期刊
DEVELOPMENTAL CELL
卷 44, 期 6, 页码 741-+出版社
CELL PRESS
DOI: 10.1016/j.devcel.2018.02.017
关键词
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资金
- Japan Agency for Medical Research and Development (AMED) through AMED-CREST [JP17gm0610004]
- AMED-Project for Elucidating and Controlling Mechanisms of Aging and Longevity [JP17gm5010001]
- Japan Society for the Promotion of Science [15K14949, 23229001, 16H06385]
The intestine has direct contact with nutritional information. The mechanisms by which particular dietary molecules affect intestinal homeostasis are not fully understood. In this study, we identified S-adenosylmethionine (SAM), a universal methyl donor synthesized from dietary methionine, as a critical molecule that regulates stem cell division in Drosophila midgut. Depletion of either dietary methionine or SAM synthesis reduces division rate of intestinal stem cells. Genetic screening for putative SAM-dependent methyltransferases has identified protein synthesis as a regulator of the stem cells, partially through a unique diphthamide modification on eukaryotic elongation factor 2. In contrast, SAM in nutrient-absorptive enterocytes controls the interleukin-6-like protein Unpaired 3, which is required for rapid division of the stem cells after refeeding. Our study sheds light upon a link between diet and intestinal homeostasis and highlights the key metabolite SAM as a mediator of cell-type-specific starvation response.
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