Article
Developmental Biology
Aliia Murtazina, Igor Adameyko
Summary: The peripheral nervous system is a heterogeneous system with diverse functions, including communication between the brain and the body, control of development and regeneration. It can be divided into sensory, motor, autonomic and enteric domains. Recent advances in single-cell transcriptomics have revealed new neuronal subtypes and improved cell-type classifications. This article discusses the roles, origin and heterogeneity of the peripheral nervous system, highlighting recent discoveries and future perspectives.
Review
Neurosciences
Artem Sinegubov, Daria Andreeva, Nikita Burzak, Maria Vasyutina, Lada Murashova, Vyacheslav Dyachuk
Summary: This review highlights the heterogeneity of peripheral glial cell populations, covering the origin of the first glial precursors from neural crest cells to the diversity of embryonic glia and adult glial populations. The communication of glial cells with axons of neurons and potential therapeutic strategies for neurodiseases are also discussed.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Werend Boesmans, Amelia Nash, Kinga R. Tasnady, Wendy Yang, Lincon A. Stamp, Marlene M. Hao
Summary: Enteric glia are support cells of the enteric nervous system that play a vital role in regulating gut functions and maintaining homeostasis. Their plasticity and heterogeneity make them neural precursors with the potential for neurogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Yan Li, Zhenghang Cheng, Fanhui Yu, Qi Zhang, Shu Yu, Fei Ding, Qianru He
Summary: The study demonstrates the differential effects of peripheral nerve fibroblasts and cardiac fibroblasts on Schwann cells, with peripheral nerve fibroblasts significantly promoting Schwann cell proliferation and migration. Cytokine array analysis identified differentially expressed proteins between peripheral nerve fibroblasts and cardiac fibroblasts, with activin A being the protein with the greatest differential expression. In vitro experiments confirmed that activin A secreted from nerve fibroblasts is responsible for boosting proliferation and migration of Schwann cells through specific signaling pathways.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Robert T. Flemmer, Sarah P. Connolly, Brittany A. Geizer, Joseph T. Opferman, Jacqueline L. Vanderluit
Summary: Mcl-1 plays a crucial role in promoting neural precursor cell survival by inhibiting the activation of Bax during development, although there are other pro-apoptotic targets. Co-deletion of Bax and Mcl-1 can rescue most NPC apoptosis but may lead to embryonic lethality.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
So-Young Chang, Min Young Lee
Summary: Photobiomodulation (PBM) is a therapeutic method that uses light energy to regulate biological processes, and it has potential applications in neural regeneration and the treatment of neural degenerative disorders. By promoting cell differentiation, PBM can enhance the regenerative capacity of the nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Eraqi R. Khannoon, Christian Alvarado, Rafael Poveda, Maria Elena de Bellard
Summary: The neural crest is a stem cell population that forms in the neurectoderm of all vertebrates and gives rise to a diverse set of cells such as sensory neurons, Schwann cells and melanocytes. Neural crest development in snakes is still poorly understood. The aim of the study was to characterize how trunk neural crest cells (TNCC) migrate in the developing elapid snake Naja haje haje and consequently, look at the beginnings of development of neural crest derived sensory ganglia (DRG) and spinal nerves. We found that trunk neural crest and DRG development in Naja haje haje is like what has been described in other vertebrates and the colubrid snake strengthening our knowledge on the conserved mechanisms of neural crest development across species.
Article
Materials Science, Multidisciplinary
Sunghee Estelle Park, Jinchul Ahn, Hyo-Eun Jeong, Inchan Youn, Dongeun Huh, Seok Chung
Summary: The study presented an in vitro model of the peripheral nervous system (PNS) by establishing a coculture model of motor neurons (MNs) and Schwann cells (SCs) in a 3D extracellular matrix hydrogel scaffold. The model successfully reproduced myelination process in the PNS and demonstrated the potential to manipulate myelination and demyelination processes in motor neuron diseases.
NPG ASIA MATERIALS
(2021)
Article
Clinical Neurology
Simon Rinaldi, Alexander Davies, Janev Fehmi, Heidi N. Beadnall, Justine Wang, Todd A. Hardy, Michael H. Barnett, Simon A. Broadley, Patrick Waters, Stephen W. Reddel, Sarosh R. Irani, Fabienne Brilot, Russell C. Dale, Sudarshini Ramanathan
Summary: Antibodies to myelin oligodendrocyte glycoprotein (MOG) are associated with CNS demyelination including optic neuritis and transverse myelitis. The study of an Australasian MOGAD cohort revealed a subgroup possibly mediated by coexistent autoantibodies, presenting with myeloradiculitis, combined central and peripheral demyelination syndromes, and inflammatory neuropathies, being responsive to immunotherapy.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Cell & Tissue Engineering
Kenyi Saito-Diaz, Jonathan Roy Street, Heidi Ulrichs, Nadja Zeltner
Summary: This study presents a chemically defined differentiation protocol that successfully generates three subtypes of peripheral sensory neurons from human pluripotent stem cells, with methods to enhance the purity of each subtype. The resulting cultures are responsive to stimuli and electrically active, enabling modeling of human neurologic disorders and study of human development.
Review
Neurosciences
Chengxiao Ma, Wen Zhang, Maohong Cao
Summary: While most studies on Parkinson's disease have focused on the central nervous system, recent research has highlighted the importance of the peripheral nervous system, particularly in understanding non-motor symptoms associated with the disease. Abnormalities in alpha-synuclein deposition and neuroinflammation in the PNS have been identified, leading to potential implications for clinical diagnosis and treatment of PD.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Cell Biology
Yuuki Shikaya, Yuta Takase, Ryosuke Tadokoro, Ryo Nakamura, Masafumi Inaba, Yoshiko Takahashi
Summary: Gut peristaltic movements are crucial for effective transportation and digestion/absorption of ingested materials. The cellular functions underlying these movements along the gut axis during development are largely unexplored. By studying chicken embryonic gut, we found that peristaltic movements start from the posterior duodenum and become confined to specific regions during development. Manipulations of the enteric nervous system disrupted the distribution patterns of peristaltic waves and affected the transportation of ingested material. We also discovered a functional coupling between the hindgut and cloaca.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Neurosciences
Qing Min, David B. Parkinson, Xin-Peng Dun
Summary: Schwann cells in the peripheral nervous system have the ability to promote repair of various tissues, including nerve gaps, skin wounds, digit tips, and tooth regeneration. They are highly motile, secrete signaling molecules, attract macrophages, support neuronal survival, promote axonal regrowth, and interact with other cell types in the regeneration process. The migration of Schwann cells is essential for successful tissue repair, especially in cases of peripheral nerve transection injuries where the cells form cords to guide axon regeneration. Understanding the molecular mechanisms of Schwann cell migration may lead to new therapeutic strategies for peripheral nerve repair.
Article
Biochemistry & Molecular Biology
Leah C. Ott, Christopher Y. Han, Jessica L. Mueller, Ahmed A. Rahman, Ryo Hotta, Allan M. Goldstein, Rhian Stavely
Summary: Neurons and glia of the peripheral nervous system are derived from progenitor cell populations originating from embryonic neural crest, and these cells have previously been shown to possess neural stem cell qualities. In this study, a population of neural crest-derived Schwann cells residing in the bone marrow, in association with nerve fibers, were found to exhibit plasticity and generate neural stem cells with neurogenic potential. These cells can form neural networks within the enteric nervous system following transplantation, making them a novel source of autologous neural stem cells for the treatment of neurointestinal disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Richard A. Guyer, Jessica L. Mueller, Allan M. Goldstein
Summary: With the advancement of technology, single-cell sequencing has become a common tool to analyze cellular diversity and reveal cellular diversity within organs. The application of these methods in the study of the enteric nervous system has provided abundant data and biological insights. As technology continues to evolve, these methods may become commonplace in enteric nervous system research and diagnostic testing.
Article
Microbiology
Lucia M. Mendoza, Guillermo A. Vega-Lopez, Miguel Fernandez de Ullivarri, Raul R. Raya
ARCHIVES OF MICROBIOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Silvana Carolina Vinarta, Maria Virginia Angelicola, Carina Van Nieuwenhove, Manuel Javier Aybar, Lucia Ines Castellanos de Figueroa
BIOTECHNOLOGY LETTERS
(2020)
Article
Biotechnology & Applied Microbiology
D. Daniela Maza, Silvana C. Vinarta, Ying Su, Jose Manuel Guillamon, Manuel J. Aybar
JOURNAL OF BIOTECHNOLOGY
(2020)
Review
Developmental Biology
Santiago Cerrizuela, Guillermo A. Vega-Lopez, Manuel J. Aybar
BIRTH DEFECTS RESEARCH
(2020)
Review
Cell Biology
Karla Mendez-Maldonado, Guillermo A. Vega-Lopez, Manuel J. Aybar, Ivan Velasco
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Gabriela C. Somaini, Manuel J. Aybar, Nancy R. Vera, Celeste Tribulo
Summary: The study found that Geoffroea decorticans extracts can regulate embryonic development signaling pathway, reduce beta-catenin levels, inhibit cancer cell growth, and may have anticancer effects.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
D. Daniela Maza, Silvana C. Vinarta, Estefani Garcia-Rios, Jose M. Guillamon, Manuel J. Aybar
Summary: Single cell oils are a promising source of oils for various industrial applications, offering advantages such as circumventing the food vs. fuel controversy, independence from climate and seasonal variations, and having potential for suitable growth parameters. In this study, a red yeast strain showed high lipid production potential and fuel properties in good agreement with international biodiesel standards.
JOURNAL OF BIOTECHNOLOGY
(2021)
Article
Medicine, Research & Experimental
Lukas P. M. Kremer, Santiago Cerrizuela, Sascha Dehler, Thomas Stiehl, Jonas Weinmann, Heike Abendroth, Susanne Kleber, Alexander Laure, Jihad El Andari, Simon Anders, Anna Marciniak-Czochra, Dirk Grimm, Ana Martin-Villalba
Summary: The study identified AAV variants with high regional tropism towards adult neural stem cells, paving the way for preclinical testing of regenerative gene therapy.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2021)
Article
Biotechnology & Applied Microbiology
M. Virginia Angelicola, Pablo M. Fernandez, Manuel J. Aybar, Carina P. Van Nieuwenhove, Lucia I. C. Figueroa, Silvana C. Vinarta
Summary: The ability of Rhodotorula glutinis R4 to produce single-cell oils (SCO) using different concentrations of commercial and crude glycerol was evaluated. The lipid accumulation of R4 grown with 25-100 g L-1 of glycerol ranged from 41-57%. The highest lipid accumulation at 216 h of culture was achieved using 100 g L-1 of glycerol, but with a decrease in lipid productivity. Biodiesels derived from R4 using crude glycerol comply with international biodiesel standards, advancing the circular economy in the biodiesel industry.
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2023)
Review
Medicine, Research & Experimental
Santiago Cerrizuela, Guillermo A. Vega-Lopez, Karla Mendez-Maldonado, Ivan Velasco, Manuel J. Aybar
Summary: Animal models are valuable in studying normal and pathological development at the molecular, cellular, and morphogenetic levels. Cell-based models offer an alternative approach to understanding human embryonic development and diseases. Neural crest (NC) cells are transient, multipotent embryonic cells that play a crucial role in generating various cell types during vertebrate development, and abnormalities in NC development can lead to neurocristopathies with diverse functional and morphological alterations.
WIRES MECHANISMS OF DISEASE
(2022)
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)