期刊
CURRENT OPINION IN IMMUNOLOGY
卷 52, 期 -, 页码 93-99出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2018.04.013
关键词
-
类别
资金
- National Institutes of Health [R01 AR048632]
- National Health and Medical Research Council
- Wellcome Trust
- Australian Research Council
- ARC Laureate Fellowship
- Translation Accelerator Grant from the Human Skin Disease Resource Center at Brigham and Women's Hospital
- Harvard Medical School [NIH P30 AR069625]
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR048632, P30AR069625] Funding Source: NIH RePORTER
Peptide and lipid antigens are presented to T cells when bound to MHC or CD1 proteins, respectively. The general paradigm of T cell antigen recognition is that T cell receptors (TCRs) co-recognize an epitope comprised of the antigen and antigen presenting molecule. Here we review the latest studies in which T cells operate outside the co-recognition paradigm: TCRs can broadly contact CD1 itself, but not the carried lipid. The essential structural feature in these new mechanisms is a large 'antigen free' zone on the outer surface of certain antigen presenting molecules. Whereas peptides dominate the exposed surface of MHC-peptide complexes, all human CD1 proteins have a closed, antigen-free surface, which is known as the A' roof. These new structural models help to interpret recent biological studies of CD1 autoreactive T cells in vivo, which have now been broadly observed in studies on TCR-transgenic mice, healthy humans and patients with autoimmune disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据