Review
Medicine, General & Internal
David G. Armstrong, Tze-Woei Tan, Andrew J. M. Boulton, Sicco A. Bus
Summary: Approximately 18.6 million people worldwide are affected by diabetic foot ulcers each year, with 1.6 million people in the United States. These ulcers precede 80% of lower extremity amputations among people with diabetes and are associated with an increased risk of death.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Rebecca Voelker
Summary: This article describes diabetic foot ulcers and their evaluation and treatment.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Endocrinology & Metabolism
Xuan Wang, Chong-Xi Yuan, Bin Xu, Zhi Yu
Summary: Diabetic foot ulceration is a severe complication of diabetes that requires comprehensive treatment and preventive measures. Classification is the important foundation for clinical diagnosis and management, focusing on common risk factors can help prevent and manage the condition in a timely manner. Preventive education and effective management approaches are equally important.
WORLD JOURNAL OF DIABETES
(2022)
Article
Polymer Science
Dong-Jin Lim, Insoo Jang
Summary: As research progresses, there is potential to improve the treatment of diabetic-related foot ulcers by utilizing oxygen-releasing composites, particularly in enhancing wound oxygenation levels.
Review
Chemistry, Multidisciplinary
Mayland Chang, Trung T. Nguyen
Summary: Diabetic foot ulcers (DFUs) are chronic wounds that affect 30% of diabetic patients, with dysregulation of the normal wound healing process. Infection in DFUs increases inflammation and delays wound healing. Selective inhibition of MMP-9 may be a promising strategy for treatment of DFUs.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Georgios Theocharidis, Beena E. Thomas, Debasree Sarkar, Hope L. Mumme, William J. R. Pilcher, Bhakti Dwivedi, Teresa Sandoval-Schaefer, Ruxandra F. Sirbulescu, Antonios Kafanas, Ikram Mezghani, Peng Wang, Antonio Lobao, Ioannis S. Vlachos, Biraja Dash, Henry C. Hsia, Valerie Horsley, Swati S. Bhasin, Aristidis Veves, Manoj Bhasin
Summary: This study utilizes single-cell RNA sequencing to reveal the distribution of specific populations of fibroblasts and macrophages in diabetic foot ulceration (DFU) patients and identifies their crucial roles in wound healing.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Qian Yu, Guo-hong Qiao, Min Wang, Li Yu, Yaoxiang Sun, Hui Shi, Tie-liang Ma
Summary: Diabetic foot ulcer poses a worldwide challenge in clinical medicine due to the ineffective traditional treatments. Researching the pathogenesis and molecular mechanisms of stem cell therapy for diabetic foot is of great importance in maximizing the repair properties of stem cells. Additionally, effective application modalities are crucial for improving stem cell survival and viability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Dermatology
David Dayya, Owen J. O'Neill, Tania B. Huedo-Medina, Nusrat Habib, Joanna Moore, Kartik Iyer
Summary: Diabetic foot ulcerations can lead to severe complications, and debridement is a common treatment method involving both nonmechanical and mechanical approaches. These methods help promote wound healing and reduce complications.
ADVANCES IN WOUND CARE
(2022)
Article
Biotechnology & Applied Microbiology
Yi Xu, Kang Han, Yongming Zhou, Jian Wu, Xin Xie, Wei Xiang
Summary: Diabetic foot ulcers (DFUs) are common complications of diabetes. Recent advancements in computerized classification based on deep learning methods have shown promising results for identifying infection and ischemia in DFUs. This study proposes the use of class knowledge banks (CKBs) to improve the performance of DFU infection and ischemia classifications by effectively extracting and representing class knowledge.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Health Care Sciences & Services
Alvaro Astasio-Picado, Alba angel Babiano, Miriam Lopez-Sanchez, Rocio Ruiz Lozano, Paula Cobos-Moreno, Beatriz Gomez-Martin
Summary: This article provides evidence on the effectiveness and safety of ozone therapy in the treatment of wounds in patients with diabetic foot. It compares ozone therapy with other treatment methods and presents the findings of a literature review.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Onno A. Mennes, Jaap J. van Netten, Jeff G. van Baal, Riemer H. J. A. Slart, Wiendelt Steenbergen
Summary: This study aimed to investigate the association between microcirculation and healing of diabetic foot ulcers, measured using LSCI and non-invasive blood pressure measurements. The results showed no significant association between healing and either type of measurement, indicating limited predictive ability of current blood pressure measurements or LSCI for diabetic foot ulcer healing.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Danielle Dixon, Michael Edmonds
Summary: Recent evidence-based treatments for diabetic foot ulcers have emerged from multicentre, randomised, controlled trials, highlighting new advances in wound therapy. The overview of current and future pharmacotherapies includes proposed mechanisms of action and supporting evidence for various treatments. Looking forward, novel therapies utilizing nanotechnology and bioactive agents may provide possibilities for pharmacotherapy in the future.
Article
Pharmacology & Pharmacy
Yanling Wang, Bang Liu, Yinzhen Pi, Li Hu, Yeling Yuan, Jiao Luo, Yixiao Tao, Ping Li, Shan Lu, Wei Song
Summary: The purpose of this study was to assess the risk factors for morbidity and mortality of diabetic foot ulcers (DFUs). The study also investigated the effectiveness of negative pressure wound therapy (NPWT) combined with platelet-rich plasma-fibrin glue (PRP) in the treatment of diabetic foot ulcers. They found new risk factors for DFUs and concluded that the combination therapy could accelerate wound healing and reduce mortality rate.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ermelindo Carreira Leal, Eugenia Carvalho
Summary: A diabetic foot ulcer is a major complication of diabetes with impaired wound healing. The enzyme heme oxygenase-1 plays a crucial role in wound healing due to its antioxidant and anti-inflammatory properties, among others. Therapeutic strategies targeting heme oxygenase-1 are important in treating diabetic foot ulcers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Microbiology
Cassandra Pouget, Catherine Dunyach-Remy, Alix Pantel, Adeline Boutet-Dubois, Sophie Schuldiner, Albert Sotto, Jean-Philippe Lavigne, Paul Loubet
Summary: Diabetic foot ulcers present a growing public health issue, with multidrug-resistant bacteria and biofilm formation as complications. New alternative solutions, such as antibiofilm approaches, can help prevent biofilm formation, reduce chronicity of wounds, and enhance the healing process.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Food Science & Technology
Patricia Quezada-Fernandez, Jhonatan Trujillo-Quiros, Sara Pascoe-Gonzalez, Walter A. Trujillo-Rangel, David Cardona-Mueller, Carlos G. Ramos-Becerra, Maricruz Barocio-Pantoja, Mariana Rodriguez-de la Cerda, Esther Nerida Sanchez-Rodriguez, Ernesto G. Cardona-Munoz, Leonel Garcia-Benavides, Fernando Grover-Paez
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2019)
Article
Cell Biology
Simon Quetzalcoatl Rodriguez-Lara, Walter Angel Trujillo-Rangel, Araceli Castillo-Romero, Sylvia Elena Totsuka-Sutto, Teresa Arcelia Garcia-Cobian, Ernesto German Cardona-Munoz, Alejandra Guillermina Miranda-Diaz, Ernesto Javier Ramirez-Lizardo, Leonel Garcia-Benavides
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Endocrinology & Metabolism
Betsabe Contreras-Haro, Sandra Ofelia Hernandez-Gonzalez, Laura Gonzalez-Lopez, Maria Claudia Espinel-Bermudez, Leonel Garcia-Benavides, Edsaul Perez-Guerrero, Maria Luisa Vazquez-Villegas, Jose Antonio Robles-Cervantes, Mario Salazar-Paramo, Diana Mercedes Hernandez-Corona, Arnulfo Hernan Nava-Zavala, Jorge I. Gamez-Nava
DIABETOLOGY & METABOLIC SYNDROME
(2019)
Article
Multidisciplinary Sciences
Adriana Diaz-Rivera, Alejandra Meza-Rios, Victoria Chagoya de Sanchez, Gabriela Velasco-Loyden, Leonel Garcia-Benavides, Luis F. Jave-Suarez, Hugo Christian Monroy-Ramirez, Arturo Santos-Garcia, Juan Armendariz-Borunda, Ana Sandoval-Rodriguez
Article
Medicine, Research & Experimental
Lidia Ariadna Rubio-Chavez, Roberto Carlos Rosales-Gomez, Keren-Hapuc Lilian Rubio-Chavez, Julia Leonila Ramos-Nunez, Teresa Arcelia Garcia-Cobian, Gabriela Camargo-Hernandez, Jose Sanchez-Corona, Susan Andrea Gutierrez-Rubio
METABOLIC SYNDROME AND RELATED DISORDERS
(2020)
Review
Nutrition & Dietetics
Jessica Lucia Barajas-Vega, Abdel Kerim Raffoul-Orozco, Diego Hernandez-Molina, Ana Elisa Avila-Gonzalez, Teresa Arcelia Garcia-Cobian, Edy David Rubio-Arellano, Ernesto Javier Ramirez-Lizardo
Summary: Naringin has been found to have positive effects on body weight, BMI, lipid profile, and adiponectin levels in patients with dyslipidemia, making it a potential therapeutic agent for the management of metabolic disorders.
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Oscar A. Newton-Sanchez, Valery Melnikov, Arnulfo H. Nava-Zavala, Maria G. Zavala-Cerna, Carmen Guzman-Bracho, Ivan Delgado-Enciso, Fabian Rojas-Larios, Abril B. Martinez-Rizo, Uriel A. Lopez-Lemus, Francisco Espinoza-Gomez
VECTOR-BORNE AND ZOONOTIC DISEASES
(2020)
Article
Chemistry, Medicinal
Sara Pascoe-Gonzalez, Maria Guadalupe Ramos-Zavala, Miguel Angel Buenrostro Ahued, Sandra Ofelia Hernandez-Gonzalez, Ernesto German Cardona-Munoz, Leonel Garcia-Benavides, Fernando Grover-Paez
Summary: This study shows that the herbarium mixture (G. ulmifolia/T. stans) improved the glycemic profile in patients with T2DM.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Endocrinology & Metabolism
J. Aguayo-Ruiz, T. A. Garcia-Cobian, S. Pascoe-Gonzalez, S. Sanchez-Enriquez, I. M. Llamas-Covarrubias, T. Garcia-Iglesias, A. Lopez-Quintero, M. A. Llamas-Covarrubias, J. Trujillo-Quiroz, E. A. Rivera-Leon
DIABETOLOGY & METABOLIC SYNDROME
(2020)
Article
Multidisciplinary Sciences
Homero Contreras-Salinas, Alejandra Meza-Rios, Jesus Garcia-Banuelos, Ana Sandoval-Rodriguez, Laura Sanchez-Orozco, Leonel Garcia-Benavides, Ricardo De la Rosa-Bibiano, Hugo Christian Monroy Ramirez, Jorge Gutierrez-Cuevas, Arturo Santos-Garcia, Juan Armendariz-Borunda
Article
Endocrinology & Metabolism
Jorge Barrera-Alcocer, Leonel Garcia-Benavides, Jose F. Munoz-Valle, Ulises de la Cruz-Mosso, Ramon A. Gonzalez, Sonia Luquin, Luz del C. Alarcon-Romero, Linda A. Marino-Ortega, Ines Matia-Garcia, Isela Parra-Rojas
Summary: The study identified the presence of HAd36 DNA in adipose tissue of women undergoing weight reduction surgery in 31% of the samples, however, it was not significantly associated with changes in adipocyte morphology, or the expression of C/EBP beta and HIF-1 alpha. Further research is needed to confirm these findings.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
M. Pena-Rodriguez, N. Vega-Magana, Leonel Garcia-Benavides, J. S. Zepeda-Nuno, G. Y. Gutierrez-Silerio, L. A. Gonzalez-Hernandez, J. F. Andrade-Villanueva, S. Del Toro-Arreola, A. L. Pereira-Suarez, M. R. Bueno-Topete
Summary: The study showed that butyrate effectively regulates inflammatory response, tight junction protein expression, and limits bacterial diversity loss in cirrhosis patients. This research suggests that butyrate could be an interesting postbiotic metabolomic intervention for intestinal epithelium dysfunction in liver disease.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Review
Cell Biology
Walter Angel Trujillo-Rangel, Leonel Garcia-Valdes, Miriam Mendez-del Villar, Rolando Castaneda-Arellano, Sylvia Elena Totsuka-Sutto, Leonel Garcia-Benavides
Summary: Ischemia-reperfusion (I-R) injury, caused by restoring blood flow to ischemic tissues or organs, involves various signaling pathways and molecular targets. These discoveries are important as they help reduce oxidative stress-induced damage and play a crucial role in resolving I-R.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Urology & Nephrology
Jonathan S. Chavez-Iniguez, Jorge L. Poo, Miguel Ibarra-Estrada, Leonel Garcia-Benavides, Guillermo Navarro-Blackaller, Cynthia Cervantes-Sanchez, Eduardo Nungaray-Pacheco, Ramon Medina-Gonzalez, Juan Armendariz-Borunda, Guillermo Garcia-Garcia
Summary: In patients with septic acute kidney injury (sAKI), prolonged-release pirfenidone (PR-PFD) did not improve the clinical course of sAKI and appeared to be safe in terms of adverse events.
INTERNATIONAL JOURNAL OF NEPHROLOGY
(2021)
Article
Medicine, Research & Experimental
Natali Vega-Magana, Antonio Galiana, Luis Felipe Jave-Suarez, Leonel Garcia-Benavides, Susana del Toro-Arreola, Jaime Federico Andrade-Villanueva, Luz Alicia Gonzalez-Hernandez, Rosa Cremades, Adriana Aguilar-Lemarroy, Maria Guadalupe Flores-Miramontes, Jesse Haramati, Jesus Meza-Arroyo, Miriam Ruth Bueno-Topete
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2020)