期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 171, 期 -, 页码 260-275出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2018.07.030
关键词
Cancer therapy; Graphene oxide; Nanostructures; Photothermal therapy; Tumors
资金
- FEDER funds through the POCI - COMPETE 2020 - Operational Programme Competitiveness and Internationalisation in Axis I - Strengthening research, technological development and innovation [POCI-01-0145-FEDER-007491]
- FCT - Foundation for Science and Technology [UID/Multi/00709/2013]
- FCT [SFRH/BD/103506/2014, SFRH/BD/103507/2014]
- [CENTRO-01-0145-FEDER-028989]
Graphene family nanomaterials' (GFN) ability to interact with near-infrared light has propelled their application in cancer photothermal therapy. Furthermore, the graphitic lattice of GFN can adsorb different types of molecules, which has motivated their use in cancer drug delivery. However, the direct application of GFN in cancer therapy is severely hindered by their poor colloidal stability, sub-optimal safety, inefficient tumor uptake and non-selectivity towards cancer cells. To overcome these limitations, GFN have been functionalized with different types of materials. This review is focused on the different functionalizations used in the design of GFN aimed for application in cancer therapy, disclosing their role on surpassing the critical issues related to GFN-based therapies.
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