Article
Immunology
Zo Andriamanantena, Fanirisoa Randrianarisaona, Maheninasy Rakotondrainipiana, Prisca Andriantsalama, Ravaka Randriamparany, Rindra Randremanana, Frederique Randrianirina, Sophie Novault, Darragh Duffy, Francois Huetz, Milena Hasan, Matthieu Schoenhals, Philippe J. Sansonetti, Pascale Vonaesch, Ines Vigan-Womas, Afribiota Investigators
Summary: This study analyzed the major systemic immune cell populations in stunted and non-stunted children using flow cytometry. The results showed that stunting had an impact on innate and adaptive immune cell percentages and activation status, with age-specific differences in regulatory T cell subsets. This study provides valuable insights into the understanding of systemic immune system changes in stunted children.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Andrew Wister, Lun Li, Carly Whitmore, Jennifer Ferris, Katarzyna Klasa, Igor Linkov
Summary: This study investigates the positive role of protective health behaviors on multimorbidity resilience among older adults with two or more chronic conditions. It found that smoking, satisfaction with sleep, appetite, and skipping meals were associated with resilience in the expected direction, highlighting the importance of modifiable health behaviors in affecting levels of multimorbidity resilience in older age.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Geriatrics & Gerontology
Quoc Dinh Nguyen, Erica M. Moodie, Marie-France Forget, Philippe Desmarais, Mark R. Keezer, Christina Wolfson
Summary: Overall health heterogeneity increases with age, but this increase is not uniform across all variables and domains. The findings highlight the importance of geriatric assessment and personalized care, emphasizing the need for research and development of improved measurement tools for different health characteristics.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Cell Biology
Chris P. Verschoor, Caitlyn Vlasschaert, Michael J. Rauh, Guillaume Pare
Summary: This study demonstrates that there is a strong association between circulating C-reactive protein (CRP) and age and health-related traits in older adults, and this association is more pronounced in EIS (comprehensive epigenetic inflammation score) than CRP. Additionally, experimental results show that EIS reflects the cellular response to chronic inflammation. Therefore, EIS has the potential to be a clinically relevant tool for stratifying patient risk of adverse outcomes prior to treatment or following illness.
Article
Public, Environmental & Occupational Health
Vanessa De Rubeis, Andrea Gonzalez, Jean-Eric Tarride, Lauren E. Griffith, Laura N. Anderson
Summary: This study investigated the impact of adverse childhood experiences (ACEs) on adulthood obesity and whether the association was mediated by nutrition and stress. The study found a strong association between ACEs and obesity among Canadian adults. However, stress and nutrition did not mediate this association.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Alyssa Grant, Marie-Jeanne Kergoat, Ellen E. Freeman
Summary: This study aimed to investigate the relationship between ambient air pollution and the onset of balance problems. Using data from the Canadian Longitudinal Study on Aging, it was found that higher ozone levels were associated with the development of balance problems over a 3-year period. The findings provide evidence for further research to confirm and explore the underlying mechanism.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Geriatrics & Gerontology
Marla K. Beauchamp, Qiukui Hao, Ayse Kuspinar, Cassandra D'Amore, Giulia Scime, Jinhui Ma, Alexandra Mayhew, Carol Bassim, Christina Wolfson, Susan Kirkland, Lauren Griffith, Parminder Raina
Summary: The study aimed to determine the reliability of 5 key performance-based measures of physical function in the Canadian Longitudinal Study on Aging (CLSA). The results showed that these measures had moderate to excellent reliability among community-dwelling Canadians older than 50 years, with MDC values being useful in interpreting changes over time. TUG and gait speed in the youngest age group, and single-leg stance in the oldest age group, showed poor reliability.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Mario Ulises Perez-Zepeda, Judith Godin, Joshua J. Armstrong, Melissa K. Andrew, Arnold Mitnitski, Susan Kirkland, Kenneth Rockwood, Olga Theou
Summary: Frailty is becoming a growing concern in Canada, especially as the population ages. By using a standardized frailty index, levels of frailty among Canadians aged 45 and above can be accurately measured and compared. This information can provide valuable insights for clinicians, researchers, stakeholders, and the general public in understanding frailty and its implications, particularly in relation to age and gender.
Article
Health Care Sciences & Services
Chris P. Verschoor, Sabit Cakmak, Anna O. Lukina, Robert E. Dales
Summary: In an older adult population, there are several factors correlated with dyspnea, including obesity, lung disease, heart disease, lower income, and depression. These factors have significant independent and combined effects on dyspnea. The relationship between dyspnea and diabetes also requires further investigation.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Ophthalmology
Ellen E. Freeman, Joseph Bastasic, Alyssa Grant, Gareth Leung, Gisele Li, Ralf Buhrmann, Marie-Helene Roy-Gagnon
Summary: This study found an association between the APOE e4 allele and glaucoma, suggesting a possible protective effect of this allele against glaucoma. However, this association was only observed in individuals without systemic hypertension.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Clinical Neurology
Jean-Louis Zhao, Nathan Cross, Chun W. Yao, Julie Carrier, Ronald B. Postuma, Nadia Gosselin, Lisa Kakinami, Thien Thanh Dang-Vu
Summary: The study found a significant association between probable insomnia disorder and subjective memory decline in middle-aged and older adults, suggesting that insomnia may be an important target for early interventions addressing age-related cognitive decline.
Article
Geriatrics & Gerontology
Chris P. Verschoor, Daniel W. Belsky, Jinhui Ma, Alan A. Cohen, Lauren E. Griffith, Parminder Raina
Summary: While estimates of biological age (BA) closely approximating chronological age (CA) are important, the strength of associations to prospective outcomes may be even more crucial. Various panels of biological measures were compared based on their association with CA and health-related outcomes, revealing that panels focused on physical performance measures showed comparable or stronger associations compared to panels with a wider range of measures. Sex differences in associations were minimal, except for certain disease domains. Consideration of specific research goals is therefore vital when estimating BA.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Vincenzo Forgetta, Rui Li, Corinne Darmond-Zwaig, Alexandre Belisle, Cynthia Balion, Delnaz Roshandel, Christina Wolfson, Guillaume Lettre, Guillaume Pare, Andrew D. Paterson, Lauren E. Griffith, Chris Verschoor, Mark Lathrop, Susan Kirkland, Parminder Raina, J. Brent Richards, Jiannis Ragoussis
Summary: The Canadian Longitudinal Study on Aging (CLSA) Comprehensive cohort collected genomic data from 26,622 individuals aged 45-85 to study the genetic and environmental contributions to human disease and aging process. The data revealed novel loci associated with glaucoma and validated the use of polygenic risk score in identifying individuals at high fracture risk. Future studies will focus on genetic factors in cognitive decline and cardiovascular diseases.
Article
Geriatrics & Gerontology
Anne-Julie Tessier, Nancy Presse, Elham Rahme, Guylaine Ferland, Louis Bherer, Stephanie Chevalier
Summary: In this study involving older adults, dairy product intake was positively associated with executive function, verbal fluency, and memory domains independently of important covariates. These findings suggest a specific role for dairy components in cognitive performance, particularly in phonemic verbal fluency and memory. Dairy product intake may be a modifiable factor targeted in interventions promoting cognitive health.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Stephanie A. Chamberlain, Rachel Savage, Susan E. Bronskill, Lauren E. Griffth, Paula Rochon, Jesse Batara, Andrea Gruneir
Summary: Loneliness is associated with emergency department visits in the previous 12 months, with women having higher odds of ED visit than men.
Article
Geriatrics & Gerontology
Chris P. Verschoor, Daniel W. Belsky, Jinhui Ma, Alan A. Cohen, Lauren E. Griffith, Parminder Raina
Summary: While estimates of biological age (BA) closely approximating chronological age (CA) are important, the strength of associations to prospective outcomes may be even more crucial. Various panels of biological measures were compared based on their association with CA and health-related outcomes, revealing that panels focused on physical performance measures showed comparable or stronger associations compared to panels with a wider range of measures. Sex differences in associations were minimal, except for certain disease domains. Consideration of specific research goals is therefore vital when estimating BA.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Surgery
Antonio Caycedo-Marulanda, Sunil Patel, Chris P. Verschoor, Johanna P. Uscategui, Sami A. Chadi, Gabriela Moeslein, Manish Chand, Yasuko Maeda, John R. T. Monson, Steven D. Wexner, Julio Mayol
Summary: This study utilized an online survey to provide a rapid assessment of the consistency and variability in rectal cancer patient care across multiple regions worldwide. Variations in treatments across different regions were identified, potentially offering opportunities to standardize care for rectal cancer patients.
WORLD JOURNAL OF SURGERY
(2021)
Article
Immunology
E. Picard, D. M. E. Bowdish, J. E. McElhaney, G. Pawelec, M. Loeb, C. P. Verschoor
Summary: Previous studies have shown that T cell compartment status and inflammation-related factors are associated with the immunogenicity of the varicella-zoster virus (VZV) vaccine in older adults. This study explored the roles of different immune cell subsets in VZV vaccine responses in older adults, finding that IL-1 beta(+) monocytes mediate the response of long-lived VZV-reactive memory T cells, while IL-6(+) monocytes have an opposing effect. The impact of monocyte status on the induction and maintenance of memory T cells in later life remains to be determined.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Antonio Caycedo-Marulanda, Chris P. Verschoor, Carl P. Brown, Ahmer Karimuddin, Manoj Raval, Terry Phang, Elena Vikis, George Melich
Summary: This study compares the oncological outcomes of patients undergoing taTME-APR and taTME-LAR procedures and finds inferior outcomes in taTME-APR. The use of this technique for this specific indication needs careful consideration.
COLORECTAL DISEASE
(2022)
Article
Geriatrics & Gerontology
Oxana Mian, Laura N. Anderson, Daniel W. Belsky, Andrea Gonzalez, Jinhui Ma, Deborah M. Sloboda, Dawn M. E. Bowdish, Chris P. Verschoor
Summary: This study found an association between exposure to adverse childhood experiences (ACEs) and frailty in older adults, with different types of ACEs having different impacts and the number of ACEs reported being positively correlated with frailty. The research also indicated that the effect of ACEs on frailty was more pronounced in women and men aged 45-64.
Article
Multidisciplinary Sciences
Jacqueline Lim, Sureka Pavalagantharajah, Chris P. Verschoor, Eric Lentz, Mark Loeb, Mitchell Levine, Marek Smieja, Lawrence Mbuagbaw, Dale Kalina, Jean-Eric Tarride, Tim O'Shea, Anna Cvetkovic, Sarah van Gaalen, Aidan Reid Findlater, Robin Lennox, Carol Bassim, Cynthia Lokker, Elizabeth Alvarez
Summary: This study examines the outcomes of individuals who inject drugs after admission, finding a high rate of hospitalization for infectious diseases. Among various infectious diagnoses, bacteremia, abscess, and endocarditis are the most common. Some patients seek emergency care or readmitted after discharge.
Article
Endocrinology & Metabolism
Oxana Mian, Daniel W. Belsky, Alan A. Cohen, Laura N. Anderson, Andrea Gonzalez, Jinhui Ma, Deborah M. Sloboda, Dawn Me Bowdish, Chris P. Verschoor
Summary: People exposed to adverse childhood experiences have an increased risk of chronic disease, shorter lifespan, accelerated reproductive development, and signs of advanced cellular aging. This suggests that adverse childhood experiences may accelerate biological aging through direct or indirect mechanisms.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Emilie Picard, Sarah Armstrong, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, George A. Kuchel, Janet E. McElhaney, Chris P. Verschoor
Summary: The study found a significant association between systemic inflammation levels and antibody responses to the seasonal influenza vaccine, particularly in older adults receiving high vaccine doses.
Article
Health Care Sciences & Services
Chris P. Verschoor, Sabit Cakmak, Anna O. Lukina, Robert E. Dales
Summary: In an older adult population, there are several factors correlated with dyspnea, including obesity, lung disease, heart disease, lower income, and depression. These factors have significant independent and combined effects on dyspnea. The relationship between dyspnea and diabetes also requires further investigation.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Chris P. Verschoor, Daniel W. Belsky, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, Janet E. McElhaney, George A. Kuchel
Summary: Biological age was found to be associated with improved antibody responses to influenza vaccination, depending on vaccine dose and cytomegalovirus (CMV) serostatus.
Article
Immunology
Jessica A. Breznik, Angela Huynh, Ali Zhang, Lucas Bilaver, Hina Bhakta, Hannah D. Stacey, Jann C. Ang, Jonathan L. Bramson, Ishac Nazy, Matthew S. Miller, Judah Denburg, Andrew P. Costa, Dawn M. E. Bowdish, Eric D. Brown, Gerry Wright, David C. Bulir, Mark Loeb, Marek Smieja, Aaron Jones, Parminder Raina, Chris Verschoor, Janet E. McElhaney, Kevin Brown, George A. Heckman, John P. Hirdes, Michael P. Hillmer, Ahmad Von Schlegell, Nathan M. Stall, Kevin Stinson, Arthur Sweetman
Summary: Chronic infection with human CMV does not affect antibody levels and quality, as well as cellular memory recall responses, after SARS-CoV-2 mRNA vaccination in older adults. However, CMV seropositivity may alter T cell composition without impeding the durability of humoral protection or cellular memory responses.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Virology
Aisha Nazli, Ryan Chow, Muhammad Atif Zahoor, Samuel Tekeste Workenhe, Tushar Dhawan, Chris Verschoor, Charu Kaushic
Summary: The study shows that HSV-2 is taken up by human vaginal epithelial cells through an endosomal-lysosomal pathway in association with LAMP3, which plays a crucial role in enhancing HSV-2 replication. These findings provide the basis for the future development of antiviral agents for preventive measures against HSV-2 infection.
JOURNAL OF VIROLOGY
(2022)
Article
Geriatrics & Gerontology
Jessica A. Breznik, Ahmad Rahim, Tara Kajaks, Megan Hagerman, Lucas Bilaver, Karen Colwill, Roaya M. Dayam, Anne -Claude Gingras, Chris P. Verschoor, Janet E. McElhaney, Jonathan L. Bramson, Dawn M. E. Bowdish, Andrew P. Costa
Summary: A longitudinal cohort study in nursing and retirement homes in Ontario, Canada, identified vaccine type, number of doses, and recent infection history as important factors for protection against Omicron variant infection in older adults.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Clinical Neurology
Anna Taddio, Katherine S. McGilton, Nancy Zheng, Lydia Yeung, Benoit Lafleur, Jollee S. T. Fung, Noni E. MacDonald, Melissa K. Andrew, Chris P. Verschoor
Summary: This study evaluated the drivers to implementation for COVID-19 vaccinations in a long-term care facility. The results showed that staff commitment, resource availability, and alignment with external policies were important factors for successful implementation. Future research is recommended to expand the strategies employed and involve residents more directly.
CANADIAN JOURNAL OF PAIN-REVUE CANADIENNE DE LA DOULEUR
(2022)
Article
Medicine, General & Internal
Vincenzo Forgetta, Rui Li, Corinne Darmond-Zwaig, Alexandre Belisle, Cynthia Balion, Delnaz Roshandel, Christina Wolfson, Guillaume Lettre, Guillaume Pare, Andrew D. Paterson, Lauren E. Griffith, Chris Verschoor, Mark Lathrop, Susan Kirkland, Parminder Raina, J. Brent Richards, Jiannis Ragoussis
Summary: The Canadian Longitudinal Study on Aging (CLSA) Comprehensive cohort collected genomic data from 26,622 individuals aged 45-85 to study the genetic and environmental contributions to human disease and aging process. The data revealed novel loci associated with glaucoma and validated the use of polygenic risk score in identifying individuals at high fracture risk. Future studies will focus on genetic factors in cognitive decline and cardiovascular diseases.