Review
Immunology
Zhongwei Zhang, Peter B. Ernst, Hiroshi Kiyono, Yosuke Kurashima
Summary: Mast cells are widely distributed immune cells with diverse phenotypes and functions. They exhibit high functional heterogeneity and plasticity due to their unique maturation mechanism. Mast cells can adapt to different microenvironments and regulate allergy and inflammation under the peripheral immune education system. This review focuses on the mechanism and heterogeneity of mast cell migration to mucosal tissues, such as the gastrointestinal tract. The immunosuppressive properties of mast cells suggest a potential new approach for treating inflammatory and allergic disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Natasha A. Winter, Ling Qin, Peter G. Gibson, Vanessa M. McDonald, Katherine J. Baines, Jack Faulkner, Tiffany-Jane Evans, Michael Fricker
Summary: This study identified 8 MC/basophil-related genes in sputum and found correlations with eosinophilic inflammation, lung function, and exacerbation history in severe asthma. The gene signature may reflect variations in sputum MC/basophil abundance and their associations with clinical and inflammatory characteristics in severe asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Cell Biology
Jason R. Burchett, Jordan M. Dailey, Sydney A. Kee, Destiny T. Pryor, Aditya Kotha, Roma A. Kankaria, David B. Straus, John J. Ryan
Summary: The incidence of allergic disease has increased significantly over the past three generations. Current treatments are not sufficient to meet the needs of all patients. Mast cells play a crucial role in allergic inflammation and have been targeted for allergy therapy. New drugs are now focusing on blocking interactions between IgE, IL-4, IL-13, and their receptors. This review summarizes the latest therapies targeting mast cells and discusses the potential repurposing of FDA-approved drugs. The repurposing of drugs offers optimism for the future of allergy therapy, given the availability of highly selective drugs for other diseases.
Review
Immunology
Despina Michailidou, Daniella Muallem Schwartz, Tomas Mustelin, Grant C. Hughes
Summary: IgG4-related disease shares pathogenic mechanisms with allergic disease, including activation of Th2 and Treg cells, overproduction of IgG4 and IgE, and increase in blood/tissue eosinophils. Tissue fibrosis in IgG4-RD involves activation of basophils and mast cells and release of alarmins.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xin Liu, Yufei Zhang, Xu Cui, Ting Fan, Jin Shu, Hui Li, Xiaojing Huo, Chao Lu
Summary: Gd-DTPA induced severe allergic reactions and mast cells activation, leading to histamine, tryptase, and cytokines release in both mice serum and LAD2 cells supernatant. RNAseq analysis showed changes in mRNA levels related to inflammation signaling pathways after Gd-DTPA activated MCs.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Young-Ae Choi, Hima Dhakal, Soyoung Lee, Namkyung Kim, Byungheon Lee, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kim
Summary: This study elucidated the non-transcriptional role of IRF3 in mast cell activation and allergic inflammation. In vitro and in vivo experiments showed that IRF3 played a significant role in mast cell-mediated allergic inflammation. The activation of IRF3 was observed during mast cell activation process, and it affected the production of granule contents and the anaphylaxis responses. Overall, IRF3 is an important factor inducing mast cell activation and regulating HDC activity.
Article
Immunology
Olga Krysko, Darya Korsakova, Andrea Teufelberger, Amse De Meyer, Jill Steels, Natalie De Ruyck, Judith van Ovost, Sharon Van Nevel, Gabriele Holtappels, Frauke Coppieters, Mikhail Ivanchenko, Harald Braun, Maria Vedunova, Dmitri V. V. Krysko, Claus Bachert
Summary: This study found that there are differences in the number and protease content of lung mast cells between C57BL/6 and BALB/c mice, which may affect the processing of IL-33 and the inflammatory outcome of Alt-induced airway inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Pier Giorgio Puzzovio, Hadas Pahima, Tresa George, David Mankuta, Ron Eliashar, Ekaterini Tiligada, Bruce D. Levy, Francesca Levi-Schaffer
Summary: This study investigates the pro-resolution role of mast cells in allergic inflammation. The results show that activated mast cells release a significant amount of resolvin D1 after 30 minutes, which can actively contribute to the resolution of allergic inflammation.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Zhirong Fu, Srinivas Akula, Anna-Karin Olsson, Jukka Kervinen, Lars Hellman
Summary: Various parasites inject anticoagulant proteins to prevent the host's blood from coagulating during feeding, while ticks produce serpins to inhibit host mast cell proteases, indicating an ongoing arms race between blood-feeding animals and the mammalian immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Tamara T. Haque, Pamela A. Frischmeyer-Guerrerio
Summary: This article discusses cytokines that regulate mast cell-mediated allergic immune responses. Understanding the mechanisms of these cytokines is important for the development of effective treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Ekaterini Tiligada, Bernhard F. Gibbs, Satoshi Tanaka
Summary: This joint webinar focused on the roles of mast cells and basophils, highlighting their contributions to inflammatory and immune-related diseases and introducing potential targets for novel treatments.
INFLAMMATION RESEARCH
(2022)
Article
Medical Laboratory Technology
Didier G. Ebo, Kevin Heremans, Michiel Beyens, Marie-Line M. van der Poorten, Athina L. Van Gasse, Christel Mertens, Michel Van Houdt, Vito Sabato, Jessy Elst
Summary: The basophil activation test (BAT) is a reliable complementary diagnostic for IgE-dependent allergies, but it has limitations. In contrast, the mast cell activation test (MAT) using passively sensitized mast cells (MCs) has advantages such as using frozen serum samples and studying IgE-independent mechanisms.
CLINICA CHIMICA ACTA
(2022)
Article
Immunology
Hima Dhakal, Min -Jong Kim, Soyoung Lee, Young-Ae Choi, Namkyung Kim, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kim
Summary: The study demonstrated that ursolic acid (UA) exerts anti-allergic effects by inhibiting FceRI-mediated mast cell activation. It suppresses mast cell degranulation by reducing intracellular calcium levels and inhibits the expression and release of inflammatory cytokines. Furthermore, UA also inhibits passive cutaneous anaphylaxis and active systemic anaphylaxis reactions in a mouse model in a dose-dependent manner.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lucia Garcia-Garcia, Laia Olle, Margarita Martin, Jordi Roca-Ferrer, Rosa Munoz-Cano
Summary: Adenosine, through its binding to different G protein-coupled receptors, can have either anti-inflammatory or pro-inflammatory effects, with A2a receptor typically showing anti-inflammatory activity. Understanding the mechanisms of action of adenosine on specific receptors may lead to the development of more effective therapies for allergic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Giuseppe Murdaca, Mario Di Gioacchino, Monica Greco, Matteo Borro, Francesca Paladin, Claudia Petrarca, Sebastiano Gangemi
Summary: Basophils play a crucial role in immune response to SARS-CoV-2 and their depletion may impact the antibody response, while mast cells participate in the initial immune response but their activation can lead to hyperinflammatory syndrome. Both basophil counts and mast cell activation could be important factors in the prognosis and treatment of COVID-19.