期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 48, 期 -, 页码 6-15出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2017.08.006
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资金
- RGC of Hong Kong [664113, 16103614, AoE-M09-12]
- 973 program grant from the Minister of Science and Technology of China [2014CB910204]
- Asia Fund for Cancer Research
Membrane-associated guanylate kinases (MAGUKs) are a family of scaffold proteins that are enriched in cellular junctions and essential for tissue development and homeostasis. Mutations of MAGUKs are linked to many human diseases including cancers, psychiatric disorders, and intellectual disabilities. MAGUKs share a common PDZ-SH3-GK tandem domain organization at the C-terminal end. In this review, we summarize the mechanistic basis governing target recognition and regulations of this binding by the PDZ-SH3-GK tandem of various MAGUKs. We also discuss recent discoveries showing unique folding features of MAGUK PDZ-SH3-GK tandems that facilitate ligand-induced oligomerization of MAGUKs and phase transition of MAGUK-assembled synaptic signaling complexes.
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