Review
Nanoscience & Nanotechnology
Xiang He, Shentao Zhang, Yuhang Tian, Wen Cheng, Hui Jing
Summary: With the booming development of nanomedicine, mild photothermal therapy (mPTT) has shown great potential in tumor therapy. Compared with traditional PTT, mPTT has fewer side effects and better biological effects. However, the relatively low temperature of mPTT cannot completely eradicate tumors, so efforts have been made to optimize its application in tumor therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Francisco Rodriguez, Pablo Caruana, Noa De la Fuente, Pia Espanol, Maria Gamez, Josep Balart, Elisa Llurba, Ramon Rovira, Raul Ruiz, Cristina Martin-Lorente, Jose Luis Corchero, Maria Virtudes Cespedes
Summary: This review provides an overview of nanomedicine for cancer treatment, focusing on the rationale behind their designs and applications. It highlights the tumor microenvironment and tumor disseminate cells as the most attractive and effective strategies for cancer treatments. The perspectives and challenges for nanopharmaceuticals in this field are also discussed.
Article
Oncology
Roberta Giordo, Zena Wehbe, Panagiotis Paliogiannis, Ali H. Eid, Arduino A. Mangoni, Gianfranco Pintus
Summary: Tumor growth and progression are dependent on adequate blood supply. Tumor cells drive the formation of new blood vessels through the release of pro-angiogenic molecules. The processes involved in tumor angiogenesis are similar to normal vascular development, but with less control mechanisms. Targeting tumor blood vessels has been a focus of research, and nanomedicine offers advantages in specific drug delivery. This review comprehensively assesses key modulators of tumor vascular biology, promising nano-strategies, and future directions.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Environmental Sciences
Neha Benedicta Fernandes, Raghavendra Udaya Kumar Shenoy, Mandira Kashi Kajampady, Cleona E. M. DCruz, Rupesh K. Shirodkar, Lalit Kumar, Ruchi Verma
Summary: This article discusses the potential applications of fullerenes in cancer treatment, emphasizing their unique physicochemical and photosensitizer properties.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Shan Gao, Xiaoye Yang, Jiangkang Xu, Na Qiu, Guangxi Zhai
Summary: Immunotherapy utilizing the human immune system against cancer has become a mainstream strategy, with the potential to eliminate tumors and treat metastasis and recurrence. The development of nanotechnology has enabled the application of nanomaterials in cancer immunotherapy, offering significant potential for improving treatment efficacy. Nanotechnology-based immunotherapy aims to produce effective anti-tumor immune responses and enhance tumor immune defense by modulating the immune suppression mechanism in the tumor microenvironment.
Review
Pharmacology & Pharmacy
Tingting Hu, Hanlin Gong, Jiayue Xu, Yuan Huang, Fengbo Wu, Zhiyao He
Summary: This paper reviews the mechanisms of cancer drug resistance to chemotherapy, targeted therapy, and immunotherapy, and discusses the latest developments in nanomedicines for overcoming cancer drug resistance.
Review
Biotechnology & Applied Microbiology
Paula Fernandez-Gomez, Carmen Perez de la Lastra Aranda, Carlota Tosat-Bitrian, Jesus Alejandro Bueso de Barrio, Sebastian Thompson, Begona Sot, Gorka Salas, Alvaro Somoza, Ana Espinosa, Milagros Castellanos, Valle Palomo
Summary: The new and unique possibilities offered by nanomaterials have had a significant impact on biomedicine, particularly in disease treatment and diagnosis as well as targeted drug delivery. Technological advancements in the synthesis, characterization, standardization, and therapeutic performance of nanoparticles have enabled the approval of various nanomedicines and novel applications. Research in nanodiagnostics and nanomedicines is actively pursued in Spain, with exponential discoveries in various disease areas. This review provides an overview of the current state of nanotechnology, specifically nanoparticles, for disease treatment in Spain (2017-2022), and offers insights into future trends and directions in nanomedicine research.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Anine Crous, Heidi Abrahamse
Summary: Lung cancer remains the leading cause of death globally, with novel treatments like photodynamic therapy showing promising results in selective destruction of malignant cells. Further research and clinical trials are needed to determine the efficacy of these new treatment options.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Hanane Aliouat, Ying Peng, Zoya Waseem, Shengfeng Wang, Wenhu Zhou
Summary: This article reviews drug delivery systems that purely consist of DNA and discusses their applications in targeted tumor therapy. Drugs can be incorporated into DNA via distinct mechanisms, and various DNA architectures have been developed for different types of anti-tumor therapeutics. The focus is on their intracellular delivery and drug release, with discussions on DNA-based platforms with different cellular uptake pathways and stimuliresponsive drug release profiles. Research opportunities in the field are speculated to pave the way for future research direction.
Review
Materials Science, Multidisciplinary
Li-Han Liu, Xian-Zheng Zhang
Summary: The past decade has seen significant advances in the development of carrier-free nanomedicines, which are attractive due to their high biosafety, drug loading capacities, simple compositions, and simplified synthesis procedures. Extensive efforts have been made to expand the scope of carrier-free nanomedicines and improve their therapeutic performance through the exploration of new excipients, therapeutic agents, self-assembly methods, and mechanisms. This review summarizes the research progress and practical applications of carrier-free nanomedicines in cancer therapy.
PROGRESS IN MATERIALS SCIENCE
(2022)
Review
Engineering, Biomedical
Xueli Xu, Shanbin Xu, Jipeng Wan, Diqing Wang, Xinlong Pang, Yuan Gao, Nengyi Ni, Dawei Chen, Xiao Sun
Summary: Cytoskeleton plays a crucial role in various processes of tumor cells, and nanomedicine has shown superiority in cancer treatment by disturbing cytoskeleton. This review summarizes the recent advancements in using different nanomaterials to enhance cancer therapeutics by targeting cytoskeleton. It also discusses the characteristics, future prospects, and challenges of cytoskeletal therapy, providing valuable information for the development of cancer nanomedicine.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Feng Li, Zhaoyue Lv, Xue Zhang, Yuhang Dong, Xiaohui Ding, Zhemian Li, Shuai Li, Chi Yao, Dayong Yang
Summary: This study reports a supramolecular self-assembled DNA nanosystem that reprogrammed the cellular antioxidant system through synergistic chemical and gene regulations, significantly promoting metabolic reprogramming of cancer cells, showing great potential in cancer therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Engineering, Biomedical
David Caballero, Catarina M. Abreu, Ana C. Lima, Nuno N. Neves, Rui L. Reis, Subhas C. Kundu
Summary: Traditional cancer treatment approaches are becoming obsolete, leading to more patients failing to respond to treatments. Personalized genetic profiling offers a more accurate method of treatment, but still faces issues like low local drug efficacy. Efforts are now focused on developing precision medicine-based strategies to improve cancer treatment efficiency.
Review
Chemistry, Multidisciplinary
Wenlu Yan, Tianqun Lang, Runqi Zhu, Xiao Zhu, Yu Li, Ting Wu, Qi Yin, Yaping Li
Summary: This review summarizes the latest research progress on improving cancer therapy using anti-hypoxia nanosized drug delivery systems (NDDSs), including mechanisms such as increasing oxygen supply, reducing oxygen consumption, and inhibiting hypoxia-related signaling pathways.
Article
Medicine, Research & Experimental
Mahzad Motallebi, Mohammed Bhia, Huda Fatima Rajani, Iman Bhia, Hadi Tabarraei, Niloufar Mohammadkhani, Miguel Pereira-Silva, Maryam Sadat Kasaii, Saeedeh Nouri-Majd, Anna-Lena Mueller, Francisco J. B. Veiga, Ana Claudia Paiva-Santos, Mehdi Shakibaei
Summary: Naringenin is an important phytochemical with anti-inflammatory, antioxidant, neuroprotective, hepatoprotective, and anti-cancer activities, and can inhibit cancer progression through multiple mechanisms.
Review
Oncology
Jie Wang, Haiyan Dong, Jian Liu, Ning Zheng, Xiaodong Xie, Lee Jia
CURRENT CANCER DRUG TARGETS
(2019)
Article
Oncology
Yusheng Lu, Shu Lian, Yunlong Cheng, Yuying Ye, Xiaodong Xie, Chengbin Fu, Chen Zhang, Yewei Zhu, M. Iqbal Parker, Lee Jia
EXPERIMENTAL CELL RESEARCH
(2019)
Correction
Multidisciplinary Sciences
Xiaodong Xie, Huifang Nie, Yu Zhou, Shu Lian, Hao Mei, Yusheng Lu, Haiyan Dong, Fengqiao Li, Tao Li, Bifei Li, Jie Wang, Min Lin, Chaihung Wang, Jingwei Shao, Yu Gao, Jianming Chen, Fangwei Xie, Lee Jia
NATURE COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Zhongyu Li, William Ho, Xin Bai, Fengqiao Li, Yen-jui Chen, Xue-Qing Zhang, Xiaoyang Xu
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Multidisciplinary Sciences
Ying Ji, Xiangsheng Liu, Juan Li, Xiaodong Xie, Max Huang, Jinhong Jiang, Yu-Pei Liao, Timothy Donahue, Huan Meng
NATURE COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Xiaodong Xie, Shu Lian, Yu Zhou, Bifei Li, Yusheng Lu, Iwin Yeung, Lee Jia
Summary: This study demonstrates that drug-loaded extracellular vesicles derived from breast cancer plasma can inhibit breast cancer metastasis to the lungs, while the CD47 protein helps extend their circulation time in blood, and their tissue distribution ratio mirrors that of companion extracellular vesicles.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Engineering, Biomedical
William Ho, Mingzhu Gao, Fengqiao Li, Zhongyu Li, Xue-Qing Zhang, Xiaoyang Xu
Summary: Nucleic acid vaccines hold promise as an immunization method for combating pandemics, with nanoparticles being a top candidate for successful DNA/mRNA vaccine delivery due to their unique properties.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Xiangsheng Liu, Xiaodong Xie, Jinhong Jiang, Matthew Lin, Emily Zheng, Waveley Qiu, Iwin Yeung, Motao Zhu, Qinglin Li, Tian Xia, Huan Meng
Summary: Macrophages are vital immune cells that can interact with engineered nanomaterials. Utilizing nanoparticles to target macrophages shows potential in various disease treatments. Understanding the impact of therapeutic NMs on macrophages is crucial for developing effective treatment strategies.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Xiaodong Xie, Jinhong Jiang, Xiangsheng Liu, Yuhong Cao, Jiulong Li, Tian Xia, Huan Meng
Summary: We developed a custom-designed nanocarrier for delivering an immunomodulatory plasmid in mice to facilitate tissue repair in acute muscle damage. Through high throughput screening, we identified the best-performing formulation and demonstrated successful delivery of the plasmid to the injured muscle, resulting in accelerated tissue repair. This study highlights the potential of nanocarriers in treating muscle injuries.
Article
Pharmacology & Pharmacy
Weiyu Wang, Chengbin Fu, Mengting Lin, Yusheng Lu, Shu Lian, Xiaodong Xie, Guiyu Zhou, Wulin Li, Yiping Zhang, Lee Jia, Chunlian Zhong, Mingqing Huang
Summary: This study found that fucoxanthin (Fx) can interrupt the adhesion and migration of breast cancer cells, thereby inhibiting the formation of lung metastasis, and it works by affecting cell adhesion molecules and signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xiaodong Xie, Yumei Li, Shu Lian, Yusheng Lu, Lee Jia
Summary: This article presents a new cancer pre-metastasis chemoprevention strategy that can potentially prevent lethal metastasis by interrupting the adhesion of circulating tumor cells (CTCs) to their metastasis niche.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Oncology
Yu Zhou, Fan Chen, Xiaodong Xie, Huifang Nie, Shu Lian, Chunlian Zhong, Chengbin Fu, Weiyu Shen, Bifei Li, Yongqing Ye, Yusheng Lu, Lee Jia
Summary: The study revealed significant differences in inclusions and functions between early and late exosomes of the same tumor, with late tumor exosomes showing a greater ability to promote cell migration. These findings emphasize the importance of exosomes in cancer metastasis and suggest their potential as biomarkers and therapeutic targets for cancer metastasis.
Article
Chemistry, Multidisciplinary
Huifang Nie, Xiaodong Xie, Doudou Zhang, Yu Zhou, Bifei Li, Fengqiao Li, Feiyang Li, Yunlong Cheng, Hao Mei, Huan Meng, Lee Jia
