期刊
CONTRACEPTION
卷 98, 期 2, 页码 130-134出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.contraception.2018.04.008
关键词
Cervical dysplasia; Cervical cancer; Intrauterine contraception; IUD
资金
- National Center for Advancing Translational Sciences, National Institutes of Health (NIH), through UCSF-CTSI Grant [UL1TR000004]
- National Cancer Institute, NIH [1R01CA169093-01A1]
- NIH [K12 HD001259]
Objective: Understanding the effect of contraceptives on the development of precancerous lesions of the cervix and cervical cancer may provide information that is valuable to women in contraceptive decision-making. The purpose of this study was to evaluate the association between recent intrauterine device (IUD) use (by type) and cervical intraepithelial neoplasia 2, 3, adenocarcinoma in situ or cancer (CIN2+ or CIN3+). Study Design: Case-control study of 17,559 women age 18-49 with incident CIN2+ cases and 5:1 age-matched, incidence-density selected controls (N=87,378) who were members of Kaiser Permanente Northern California Healthcare System from 1996 to 2014. Recent IUD use, within 18 months prior to index, was the exposure of interest. Results: We identified 1,657 IUD users among the cases and 7,925 IUD users among controls. After adjusting for sexually transmitted infection testing, smoking, HPV vaccination, hormonal contraceptive use, parity, race and number of outpatient healthcare system visits, IUD use was associated with an increased rate of CIN2+ [rate ratio (RR) 1.12, 95% confidence interval (1.05-1.18), p<0.001] but not CIN3+ [RR 1.02 (0.93-1.11), p=0.71]. Levonorgestrel-IUD use was associated with an increased rate of CIN2+ [RR 1.18 (1.08-130), p<0.001] but not CIN3 + [RR 1.05 (0.91-1.21), p=0.48]. Copper-IUD use was not associated with CIN2 + [RR 0.88 (0.75-1.04), p=0.13] or CIN3+ [RR 0.81 (0.64-1.02), p=0.07]. Conclusion: Recent IUD use had variable weak associations with CIN2 + but was not associated with increased risk of CIN3+. (C) 2018 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据