期刊
CURRENT OPINION IN IMMUNOLOGY
卷 51, 期 -, 页码 76-82出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2018.03.009
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资金
- National Institutes of Health [CA084488, CA100062]
- NATIONAL CANCER INSTITUTE [R01CA216936, R01CA100062, P30CA010815, R01CA084488] Funding Source: NIH RePORTER
In recent years, myeloid-derived suppressor cells (MDSC) have emerged as one of the major inhibitors of immune effector cell function in cancer. MDSC represent a heterogeneous population of largely immature myeloid cells that are characterized by a pathological state of activation and display potent immune suppressive activity. Two major subsets of MDSC have been identified: monocytic (M-MDSC) and polymorphonuclear (PMN-MDSC). PMN-MSDC share phenotypic and morphologic features with neutrophils, whereas M-MDSC are similar to monocytes and are characterized by high plasticity. Differentiation of M-MDSC to macrophages and dendritic cells is shaped by tumor microenvironment. In recent years, the mechanisms of this process start to emerge.
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