期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 48, 期 -, 页码 128-133出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2018.01.001
关键词
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资金
- NIH/NCI grant [R01CA215753]
- Hyundai Hope on Wheels grant
- Jean Perkins Foundation grant
- Nautica Malibu Triathlon Funds
- STOP Cancer grant
- Hugh and Audy Lou Colvin Foundation grant
- Alex's Lemonade Stand Foundation grant
- National Cancer Institute [P30CA014089]
MicroRNAs (miRNAs) have emerged as important regulators of human carcinogenesis by affecting the expression of key oncogenes and tumor suppressor genes. MiRNAs elicit their function through post-transcriptional regulation of the mRNA translation into protein as well as functioning as ligands for proteic receptors called miRceptors. Our understanding of the role of miRNAs in cancer biology has enormously improved in the last few years, providing the rationale for new therapeutics. Here we discuss the most recent findings on the role of miRNAs in modulating cancer biology with a specific focus on their role as modulators of the biology of the tumor microenvironment both as cargo of extracellular vesicles and as extra-vesicular miRNAs.
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