期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 84, 期 -, 页码 353-360出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2018.03.004
关键词
Peroxiredoxin 1 (Prdx1); Immune regulatory function; Initiation of adaptive immunity; Molecular adjuvant; Fish disease
资金
- National Natural Science Foundation of China [31630083, 31372554, 31472298, 31572641, 31272691]
- Stem Cell and Translational Research
- National Key Research and Development Program of China [2016YFA0101001]
- Zhejiang Major Special Program of Breeding [2016C02055-4]
- Open Fund of Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China [OF2017NO02]
Peroxiredoxin 1 (Prdx1/Prx1), a ubiquitous antioxidant enzyme involved in preventing oxidative damage and maintaining redox homeostasis, is essential for various cellular activities. Extracellular Prdx1 also plays important roles in innate immune responses. However, little is known about the regulatory functions of Prdx1 in adaptive immunity. In the present study, we report the stimulatory role of Prdx1 in the initiation of adaptive humoral immunity in a zebrafish model. Administration of Prdx1 protein to zebrafish significantly induced the expression of THF-alpha, 1L-1 beta, and IL-6 by the Toll-like-receptor-4a-mediated NF-kappa B signaling pathway and enhanced the activation of MHC-II+ antigen-presenting cells, CD4(+) T cells, and mIgM(+) B cells. Subsequently, increased production of antigen-specific IgM antibody was observed. Thus, Prdx1 can be used as a novel molecular adjuvant with great therapeutic value for the vaccination of fish diseases. Our study improved the understanding of the biology of Prdx1 family. (C) 2018 Elsevier Ltd. All rights reserved.
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