Article
Medicine, Research & Experimental
Xiangjun Chen, Huayu He, Xinyu Guo, Mingyi Hou, Xinzhong Zhang, Shengnan Li, Changrong Wang, Guodong Zhao, Wenting Li, Xiuping Zhang, Wei Hong
Summary: This study developed highly effective pH-responsive and biodegradable nanoparticles that can deliver drugs to tumor sites through the enhanced permeability and retention effect. The nanoparticles showed a switchable charge and excellent drug loading efficiency. In vitro and in vivo experiments demonstrated the effectiveness and safety of this drug delivery system, resulting in a significant inhibition of tumor growth.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Shiyan Dong, Ye Bi, Xiangshi Sun, Yarong Zhao, Rongze Sun, Fei Hao, Yating Sun, Yifan Wang, Xuefeng Li, Weiye Deng, Xuan Liu, JongHoon Ha, Lirong Teng, Ping Gong, Jing Xie, Betty Y. S. Kim, Zhaogang Yang, Wen Jiang, Lesheng Teng
Summary: This study describes a TNBC-specific targeted liposomal formulation that effectively targets TNBC tumor cells through hyaluronic acid modification and has synergistic effects on inhibiting tumor cell proliferation and metastasis.
Article
Medicine, Research & Experimental
Shouhui Yi, Rongqiang Liao, Wei Zhao, Yusheng Huang, Yi He
Summary: Combination therapy offers advantages for cancer treatment, but different types of therapeutic agents exhibit different pharmacokinetic properties and action targets in vivo, leading to uncontrollable concentration ratio of therapeutic agents. Multifunctional co-delivery systems can provide targeted delivery and controlled release in response to tumor microenvironment, resulting in better synergistic anticancer effect and potential clinical applications.
Article
Nanoscience & Nanotechnology
Qian Wang, Yuxuan Ma, Zhangwei Lu, Hanyang Yu, Zhe Li
Summary: DNA nanostructures are used as drug delivery systems to achieve synergistic therapeutic effects in chemoimmunotherapy, showing excellent biocompatibility and superior treatment efficacy.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xiaohai Song, Hao Cai, Zhaochen Shi, Zhiqian Li, Xiuli Zheng, Kun Yang, Qiyong Gong, Zhongwei Gu, Jiankun Hu, Kui Luo
Summary: Combined chemotherapy and targeted therapy using a cathepsin B-responsive polymeric nanoparticle prodrug system, BPGP@CAP, shows promise in enhancing the cytotoxicity of paclitaxel (PTX) and capivasertib (CAP) against advanced gastric cancer by inhibiting AKT expression and suppressing the PI3K/AKT signaling pathway.
Article
Nanoscience & Nanotechnology
Shuhang Wang, Jingxin Gou, Yue Wang, Xinyi Tan, Linxuan Zhao, Xiangqun Jin, Xing Tang
Summary: The study developed a promising liposomal formulation for targeted therapy in non-small cell lung cancer, co-delivering vinorelbine and cisplatin. The liposomes showed sustained drug release, synergistic cytotoxic effect, and enhanced antitumor efficacy in a mouse xenograft model. The formulation exhibited increased plasma half-life and drug accumulation in tumors, highlighting its potential as an effective treatment approach for NSCLC.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Multidisciplinary Sciences
Zhenkun Ren, Xibin Han, Lixin Wang, Yi Wang
Summary: The study found that AS/GOD@HAZnO nanoparticles could effectively inhibit tumors and improve drug efficacy through responsive release. These nanoparticles, which can be efficiently taken in by tumor cells through the affinity between hyaluronic acid and CD44 receptors, release drugs in an acidic environment, thereby inhibiting tumor growth.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Multidisciplinary
Milad Ashrafizadeh, Masoud Delfi, Ali Zarrabi, Ashkan Bigham, Esmaeel Sharifi, Navid Rabiee, Ana Claudia Paiva-Santos, Alan Prem Kumar, Shing Cheng Tan, Kiavash Hushmandi, Jun Ren, Ehsan Nazarzadeh Zare, Pooyan Makvandi
Summary: This review discusses the use of stimuli-responsive liposomes for targeted drug delivery in cancer therapy. These liposomes can be triggered by various stimuli such as pH, redox, enzymes, light, heat, and magnetic field to release drugs at tumor sites. The stimuli-responsive liposomes have shown great potential in improving the efficacy of anticancer drugs.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Ana Raquel Neves, Tania Albuquerque, Ruben Faria, Milan Paul, Swati Biswas, Angela Sousa, Diana Costa
Summary: This study developed dendrimer drug/gene ternary complexes for cancer gene therapy, showing promising cellular transfection potential and biocompatibility. It represents significant progress towards more efficient cancer therapy and encourages further in vitro studies to evaluate therapeutic potential in tumoral cells with expected synergistic effects.
Review
Pharmacology & Pharmacy
Mehrab Pourmadadi, Parisa Abbasi, Mohammad Mahdi Eshaghi, Ali Bakhshi, Amanda-Lee Ezra Manicum, Abbas Rahdar, Sadanand Pandey, Sapana Jadoun, Ana M. Diez-Pascual
Summary: This review explores different types of nanostructures that can be used as drug delivery systems for curcumin, a biologically active polyphenol with high anticancer potential. Different approaches recently developed to solve issues such as poor solubility, short biological half-life, and high metabolism rate are described. Furthermore, co-delivery systems involving curcumin and other anticancer drugs are reviewed.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zhaoran Wang, Linlin Song, Qing Liu, Run Tian, Yingxu Shang, Fengsong Liu, Shaoli Liu, Shuai Zhao, Zihong Han, Jiashu Sun, Qiao Jiang, Baoquan Ding
Summary: By utilizing the DNA origami technique, a DNA nanodevice was constructed with siRNA and doxorubicin incorporated, enabling the release of siRNA in response to intracellular glutathione in tumors. This innovative strategy combining RNA interference and chemotherapy showed potent antitumor activity and marked biocompatibility, representing a promising approach for precise drug design in cancer therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Engineering, Biomedical
Haijing Qu, Han Chen, Wei Cheng, Yanjun Wang, Yangyang Xia, Linghao Zhang, Buyong Ma, Rong Hu, Xiangdong Xue
Summary: We propose a supramolecular assembly strategy to enhance drug loading, tumor targeting, and delivery simplicity for hydrophilic drugs. By co-assembling with other drugs, we validate the effectiveness of this strategy and demonstrate its application in anti-tumor activities.
ACTA BIOMATERIALIA
(2023)
Article
Biophysics
Jiaqian Li, Na Yang, Mei Yang, Chao Lu, Meng Xie
Summary: The targeted drug delivery system based on nanomaterials has great potential for cancer therapy as it can improve treatment efficacy and reduce side effects.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Pavan Kumar Chintamaneni, Dasari Nagasen, Katta Chanti Babu, Atul Mourya, Jitender Madan, Dadi A. Srinivasarao, R. K. Ramachandra, P. Madhuri Santhoshi, Sai Kiran S. S. Pindiprolu
Summary: Breast cancer is the most common type of cancer in women, and early diagnosis and effective therapeutic interventions are crucial for improving survival and quality of life. Nanotheranostics, specifically rare earth metal-doped upconversion nanoparticles (UCNPs), show promise in providing both in vivo diagnosis and therapeutics in breast cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Multidisciplinary
Rouba D. Al Bostami, Waad H. Abuwatfa, Ghaleb A. Husseini
Summary: Cancer therapies have made significant advancements in the past decade, but there are still barriers to their success. Nanomedicines that deliver multiple drugs and genes simultaneously have shown improved effectiveness and synergistic effects. However, the development of co-delivery systems faces limitations and challenges and requires a better understanding of the therapeutic agent ratio and heterogeneity of cancer cells.
