Article
Biochemistry & Molecular Biology
Joanna Palion-Gazda, Andre Luz, Luis R. Raposo, Katarzyna Choroba, Jacek E. Nycz, Alina Bienko, Agnieszka Lewinska, Karol Erfurt, Pedro V. Baptista, Barbara Machura, Alexandra R. Fernandes, Lidia S. Shul'pina, Nikolay S. Ikonnikov, Georgiy B. Shul'pin
Summary: Methyl-substituted 8-hydroxyquinolines were used to synthesize five-coordinated oxovanadium(IV) complexes, which showed high catalytic activity in the oxidation of hydrocarbons with H2O2 in acetonitrile. The reaction led to the formation of cyclohexyl hydroperoxide, cyclohexanol, and cyclohexanone. Complexes 1 and 2 exhibited cytotoxic effects on colorectal and ovarian carcinoma cell lines, while complex 3 showed higher cytotoxicity in colorectal carcinoma cells, lower cytotoxicity in normal dermal fibroblasts, and no effect in ovarian carcinoma cells.
Article
Engineering, Environmental
Wen-Qing Liang, Minwei Xie, Qiao-Guo Tan
Summary: In aquatic environments, the ecological risks posed by metals are greatly affected by water chemistry, creating challenges for water quality management. Biotic ligand models (BLMs) are widely used tools to interpret and predict water chemistry effects, but traditional development methods have limitations. Our new method integrates BLMs into the toxicokinetic-toxicodynamic (TK-TD) framework to address these limitations and predict metal toxicity more effectively.
Article
Chemistry, Medicinal
Tamas Pivarcsik, Gabor Toth, Nikoletta Szemeredi, Anita Bogdanov, Gabriella Spengler, Jakob Kljun, Jerneja Kladnik, Iztok Turel, Eva A. Enyedy
Summary: The biological activities of eight organoruthenium(II) complexes in aqueous media were evaluated, revealing correlations with their stability and reactivity. Different complexes exhibited varied antimicrobial and anticancer activities, with the bioactivity closely related to solution stability. Structural variations significantly affected the biological properties and solution stability of the complexes.
Article
Chemistry, Multidisciplinary
Mahsa Kheirkhahi, Behrouz Shaabani, Hossein Samadi Kafil
Summary: This study designed and synthesized a calix[4]arene-based thiosemicarbazone Schiff-base ligand and its derivative complexes with Co, Ni, Cu, and Zn transition metals. The derivatives showed higher activity against gram-negative bacteria and high blood compatibility for Ni and Zn complexes at different concentrations. Additionally, the Cu complex exhibited substantial anticancer activity against the MG-63 cell line.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Maysam B. Abdulsalam, Ahmed T. Numan
Summary: The ligand [4-Chloro-5-(N-(5,5-dimethyl-3-oxocyclohex-1-en-1-yl) sulfamoyl)-2-((furan-2-ylmethyl) amino) benzoic acid] was synthesized and characterized. The mixed ligand complexes formed with different metal ions exhibited diverse geometries. The complexes and the ligand showed variable antibacterial and antifungal activities.
CHEMICAL METHODOLOGIES
(2022)
Article
Chemistry, Multidisciplinary
Nawal D. Resen, Nagham Majed, Huda Al-Rubaye, Nahida M. Jinzeel
Summary: A new generation of transition metal complexes with Cu(II), Ni(II), and Co(II) has been prepared and analyzed using various techniques. The results show that these complexes exhibit enhanced biological activity against certain bacteria and fungi compared to the ligand.
EGYPTIAN JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Matthew P. P. Sullivan, Muneebah Adams, Mie Riisom, Caitlin D. D. Herbert, Kelvin K. H. Tong, Jonathan W. W. Astin, Stephen M. F. Jamieson, Muhammad Hanif, David C. C. Goldstone, Christian G. G. Hartinger
Summary: Pt(terpyridine) complexes are known for their ability to intercalate with DNA. The addition of an NHC co-ligand significantly increased the anticancer activity of the complex compared to its chlorido derivative. While the compound showed high efficacy, it was well-tolerated by zebrafish embryos, especially when compared to cisplatin. DNA interaction studies suggest that the mode of action is related to intercalation.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Karolina Kowalczyk, Andrzej Blauz, Daniel Moscoh Ayine-Tora, Christian G. Hartinger, Blazej Rychlik, Damian Plazuk
Summary: Derivatives of ispinesib and its (S) analogue, containing ferrocenyl moieties or bulky organic substituents, were prepared to combine multiple biologically-active components in a single molecule. Several of these compounds demonstrated higher antiproliferative activity than ispinesib, with nanomolar IC50 values against cell lines. The improved activity may be attributed to synergic effects of various factors such as KSP inhibitory activity due to the ispinesib core and ability to generate ROS and induce mitotic arrest.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
William D. J. Tremlett, Tilo Soehnel, James D. Crowley, L. James Wright, Christian G. Hartinger
Summary: Using ferrocene-based ligand systems, a series of heterobimetallic architectures were designed to release and bind guest molecules. The complexes were characterized using various techniques and the disassembly and reassembly process of metallosupramolecular structures were investigated using NMR spectroscopy. Guest binding studies revealed interactions with anionic guests and the release of guests was induced by Cl- ions.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Zahid Riaz, Betty Y. T. Lee, Julia Stjarnhage, Sanam Movassaghi, Tilo Sohnel, Stephen M. F. Jamieson, Muhammad Ashraf Shaheen, Muhammad Hanif, Christian G. Hartinger
Summary: The substitution of the labile chloride ligand with phosphorus donor ligands in half-sandwich MII(cym)Cl complexes showed that Ru and Os complexes with triphenylphosphine ligands exhibited the most potent anticancer activity in submicromolar range against four cancer cell lines. This suggests that the antiproliferative activity is mainly dependent on the lipophilic properties of the phosphine ligand.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Xize Chen, Shanghai Wei, Yigang Yan, Fanglei Tong, Geoffrey I. N. Waterhouse, Tilo Sohnel, Mark P. Taylor, Peng Cao
Summary: Magnesium rechargeable batteries (MRBs) are attracting attention due to their low cost, high safety, and high theoretical volumetric capacity. The use of eutectic and hypereutectic Mg-Sn alloys as anodes for MRBs was explored. The alloys exhibited unique microstructures and the dissolution processes were studied in an all-phenyl-complex (APC) electrolyte. Hypereutectic alloys showed better battery performance due to their superior mechanical properties.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Inorganic & Nuclear
Saawan Kumar, Mie Riisom, Stephen M. F. Jamieson, Iman Kavianinia, Paul W. R. Harris, Nils Metzler-Nolte, Margaret A. Brimble, Christian G. Hartinger
Summary: Researchers conjugated a derivative of plecstatin-1 with peptides to enhance their targeting ability towards cancer cells. Metal-peptide conjugates were successfully synthesized and tested for their anticancer activity. Although the activity was relatively low, this study provides a potential strategy to design other metal complexes utilizing the targeting properties of peptides.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Myung-Geun Han, Fernando Camino, Pavel A. Vorobyev, Joseph Garlow, Rosanna Rov, Tilo So''hnel, Jan Seidel, Maxim Mostovoy, Oleg A. Tretiakov, Yimei Zhu
Summary: Electric field control of topologically nontrivial magnetic textures, such as skyrmions, in magnetoelectric Cu2OSeO3 is studied using Lorentz transmission electron microscopy combined with in situ electric and magnetic fields at liquid helium temperatures. The electric fields not only stabilize the skyrmion lattices in a hysteretic manner, but also induce the rotation of their reciprocal vector by 30°. This work demonstrates the nonvolatile and energy-efficient control of skyrmion lattices by electric fields, providing an important foundation for designing skyrmion-based qubits and memory devices.
Article
Chemistry, Multidisciplinary
Samuel Yick, Jake Reneman, Philip J. Martin, Margaret D. M. Evans, Penelope A. Bean, Tilo Sohnel, Nicholas M. K. Tse, Avi Bendavid
Summary: Orthopedic implants provide patients with an opportunity to regain lost functionality, but the low bioactivity of Ti-6Al-4V ELI implants and potential adverse effects complicate the recovery process. In this study, Ti-6Al-4V ELI samples were coated with diamond-like carbon (DLC) to improve their biological properties, and the effects were correlated to the bioactivities of the coated and uncoated samples using in vitro studies with osteosarcoma cells. The study found that DLC coating can enhance the surface bioactivity of the material and promote bone cell proliferation and maturity.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Thais A. Rossa, Jessica C. Neville, Seongmin Paul Jun, Tilo Sohnel, Jonathan Sperry
Summary: In this study, the expansion of chemical space available from chitin is reported, which can be accessed via the biogenic N-platforms 3A5AF, M4A2C, and di-HAF. The selective synthesis of biologically active heteroaromatics furo[3,2-d]pyrimidin-4-one and furo[3,2-d]pyrimidin-4-amine is achieved from 3A5AF and M4A2C, respectively. The chiral pool synthon di-HAF serves as a viable substrate for Achmatowicz rearrangement, providing a streamlined method for accessing 2-aminosugars with a versatile hydroxymethyl group at C5.
CHEMISTRY-SWITZERLAND
(2023)
Article
Biochemistry & Molecular Biology
Mie Riisom, Stephen M. F. Jamieson, Christian G. Hartinger
Summary: This study aimed to investigate different protocols for efficient and reproducible lysis of cancer cells and found that chemical lysis with the RIPA buffer was the most efficient method. Minimal differences were found for experiments measuring the overall cell uptake of the Ru complex.
Article
Chemistry, Multidisciplinary
Aston C. Pearcy, Lynn S. Lisboa, Dan Preston, Nick B. Page, Tristan Lawrence, L. James Wright, Christian G. Hartinger, James D. Crowley
Summary: A new sequential metalation strategy has been developed for the assembly of a more stable heterobimetallic [PdPtL4](4+) cage. By using a low-symmetry ditopic ligand (L) with imidazole and pyridine donor units, a [Pt(L)(4)](2+) open-cage complex was selectively formed and then reacted with Pd(ii) ions to assemble the cage C. Various spectroscopy and crystallography techniques confirmed the formation of the cage and its heterobimetallic structure. The cage C exhibited anionic guest molecule binding capability and demonstrated stimulus-responsive behavior.
Article
Chemistry, Organic
Stephanie Lee, Tilo Sohnel, Jonathan Sperry
Summary: In this study, unexpected results emerged during the synthetic study of the unique triazocane present in hicksoane alkaloids. The mechanisms behind the formation of the reaction products were elucidated through control reactions.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Betty Y. T. Lee, Andrew D. Phillips, Muhammad Hanif, Tilo Sohnel, Christian G. Hartinger
Summary: This study demonstrates the intramolecular C-C coupling reactions of a Rh (Cp*) organometallic complex with monodentate N-heterocyclic carbene (NHC) ligands bearing a pendant anthracenyl substituent. The behavior of two bidentate NHC ligands with pyridyl or triazolyl donor groups was investigated, with the triazolyl ligand undergoing the expected reaction while the pyridyl ligand showed no reactivity. Further analysis using density functional theory (DFT) calculations revealed significant differences between the two types of Rh(III) complexes and explained the contrasting behavior. The findings have important implications for understanding the reactivity of NHC ligands in organometallic chemistry.
ACS ORGANIC & INORGANIC AU
(2022)
Article
Chemistry, Inorganic & Nuclear
Vaibhav Bedi, Dipendu Mandal, Zahid Hussain, Shi-Ming Chen, Yile Wu, Zheng-Wang Qu, Stefan Grimme, Douglas W. Stephan
Summary: The reaction of (tBuO(2)CN)(2) with 9-BBN leads to the formation of a bicyclic heterocyclic compound, while its reactions with BF3 or [Et3Si][B(C6F5)(4)] result in the isolation of different compounds. Computational studies reveal that the steric and electronic properties of the Lewis acid are important in the formation of one of the compounds.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Chisa Itoh, Haruka Yoshino, Taku Kitayama, Wataru Kosaka, Hitoshi Miyasaka
Summary: A new synthetic route for constructing functional paddlewheel diruthenium(II,II) complexes was developed, utilizing Schiff base condensation reactions. The attached Schiff base groups significantly affected the electronic states of the resulting complexes, as revealed by cyclic voltammetry and DFT calculations.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Danrui Ni, Haozhe Wang, Xianghan Xu, Weiwei Xie, Robert J. Cava
Summary: A layered rhombohedral polymorph of indium(iii) triiodide is synthesized at high pressure and temperature. It has an orange color, which is different from ambient pressure InI3, which has a monoclinic molecular structure and a light-yellow color.
DALTON TRANSACTIONS
(2024)
Review
Chemistry, Inorganic & Nuclear
Juan Carlos Perez-Sanchez, Raquel P. Herrera, M. Concepcion Gimeno
Summary: Gold(II) complexes have been less utilized in catalysis compared to their gold(I) and gold(III) counterparts. However, gold(II) complexes offer potential in homo-coupling and cross-coupling reactions, as they are more easily accessible through simplified oxidation and reduction processes. Gold(II) exhibits characteristics of both soft acid gold(I) and hard acid gold(III). This review explores the unique reactivity and potential applications of gold(II) species, highlighting their significance in catalytic transformations.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Nighat Yousuf, Yanping Ma, Qaiser Mahmood, Wenjuan Zhang, Yizhou Wang, Hassan Saeed, Wen-Hua Sun
Summary: In this study, a series of structurally rigid cyclooctyl-fused iminopyridine iron complexes were synthesized and used with methylaluminoxane for isoprene polymerization. The extent of steric hindrance of the ligand framework was found to significantly affect catalytic performance, with less hindrance leading to better activity and stability.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Chenghao Song, Huiwei Du, Menglei Xu, Jie Yang, Xinyu Zhang, Jungan Wang, Yuanfang Zhang, Chengjun Gu, Rui Li, Tao Hong, Jingji Zhang, Jiangying Wang, Yongchun Ye
Summary: This study improves the performance of perovskite solar cells by using a dual-hole transport layer strategy. This strategy enhances the charge transfer efficiency of the transport layer, reduces charge recombination, and improves the quality of the perovskite film layer. Ultimately, the stability of the device is enhanced.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Mahender Singh, Aakash Yadav, Ranjit Singh, Chullikkattil P. Pradeep
Summary: A new aryl selenonium polyoxometalate hybrid was developed and compared with an aryl sulfonium polyoxometalate hybrid in terms of their photocatalytic properties. It was found that the aryl selenonium hybrid exhibited better catalytic performance, which could be attributed to the larger atomic radii of selenium stabilizing the photogenerated electron-hole pair more efficiently. Additionally, the generation of elemental selenium through cleavage of C-Se bonds during catalysis was observed.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Yuhan Xie, Boyu Dong, Xuemin Wang, Siyuan Wang, Jinxi Chen, Yongbing Lou
Summary: This study successfully fabricated visible-light-responsive three-dimensional core-shell CoSe2/ZnIn2S4 heterostructures and achieved attractive activity in photocatalytic hydrogen evolution. The presence of CoSe2 improved light absorption and accelerated charge transfer kinetics. The strong interaction between CoSe2 and ZnIn2S4 reduced charge recombination, further enhancing photocatalytic activity for hydrogen evolution.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Andre L. de O. Batista, Joao Marcos T. Palheta, Mauricio J. Piotrowski, Celso R. C. Rego, Diego Guedes-Sobrinho, Alexandre C. Dias
Summary: This study presents a simulation protocol that provides a solid foundation for exploring two-dimensional materials. Using the TiBr2 2H monolayer as an example, the study reveals its promising properties for optoelectronic and valleytronic applications, including its stability, spin-orbit coupling effects, and optical helicity selection rule.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Jiang Jiang, Zi-Wei Li, Zhi-Zhuan Zhang, Bin Tan, Zhao-Feng Wu, Xiao-Ying Huang
Summary: In this work, two metal organic frameworks (MOFs) containing {Cu2I2} clusters, Eu-CuI-INA and Sr-K-CuI-INA, were synthesized and characterized. Both materials have a three-dimensional structure with {Cu2I2} clusters coordinated by INA(-) ligands and Eu3+ or Sr2+ ions. The Sr-K-CuI-INA material exhibited sensitive fluorescence sensing behaviors towards cysteine and nitro-bearing molecules, showing potential applications in bio and explosive molecule sensing. This work provides a good reference for designing fluorescent MOF probes containing CuI molecules.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Zhiya Lin, Jiasheng Wu, Qianwen Ye, Yulong Chen, Hai Jia, Xiaohui Huang, Shaoming Ying
Summary: Na-ion batteries (NIBs) have attracted great interest as a potential technology for grid-scale energy storage due to the wide distribution, low cost, and environmental friendliness of sodium resources. However, their implementation is hindered by low rate capability and cycling stability caused by the large ionic size of Na+. In this study, a three-dimensional nanoarchitectured coral-like CoSe2@N-doped carbon (CL-CoSe2@NC) was synthesized, and it exhibited improved sodium storage properties with better electrode kinetics and a stable SEI film.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Ya-Qiong Zhang, Yu Zhang, Guoping Zeng, Rong-Zhen Liao, Man Li
Summary: The mechanism and selectivity of CO2 reduction under visible light were investigated using density functional calculations. The results showed that a tetradentate PNNP-type Iridium(III) complex exhibited high activity and selectivity in the reaction.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Sanyukta Ghosh, Shubhanth Jain, Soumya Ranjan Mishra, Gerda Rogl, Peter Rogl, Ernst Bauer, B. S. Murty, A. Govindaraj, Ramesh Chandra Mallik
Summary: In this study, reduced graphene oxide (rGO) was uniformly dispersed in the In0.5Co4Sb12 bulk material by ultrasonication, which effectively reduced the lattice thermal conductivity and improved the thermoelectric efficiency.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Mika Takeuchi, Yutaka Amao
Summary: This study developed an effective visible-light driven system for fumaric acid production using renewable resources such as biomass derivatives, providing an alternative to the current petroleum-based synthesis methods.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Juan Jian, Meiting Wang, Zhuo Wang, Jingwen Meng, Yuqin Yang, Limin Chang
Summary: Developing low-cost and self-supported bifunctional catalysts is crucial for highly efficient water splitting devices. In this study, nano-NiFe2O4 was directly grown onto iron foil surface and Sn4+ was introduced into the NiFe2O4. The resulting Sn-NiFe2O4/IF showed low overpotentials and high current densities during oxygen evolution reaction (OER) and hydrogen evolution reaction (HER), making it a promising catalyst for large-scale hydrogen production.
DALTON TRANSACTIONS
(2024)