期刊
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
卷 124, 期 -, 页码 37-40出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2018.02.004
关键词
Mathematical model; Cancer; Tumor microenvironment; Systems biology; Metabolism
资金
- MINECO [BIO2014-56092-R]
- FEDER [BIO2014-56092-R, P12-CTS-1507]
- Andalusian Government [P12-CTS-1507, B10-267]
Systemic approaches are needed and useful for the study of the very complex issue of cancer. Modeling has a central position in these systemic approaches. Metabolic reprogramming is nowadays acknowledged as an essential hallmark of cancer. Mathematical modeling could contribute to a better understanding of cancer metabolic reprogramming and to identify new potential ways of therapeutic intervention. Herein, I review several alternative approaches to metabolic modeling and their current and future impact in oncology.
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