期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 41, 期 -, 页码 10-17出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2018.04.004
关键词
IL-6; IL-6 family; Cytokine; Cancer biomarker; Immunoprevention
资金
- PanCAN/AACR Career Development Award [14-20-25 MCAL]
- AGA-Bernard L. Schwartz Designated Research Award in Pancreatic Cancer
- V Foundation
- NCI [K12CA088084-16A1]
- NATIONAL CANCER INSTITUTE [P30CA016672, K12CA088084] Funding Source: NIH RePORTER
IL-6 is a critical cytokine in acute phase response and involved in the pathogenesis of several chronic inflammatory diseases including cancer. Studies have highlighted that levels of IL-6 and its family members can be useful for diagnosis, prognosis of relapse-free survival and recurrence. IL-6 family cytokines have been identified as cancer biomarkers through screening of inflammatory mediators in different fluids including saliva, serum, and bronchoalveolar lavage fluid (BALF). IL-6 can be modulated by chemopreventive drugs, small molecules, monoclonal antibodies and immune checkpoint inhibitors. Unveiling the different sources of IL-6, the interaction between IL-6 and its cellular targets, the IL-6-dependent tumor resistance mechanisms, and the identification of novel regulators of IL-6 are some of the highly complex topics included in this review and their understanding could aid cancer biomarkers and therapy development.
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