期刊
CURRENT NEUROPHARMACOLOGY
卷 16, 期 4, 页码 338-349出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570159X15666170912110450
关键词
Neuronal nicotinic acetylcholine receptor subtypes; subunit composition; ligand binding site; stochiometry; non-neuronal nicotinic acetylcholine receptors; knockout and knockout in mice
资金
- CNR Research Project on Aging
- CNR
- Fondazione Monzino (Milano)
- Fondazione Vollaro (Milano)
- UNIMORE FAR
Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands. These receptors are also the targets of drugs such as nicotine (the main addictive agent delivered by cigarette smoke) and are involved in a variety of physiological and pathophysiological processes. Numerous studies have shown that the expression and/or function of nAChRs is compromised in many neurological and psychiatric diseases. Furthermore, recent studies have shown that neuronal nAChRs are found in a large number of non-neuronal cell types including endothelial cells, glia, immune cells, lung epithelia and cancer cells where they regulate cell differentiation, proliferation and inflammatory responses. The aim of this review is to describe the most recent findings concerning the structure and function of native nAChRs inside and outside the nervous system.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据