Article
Dentistry, Oral Surgery & Medicine
T. Maravic, E. Mancuso, A. Comba, V Checchi, L. Generali, C. Mazzitelli, U. Josic, V Hass, A. Reis, A. D. Loguercio, F. R. Tay, L. Breschi, A. Mazzoni
Summary: The study found that EDC pretreatment and aging significantly influenced bond strength and endogenous enzymatic activity. After 5 years of aging in artificial saliva, the EDC-treated groups exhibited higher bond strength and lower gelatinolytic activity, especially in the etch-and-rinse groups. Raman spectra showed less defined amide III peaks in control specimens at T5.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Engineering, Biomedical
Paula A. Baldion, Cristhian C. Cortes, Jaime E. Castellanos, Diego E. Betancourt
Summary: The use of myricetin as a treatment in operative dentistry to stabilize the resin-dentin interface by inhibiting MMPs and crosslinking the collagen has shown promising results. MYR acts as an MMP inhibitor, collagen cross-linker, and preserver of the bond strength, improving the biomechanical behavior of the demineralized dentin without cytotoxic effects.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yi Zhou, Yuming Zhao, Jianmin Han
Summary: This study compared the bonding effects of EDTA-chitosan, phosphoric acid, and SE-Bond. Through a series of experiments, it was found that EDTA-chitosan can extrafibrillarly demineralize collagen fibers, provide better bonding strength and durability compared to phosphoric acid wet bonding, and has lower cytotoxicity.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Biochemistry & Molecular Biology
Tatjana Maravic, Eugenia Baena, Claudia Mazzitelli, Uros Josic, Edoardo Mancuso, Vittorio Checchi, Luigi Generali, Laura Ceballos, Lorenzo Breschi, Annalisa Mazzoni
Summary: This study evaluated the effect of different concentrations of chitosan polymer on dentinal enzymatic activity. Results showed that higher concentrations of chitosan were correlated with increased enzymatic activity, especially in the restored dentin groups. Chitosan at 0.1% concentration showed faint expression of enzymatic activity compared to higher concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yu Luo, Ruirui Si, Yuan He, Mengmeng Wang, Yingying Yu, Xin Huang, Rong Huang, Yingyi Huang, Yang Luo, Wei Jin, Yaping Gou
Summary: The fourth-generation polyhydroxy-terminated poly(amidoamine) dendrimer (PAMAM-OH) has been found to possess anti-proteolytic activity and can protect exposed collagen fibrils within hybrid layers (HLs) from degradation, laying the foundation for achieving durable resin-dentin bonds using PAMAM-OH.
Review
Cell Biology
Louis Hardan, Umer Daood, Rim Bourgi, Carlos Enrique Cuevas-Suarez, Walter Devoto, Maciej Zarow, Natalia Jakubowicz, Juan Eliezer Zamarripa-Calderon, Mateusz Radwanski, Giovanna Orsini, Monika Lukomska-Szymanska
Summary: This study aimed to identify the role of crosslinking agents in the resin-dentin bond strength. The results showed that the use of certain crosslinking agents improved the long-term bond strength, while others improved both the immediate and long-term bond strength.
Article
Dentistry, Oral Surgery & Medicine
Wendy Chen, Huimin Jin, Heng Zhang, Leping Wu, Guoqing Chen, Hui Shao, Shengrui Wang, Xiaoxue He, Shunli Zheng, Chris Ying Cao, Quan-Li Li
Summary: This study introduced graphene quantum dots (GQDs) reinforced by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) to modify the resin-dentin bond interfaces, improving their durability and stability. The results showed that GQDs could inhibit collagenase activity, and when combined with EDC, they cross-linked collagen via covalent bonds, enhancing the anti-enzymatic hydrolysis of collagen.
Article
Dentistry, Oral Surgery & Medicine
Pedro Henrique Freitas, Carolina Bosso Andre, Bruna Marin Fronza, Marcelo Giannini, Pedro Luiz Rosalen, Simonides Consani, Rodrigo Franca
Summary: Incorporation of doxycycline into dental adhesive showed positive effects on physicochemical properties, bacterial inhibition, and maintenance of resin-dentin bond strength.
JOURNAL OF DENTISTRY
(2021)
Article
Nanoscience & Nanotechnology
Beibei Wang, Fei Han, Ran You, Chen Chen, Haifeng Xie
Summary: The objective of this study was to investigate the effects of proanthocyanidins (PA), myricetin, resveratrol, and kaempferol on dentin collagen modification and MMP activity inhibition, as well as their contributions to biomimetic remineralization and resin-dentin bonding performance. The results showed that these four polyphenols can modify dentin collagen, inhibit MMP activity, promote biomimetic remineralization, and improve resin-dentin bond durability.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Polymer Science
Saleha Nisar, Viviane Hass, Rong Wang, Mary P. Walker, Yong Wang
Summary: This study evaluated the effects of different crosslinkers on the properties of denatured dentin collagen. The results showed that denatured dentin collagen underwent structural changes, decreased biostability, and reduced mechanical properties. However, flavonoids such as theaflavins and proanthocyanidins from cranberry juice were able to significantly enhance or restore the properties of denatured dentin collagen.
Article
Dentistry, Oral Surgery & Medicine
Xin Jin, Fei Han, Qi Wang, Xiaojun Yuan, Qiyue Zhou, Haifeng Xie, Lina Niu, Chen Chen
Summary: The study investigates the mechanisms by which 10-Methacryloyloxydecyl dihydrogen phosphate (MDP) and its calcium salt preserve the adhesive-dentin hybrid layer. MDP forms a stable complex with collagen in dentin and generates MDP-Ca salts that protect the collagen scaffold from degradation. Both MDP and its Ca salt inhibit matrix metallopeptidase and exogenous proteases, with the calcium salt showing stronger inhibitory effects.
Article
Dentistry, Oral Surgery & Medicine
Yaning Zhao, Jian Yu, Jingmei Guo, Hongye Yang, Cui Huang
Summary: This study investigated the effects of a sodium carboxymethyl cellulose (SCMC)-based extrafibrillar demineralization conditioner on dentin bonding durability. The results showed that SCMC treatment improved bonding durability, inhibited gelatinolytic activity, and was non-toxic.
Article
Dentistry, Oral Surgery & Medicine
T. Shan, L. Huang, F. R. Tay, L. Gu
Summary: The concept of extrafibrillar demineralization involves selectively removing apatite crystallites from the spaces between mineralized dentin fibers without affecting the minerals within the collagen fibers. Quaternized carboxymethyl chitosan (QCMC)-based demineralization is effective in improving resin-dentin bond durability by retaining intrafibrillar minerals, preserving the elastic modulus of collagen fibers, reducing proteolytic activity, and inhibiting bacteria biofilms.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Chang Shu, Xinyu Zheng, Yang Wang, Yi Xu, Denghui Zhang, Shuli Deng
Summary: This study investigated the inhibitory effects of captopril on matrix metalloproteinases (MMPs) and its impact on dentin bonding durability. The findings showed that captopril effectively inhibited MMPs activity, leading to improved dentin bonding strength and reduced interface defects.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Viviane Hass, Yong Li, Rong Wang, Dung Nguyen, Zhonghua Peng, Yong Wang
Summary: The study aimed to investigate the effects of methacrylate-functionalized proanthocyanidins (MAPAs) on dentin collagen's bio-stabilization and crosslinking capability. Three MAPAs were synthesized and structurally characterized, showing different effectiveness in collagen stabilization and crosslinking. MAPA-1 and MAPA-2 demonstrated higher collagen stability, while MAPA-3 showed compromised efficacy, indicating the importance of appropriate MA:PA ratios. These new polymerizable crosslinkers have the potential to improve dentin bonding longevity when included in adhesives.
Article
Biochemistry & Molecular Biology
Eric Mayer-Santos, Tatjana Maravic, Allegra Comba, Patricia Moreira Freitas, Giovanna Bueno Marinho, Claudia Mazzitelli, Edoardo Mancuso, Nicola Scotti, Federica Florenzano, Lorenzo Breschi, Annalisa Mazzoni
Summary: This study investigated the activity of matrix metalloproteinases (MMPs) in human dentin after at-home and in-office bleaching, and its correlation with clinical exposure times. The results showed that bleaching treatments did not significantly affect the enzymatic activity of dentin when applied to sound teeth. However, when unprotected dentin tissue was bleached, there was an increase in expression of MMPs, particularly when carbamide peroxide was used, proportional to the exposure time.
Article
Dentistry, Oral Surgery & Medicine
Mika Huttunen, Antti Kamppi, Aapo Soudunsaari, Jari Pakkila, Leo Tjaderhane, Marja-Liisa Laitala, Vuokko Anttonen, Pertti Patinen, Tarja Tanner
Summary: Studies have found associations between self-reported physical activity and physical fitness and oral health in young men. Regular exercise is linked to a reduced need for dental restorative treatment and better dental health. Good physical fitness and higher levels of physical activity are associated with reduced caries burden.
Article
Dentistry, Oral Surgery & Medicine
Claudia Mazzitelli, Tatjana Maravic, Uros Josic, Edoardo Mancuso, Luigi Generali, Vittorio Checchi, Lorenzo Breschi, Annalisa Mazzoni
Summary: This study evaluated the influence of cement bonding strategy and polymerization mode on indirect restorations. The results showed that the combination of dual-cure resin cement and accelerator-enhancer primer had superior bonding performance compared to universal adhesive. Dual-curing the resin cement was found to enhance bonding capability over time.
JOURNAL OF ESTHETIC AND RESTORATIVE DENTISTRY
(2023)
Article
Engineering, Manufacturing
Leonardo Ciocca, Mattia Maltauro, Valerio Cimini, Lorenzo Breschi, Roberto Meneghello
Summary: Comparing the reference geometry approach with the best-fit approach for estimating geometric accuracy in the digital and analog workflow of fabricating complete dentures. The study tested both methods to estimate the accuracy of the intaglio surface of dentures made by CNC milling and injection molding. The results showed that the reference geometry approach correctly estimated error values and identified sources of errors, while the best-fit approach underestimated the mean error values and their distribution over the entire prosthesis.
INTERNATIONAL JOURNAL OF INTERACTIVE DESIGN AND MANUFACTURING - IJIDEM
(2023)
Article
Dentistry, Oral Surgery & Medicine
Giovanna Speranza Zabeu, Marina Ciccone Giacomini, Polliana Mendes Candia Scaffa, Leo Tjaderhane, Victor Mosquim, Linda Wang
Summary: This study aimed to determine the effectiveness of DMSO as a pretreatment to improve the mechanical properties and minimize degradation of the adhesive interface in different categories of dentin bonding systems. The results showed that incorporating DMSO improved the degree of conversion and bond strength in certain dentin bonding systems.
Review
Dentistry, Oral Surgery & Medicine
Shanon Patel, Gabriel Krastl, Roland Weiger, Paul Lambrechts, Leo Tjaderhane, Gianluca Gambarini, Peng-Hui Teng
Summary: This article represents the consensus of an expert committee convened by the European Society of Endodontology (ESE) on root resorption. It aims to provide authoritative information on the etiology, histopathology, clinical presentation, and management recommendations for root resorption based on current evidence and expert knowledge. The committee intends to update this statement as new evidence emerges.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Lorenzo Breschi, Uros Josic, Tatjana Maravic, Edoardo Mancuso, Federico Del Bianco, Paolo Baldissara, Annalisa Mazzoni, Claudia Mazzitelli
Summary: This article introduces the concept of Selective adhesive luting (SAL) through clinical steps and preliminary laboratory evidence. It presents a novel technique using universal resin cements/universal adhesive systems to perform reliable cementation in situations where rubber dam isolation is difficult. The SAL technique involves applying a universal adhesive system only on easily accessible abutment surfaces, allowing simultaneous adhesive and self-adhesive luting.
JOURNAL OF ESTHETIC AND RESTORATIVE DENTISTRY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Tatjana Maravic, Claudia Mazzitelli, Edoardo Mancuso, Federico Del Bianco, Uros Josic, Milena Cadenaro, Lorenzo Breschi, Annalisa Mazzoni
Summary: Currently, there is a lack of classification for resin cements, including recently formulated universal cements. The terminology used to define resin cements in scientific reports is inconsistent. This study aims to propose a new classification, evaluate the term universal cements, and provide an overview of the properties of these cements.
JOURNAL OF ESTHETIC AND RESTORATIVE DENTISTRY
(2023)
Article
Chemistry, Physical
Gaetano Paolone, Claudia Mazzitelli, Francesca Boggio, Lorenzo Breschi, Alessandro Vichi, Enrico Gherlone, Giuseppe Cantatore
Summary: This study evaluated the effect of different experimental staining procedures on the color stability and translucency of a nano-hybrid resin-based composite. The results showed that using a toothpaste with a high abrasive level resulted in greater color change compared to using a toothpaste with a low abrasive level. Repolishing procedures were able to partially reduce the color change induced by artificial staining.
Article
Chemistry, Multidisciplinary
Leonardo Ciocca, Nicolas Emiliani, Giulia Artuso, Lorenzo Breschi, Emanuela Marcelli, Laura Cercenelli
Summary: This article presents an update on the digital protocol for fabricating facial prostheses for patients who cannot undergo plastic surgery due to post-surgical complications. The aim of this innovation is to simplify the process, reduce time and cost, and improve the quality of life for inoperable patients.
APPLIED SCIENCES-BASEL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Edoardo Mancuso, Diego Durso, Claudia Mazzitelli, Tatjana Maravic, Uros Josic, Carlo D'alessandro, Luigi Generali, Vittorio Checchi, Lorenzo Breschi, Annalisa Mazzoni
Summary: This study evaluated the influence of two glutaraldehyde-based desensitizers on microtensile bond strength and enzymatic activity. The results showed that the application of these desensitizers increased bond strength and provided stabilization of the adhesive interface over time.
JOURNAL OF DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Guido Fichera, Claudia Mazzitelli, Vincenzo Picciariello, Tatjana Maravic, Uros Josic, Annalisa Mazzoni, Lorenzo Breschi
Summary: The Peripheral Build-Up technique (PBUt) is introduced as a foundation restoration strategy for structurally compromised teeth. It is a versatile direct technique that shares some strategic concepts with other techniques to address critical clinical situations and has a wider field of application.
JOURNAL OF ESTHETIC AND RESTORATIVE DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Leonardo Ciocca, Mattia Maltauro, Elena Pierantozzi, Lorenzo Breschi, Angela Montanari, Laura Anderlucci, Roberto Meneghello
Summary: The aim of this study is to evaluate the accuracy of removable partial denture frameworks produced using different digital protocols. 80 frameworks were produced using CAD-CAM technology and divided into four groups. The results showed that all digital protocols for manufacturing RPD frameworks met the clinical accuracy requirements.
JOURNAL OF ADVANCED PROSTHODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Leonardo Ciocca, Mattia Maltauro, Valerio Cimini, Lorenzo Breschi, Angela Montanari, Laura Anderlucci, Roberto Meneghello
Summary: Digital technology has improved the fitting accuracy of denture bases. This study evaluated the accuracy and precision of digital and analog techniques for manufacturing complete dentures. The monolithic process yielded better results in terms of accuracy, although all three processes produced dentures within the clinical tolerance limit.
JOURNAL OF ADVANCED PROSTHODONTICS
(2023)
Article
Medicine, General & Internal
Pertti Patinen, Tarja Tanner, Jesse Honkanen, Leo Tjaderhane, Jari Pakkila, Vuokko Anttonen, Antti Kamppi
Summary: This study compares the general and oral health habits between Finnish conscripts who interrupt their service and those who completed their military service, and aims to identify the factors that could be used to predict interruption of service. Lack of weekly physical exercise is found to be the most obvious predisposing factor, and the risk of interruption of military service is significantly higher for individuals with multiple predisposing factors.