in individuals affected by sepsis.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Michael Sampson, Allan Clark, Max Bachmann, Nikki Garner, Lisa Irvine, Amanda Howe, Colin Greaves, Sara Auckland, Jane Smith, Jeremy Turner, Dave Rea, Gerry Rayman, Ketan Dhatariya, W. Garry John, Garry Barton, Rebecca Usher, Clare Ferns, Melanie Pascale
Summary: The study showed that the NDPS lifestyle intervention significantly improved glycemic control in people with newly diagnosed screen-detected type 2 diabetes when supported by trained peer mentors with type 2 diabetes, especially in those receiving oral hypoglycemic medication and those under 65 years old. The effect size was modest and not sustained after 24 months.
Article
Endocrinology & Metabolism
Edward B. Jude, Carlos Trescoli, Rifat Emral, Amar Ali, Robert Lubwama, Karen Palmer, Alka Shaunik, Nithya Nanda, Philip Raskin, Fernando Gomez-Peralta
Summary: The study aimed to investigate the effectiveness of premixed insulin in achieving glycaemic outcomes in clinical practice in the UK. Results showed that while there was some initial effectiveness in controlling blood sugar levels in patients with uncontrolled type 2 diabetes, the long-term clinical benefits were limited. Therefore, early and timely treatment changes with more effective and simpler therapies may be necessary for patients with poor blood glucose control.
DIABETES OBESITY & METABOLISM
(2021)
Article
Rheumatology
Dawit T. Zemedikun, Krishna Gokhale, Joht Singh Chandan, Jennifer Cooper, Janet M. Lord, Andrew Filer, Marie Falahee, Krishnarajah Nirantharakumar, Karim Raza
Summary: Patients with type 2 diabetes mellitus have a reduced risk of developing rheumatoid arthritis, which may be attributed to the use of statins.
Review
Pharmacology & Pharmacy
Merlin L. Willcox, Christina Elugbaju, Marwah Al-Anbaki, Mark Lown, Bertrand Graz
Summary: Several medicinal plants have shown to be effective in reducing HbA1c in patients with Type 2 Diabetes, with some showing effects comparable to conventional antidiabetic treatments. Rigorous trials with at least 3 months' follow-up are required to evaluate the effects of promising plant-based preparations on diabetes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Evelyn B. Parr, Nikolai Steventon-Lorenzen, Richard Johnston, Nirav Maniar, Brooke L. Devlin, Karen H. C. Lim, John A. Hawley
Summary: This study aimed to examine the effect of a 5-day, 9-hour time-restricted eating protocol on 24-hour glycemic control in adults with type 2 diabetes. The results showed that time-restricted eating did not affect dietary intake or physical activity, but it reduced the daily eating window and significantly improved glycemic control.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Public, Environmental & Occupational Health
Marwa Alaradi, Asma Ouagueni, Rim Khatib, Grace Attieh, Hiba Bawadi, Zumin Shi
Summary: The study found an inverse association between the modern dietary pattern (high intake of fast food, croissants, white bread and cheese) and poor glycaemic control among Qatari adults with type 2 diabetes. It also highlighted a significant positive association between the modern dietary pattern and poor glycaemic control in men who were not taking diabetes medication. Promoting healthy eating habits, especially among those under diabetes medication, is crucial for maintaining good glycaemic control.
PUBLIC HEALTH NUTRITION
(2021)
Article
Endocrinology & Metabolism
Luca D'Onofrio, Silvia Pieralice, Ernesto Maddaloni, Carmen Mignogna, Sara Sterpetti, Lucia Coraggio, Cecilia Luordi, Gloria Guarisco, Gaetano Leto, Frida Leonetti, Silvia Manfrini, Raffaella Buzzetti
Summary: The study found that the COVID-19 lockdown did not significantly affect glycemic control in T2D patients, but those with poor psychological well-being may experience worsening glycemic control due to lockdown restrictions. These findings could help healthcare providers in managing diabetes after the end of the second wave of COVID-19.
DIABETES OBESITY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Vanita R. Aroda, Robert H. Eckel
Summary: Multiple factors contribute to the development of type 2 diabetes and increase the risk of cardiovascular disease. The contribution of hyperglycemia to cardiovascular events has been debated, but recent studies have shown the cardioprotective effects of certain medications. Individualized glycemic targets are important because intensive therapy might have negative effects on cardiovascular disease.
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Julia De Groot, Dongjun Wu, Declan Flynn, Dylan Robertson, Gary Grant, Jing Sun
Summary: The study evaluated the effects of telemedicine interventions on type 2 diabetes patients, showing significant improvement in HbA1c, blood pressure, blood glucose, weight, and other health outcomes. Subgroup analysis highlighted that interventions with specific characteristics (such as video conferencing, clinical treatment models) and frequencies (such as less than weekly) had the greatest effect on HbA1c reduction.
WORLD JOURNAL OF DIABETES
(2021)
Article
Cardiac & Cardiovascular Systems
Edouard L. Fu, Elisabetta Patorno, Brendan M. Everett, Muthiah Vaduganathan, Scott D. Solomon, Raisa Levin, Sebastian Schneeweiss, Rishi J. Desai
Summary: This study aimed to evaluate the comparative effectiveness of SGLT2i vs. sitagliptin in older adults with HF and type 2 diabetes and found that initiating SGLT2i was associated with a lower risk of the primary composite outcome compared to sitagliptin.
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Timothy M. E. Davis, Peter G. Colman, Charlotte Hespe, Sarah E. Heywood, Michael d'Emden
Summary: This study evaluated whether the clinical management of Australians with type 2 diabetes is in line with recent national and international guidelines. The results suggest that there is room for improvement in cardiovascular disease risk management in Australia.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Endocrinology & Metabolism
Emma J. Hamilton, Wendy A. Davis, Mendel Baba, Timothy M. E. Davis
Summary: This study aimed to determine whether there has been a decline in incident minor and major lower extremity amputations (LEAs) in type 2 diabetes patients in recent decades. The results showed non-significant reductions of approximately 40% in incident minor and major LEA among community-based individuals with type 2 diabetes during the 15 years between FDS Phases. The study identified predictors of minor/major LEAs, which can help inform clinical management.
DIABETES & VASCULAR DISEASE RESEARCH
(2023)
Article
Genetics & Heredity
Fang Chen, Xingyan Wang, Seon-Kyeong Jang, Bryan C. Quach, J. Dylan Weissenkampen, Chachrit Khunsriraksakul, Lina Yang, Renan Sauteraud, Christine M. Albert, Nicholette D. D. Allred, Donna K. Arnett, Allison E. Ashley-Koch, Kathleen C. Barnes, R. Graham Barr, Diane M. Becker, Lawrence F. Bielak, Joshua C. Bis, John Blangero, Meher Preethi Boorgula, Daniel Chasman, Sameer Chavan, Yii-Der Chen, Lee-Ming Chuang, Adolfo Correa, Joanne E. Curran, Sean P. David, Lisa de Las Fuentes, Ranjan Deka, Ravindranath Duggirala, Jessica D. Faul, Melanie E. Garrett, Sina A. Gharib, Xiuqing Guo, Michael E. Hall, Nicola L. Hawley, Jiang He, Brian D. Hobbs, John E. Hokanson, Chao A. Hsiung, Shih-Jen Hwang, Thomas M. Hyde, Marguerite R. Irvin, Andrew E. Jaffe, Eric O. Johnson, Robert Kaplan, Sharon L. R. Kardia, Joel D. Kaufman, Tanika N. Kelly, Joel E. Kleinman, Charles Kooperberg, I-Te Lee, Daniel Levy, Sharon M. Lutz, Ani W. Manichaikul, Lisa W. Martin, Olivia Marx, Stephen T. McGarvey, Ryan L. Minster, Matthew Moll, Karine A. Moussa, Take Naseri, Kari E. North, Elizabeth C. Oelsner, Juan M. Peralta, Patricia A. Peyser, Bruce M. Psaty, Nicholas Rafaels, Laura M. Raffield, Muagututi'a Sefuiva Reupena, Stephen S. Rich, Jerome Rotter, David A. Schwartz, Aladdin H. Shadyab, Wayne H-H Sheu, Mario Sims, Jennifer A. Smith, Xiao Sun, Kent D. Taylor, Marilyn J. Telen, Harold Watson, Daniel E. Weeks, David R. Weir, Lisa R. Yanek, Kendra A. Young, Kristin L. Young, Wei Zhao, Dana B. Hancock, Bibo Jiang, Scott Vrieze, Dajiang J. Liu
Summary: Most TWASs conducted so far have focused on European ancestry and lacked diversity. To address this limitation, researchers aggregated GWAS summary statistics, whole-genome sequences, and eQTL data from diverse ancestries. They developed a new approach called TESLA, which integrates eQTL datasets with multi-ancestry GWAS, improving power and identifying more genes associated with tobacco use phenotypes compared to alternative TWAS methods. The study also suggests potential drug repurposing options for treating nicotine addiction.
Letter
Cardiac & Cardiovascular Systems
G. Michael Felker, Rebecca North, Hillary Mulder, W. Schuyler Jones, Kevin J. Anstrom, Mahesh J. Patel, Javed Butler, Justin A. Ezekowitz, Carolyn Lam, Christopher M. O'Connor, Lothar Roessig, Adrian F. Hernandez, Paul W. Armstrong, VICTORIA Study Group
Article
Cardiac & Cardiovascular Systems
Rebecca Shen, Hillary Mulder, Lisa Wruck, E. Hope Weissler, Holly R. Robertson, Amber G. Sharlow, Sunil Kripalani, Daniel Munoz, Mark B. Effron, Kamal Gupta, Saket Girotra, Jeff Whittle, Catherine P. Benziger, Jeffrey J. VanWormer, Tamar S. Polonsky, Russell L. Rothman, Robert A. Harrington, Adrian F. Hernandez, W. Schuyler Jones
Summary: By comparing internet and noninternet/telephone participants in a large remote, pragmatic trial, this study found significant differences in demographic characteristics and baseline health between the two groups. Noninternet participants had poorer clinical outcomes and higher rates of study drug nonadherence. These results suggest that internet-based trials may select for younger, healthier participants, while allowing noninternet participation can enhance diversity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Biochemistry & Molecular Biology
Chin-Feng Hsuan, Sean I. F. Teng, Chih-Neng Hsu, Daniel Liao, Allen Jiun-Wei Chang, Hsiao-Lin Lee, Siow-Wey Hee, Yi-Cheng Chang, Lee-Ming Chuang
Summary: Diabetic cardiomyopathy refers to abnormal myocardial structure or performance in diabetes patients without coronary artery disease or significant valvular heart disease. The disease ranges from subtle changes to heart fibrosis and diastolic dysfunction, eventually leading to heart failure. Currently, there is no specific treatment for this disease except for sodium-glucose transport protein 2 inhibitors and possibly bariatric and metabolic surgery. The molecular mechanisms of diabetic cardiomyopathy include impaired nutrient-sensing signaling, dysregulated autophagy, impaired mitochondrial energetics, altered fuel utilization, oxidative stress, inflammation, and fibrosis. This article summarizes emerging treatments targeting specific molecular mechanisms, supported by preclinical studies and clinical trials.
Letter
Endocrinology & Metabolism
Timothy M. E. Davis, Sharon Maxwell, Cathy Chan, Helen I. Keen, Wendy A. Davis
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Timothy M. E. Davis, Wendy Davis
Summary: This study examines the relationship between glycaemia and treatment complexity in type 2 diabetes patients and finds that diabetes duration has an impact on glycemic and treatment characteristics, which is of great importance for managing the disease.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Timothy M. E. Davis, Stephen A. P. Chubb, Kirsten E. Peters, Wendy A. Davis
Summary: This study investigated the relationship between metformin therapy and vitamin B12 deficiency in 1492 patients with type 2 diabetes. The results showed that although metformin treatment increased the risk of vitamin B12 deficiency, there was no significant association between vitamin B12 status and neuropathy or anemia.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Endocrinology & Metabolism
Wendy A. Davis, Emma Hamilton, Timothy M. E. Davis
Summary: This study aimed to investigate the temporal changes in the prevalence and incidence rates of distal symmetric polyneuropathy (DSPN) in community-based Australians with type 2 diabetes. The results showed that the prevalence and incidence rates of DSPN varied between different phases, and further research is needed to understand the specific trends and contributing factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Yi-Cheng Chang, Hsiao-Lin Lee, Wenjin Yang, Meng-Lun Hsieh, Cai-Cin Liu, Tung-Yuan Lee, Jing-Yong Huang, Jiun-Yi Nong, Fu-An Li, Hsiao-Li Chuang, Zhi-Zhong Ding, Wei-Lun Su, Li-Yun Chueh, Yi-Ting Tsai, Che-Hong Chen, Daria Mochly-Rosen, Lee-Ming Chuang
Summary: Obesity and type 2 diabetes are global pandemics. Mutations in the ALDH2 gene result in reduced enzymatic activity, leading to metabolic disorders. Activating ALDH2 can improve diet-induced obesity, fatty liver, and glucose homeostasis.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Kathryn Recto, Priyadarshini Kachroo, Tianxiao Huan, David Van Den Berg, Gha Young Lee, Helena Bui, Dong Heon Lee, Jessica Gereige, Chen Yao, Shih-Jen Hwang, Roby Joehanes, George T. O'Cornor, Daniel Levy, Dawn L. DeMeo
Summary: By integrating eQTM and MR analyses in general and clinical asthma populations, our findings provide a deeper understanding of the multidimensional inter-relations of DNA methylation, gene expression, and IgE levels. We identified differentially methylated CpGs associated with IgE levels and replicated them in other populations. We also identified biological pathways related to IgE regulation and proposed CTSB and USP20 as potential therapeutic targets for IgE levels.
Article
Multidisciplinary Sciences
Siow-Wey Hee, Yi-Cheng Chang, Lynn Su, Ing-Jung Chen, Yung-Ming Jeng, Meng-Lun Hsieh, Yu-Chia Chang, Fu-An Li, Daniel Liao, Shiau-Mei Chen, Lee-Ming Chuang
Summary: 15-keto-PGE(2) has been shown to have anti-inflammatory properties by modifying the subunits of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B). In high-fat and high-sucrose diet and non-alcoholic steatohepatitis models, treatment with 15-keto-PGE(2) reduces inflammation and improves liver damage.
Article
Endocrinology & Metabolism
S. A. Paul Chubb, Wendy A. Davis, Timothy M. E. Davis
Summary: The study found that serum bicarbonate concentration below the laboratory reference interval is independently associated with all-cause mortality. Multiple logistic regression analysis was used to determine the independent factors of low baseline serum bicarbonate, and Cox regression model was used to evaluate the association between bicarbonate and mortality. The results showed that low serum bicarbonate is associated with increased mortality, and this association remained significant after adjusting for factors associated with mortality but not low serum bicarbonate.
ACTA DIABETOLOGICA
(2023)
Article
Cell Biology
Chu-Hsuan Chiu, Chin-Feng Hsuan, Shih-Hua Lin, Yi-Jen Hung, Chii-Min Hwu, Siow-Wey Hee, Shu-Wha Lin, Sitt-Wai Fong, Patrick Ching-Ho Hsieh, Wei-Shun Yang, Wei-Chou Lin, Hsiao-Lin Lee, Meng-Lun Hsieh, Wen-Yi Li, Jou-Wei Lin, Chih-Neng Hsu, Vin-Cent Wu, Gwo-Tsann Chuang, Yi-Cheng Chang, Lee-Ming Chuang
Summary: Genetic variants of the RRBP1 gene have been found to be associated with blood pressure variation. Deficiency of RRBP1 can lead to lower blood pressure, hyperkalemia, and sudden cardiac death.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)