期刊
CURRENT OPINION IN CELL BIOLOGY
卷 54, 期 -, 页码 121-129出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2018.05.016
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资金
- Era of Hope Scholar Award from the Congressionally Directed Medical Research Programs Breast Cancer Research Program [BC141351]
- National Institute on Aging [R01AG040081]
- City of Hope Center for Cancer and Aging
Aging is driven by unavoidable entropic forces, physicochemical in nature, that damage the raw materials that constitute biological systems. Single cells experience and respond to stochastic physicochemical insults that occur either to the cells themselves or to their microenvironment, in a dynamic and reciprocal manner, leading to increased age-related cell-to-cell variation. We will discuss the biological mechanisms that integrate cell-to-cell variation across tissues resulting in stereotypical phenotypes of age.
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