Review
Chemistry, Multidisciplinary
Yutian Xia, Jianzhong Zhang, Gang Liu
Summary: Apoptosis, as a fundamental process of cell death, has provided broad prospects for tumor treatment in nanomedicine. However, apoptosis resistance caused by various factors has led to therapeutic failure or tumor recurrence. Ferroptosis, a newly identified form of programmed cell death, offers a new approach to killing cancer cells beyond apoptosis. Combination therapy, which synergizes ferroptosis with apoptosis, has shown promising results in clinical applications. This review summarizes the latest research progress in combining ferroptosis with apoptosis for enhanced tumor therapeutic effects in nanomedicine and suggests a potential research focus for the future.
Article
Multidisciplinary Sciences
Naoki Takada, Hiroshi Sugano, Yoshihiro Shirai, Nobuhiro Saito, Ryoga Hamura, Tomohiko Taniai, Tadashi Uwagawa, Katsuhiko Yanaga, Toru Ikegami, Toya Ohashi, Ken Eto
Summary: NF-kappa B can be activated by radiotherapy and chemotherapy, but its activity can be inhibited by the synthetic protease inhibitor nafamostat mesilate. In this study, nafamostat mesilate was found to enhance the antitumor action of radiotherapy on gallbladder cancer cells by suppressing radiation-induced NF-kappa B activity. The combination of radiotherapy and nafamostat mesilate may provide a promising treatment option for locally advanced unresectable gallbladder cancer.
Article
Hematology
Alexander B. Kim, Ssu-Yu Chou, Solomon Kang, Eric Kwon, Matthew Inkman, Jeff Szymanski, Neal Andruska, Cian Colgan, Jin Zhang, Joanna C. Yang, Nathan Singh, Carl J. Deselm
Summary: Chimeric antigen receptor (CAR) T-cell therapy is a significant breakthrough for hematologic malignancies, but majority of patients still die from the disease. Tumor quantity and quality are predictors of response, with higher disease burden and intrinsic tumor resistance leading to worse prognosis. High-dose radiation to bulky disease areas reduces systemic tumor quantity, but low-dose total tumor irradiation (TTI) targeting all disease sites before CAR T-cell therapy has a greater impact on overall survival in mice. This study suggests that intrinsic tumor attributes are equally or more important predictors of CAR T-cell response as tumor burden, and low-dose TTI can temporarily increase tumor sensitivity to CAR T cells.
Review
Biochemistry & Molecular Biology
David Kessel
Summary: Photodynamic therapy (PDT) is capable of eradicating neoplastic cells accessible to sufficient light and oxygen. Despite adequate information available for assessing the conditions where PDT might be the therapy of choice, limited access to clinical facilities and barriers to regulatory approval of new agents have restricted its clinical usage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Seyed Mohsen Aghaei-Zarch, Amir Hosein Sanjari Nia, Morteza Nouri, Fatemehsadat Mousavinasab, Sajad Najafi, Saeed Bagheri-Mohammadi, Fatemehsadat Aghaei-Zarch, Ali Toolabi, Hassan Rasoulzadeh, Jalaledin Ghanavi, Masomeh Nasiri Moghadam, Mehrdad Talebi
Summary: This article discusses the influence of particulate matter on apoptosis and its relationship with human disease development. Several treatment methods for diseases caused by particle pollution, such as small molecules, miRNA replacement therapy, vitamins, and PDRN, are also proposed.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Elizaveta Belyaeva, Nina Loginova, Brett A. Schroeder, Ian S. Goldlust, Arbind Acharya, Sandeep Kumar, Peter Timashev, Ilya Ulasov
Summary: The balance between cell death and cell survival involves the breakdown and removal of unnecessary or harmful materials in a controlled manner. Autophagy, initiated by various stresses, is a well-regulated process with specific genes and proteins. Targeting autophagy shows promise as an anti-tumor therapy, but its effects on different tumor cells remain unclear. This review investigates autophagy as a potential therapeutic target for aggressive sarcomas.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Biomedical
Sijie Song, Qi Wang, Jiangao Xie, Junduan Dai, Dilan Ouyang, Guoming Huang, Yuheng Guo, Chen Chen, Mengnan Wu, Tingjing Huang, Jingwen Ruan, Xiaofeng Cheng, Xucong Lin, Yu He, Elena A. A. Rozhkova, Zhaowei Chen, Huanghao Yang
Summary: This study developed a dual-stimulation activated turn-on T-1 imaging-based nanoparticulate system for precise apoptotic cancer therapy. The system utilizes a DNAzyme molecular device to connect a superparamagnetic quencher and a paramagnetic enhancer, which are released upon activation by the FTO enzyme. The restored T-1 signal from released Gd-DOTA complexes guides the location and time of laser irradiation, and the combination with HSP70 antisense oligonucleotides promotes tumor cell apoptosis.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cell Biology
Xi Zhang, Hui Xu, Xiaoyang Bi, Guoqing Hou, Andong Liu, Youyun Zhao, Guoping Wang, Xuan Cao
Summary: Matrine targets Src, inhibits its kinase activity, and suppresses the proliferation of cancer cells by down-regulating phosphorylation signaling pathways including MAPK/ERK, JAK2/STAT3, and PI3K/Akt.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Medicinal
Junhao Wu, Jing Ye, Qiang Xie, Bo Liu, Ming Liu
Summary: Regulated cell death is an important topic in cancer therapy and has led to the discovery of targeted anticancer drugs. Nonapoptotic regulated cell death has been found to be involved in the therapeutic responses of various human cancers. Targeting autophagy-dependent cell death, ferroptosis, and necroptosis can bypass apoptosis resistance and improve cancer treatment.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Engineering, Environmental
Aimin Wu, Ming Han, Hao Ding, Hanbing Rao, Zhiwei Lu, Mengmeng Sun, Yanying Wang, Yinyin Chen, Yu Zhang, Xianxiang Wang, Daiwen Chen
Summary: In this study, a novel peroxidase nanozyme (Fe3S4) was developed, which exhibited excellent H2O2 affinity and high catalytic activity. Fe3S4 nanozyme not only induced apoptosis and ferroptosis of tumor cells, but also amplified the Fenton reaction. Additionally, Fe3S4 nanozyme showed ultrahigh glutathione peroxidase-like activity, which increased the sensitivity of tumor cells to ferroptosis. This strategy provides a superior platform for enhancing the therapeutic effect of nanozymes.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Oncology
Abel Soto-Gamez, Yizhou Wang, Xinyu Zhou, Lorina Seras, Wim Quax, Marco Demaria
Summary: Genotoxic agents are commonly used in cancer therapy to induce cellular senescence, but senescent cancer cells may exhibit resistance to apoptosis and increase the risk of relapse. Targeting DR5 with a selective TRAIL variant has shown more effective apoptosis induction in therapy-induced senescent cancer cells compared to wild-type TRAIL, with no impact on non-cancerous cells. This suggests that DR5 targeting could be a novel therapeutic strategy to eliminate therapy-induced senescent cancer cells.
Article
Engineering, Biomedical
Qi Dong, Jie Wang, Jiahui Liu, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue
Summary: Intracellular redox homeostasis is essential for tumor progression and treatment. This study developed a manganese-based homeostasis modulator that induces reactive oxygen species accumulation and glutathione deprivation, leading to ferroptosis and apoptosis. Moreover, the nanocarriers can release loaded cargo, promoting sonodynamic and chemodynamic therapy. The suppression of cystine antiporter xCT interrupts glutathione biosynthesis and reduces glutathione peroxidase 4 (GPx4) levels, causing lipid peroxide-induced ferroptosis. The MHS treatment demonstrates excellent outcomes in vitro and in vivo, indicating the potential of manganese-derived nanoagents in medical applications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Wei Li, Shulu Yin, Yang Shen, Haiyan Li, Lin Yuan, Xiao-Bing Zhang
Summary: Researchers developed an oxazine-based activatable molecular assembly (PTO-Biotin Nps) that can trigger lysosomal dysfunction-mediated Fenton pathway to induce tumor ferroptosis with excellent spatiotemporal resolution using near-infrared light. The assembly selectively accumulates in lysosomes of tumor cells and exhibits enhanced photothermal activity in the acidic tumor microenvironment. Upon activation, PTO-Biotin Nps induce lysosomal dysfunction, cytosolic acidification, impaired autophagy, and enhanced cellular Fenton reactions to induce ferroptosis, leading to improved antitumor efficacy and reduced systemic side effects.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Wei Tan, Liang Gao, Ye Yuan, Hao Huang, Yadong Li, Yuanqing Gou, Zili Hu
Summary: Research has shown a higher occurrence of bladder cancer in men compared to women, leading researchers to investigate the role of androgen in bladder cancer. A study was conducted with 147 patients diagnosed with primary bladder cancer and 154 non-tumor patients as the control group. The results revealed a significant correlation between serum total testosterone levels and the occurrence of bladder cancer, along with other factors such as hemoglobin, hypertension, diabetes, and smoking.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Chaolin Li, Yan Tang, Qin Li, Haiyan Liu, Xiaoying Ma, Liu He, Hao Shi
Summary: This study found that C15orf48 is differentially expressed in various cancer types and can serve as an independent prognostic factor for glioma. The epigenetic alterations of C15orf48 are highly heterogeneous in multiple cancers and its aberrant methylation and copy number variation are associated with poor prognosis. In thyroid cancer, C15orf48 is significantly associated with macrophage immune infiltration and multiple immune checkpoints, and is a potential biomarker for PTC. Knockdown of C15orf48 reduces the proliferation, migration, and apoptosis abilities of thyroid cancer cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Sheng-Yao Peng, Chien-Chou Hsiao, Ting-Hsun Lan, Ching-Yui Yen, Ammad A. Farooqi, Chih-Mei Cheng, Jen-Yang Tang, Tzu-Jung Yu, Yun-Chiao Yeh, Ya-Ting Chuang, Chien-Chih Chiu, Hsueh-Wei Chang
ENVIRONMENTAL TOXICOLOGY
(2020)
Review
Food Science & Technology
Haroon Khan, Tarun Belwal, Thomas Efferth, Ammad Ahmad Farooqi, Ana Sanches-Silva, Rosa Anna Vacca, Seyed Fazel Nabavi, Fazlullah Khan, Hari Prasad Devkota, Davide Barreca, Antoni Sureda, Silvia Tejada, Marco Dacrema, Maria Daglia, Ipek Suntar, Suowen Xu, Hammad Ullah, Maurizio Battino, Francesca Giampieri, Seyed Mohammad Nabavi
Summary: Cancer is the leading cause of mortality worldwide, with therapeutic challenges such as non-compliance, side effects, and economic burdens. Plant-derived flavonoids are being studied for their epigenetic regulation of cancer, with different classes of flavonoids having varying mechanisms of action.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Genetics & Heredity
Ammad Ahmad Farooqi, Aima Adylova, Uteuliyev Yerzhan Sabitaliyevich, Rukset Attar, Muhammad Imran Sohail, Seher Yilmaz
Review
Oncology
Ammad Ahmad Farooqi, Marina Pinheiro, Andreia Granja, Fulvia Farabegoli, Salette Reis, Rukset Attar, Uteuliyev Yerzhan Sabitaliyevich, Baojun Xu, Aamir Ahmad
Review
Cell Biology
David R. Wallace, Yasmeen M. Taalab, Sarah Heinze, Blanka Tariba Lovakovic, Alica Pizent, Elisavet Renieri, Aristidis Tsatsakis, Ammad Ahmad Farooqi, Dragana Javorac, Milena Andjelkovic, Zorica Bulat, Biljana Antonijevic, Aleksandra Buha Djordjevic
Review
Oncology
Ammad Ahmad Farooqi, Evangelia Legaki, Maria Gazouli, Silvia Rinaldi, Rossana Berardi
Summary: The discovery of miRNA and LncRNA has altered the central dogma of molecular biology, while research on MALAT1 has revealed its crucial role in various oncogenic signaling pathways, thereby promoting cancer progression.
CURRENT CANCER DRUG TARGETS
(2021)
Article
Oncology
Ammad Ahmad Farooqi, Sundas Fayyaz, Palmiro Poltronieri, George Calin, Massimo Mallardo
Summary: Cutting-edge research has revealed that deregulated epigenetic marks play a critical role in cancer development. This research provides valuable insights into the mechanisms that control cellular functions, including changes in chromatin accessibility, transcription and translation, and post-translational modifications. The study discusses DNA and RNA modifications, chromatin modifying proteins, and histone deacetylases. It also explores the role of non-coding RNAs and the impact of mitochondrial dysfunction on epitranscriptome marks. Overall, this research has the potential to lead to the development of novel drugs and personalized medicine for cancer patients.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ammad Ahmad Farooqi, Ghazala Butt, Sally A. El-Zahaby, Rukset Attar, Uteuliyev Yerzhan Sabitaliyevich, Jovana Joksimovic Jovic, Kai -Fu Tang, Humaira Naureen, Baojun Xu
PHARMACOLOGICAL RESEARCH
(2020)
Article
Oncology
Xiukun Lin, Ammad Ahmad Farooqi
Summary: This review highlights the advancements in cancer research, emphasizing the crucial role of deregulation of cell signaling pathways in carcinogenesis and metastasis. It discusses the mechanistic regulation of oncogenic pathways by cucurbitacins in different cancers, along with the potential future research areas focusing on exploring the full therapeutic potential of cucurbitacins in targeting specific pathways.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sheng-Yao Peng, Li-Ching Lin, Shu-Rong Chen, Ammad A. Farooqi, Yuan-Bin Cheng, Jen-Yang Tang, Hsueh-Wei Chang
Summary: Pomegranate polyphenolic extract POMx inhibits proliferation and induces apoptosis in oral cancer cells by impairing mitochondrial function.
Review
Biochemistry & Molecular Biology
Konstantinos Georgiou, Blagoi Marinov, Ammad Ahmad Farooqi, Maria Gazouli
Summary: The gut microbiota is a powerful organ that can influence the metabolic, nutritional, physiological, and immunological processes of the human body. While the lung microbiota is less understood, there may exist a complex relationship between the human microbiome and lung cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Pei-Feng Liu, Ammad Ahmad Farooqi, Sheng-Yao Peng, Tzu-Jung Yu, Hans-Uwe Dahms, Cheng-Hsin Lee, Jen-Yang Tang, Sheng-Chieh Wang, Chih-Wen Shu, Hsueh-Wei Chang
Summary: This article reviews the regulatory effects of ncRNAs on ROS and autophagy in cancer, analyzes their modulation effects on antioxidant genes and ATG genes, and analyzes the differential expression of ncRNAs in tumors and normal tissues of cancer patients using the TCGA database.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sawera Nayyab, Humaira Naureen, Areesha Maryam, Rukset Attar, Uteuliyev Yerzhan Sabitaliyevich, Konysbayeva Kenzhekul Konysbayevna, Ammad Ahmad Farooqi
CELLULAR AND MOLECULAR BIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Kadriye Nur Kasapoglu, Gokce Altin, Ammad Ahmad Farooqi, Bahare Salehi, Beraat Ozcelik, William N. Setzer, Javad Sharifi-Rad
CELLULAR AND MOLECULAR BIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Ammad Ahmad Farooqi, Rabbia Zahid, Areesha Maryam, Humaira Naureen, Rukset Attar, Uteuliyev Yerzhan Sabitaliyevich, Konysbayeva Kenzhekul Konysbayevna
CELLULAR AND MOLECULAR BIOLOGY
(2020)