期刊
CRITICAL CARE CLINICS
卷 34, 期 3, 页码 357-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccc.2018.03.005
关键词
Limb muscle weakness; Respiratory muscle weakness; Ventilator dependence; Intensive care unit; Mechanical ventilation
Both limb muscle weakness and respiratory muscle weakness are exceedingly common in critically ill patients. Respiratory muscle weakness prolongs ventilator dependence, predisposing patients to nosocomial complications and death. Limb muscle weakness persists for months after discharge from intensive care and results in poor long-term functional status and quality of life. Major mechanisms of muscle injury include critical illness polymyoneuropathy, sepsis, pharmacologic exposures, metabolic derangements, and excessive muscle loading and unloading. The diaphragm may become weak because of excessive unloading (leading to atrophy) or because of excessive loading (either concentric or eccentric) owing to insufficient ventilator assistance.
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