期刊
CURRENT OPINION IN IMMUNOLOGY
卷 53, 期 -, 页码 124-129出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2018.04.026
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资金
- Rockefeller University
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [U19AI111825, U19AI109946]
A critical factor in the maturation of influenza vaccine responses is the nearly inevitable binding of vaccine antigens by exiting anti-influenza IgGs. These antigen-IgG immune complexes direct the response to immunization by modulating cellular processes that determine antibody and T-cell repertoires: maturation of dendritic cells, processing and presentation of antigens to T cells, trafficking of antigens to the germinal center, and selection of B cells for antibody production. By focusing on the recent advances in the study of the immunomodulatory processes mediated by IgG immune complexes upon influenza vaccination, we discuss a pathway that is critical for modulating the breadth and potency of anti HA antibody responses and has previously led to the development of strategies to improve influenza vaccine efficacy.
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