Review
Biochemistry & Molecular Biology
Yuan He, Xin-Hui-Zi Hong, Meng Xu, Yuan-Fa Liu, Yong-Jiang Xu
Summary: This study conducted a meta-analysis to explore the relationship between BCFAs and metabolic syndrome (MetS), and found a significant negative correlation between endogenous BCFAs and the risk of developing MetS. The study provides insights for the development of novel biomarkers for diagnosing MetS in the future.
Review
Medicine, Research & Experimental
Jingtong Wang, Wei Wang, Feng Zhu, Qiuhong Duan
Summary: Branched-chain amino acids (BCAAs) play a crucial role in human bodies and their metabolic disorders are closely associated with tumorigenesis and progression. This review discusses the significant role of BCAAs metabolic disorders in different tumor types and explores related proteins and therapeutic approaches.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Nutrition & Dietetics
Katarzyna Paczkowska, Dominik Rachon, Andrzej Berg, Jacek Rybka, Katarzyna Kapczynska, Marek Bolanowski, Jacek Daroszewski
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that predisposes women to metabolic disturbances. Recent research suggests that alterations in amino acid profiles may be indicative of metabolic disorders. This study found elevated levels of aromatic amino acids in PCOS women, and significant differences in amino acid concentrations between metabolically healthy and unhealthy obesity subgroups of PCOS women.
Review
Nutrition & Dietetics
Chuang Du, Wen-Jie Liu, Jing Yang, Shan-Shan Zhao, Hui-Xin Liu
Summary: This article introduces the importance of branched-chain amino acids in human physiology and their association with various metabolic disorders. It also discusses the relationship between the alteration of the branched-chain amino acid catabolism enzyme BCKDK and related diseases. Additionally, the article highlights the interaction between branched-chain amino acids and the gut microbiota.
FRONTIERS IN NUTRITION
(2022)
Review
Biotechnology & Applied Microbiology
Yoichi Toyokawa, Jirasin Koonthongkaew, Hiroshi Takagi
Summary: BCAT catalyzes transamination between BCAAs and BCKAs in the cell. Eukaryotic cells have mitochondrial BCAT (BCATm) and cytosolic BCAT (BCATc) isozymes, which have similar enzymatic functions but differences in physiological functions and regulatory mechanisms. The variations of BCAT could have significant implications for research into the relationship between their primary structures and protein functions.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Genetics & Heredity
Can Chen, Hassan Naveed, Keping Chen
Summary: This article introduces the important role of branched-chain amino acid aminotransferases in cellular metabolism, summarizes the related research in animals, plants, microorganisms, and humans, and analyzes the molecular mechanism. It has been found that disorders in branched-chain amino acid metabolism are closely related to various diseases, especially tumor development.
FRONTIERS IN GENETICS
(2023)
Article
Microbiology
Soumita Dutta, Ileana D. Corsi, Naomi Bier, Theresa M. Koehler
Summary: Research has shown that branched-chain amino acid synthesis is not sufficient for the robust growth of Bacillus anthracis; access to branched-chain amino acids is necessary for the proliferation of the pathogen in culture and during infection in a murine model. B. anthracis produces a large repertoire of branched-chain amino acid-related transporters, with three isoleucine/valine transporters identified with partial functional redundancy. Deletion of one of these transporters, BrnQ3, led to attenuated virulence. A mutant deficient in branched-chain amino acid biosynthesis grew well in medium containing these amino acids, but was also attenuated in virulence. These findings suggest that branched-chain amino acids are limited in multiple niches during infection and contribute to understanding the nutritional requirements of this important pathogen.
Article
Microbiology
Soumita Dutta, Ileana D. Corsi, Naomi Bier, Theresa M. Koehler
Summary: The expression of branched-chain amino acid (BCAA)-related genes is important for the virulence of Bacillus anthracis. BCAA transport is required for optimal growth of B. anthracis in vitro, and BCAAs enhance the activity of the virulence regulator AtxA. BCAAs also serve as a signal for virulence gene expression. This study provides insights into the metabolic and nutritional requirements of B. anthracis.
Article
Fisheries
Yuliang Wei, Zhiyuan Sun, Mei Duan, Qiang Ma, Houguo Xu, Mengqing Liang
Summary: The study found that the growth of tiger puffer was not affected by diets containing 12.6-55.9 g kg(-1) leucine. An excess of dietary leucine, isoleucine, or valine possibly resulted in antagonism between BCAAs, showing that excessive intake of one BCAA may lead to antagonistic effects when the other two BCAAs met the requirements for tiger puffer.
Article
Endocrinology & Metabolism
Daniel Ferguson, Sophie J. Eichler, Nicole K. H. Yiew, Jerry R. Colca, Kevin Cho, Gary J. Patti, Trevor M. Shew, Andrew J. Lutkewitte, Sandip Mukherjee, Kyle S. McCommis, Natalie M. Niemi, Brian N. Finck
Summary: The study evaluated the effects of MPC inhibitors (MPCi) on branched chain amino acid (BCAA) metabolism and found that MPCi can lower plasma BCAA concentrations and activate AMPK and mTOR signaling pathways. However, the effects on glucose homeostasis may be separate from BCAA concentrations.
MOLECULAR METABOLISM
(2023)
Article
Chemistry, Multidisciplinary
Jia-yu Yu, Nancy Cao, Christoph D. Rau, Ro-Po Lee, Jieping Yang, Rachel J. Roth Flach, Lauren Petersen, Cansheng Zhu, Yea-Lyn Pak, Russell A. Miller, Yunxia Liu, Yibin Wang, Zhaoping Li, Haipeng Sun, Chen Gao
Summary: Parallel to changes in fatty acid and glucose metabolism, defects in branched-chain amino acid (BCAA) catabolism have been recognized as a metabolic hallmark and potential therapeutic target for heart failure. This study developed two mouse models to investigate the impact of BCAA catabolic defects in cardiomyocytes. The results showed that inactivation of the BCKDHA gene in cardiomyocytes led to loss of cardiac function and pathological changes, while inactivation of the BCKDK gene did not impact cardiac function. These findings establish the cell-autonomous role of BCAA catabolism in cardiac physiology and provide valuable models for studying BCAA-targeted therapy for heart failure.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Leo Man-Yuen Lee, Zhi-Qiang Lin, Lu-Xi Zheng, Yi-Fan Tu, Yik-Hing So, Xiu-Hua Zheng, Tie-Jun Feng, Xi-Yue Wang, Wai-Ting Wong, Yun-Chung Leung
Summary: Growing evidence shows that restricting amino acid intake can reverse obesity by reducing adipose tissue mass. Amino acids not only serve as building blocks for proteins but also play a role as signaling molecules in various biological processes. Understanding how adipocytes respond to changes in amino acid levels is crucial for studying obesity and developing potential treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
Summary: The study demonstrates that BCAA metabolism is involved in the development of colorectal cancer (CRC). BCAT2 deficiency promotes CRC progression by inhibiting BCAA metabolism and chronically activating the mTORC1 pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Cell Biology
Xiaoyu Zhang, Yan Liu, Froylan Sosa, Sumedha Gunewardena, Peter A. Crawford, Amanda C. Zielen, Kyle E. Orwig, Ning Wang
Summary: Nutrient transporter genes are downregulated in germ cells during meiotic initiation, and this process requires the presence of Stra8. Stra8 binds to these genes and induces their H3K27 deacetylation. In the absence of Stra8, germ cells continue to uptake glutamine and glucose, leading to hyperactive mTORC1/PKA activities.
Article
Cell Biology
Sonia Ravanelli, Qiaochu Li, Andrea Annibal, Aleksandra Trifunovic, Adam Antebi, Thorsten Hoppe
Summary: Using genetics and multi-omics analyses, researchers have found a link between branched-chain amino acid metabolism and the regulation of the ubiquitin-proteasome system. This sheds light on the role of branched-chain amino acids in the aging process and opens up possibilities for future therapeutic interventions.
Article
Biotechnology & Applied Microbiology
Dubhe B. Bulte, Laura A. Palomares, Carolina Gomez Parra, Juan Andres Martinez, Martha A. Contreras, Lilia G. Noriega, Octavio T. Ramirez
BIOTECHNOLOGY AND BIOENGINEERING
(2020)
Article
Multidisciplinary Sciences
K. Zamora-Lopez, L. G. Noriega, A. Estanes-Hernandez, I. Escalona-Nandez, S. Tobon-Cornejo, A. R. Tovar, V. Barbero-Becerra, C. Perez-Monter
SCIENTIFIC REPORTS
(2020)
Article
Endocrinology & Metabolism
Laura Velazquez-Villegas, Lilia G. Noriega, Adriana M. Lopez-Barradas, Sandra Tobon-Cornejo, Ana Luisa Mendez-Garcia, Armando R. Tovar, Nimbe Torres, Victor M. Ortiz-Ortega
Summary: This study demonstrates that ChREBP controls glucogenic amino acid uptake in rats consuming a high-carbohydrate diet by repressing SNAT2 expression. The interaction between ChREBP and SMRT forms a complex to reduce SNAT2 transcription.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Andrea Torres, Lilia G. Noriega, Claudia Delgadillo-Puga, Armando R. Tovar, Arturo Navarro-Ocana
Summary: The study demonstrates the potential of CQA derivatives in improving mitochondrial function in hepatic cells, especially in conditions like obesity, diabetes, and metabolic syndrome. Among the tested compounds, 3,4-diCQA shows significant promise by increasing glycolytic reserve, while 4,5-diCQA enhances glycolysis activity at low concentrations, improving the ability to oxidize fatty acids.
Article
Biochemistry & Molecular Biology
Elizabeth Figueroa-Juarez, Lilia G. Noriega, Carlos Perez-Monter, Gabriela Aleman, Rogelio Hernandez-Pando, Ricardo Correa-Rotter, Victoria Ramirez, Armando R. Tovar, Ivan Torre-Villalvazo, Claudia Tovar-Palacio
Summary: The study demonstrates that pharmacological induction of ER stress in mice leads to kidney structural abnormalities, in situ lipid synthesis, renal lipid accumulation, and functional alterations. Future strategies should focus on targeting renal ER stress to prevent kidney damage and metabolic diseases.
Article
Nutrition & Dietetics
Rocio Guizar-Heredia, Armando R. Tovar, Omar Granados-Portillo, Edgar Pichardo-Ontiveros, Adriana Flores-Lopez, Luis E. Gonzalez-Salazar, Liliana Arteaga-Sanchez, Isabel Medina-Vera, Ximena Orozco-Ruiz, Nimbe Torres, Lilia G. Noriega, Martha Guevara-Cruz
Summary: The amino acid profile of subjects with obesity is differentially affected by age, insulin resistance, and specific gene polymorphisms. Young adults with obesity have higher levels of certain amino acids compared to older adults, and the presence of insulin resistance and specific gene polymorphisms can alter amino acid concentrations in this population.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Alain Aguilar-Valdes, Lilia G. Noriega, Armando R. Tovar, Maria de J. Ibarra-Sanchez, Victor A. Sosa-Hernandez, Jose L. Maravillas-Montero, Juan Martinez-Aguilar
Summary: This study compared protein expression differences between pancreatic cancer cells with sensitivity and resistance to MEK and PI3K kinase inhibitors, discovering tumor suppressor protein phosphatase 2A (PP2A) and proteins from mitochondrial respiratory complex I as alternative drug targets for cells resistant to MEK and PI3K inhibition.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Lilia G. Noriega, Zesergio Melo, Renuga D. Rajaram, Adriana Mercado, Armando R. Tovar, Laura A. Velazquez-Villegas, Maria Castaneda-Bueno, Yazmin Reyes-Lopez, Dongryeol Ryu, Lorena Rojas-Vega, German Magana-Avila, Adriana M. Lopez-Barradas, Mariana Sanchez-Hernandez, Anne Debonneville, Alain Doucet, Lydie Cheval, Nimbe Torres, Johan Auwerx, Olivier Staub, Gerardo Gamba
Summary: SIRT7 interacts with, stabilizes, and modulates the activity of KCC4 through deacetylation, revealing a novel role for SIRT7 in renal physiology.
Article
Biochemistry & Molecular Biology
Valeria Lopez-Salazar, Monica Sanchez Tapia, Sandra Tobon-Cornejo, Daniel Diaz, Gabriela Aleman-Escondrillas, Omar Granados-Portillo, Lilia Noriega, Armando R. Tovar, Nimbe Torres
Summary: The study showed that consuming soybean oil rich in polyunsaturated fats benefits gut microbiota diversity, increases insulin sensitivity, and reduces inflammation. Meanwhile, consuming olive oil rich in monounsaturated fats increases Bifidobacterium levels, enhances fatty acid oxidation, and decreases inflammation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Sarai Vasquez-Reyes, Laura A. Velazquez-Villegas, Ariana Vargas-Castillo, Lilia G. Noriega, Nimbe Torres, Armando R. Tovar
Summary: This review focuses on the impact of dietary bioactive compounds on mitochondrial activity and their relationship in pathological contexts. While evidence supports the beneficial effects of bioactive compounds, further studies are needed to determine their effectiveness in humans.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Luis E. Gonzalez-Salazar, Omar Granados-Portillo, Isabel Medina-Vera, Edgar Pichardo-Ontiveros, Ana Vigil-Martinez, Rocio Guizar-Heredia, Berenice Palacios-Gonzalez, Liliana Arteaga-Sanchez, Karla G. Hernandez-Gomez, Azalia Avila-Nava, Aurora E. Serralde-Zuniga, Adriana Flores-Lopez, Lilia G. Noriega, Nimbe Torres, Viridiana Olin-Sandoval, Natalia Vazquez-Manjarrez, Natali Dominguez-Velazquez, Juan G. Reyes-Garcia, Armando R. Tovar, Martha Guevara-Cruz
Summary: This study found that the presence of BCAT2 SNP can modify the effect of dietary intervention on plasma BCAA concentration in subjects with obesity and insulin resistance, leading to a greater reduction in BCAA levels after an energy-restricted dietary intervention.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Juan M. Vargas-Morales, Rocio Guizar-Heredia, Ana L. Mendez-Garcia, Berenice Palacios-Gonzalez, Alejandro Schcolnik-Cabrera, Omar Granados, Adriana M. Lopez-Barradas, Natalia Vazquez-Manjarrez, Isabel Medina-Vera, Miriam Aguilar-Lopez, Claudia Tovar-Palacio, Guillermo Ordaz-Nava, Ana K. Rocha-Viggiano, Eduardo Medina-Cerda, Nimbe Torres, Jose M. Ordovas, Armando R. Tovar, Martha Guevara-Cruz, Lilia G. Noriega
Summary: The study found that individuals with genetic variants in BCAT2 and BCKDH genes had significant differences in body weight, BMI, blood pressure, glucose, and certain circulating amino acid levels compared to those without these variants.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Food Science & Technology
Sarai Vasquez-Reyes, Ariana Vargas-Castillo, Lilia G. Noriega, Laura A. Velazquez-Villegas, Berenice Perez, Monica Sanchez-Tapia, Guillermo Ordaz, Renato Suarez-Monroy, Alfredo Ulloa-Aguirre, Halina Offner, Nimbe Torres, Armando R. Tovar
Summary: This study aims to determine whether genistein activates thermogenesis and mitochondrial activity in white adipose tissue (WAT) through the G-coupled receptor GPR30. The results show that GPR30 partially mediates genistein stimulation of WAT thermogenesis and the improvement of glucose tolerance.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Nutrition & Dietetics
Claudia Tovar-Palacio, Lilia G. Noriega, Adriana Mercado
Summary: SIRT1 and NAD(+) metabolism play important roles in renal diseases. Polyphenols derived from natural sources can activate SIRT1 and regulate NAD(+) metabolism, thus preventing and treating various diseases.
Article
Nutrition & Dietetics
Luis E. Gonzalez-Salazar, Edgar Pichardo-Ontiveros, Berenice Palacios-Gonzalez, Ana Vigil-Martinez, Omar Granados-Portillo, Rocio Guizar-Heredia, Adriana Flores-Lopez, Isabel Medina-Vera, Pamela K. Heredia-G-Canton, Karla G. Hernandez-Gomez, Georgina Castelan-Licona, Liliana Arteaga-Sanchez, Aurora E. Serralde-Zuniga, Azalia Avila-Nava, Lilia G. Noriega-Lopez, Juan G. Reyes-Garcia, Carlos Zerrweck, Nimbe Torres, Armando R. Tovar, Martha Guevara-Cruz
Summary: The study demonstrates that high-protein hypocaloric diets can significantly improve insulin sensitivity in subjects with obesity and insulin resistance, regardless of the source of protein being animal or vegetable.
EUROPEAN JOURNAL OF NUTRITION
(2021)
