期刊
COORDINATION CHEMISTRY REVIEWS
卷 372, 期 -, 页码 117-140出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2018.06.002
关键词
Vanadium complexes; Amino acids; Antidiabetics; Antitumors; Chemical speciation
资金
- Deanship of Investigation and Development of the Universidad Simon Bolivar
- Pharmaceutical Research Institute of the Faculty of Pharmacy of the Universidad Central de Venezuela
In the last 30 years, since the discovery that vanadium is a cofactor found in certain enzymes of tunicates and possibly in mammals, different vanadium-based drugs have been developed targeting to treat different pathologies. So far, the in vitro studies of the insulin mimetic, antitumor and antiparasitic activity of certain compounds of vanadium have resulted in a great boom of its inorganic and bioinorganic chemistry. Chemical speciation studies of vanadium with amino acids under controlled conditions or, even in blood plasma, are essential for the understanding of the biotransformation of e.g. vanadium antidiabetic complexes at the physiological level, providing clues of their mechanism of action. The present article carries out a bibliographical research emphaticizing the chemical speciation of the vanadium with different amino acids and reviewing also some other important aspects such as its chemistry and therapeutical applications of several vanadium complexes. (C) 2018 Elsevier B.V. All rights reserved.
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