Review
Biochemistry & Molecular Biology
Joanna Kubik, Ewelina Humeniuk, Grzegorz Adamczuk, Barbara Madej-Czerwonka, Agnieszka Korga-Plewko
Summary: Cancer, the second leading cause of global death, necessitates the development of new treatment strategies that are highly effective and have few side effects. This review presents the changes in metabolic pathways in cancer cells and highlights the differences in metabolic phenotype between cancer cells and normal cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Kexin Fan, Zhan Liu, Min Gao, Kangsheng Tu, Qiuran Xu, Yilei Zhang
Summary: Metabolic reprogramming is a hallmark of tumors, and the dependency of tumor cells on specific nutrients can be exploited for cancer treatment. This review discusses the mechanisms and applications of nutrient dependency, as well as the strategies and challenges in targeting nutrient dependency in different types of cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Elisabet Cuyas, Sara Verdura, Begona Martin-Castillo, Javier A. Menendez
Summary: Research suggests that the anti-diabetic drug metformin can modulate the chromatin state of cancer cells, affecting their function. Metformin has the ability to target global metabolic pathways or specific metabolic enzymes, regulating the production of chromatin-modifying metabolites, and indirectly or directly adjusting the activation status of chromatin-modifying enzymes.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Zsuzsanna Nemeth, Attila Patonai, Laura Simon-Szabo, Istvan Takacs
Summary: The prevention and control of non-communicable diseases, especially in the aging population, is crucial for healthcare sustainability. Adequate lifestyle changes and regulation of vitamin D and SIRT1 play a significant role in reducing mortality and improving quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Anna Halama, Karsten Suhre
Summary: Dysregulated glutamine metabolism is a distinct feature of cancer cells compared to normal cells, and targeting this pathway can effectively inhibit cancer cell growth. However, cancer cells can activate alternative metabolic pathways to survive, limiting the effectiveness of treatments solely based on glutamine inhibition. Therefore, combination therapies targeting glutamine metabolism along with other pathways show potential for improving clinical outcomes.
Review
Pharmacology & Pharmacy
Ruimin Kong, Guojuan Sun
Summary: This article reviews the potential strategy of targeting copper metabolism in cancer treatment and discusses the role of copper in biological processes and various treatment methods. By disrupting copper homeostasis in cancer cells and inducing cell death through copper-dependent mechanisms (cuproplasia and cuprotosis), therapies with improved efficacy and reduced side effects can be developed.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Immunology
Jiaxin Yong, Songqing Cai, Zhaolei Zeng
Summary: This article summarizes the detrimental effects of increased NAD(+) production, the functions of NAD(+) metabolic enzymes in creating an immunosuppressive tumor microenvironment, and discusses the progress and clinical translational potential of inhibitors for NAD(+) synthesis and therapies targeting NADase.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Aiora Cenigaonandia-Campillo, Roberto Serna-Blasco, Laura Gomez-Ocabo, Sonia Solanes-Casado, Natalia Banos-Herraiz, Laura Del Puerto-Nevado, Jose Antonio Canas, Maria Jesus Acenero, Jesus Garcia-Foncillas, Oscar Aguilera
Summary: The study revealed a significant role of vitamin C in regulating pyruvate dehydrogenase (PDH) activity, thus modulating the TCA cycle and mitochondrial metabolism in KRAS mutant colon cancer. Vitamin C downregulated PDK-1 expression in KRAS mutant CRC cells and murine xenografts by reducing proline hydroxylation of HIF-1α, leading to decreased GLUT-1 expression.
Article
Oncology
Che-Chia Hsu, Danni Peng, Zhen Cai, Hui-Kuan Lin
Summary: The activation of AMPK is crucial for maintaining energy homeostasis and metabolic regulation. AMPK has been identified as a potential therapeutic target for metabolic disorders and cancer. However, its role in cancer is complex and can either suppress or promote tumor growth.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Ziwen Zhu, Pooja Parikh, Hongyun Zhao, Nathan T. Givens, Damien B. Beck, Conner M. Willson, Qian Bai, Mark R. Wakefield, Yujiang Fang
Summary: Tumor metabolism has emerged as a prominent research area, leading to new opportunities in metabolism-based cancer therapy. Intratumoral heterogeneity in tumors results in complex energy metabolism phenotypes in tumor cells, with metabolic reprogramming during tumor progression.
Review
Oncology
Ling-Chu Chang, Shih-Kai Chiang, Shuen-Ei Chen, Mien-Chie Hung
Summary: This review describes the molecular interactions, regulation, and disease relationships of OGDHc, a key enzyme in the tricarboxylic acid (TCA) cycle. Dysregulation of OGDHc can disrupt cellular redox homeostasis and lead to the accumulation of oncometabolites in cancer development. The potential of OGDHc as a therapeutic target for cancer treatment is discussed.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Nadine Abdel Hadi, Gabriela Reyes-Castellanos, Alice Carrier
Summary: Cell metabolism in cancer cells is reprogrammed to meet their high energy and biosynthetic demands, leading to alterations in redox metabolism and accumulation of reactive oxygen species (ROS). Cancer cells adapt to high ROS levels, contributing to tumorigenesis, metastasis, therapy resistance, and relapse. Combining strategies to increase ROS production and inhibit antioxidant capacity is a promising approach for pancreatic cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Yi Zhang, Qiong Li, Zhao Huang, Bowen Li, Edouard C. Nice, Canhua Huang, Liuya Wei, Bingwen Zou
Summary: Reprogramming glucose metabolism is an important strategy for targeted cancer treatment. Although advanced and effective drugs have been developed, there are still challenges in translating them into clinical applications due to limitations such as short half-life, poor solubility, and multiple side effects. Combining glucose metabolism modulators with conventional anticancer drugs may be a future direction for cancer treatment.
Review
Nutrition & Dietetics
Stephanie Marie Cruz-Pierard, Teresa Nestares, Francisco J. Amaro-Gahete
Summary: Vitamin D supplementation has a protective effect in the prevention and treatment of CRC, while calcium intake shows contradictory effects and further studies are needed to understand its relevance in patients with CRC.
Review
Nutrition & Dietetics
Jesus Rodriguez-Molinero, Blanca del Carmen Miguelanez-Medran, Cristina Puente-Gutierrez, Esther Delgado-Somolinos, Carmen Martin Carreras-Presas, Javier Fernandez-Farhall, Antonio Francisco Lopez-Sanchez
Summary: Oral cancer, the sixth most common malignant neoplasm in the world, is mainly caused by tobacco and alcohol, with diet also considered an important factor. Some dietary nutrients, such as fruits, vegetables, curcumin, and green tea, have anti-cancer effects, while a diet rich in red meat and fried foods may increase the risk. Research suggests that a diet rich in vegetables and fruits can have preventive effects against oral and other types of cancer.
Review
Oncology
Kanika Sharma, Payal Kesharwani, Shiv Kumar Prajapati, Ankit Jain, Dolly Jain, Nishi Mody, Swapnil Sharma
Summary: Cancer is a major cause of death worldwide. This review focuses on the use of pomegranate as an alternative source of medication for cancer treatment. The polyphenols found in pomegranate have shown promising anticancer activity. The review discusses the chemical structure, properties, and role of pomegranate in the treatment of breast, lung, thyroid, colon, and prostate cancer. It also explores targeted drug delivery approaches and ongoing clinical trials related to pomegranate compounds.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Sarjana Raikwar, Ankit Jain, Shivani Saraf, Pooja Das Bidla, Pritish Kumar Panda, Ankita Tiwari, Amit Verma, Sanjay K. Jain
Summary: Breast carcinoma is a leading cause of cancer-related death in women due to poor response to traditional therapies. Combining chemotherapy and immunotherapy has been introduced to overcome challenges such as cytotoxicity and drug resistance. Nanotechnology-based drug delivery systems show promise in targeted and controlled drug release for more effective treatment.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Automation & Control Systems
Ankit Jain, Abhishek Srivastava
Summary: This research proposes a novel vision-based fire detection framework that preserves privacy by using a near infrared camera. The framework proves to have superior performance and model size compared to existing techniques. The effectiveness of the system in resource-constrained environments is validated through a real-world implementation.
IEEE TRANSACTIONS ON INDUSTRIAL INFORMATICS
(2022)
Article
Chemistry, Analytical
Ankita Tiwari, Devasish Bose, Pooja Mishra, Ankit Jain, Sanjay K. Jain
Summary: A micellar-HPLC method was developed for the determination of oxaliplatin and curcumin, aiming to provide a rapid, cost-effective, environmentally friendly, time-efficient, easy-to-handle, and safe analytical approach. The optimized conditions and compliance with ICH guidelines ensured accuracy and precision in the analysis. The results demonstrated the method's robustness and capability for quantitative analysis of the drugs in mice serum/blood, potentially contributing to the development of pharmaceutical preparations for colorectal cancer treatment.
JOURNAL OF AOAC INTERNATIONAL
(2022)
Article
Plant Sciences
Shiv Kumar Prajapati, Akanksha Malaiya, Gaurav Mishra, Dolly Jain, Payal Kesharwani, Nishi Mody, Amirhossein Ahmadi, Rishi Paliwal, Ankit Jain
Summary: The review emphasizes the potential of herbal medicines in enhancing immunity and treating COVID-19, highlighting their importance in combating SARS-COV-2 infection and potential future applications.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Orthopedics
Ankit Jain, Anil Agarwal, Ravi Jethwa, Jatin Raj Sareen, Yogesh Patel
Summary: Migration of epiphyseal screws into growing physis is a known complication in tension band plating. This study investigated the technical details contributing to this complication in 10 patients. The length of the screw, proximity to the physis, trajectory angle, and correction rate were analyzed. Migrated plates had a closer starting point to the physis and a more divergent screw trajectory compared to uncomplicated plates. Osteopenic bone and pathological physis were identified as predisposing factors.
JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
(2023)
Article
Instruments & Instrumentation
Shivani Saraf, Sanjay K. Jain
Summary: This project aims to increase the delivery of drugs to solid tumors by using endosomal escape. Topotecan and capsaicin were encapsulated in liposomes to improve therapeutic efficacy. The developed pH-sensitive liposomes showed improved intracellular drug delivery and demonstrated potential for targeted drug delivery to solid tumors.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Ashwini Kumar Mishra, S. L. Neha, Laxmi Rani, Ankit Jain, Hitesh Kumar Dewangan, Pravat Kumar Sahoo
Summary: The proposed research focuses on utilizing a nanoplatform based on eudragit RL for the delivery of drugs and natural bioenhancers. This approach aims to enhance efficacy, bioavailability, synergistic effects, and minimize toxic effects. The study successfully encapsulated Silymarin and Piperine in nanoparticles and demonstrated their effectiveness in enhancing antioxidant characteristics and hepatoprotective effects.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Letter
Dermatology
Sumit Goel, Ankit Jain, Swati Gupta, Kamarthi Nagaraju, Sangeeta S. Malik, Isha Maheshwari
INDIAN JOURNAL OF DERMATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ahsas Goyal, Neetu Agrawal, Ankit Jain, Jeetendra Kumar Gupta, Debapriya Garabadu
Summary: Caveolin interacts with eNOS to suppress its activity, leading to reduced NO production. Ischemic preconditioning disrupts this interaction, activating eNOS and providing cardioprotection. Estrogen deficiency upregulates Caveolin-1 expression, increasing the risk of coronary artery diseases in postmenopausal women.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Meeting Abstract
Critical Care Medicine
Benjamin Kozyak, Maria Fraga, Courteny Juliano, Shazia Bhombal, David Munson, Erik Brandsma, Jason Stoller, Ankit Jain, Russell Kesman, Malorie Meshkati, Caroline Noh, Aaron DeWitt, Andrew Costarino, David Hehir, Alan Groves
CRITICAL CARE MEDICINE
(2022)
Article
Medicine, General & Internal
Yogita Dwivedi, Ankit Jain, Vijay Pratap Yadav, Atiharsh Mohan Agarwal
Summary: This study aimed to evaluate the clinical efficacy of Airtraq laryngoscope compared to Macintosh laryngoscope for intubation in pediatric patients. The results showed that the intubation time was significantly shorter with Airtraq compared to Macintosh, and Airtraq also provided better ease of intubation and glottic opening scoring. Hemodynamically, Airtraq was found to be superior with lower post-intubation heart rate. Therefore, Airtraq can be considered a reliable and promising alternative to Macintosh for endotracheal intubation in pediatric patients.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
(2022)
Meeting Abstract
Pediatrics
Benjamin W. Kozyak, Alan M. Groves, Maria V. Fraga, Courtney E. Juliano, Shazia Bhombal, David A. Munson, Erik Brandsma, Jason Z. Stoller, Ankit Jain, Andrew T. Costarino, David A. Hehir
