期刊
CYTOKINE
卷 106, 期 -, 页码 165-168出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2017.10.028
关键词
Diabetes mellitus; Fetuin B; Hepatic steatosis; Lipodystrophy; Obesity
资金
- Deutsche Forschungsgemeinschaft (DFG) [SFB 1052/2, C06]
- Bundesministerium fur Bildung and Forschung (BMBF), Germany [FKZ: 01E01501, K6a-87]
- Deutsche Hochdruckliga e.V.
Objective: Fetuin B is an adipokine/hepatokine which is significantly elevated in insulin resistance/type 2 diabetes mellitus and hepatic steatosis. Regulation of fetuin B in patients with lipodystrophy (LD) - a disease group which is characterized by subcutaneous adipose tissue loss, hypertriglyceridemia, hepatic steatosis, insulin resistance , and dysregulation of several adipokines - has not been elucidated so far. Material and methods: Serum fetuin B levels were determined in 37 patients with LD, as well as in a control cohort consisting of 37 non-LD participants matched for age, gender, and body mass index. Furthermore, fetuin B was correlated with parameters of lipid metabolism, glucose control, renal function, and inflammation. Results: Median fetuin B serum levels were not significantly different between patients with LD (2980.7 mu g/l; interquartile range: 841.7 mu g/l) and non-LD controls (2647.3 mu g/l; interquartile range: 923.6 mu g/l; p = .105). Fetuin B was associated with age, body mass index, markers of renal function, and C reactive protein (CRP) in univariate correlation analyses. The associations with age and creatinine remained significant in multiple linear regression analysis. Conclusions: Fetuin B serum concentrations are not significantly different between patients with LD and non-LD controls. Fetuin B does not seem to be a major pathogenetic factor in LD.
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