Article
Biochemistry & Molecular Biology
Bing-Bing Chen, Nan-Lian Pan, Jia-Xin Liao, Min-Ying Huang, Dong-Chun Jiang, Jun-Jie Wang, Hai-Jun Qiu, Jia-Xi Chen, Lin Li, Jing Sun
Summary: Four cyclometalated iridium(III) complexes synthesized in this study show excellent cytotoxicity to cancer cells by targeting mitochondria and inducing autophagy and apoptosis, while also demonstrating moderate antibacterial activity against S. aureus and P. aeruginosa.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jiayi Zhu, Yan Liu, Zhao Zhang, Xili Yang, Feng Qiu
Summary: In this study, we designed and synthesized two complexes as photosensitizers, which exhibited strong phosphorescence and high toxicity against cancer cells. These complexes rapidly accumulated in lysosomes after entering cancer cells, and when exposed to light irradiation, they produced a large amount of oxidizing stress substances, eventually leading to cancer cell death. This provides promising potential application in photodynamic therapy.
Article
Biophysics
Shanmughan Shamjith, Manu M. Joseph, Vishnu Priya Murali, Geetha S. Remya, Jyothi B. Nair, Cherumuttathu H. Suresh, Kaustabh Kumar Maiti
Summary: In this study, a quinoline-appended iridium complex was developed as a molecular probe for evaluating the endogenous NADH status using fluorescence and surface-enhanced Raman spectroscopy (SERS) techniques. The activated probe showed luminescence (turn-ON) and SERS (turn-OFF) switching phenomenon upon NADH-triggered activation. Additionally, the molecular probe was also demonstrated to function as a photosensitizer for generating singlet oxygen, which could be applied in multiphase photodynamic therapy.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Marie Peng, Jinqiang Lin, Wei Lu, Thierry Roisnel, Veronique Guerchais, Henri Doucet, Jean-Francois Soule
Summary: The utility of C-H bond functionalization of metalated ligands for the elaboration of aryl-functionalized difluorinated-1-arylisoquinolinyl Ir(III) complexes has been explored, resulting in the regioselective arylation of C-H bonds flanked by difluoroaryl units. Post-functionalization allows for the introduction of thermally sensitive functional groups, and all obtained complexes emit red phosphorescence with similar lifetimes.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Gloria Mazzone, Stefano Scoditti, Rossella Caligiuri, Loredana Ricciardi, Emilia Sicilia, Maria Giovanna Lupo, Isabella Rimoldi, Nicolas Godbert, Massimo La Deda, Andreea Ionescu, Mauro Ghedini, Iolinda Aiello, Giorgio Facchetti
Summary: This study used computational and experimental methods to investigate the relationship between internalization, aquation, and DNA binding of two theranostic complexes. The results showed comparable aquation rates for the complexes, with one of them exhibiting slightly higher reactivity. Furthermore, the study demonstrated that one of the complexes targets DNA as its main binding site, supported by computational and experimental data.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Wenting Wang, Pengchao Wang, Xiali Liao, Bo Yang, Chuanzhu Gao, Jing Yang
Summary: In this study, four planar cyclometalated platinum(II) complexes with enlarged aromatic rings were evaluated as effective anticancer theranostic agents for the first time. The increased number of aromatic rings in the N?N ligand led to increased lipophilicity and cytotoxicity selectivity. The interaction between the complexes and biomolecules was indicated by enhanced NIR and green emissions, with different distributions and induction of cell death efficiency.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Svetlana A. Katkova, Daria O. Kozina, Kristina S. Kisel, Maria A. Sandzhieva, Dmitriy A. Tarvanen, Sergey V. Makarov, Vitaly V. Porsev, Sergey P. Tunik, Mikhail A. Kinzhalov
Summary: A series of cyclometalated platinum(ii) complexes with acyclic diaminocarbene (ADC) ancillary ligands were designed and synthesized. Their photophysical properties were investigated both experimentally and theoretically. The complexes showed green phosphorescence with high quantum efficiency of up to 45% in 2 wt% doped PMMA film at room temperature. These complexes were further utilized as light-emitting dopants for OLED fabrication. The resulting devices demonstrated green emission with a maximum current efficiency of 2.9 cd A(-1) and a luminance of 2700 cd m(-2), highlighting the potential of these cyclometalated platinum(ii) complexes as efficient green emitters for OLED devices.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Yuting Wu, Jinfeng Liu, Mingxiao Shao, Pei Zhang, Shaohua Song, Ge Yang, Xicheng Liu, Zhe Liu
Summary: Four neutral cyclometalated iridium(III) dithioformic acid complexes were designed and synthesized, with favorable anticancer activity against non-small cell lung cancer cells through targeting mitochondria and inducing apoptosis.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Angela Vivancos, Delia Bautista, Pablo Gonzalez-Herrero
Summary: This study reports the synthesis, structure, photophysical properties, and electrochemistry of the first series of Pt(IV) tris-chelates bearing cyclometalated aryl-NHC ligands. The complexes exhibit significant photostability, long-lived phosphorescence, and potential application for Pt(IV) emitters with tunable properties.
INORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Anastasia I. Solomatina, Daria O. Kozina, Vitaly V. Porsev, Sergey P. Tunik
Summary: In this study, four iridium complexes containing cyclometallated N^C ligand and various bidentate L^L ligands were synthesized and characterized. These complexes exhibit moderate to strong phosphorescence in the 550-670 nm range, with emission properties strongly dependent on pH. The complexes localize in lysosomes and acidified endosomes within living cells, demonstrating low toxicity.
Article
Chemistry, Inorganic & Nuclear
Jebiti Haribabu, Yuichi Tamura, Kenta Yokoi, Chandrasekar Balachandran, Masakazu Umezawa, Koji Tsuchiya, Yasuyuki Yamada, Ramasamy Karvembu, Shin Aoki
Summary: The study discusses the design and synthesis of two IPHs, 4 and 5, with different numbers of KKKGG sequences, and found that 3 and 4 are more cytotoxic than 5 against Jurkat cells, indicating a positive relationship between the number of peptide units in 3-5 and their anticancer activity. Additionally, a parallel relationship was observed between the cytotoxicity of 3-5 and Ca2+ overload in mitochondria, suggesting the direct transfer of Ca2+ from the endoplasmic reticulum to mitochondria.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Lincoln Dkhar, Akalesh Kumar Verma, Venkanna Banothu, Werner Kaminsky, Mohan Rao Kollipara
Summary: Coumarin hydrazone derivatives were synthesized by Knoevenagel condensation and used to prepare half-sandwich transition metal complexes. The structures of the complexes were confirmed by spectroscopic analysis and X-ray crystallography. Some of the complexes showed stability in solution and nonhygroscopic properties. Among them, two complexes demonstrated significant antibacterial and cytotoxic activities.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Kengo Hara, Ami Morimoto, Kana Matsudaira, Satoko Suzuki, Shigeyuki Yagi, Michiya Fujiki, Yoshitane Imai
Summary: This work focuses on the development of external magnetic field driven, ambidextrous, circularly polarized electroluminescence devices. The use of racemic mixtures of phosphorescent organoiridium(III) emitters in the active emitting layer enables the chiroptical inversion of circularly polarized electroluminescence. The results demonstrate that the ligand environment and Faraday geometry have an influence on the chiroptical inversion of CPEL.
Article
Chemistry, Inorganic & Nuclear
Chenggang Jiang, Louise M. Canada, Ngoc Bao Nguyen, Thomas S. Teets
Summary: This work describes the synthesis and characterization of a series of neutral Chugaev-type chelating dicarbene iridium complexes with different cyclometalating ligands. The effects of these ligands on the emission properties of the complexes are evaluated, and it is found that the complexes exhibit blue-shifted phosphorescence compared to previously described analogues. The study also investigates the electrochemical properties of the compounds and determines the dependence of HOMO and LUMO energies on the cyclometalating ligands.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Plant Sciences
Farzana Kausar, Kyung-Hwan Kim, Hafiz Muhammad Umer Farooqi, Muhammad Awais Farooqi, Muhammad Kaleem, Rooma Waqar, Atif Ali Khan Khalil, Fazli Khuda, Chethikkattuveli Salih Abdul Rahim, Kinam Hyun, Kyung-Hyun Choi, Abdul Samad Mumtaz
Summary: This study investigated the anticancer and antimicrobial activities of Prunus cornuta and Quercus semicarpifolia. The results showed significant inhibitory effects on various cancer cell lines and antibacterial effects against different strains.
Article
Biochemistry & Molecular Biology
Lenka Markova, Vojtech Novohradsky, Jana Kasparkova, Jose Ruiz, Viktor Brabec
Summary: This study investigates the mechanism of the anticancer activity of a photoactivatable Ir(III) compound on highly aggressive and poorly treatable Rhabdomyosarcoma cells. The compound demonstrates potent activity in both differentiated cancer cells and cancer stem cells, and it affects mitochondrial function in a novel way. The findings suggest that this compound could be a promising chemotherapeutic agent for the treatment of hard-to-treat Rhabdomyosarcoma.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Enrique Ortega-Forte, Samanta Hernandez-Garcia, Gloria Vigueras, Paula Henarejos-Escudero, Natalia Cutillas, Jose Ruiz, Fernando Gandia-Herrero
Summary: This study reports a novel mitochondria-targeted iridium(III) complex, OncoIr3, which exhibits advantageous properties as a bioimaging agent and shows potent anticancer activity in vitro and in vivo through an oncosis process.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Chemistry, Applied
Francisco J. Ballester, Enrique Ortega-Forte, Delia Bautista, M. Dolores Santana, Giampaolo Barone, Jose Ruiz
Summary: In this study, a series of compounds with different substituents were synthesized and characterized using NMR and X-ray diffraction. It was found that compounds with stronger electron-donating groups exhibited larger Stokes shift and higher quantum yield. Additionally, some of the compounds showed higher activity in cancer cell lines while displaying low cytotoxicity in healthy cells. One of the compounds also showed the ability to stain the cytoplasm.
Article
Chemistry, Inorganic & Nuclear
Alba Hernandez-Garcia, Lenka Markova, Maria Dolores Santana, Jitka Pracharova, Delia Bautista, Hana Kostrhunova, Vojtech Novohradsky, Viktor Brabec, Jose Ruiz, Jana Kasparkova
Summary: This study presents the synthesis and characterization of six new heteroleptic osmium(II) complexes with varying substituents in the R3 position of the phenyl ring of the cyclometalating C^N ligand. These complexes are highly kinetically inert and absorb a full-wavelength range of visible light. The antiproliferative activity of these complexes has been investigated using human cancer and noncancerous cell cultures, showing that they are more potent than conventional cisplatin. The mechanism of action involves the activation of the endoplasmic reticulum stress pathway and disruption of calcium homeostasis.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Anna Rovira, Enrique Ortega-Forte, Cormac Hally, Mireia Jorda-Redondo, Diego Abad-Montero, Gloria Vigueras, Jesus I. Martinez, Manel Bosch, Santi Nonell, Jose Ruiz, Vicente Marchan
Summary: Photodynamic therapy shows potential as a non-invasive anticancer tool, but the development of highly effective and non-toxic photosensitizers that can work under hypoxic conditions is still needed. In this study, Ir(III)-COUPY conjugates were developed based on the advantageous properties of COUPY fluorophores and cyclometalated Ir(III) complexes, aiming to explore structure-activity relationships. The structural modifications within the coumarin scaffold had a significant impact on the photophysical properties and cellular uptake of the conjugates. All Ir(III)-COUPY conjugates exhibited high phototoxicity under green light irradiation, attributed to the photogeneration of reactive oxygen species (ROS), while remaining non-toxic in the dark. Two hit conjugates showed excellent phototherapeutic indexes in cisplatin-resistant A2780cis cancer cells, indicating the potential of photoactive therapy approaches based on the conjugation of far-red/NIR-emitting COUPY dyes and transition metal complexes to overcome acquired resistance to cisplatin.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Vojtech Novohradsky, Alicia Marco, Lenka Markova, Natalia Cutillas, Jose Ruiz, Viktor Brabec
Summary: In this study, a series of new octahedral iridium(III) complexes Ir1-Ir9 were reported, which showed potential for inhibiting metastasis in triple-negative breast cancer. The results demonstrated that the structural modifications within the complexes strongly influenced their anti-metastatic properties, with complex Ir1 exhibiting the highest activity. Contrary to the effects of the conventional chemotherapy drug doxorubicin, which promoted metastatic properties of TNBC cells, the results suggested that doxorubicin therapy may increase the risk of breast cancer metastasis.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Editorial Material
Chemistry, Multidisciplinary
Gloria Vigueras, Gilles Gasser
Summary: Pharmacologically inactive prodrugs activated by near-infrared light have potential clinical applications. Platinum-based photo-oxidants have been shown to eliminate tumors in mice through a new mode of action.
Article
Chemistry, Multidisciplinary
Enrique Ortega-Forte, Anna Rovira, Marta Lopez-Corrales, Alba Hernandez-Garcia, Francisco Jose Ballester, Eduardo Izquierdo-Garcia, Mireia Jorda-Redondo, Manel Bosch, Santi Nonell, Maria Dolores Santana, Jose Ruiz, Vicente Marchan, Gilles Gasser
Summary: Photodynamic therapy (PDT) is a promising cancer treatment method, but it is limited by its oxygen dependency and poor tissue penetration of some photosensitizers (PSs) activatable with short wavelengths. In this study, a novel hypoxia-active PS with operability in the near-infrared (NIR) region was developed, which showed high photoactivity toward cancer cells even under hypoxic environments. This strategy could potentially pave the way for the development of novel NIR- and hypoxia-active Ru(ii)-based theragnostic PSs.
Article
Chemistry, Inorganic & Nuclear
Alicia Marco, Gloria Vigueras, Natalia Busto, Natalia Cutillas, Delia Bautista, Jose Ruiz
Summary: New valproate Ir(iii) and Rh(iii) half-sandwich conjugates with a C,N-phenylbenzimidazole chelated ligand have been synthesized and characterized. The conjugation of valproic acid to organometallic fragments appears to enhance the antibacterial activity of the complexes against Enterococcus faecium and Staphylococcus aureus Gram-positive bacteria.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Natalia Busto, Gloria Vigueras, Natalia Cutillas, Begona Garcia, Jose Ruiz
Summary: This study found that a new series of heteroleptic iridium(III) complexes showed remarkable effectiveness against Gram positive strains, especially Ir1 and Ir2, which were even 10 times more active than the fluoroquinolone antibiotic norfioxacin. The antimicrobial activity of these complexes is achieved by inducing ROS generation.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Joaquin Bonelli, Enrique Ortega-Forte, Gloria Vigueras, Manel Bosch, Natalia Cutillas, Josep Rocas, Jose Ruiz, Vicente Marchan
Summary: By encapsulating poorly soluble cyclometalated Ir(III) complexes using polyurethane-polyurea hybrid nanocapsules, their solubility is improved and the nanocapsules can enhance cellular uptake and cytotoxicity, leading to inhibition of tumor growth.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Review
Chemistry, Inorganic & Nuclear
Pegah Hajivand, Johannes Carolus Jansen, Emilio Pardo, Donatella Armentano, Teresa F. Mastropietro, Amirreza Azadmehr
Summary: VOCs in human breath can be used as biomarkers for diseases, and MOFs have been extensively studied as gas sensors for VOCs. This review provides a comprehensive summary of the latest MOF-derived composites used as VOCs biomarkers' sensors, and discusses the structural and functional characteristics of MOFs, sensing properties, and the potential of bio-MOFs in VOCs sensing.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Seoyoon Song, Deborah Lee, Lucia C. Dalle Ore, Sungjun Kwak, Lifeng Kang, Hyung Kyo Kim, Noah Malmstadt, Sun Min Kim, Tae-Joon Jeon
Summary: This paper introduces the latest advancements in photoactivable liposomes in drug delivery, highlighting their advantages in precise control over drug release and targeted delivery, as well as the fine control over release kinetics achieved through the manipulation of light-responsive components. Additionally, the paper emphasizes the design considerations of physicochemical properties and light-related constituents.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shudi Liu, Liangwei Zhang, Heejeong Kim, Jinyu Sun, Juyoung Yoon
Summary: Chromium is a strategic and critical transition metal element with extensive applications. Efficient detection methods, such as fluorescence and colorimetry, have been developed for monitoring its concentrations. However, existing reviews on fluorescent probes for chromium lack comprehensive coverage. This review aims to consolidate information and promote the development of novel fluorescent probes for chromium detection.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rehab H. Elattar, Samah F. El-Malla, Amira H. Kamal, Fotouh R. Mansour
Summary: Metal complexes have strong analysis potential and can be used to measure analytes lacking essential chemical properties. Their analytical methods based on different mechanisms offer superior performance.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Nem Singh, Miae Won, Yunjie Xu, Changyu Yoon, Jiyoung Yoo, Mingle Li, Heemin Kang, Jong Seung Kim
Summary: Hypoxia is a common occurrence in the tumor microenvironment and poses challenges for cancer treatment. The introduction of covalent organic frameworks (COFs) offers promising prospects for addressing hypoxia-related issues. This article explores the role of COFs in enhancing oxygen delivery, generating reactive oxygen species, optimizing drug delivery, and enabling hypoxia-specific imaging, as well as outlining their applications in various hypoxia-targeting therapeutic modalities.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Priyadarshi Roy Chowdhury, Himani Medhi, Krishna G. Bhattacharyya, Chaudhery Mustansar Hussain
Summary: This review critically analyzes the production of waste-derived layered double hydroxides (LDH) and their utility in electrochemical water splitting for the generation of green hydrogen as sustainable energy. It highlights the importance of waste-derived LDH and discusses the challenges and future directions in this field.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rajamanickam Sivakumar, Nae Yoon Lee
Summary: This article reviews the progress in imaging reactive oxygen, nitrogen, and sulfur species (RONSS) using luminescent metal complex-based probes. This technology is selective and sensitive, which is of great significance for studying the impact of RONSS in cells and tissues and preventing diseases.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Xinyang Li, Binbin Ding, Pan Zheng, Ping'an Ma, Jun Lin
Summary: The main goal of immunotherapy is to enhance the response and cytotoxicity of tumor-specific T cells by turning cold tumors into hot tumors. However, metabolic reprogramming in the tumor microenvironment can depress the cytotoxicity of T cells and hinder the effectiveness of immunotherapy. This review discusses the role of metabolic reprogramming in the interplay between cancer cells and immune cells in the tumor microenvironment and explores the use of nanomaterials to modulate metabolic pathways and improve immunotherapy outcomes.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Kingsley Poon, Abhishek Gupta, William S. Price, Hala Zreiqat, Gurvinder Singh
Summary: Progress in the development of manganese oxide nanoparticles (MONPs) has provided an alternative for early-stage diagnosis of life-threatening diseases and therapeutic delivery of drugs and genes. The synthesis and characterization of MONPs have enabled the production of multi-functional targeted nanoparticles in various sizes and shapes. The integration of diagnosis and therapeutic capabilities within a single entity, known as nanotheranostics, is promising for real-time monitoring of disease progression and evaluating therapeutic treatment efficacy.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Reza Abedi-Firoozjah, Hadiseh Ebdali, Mahya Soltani, Parastoo Abdolahi-Fard, Mahshid Heydari, Elham Assadpour, Maryam Azizi-Lalabadi, Fuyuan Zhang, Seid Mahdi Jafari
Summary: With the increasing awareness of food safety, there is a growing demand for efficient and affordable sensing methods for the detection of pathogens and toxins in food products. Nanosensors offer promising solutions with their quick and reliable detection capabilities, although challenges remain in their fabrication and practical application.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Demei Sun, Xuesong Feng, Xinyuan Zhu, Youfu Wang, Jinghui Yang
Summary: Metal organic cages (MOCs) with precise and tunable nano structures show great potential in cancer therapy. Their diverse functions and ultrasmall size make them excellent nanoagents for different anticancer strategies, demonstrating outstanding anticancer performances.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Li Li, Yang-Tao Yu, Ning-Ning Zhang, Shu-Hao Li, Jian-Ge Zeng, Yang Hua, Hong Zhang
Summary: This article summarizes recent advances in POM-based hybrid photochromic materials (PCHPMs), including structure types, new photochromic mechanisms, and applications. It can provide valuable guidance for researchers investigating POM-based hybrid photochromic materials.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Chien Ing Yeo, Clariss Hui Peng Goh, Edward R. T. Tiekink, Jactty Chew
Summary: This review article provides an overview of the antibacterial activity of gold complexes, with a focus on gold(I) and gold(III) complexes. It also summarizes the repurposing of Auranofin for antibacterial purposes and the associated mechanism(s) of action.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Sangharaj Diyali, Nilankar Diyali, Bhaskar Biswas
Summary: This study discusses the recent progress in the design and development of catalysts, focusing on the factors influencing overpotential, catalytic rate, and stability, as well as the mechanisms of the hydrogen evolution reaction in acidic and alkaline media. Moreover, it outlines the challenges in future design of robust and active electrocatalysts.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shaik Gouse Peera, Rahul S. Menon, Sumanta Kumar Das, Akram Alfantazi, K. Karuppasamy, Chao Liu, Akhila Kumar Sahu
Summary: Doped carbon materials, especially F-doped carbon catalysts, have gained significant attention as metal-free catalysts for oxygen reduction reactions and as corrosion-resistant supports for Pt and non-Pt nanoparticles. F-doped carbon materials possess unique properties and greatly improve the activity and durability of the ORR compared to N-doped carbon materials. The high electronegativity of F-doping can efficiently modify the electronic band structure of carbon materials, favoring the ORR. This review systematically discusses the effect of F-doping/F co-doping on the electrocatalytic reduction of O2 in acidic and alkaline conditions, the stability and durability of fuel cell catalysts, and provides guidelines for working with F-doped carbons. Future research directions on F-doped carbons are also proposed to bridge the gap between laboratory-scale assessments and commercial applications.
COORDINATION CHEMISTRY REVIEWS
(2024)