Article
Biochemistry & Molecular Biology
Wei Zhou, Ce Cheng, Li Ma, Liqiang Zou, Wei Liu, Ruyi Li, Yupo Cao, Yuhuan Liu, Roger Ruan, Jihua Li
Summary: The study developed chitosan-coated rhamnolipid liposome delivery system, which showed higher stability and bioavailability of curcumin compared to uncoated liposomes. However, the system exhibited poor stability to salt addition.
Article
Multidisciplinary Sciences
Alya Elzoheiry, Esraa Ayad, Nahed Omar, Kadry Elbakry, Ayman Hyder
Summary: Liver fibrosis can be inhibited by curcumin through direct binding to fibrosis-mediating proteins. Nano-formulation of curcumin using green silver nanoparticles coated with chitosan can enhance its efficacy as a drug for targeting liver fibrosis.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Huijuan Zheng, Weilin Liu, Shuibing Yang
Summary: A nutraceutical carrier system was developed to increase the solubility of MCFA in aqueous foods, showing improved stability and sustained release of MCFAs in gastrointestinal fluid. The successful coating of nanoliposomes with CMCS resulted in negative surface charge, preventing particle aggregation and allowing safe retention of encapsulated MCFAs for up to 90 days at 4 degrees Celsius.
Article
Biochemistry & Molecular Biology
Sayali Pravin Metkar, Gasper Fernandes, Ajinkya Nitin Nikam, Soji Soman, Sumit Birangal, Raviraja N. Seetharam, Manjunath Bandu Joshi, Srinivas Mutalik
Summary: This study aimed to enhance the oral bioavailability of andrographolide (AG), a key diterpene lactone of Andrographis paniculata, by formulating and optimizing AG-loaded nanoliposomes (AGL) using the Design of Experiment (DOE) approach and modifying the liposomes surface with mannosylated chitosan. The results showed that the modified nanoliposomes (MCS-AGL) exhibited sustained drug release, improved drug permeation, and enhanced bioavailability compared to plain AG and AGL. Therefore, the use of mannosylated chitosan-coated nanocarriers has the potential to improve the intestinal permeability and bioavailability of poorly soluble and permeable drugs or phytoconstituents.
Article
Food Science & Technology
Wei -Ting Chen, Yu-Lin Kuo, Chien-Hua Chen, Hung-Ta Wu, Hua-Wei Chen, Wu -Po Fang
Summary: Through the preparation of chitosan-coated curcumin liposomes, the stability and encapsulation efficiency of curcumin can be significantly improved, while effectively inhibiting microbial growth and sterilization.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Physical
Ruxin Chang, Liran Chen, Muhammad Qamar, Yanjun Wen, Linzheng Li, Jiayin Zhang, Xing Li, Elham Assadpour, Tuba Esatbeyoglu, Mohammad Saeed Kharazmi, Yuan Li, Seid Mahdi Jafari
Summary: This review discusses the applications of curcumin, the major active component in turmeric, in food industry, which is restricted by low solubility, stability, and bioavailability. Recent strategies using nanocarriers such as complex coacervates, nanocapsules, liposomes, and nanoparticles have been developed to overcome these limitations. The review focuses on delivery systems responsive to environmental stimuli, metabolites and biodistribution of curcumin, interaction with gut micro biota, and the feasibility of applying curcumin nanocarriers in food industry.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Paulina Dalek, Dominik Drabik, Halina Wolczanska, Aleksander Forys, Malgorzata Jagas, Natalia Jedruchniewicz, Magdalena Przybylo, Wojciech Witkiewicz, Marek Langner
Summary: Vitamin D-3 deficiency has significant health consequences and affects the severity and recovery of COVID-19 infection. Absorption and distribution of vitamin D-3 in the body depend on accompanying lipids and/or proteins due to its high hydrophobicity. Clinical experiments comparing liposomal and oily formulations of vitamin D-3 showed that liposomal vitamin D-3 caused a rapid increase in plasma calcidiol concentration, particularly in individuals with severe vitamin D-3 deficiency.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Chen Guo, Xichun Zhu, Haoyang Yuan, Haoyu Liu, Yu Zhang, Tian Yin, Haibing He, Jingxin Gou, Xing Tang
Summary: Chitosan-coated vinorelbine liposomes were successfully developed, reducing gastrointestinal toxicity, increasing drug bioavailability, and prolonging drug residence time in the body.
Article
Biophysics
Maria Estephan, Riham El Kurdi, Digambara Patra
Summary: This study elaborates on the physical properties of diarachidonyl phosphatidyl choline (DAPC) liposome using fluorescence method with curcumin as a probe molecule at low concentration. The results show that curcumin has a higher partition coefficient above the phase transition temperature of DAPC liposomes, and the presence of chitosan oligosaccharide lactate layer affects membrane permeability.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Qiaobin Hu, Yangchao Luo
Summary: This review highlights the use of chitosan-based nanocarriers for encapsulating and delivering curcumin, and discusses the fabrication techniques and functionalities of different types of chitosan-based nanocarriers. Furthermore, it elaborates on the current pharmaceutical applications of curcumin-loaded chitosan nanoparticles and their role in improving therapeutic effects on chronic diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Jianqing Peng, Qin Wang, Mingyang Guo, Chunyuan Liu, Xuesheng Chen, Ling Tao, Ke Zhang, Xiangchun Shen
Summary: In this study, a CS-coated liposome loaded with OMT was used for the treatment of lethal RSV infection. The CS-coated liposome enhanced the distribution and retention of OMT in lung tissue, effectively alleviating RSV infection. Thus, the CS-coated liposome could be a potential inhalable nanocarrier for preventing pulmonary infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Shima Afrasiabi, Alireza Partoazar, Nasim Chiniforush
Summary: The excessive inappropriate use of systemic antibiotics has led to the emergence of antibiotic-resistant pathogens. This study developed a doxycycline-loaded liposome doped with curcumin (NL-Cur(+Dox)) for combination antibacterial therapy against Aggregatibacter actinomycetemcomitans. The formulation showed encapsulation of both drugs in NL-Cur(+Dox) with sustained release behavior and demonstrated potential application in reducing periodontitis-causing bacteria.
SCIENTIFIC REPORTS
(2023)
Article
Food Science & Technology
Leila Ramezanzade, Seyed Fakhreddin Hosseini, Behrouz Akbari-Adergani, Anan Yaghmur
Summary: The study aimed to develop novel hybrid nanocarriers for fish-purified antioxidant peptide, utilizing liposomes coated with chitosan cross-linked with sodium tripolyphosphate. The produced nanodispersion demonstrated good stability and retained antioxidant activity, presenting a promising approach for delivering protein hydrolysates and peptide fractions in nutraceutical and functional foods.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Physical
Celine Arab, Riham El Kurdi, Digambara Patra
Summary: Zinc curcumin oxide nanoparticles coated with chitosan were successfully synthesized and proved to be an excellent nanoprobe for detecting ascorbic acid. The nanoparticles showed high crystallinity and stability at high temperatures. The detection method based on fluorescence emission technique was found to be fast, stable, easy to manipulate, and selective with high recovery rates.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Applied
Sahar Salehi, Mohammad Sadegh Nourbakhsh, Mardali Yousefpour, Ghadir Rajabzadeh, Sajad Sahab-Negah
Summary: In this study, chitosan-coated niosome was used to enhance the bioavailability of curcumin and boswellic acids. The chitosan layer improved the physical stability of the niosome and increased the bioavailability of the drugs.
JOURNAL OF MICROENCAPSULATION
(2022)
Article
Food Science & Technology
Maria Cristina Messia, Francesca Cuomo, Luisa Falasca, Maria Carmela Trivisonno, Elisa De Arcangelis, Emanuele Marconi
Summary: A combination of various high-protein raw materials can improve the biological value of pasta proteins, resulting in high-protein pasta with excellent cooking properties.
Review
Biochemistry & Molecular Biology
Francesca Cuomo, Silvio Iacovino, Pasquale Sacco, Antonella De Leonardis, Andrea Ceglie, Francesco Lopez
Summary: This review presents recent advances in the delivery of bioactive phenolic compounds mediated by colloid systems. The focus is on the progress made in this field in recent years. The structural and dynamic aspects of different colloid delivery systems, as well as the interactions with two bioactive constituents, are discussed. Two case studies are presented, one representing hydrophobic phenolic compounds and the other representing hydrophilic compounds.
Article
Food Science & Technology
Francesca Cuomo, Maria Carmela Trivisonno, Silvio Iacovino, Maria Cristina Messia, Emanuele Marconi
Summary: Brewer's spent grains, a by-product of the brewing industry, were utilized to create innovative dry pasta with enriched protein and fiber content. These newly formulated pasta products showed excellent quality characteristics compared to traditional pasta, highlighting the successful combination of technological aptitude, nutritional/sensorial quality, and sustainability.
Article
Food Science & Technology
Antonella De Leonardis, Vincenzo Macciola, Ayesha Iftikhar, Francesco Lopez
Summary: In this study, a potentially functional oil/vinegar dressing was formulated using an enriched omega-3 fatty acids oil blend and several kinds of naturally occurring biophenols. The use of ultrasound bath enabled effective emulsification without the addition of emulsifiers. Olive vinegar and olive leaf vinegar exhibited clear antioxidant activity.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2022)
Article
Chemistry, Applied
Giovanni Ferraro, Emiliano Fratini, Pasquale Sacco, Fioretta Asaro, Francesca Cuomo, Ivan Donati, Francesco Lopez
Summary: This study investigated the effect of biomacromolecule concentration and ageing on the structural integrity of chia mucilage-based hydrogel networks. The results showed that ageing destabilizes the hydrogel architecture, leading to a decrease in strength and viscosity, as well as an increase in mesh size.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Multidisciplinary
Antonio Mino, Giuseppe Cinelli, Francesco Lopez, Luigi Ambrosone
Summary: A simple model is proposed to calculate the dimerization constant of Nile Red dye in non-aqueous solvents using various Alkan-1ols. The spectroscopic behavior of the dye is studied by varying the hydrophobicity of the medium. The aggregation process is found to be solvent-assisted, and the fluorescence emission spectra can be used to determine adjustable parameters.
APPLIED SCIENCES-BASEL
(2023)
Article
Food Science & Technology
Onofrio Corona, Luciano Cinquanta, Caterina Li Citra, Francesca Mazza, Vincenzo Ferrantelli, Gaetano Cammilleri, Emanuele Marconi, Francesca Cuomo, Maria Cristina Messia
Summary: This study investigates the safety, nutritional, and volatile profile evolution of a traditional Italian anchovy sauce with PDO after aging in wooden barrels for 12, 24, and 48 months. Physicochemical parameters, free amino acids, volatile compounds, and histamine contents were evaluated. Glutamate was the predominant free amino acid, showing a significant increase after 48 months of maturation. The total amino acid content increased with longer aging periods. Histamine content decreased significantly during the ripening process. Prolonged maturation improved the safety, nutritional, and volatile components of the seasoning colatura di alici.
Article
Food Science & Technology
Antonella De Leonardis, Vincenzo Macciola, Ayesha Iftikhar, Francesco Lopez
Summary: This study developed a healthier and tastier mayonnaise by using unconventional ingredients such as olive leaf vinegar, soybean/high oleic sunflower oil blend, and soymilk. Olive leaf vinegar, a rich source of bioactive substances, especially polyphenols, can enhance the value of olive oil by-products. The sensory evaluation and oxidative stability of the mayonnaise were improved with the incorporation of olive leaf vinegar.
Article
Food Science & Technology
Maria Cristina Messia, Francesca Cuomo, Michela Quiquero, Vito Verardo, Emanuele Marconi
Summary: Evaluating the nutritional quality and thermal damage effects of gluten-free foods is crucial for individuals with gluten intolerance or celiac disease. This study analyzed fifteen different commercial gluten-free pasta samples to assess their nutritional value, amino acid composition, and protein chemical score. The occurrence of the Maillard reaction was investigated, and heat treatment markers were determined. The results showed that pasta made with the same raw materials can have varying degrees of thermal damage.
Article
Chemistry, Applied
Martina Cofelice, Maria Cristina Messia, Emanuele Marconi, Francesca Cuomo, Francesco Lopez
Summary: Hydrogels of alginate and xanthan gum were prepared by in-situ gelation method. The rheological behavior of the hydrogels was studied, and it was found that the viscosity and elasticity of the hydrogels were influenced by the concentrations of calcium ions and xanthan gum. The crosslinking with low calcium concentration was affected by xanthan gum even at lower concentrations.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
Francesco Letizia, Alessandra Fratianni, Martina Cofelice, Bruno Testa, Gianluca Albanese, Catello Di Martino, Gianfranco Panfili, Francesco Lopez, Massimo Iorizzo
Summary: In recent times, there has been a growing consumer interest in replacing animal foods with alternative plant-based products. In this study, soymilk was fermented with Lactiplantibacillus plantarum LP95, resulting in a significant increase in aglycone isoflavones and antioxidant activity. The use of Lp. plantarum LP95 as a starter for fermented soymilk production shows promise.
Article
Chemistry, Applied
Silvio Iacovino, Maria Carmela Trivisonno, Maria Cristina Messia, Francesca Cuomo, Francesco Lopez, Emanuele Marconi
Summary: By combining empirical rheology and fundamental rheology, this study found that the viscoelastic properties of wheat flour dough, especially those with high bran content, can be more accurately evaluated. Fundamental rheology provides a more comprehensive assessment of the dough's viscoelastic character, determining a direct correlation between flour extraction rate and dough consistency.
FOOD HYDROCOLLOIDS
(2024)
Article
Engineering, Multidisciplinary
Francesco Piazza, Matilde Colella, Giuseppe Cinelli, Francesco Lopez, Ivan Donati, Pasquale Sacco
Summary: This study investigates the structural changes of chia seed mucilage when treated with alpha-amylase, the most abundant enzyme in human saliva. The results reveal that the material thickens and the elastic modulus increases after enzyme treatment, indicating a restructuring of the chia mucilage network mediated by alpha-amylase. This finding has implications for the commercial processing of chia seed mucilage.
Article
Engineering, Chemical
Antonio Mino, Giuseppe Cinelli, Gianluca Paventi, Gianluca Testa, Fabiana Passaro, Francesco Lopez, Luigi Ambrosone
Summary: Biomaterials play a crucial role in tissue regeneration, but their success depends on simple and inexpensive technologies that stimulate regenerative processes. This study explored the possibility of creating materials for heart tissue regeneration. By modifying the experimental procedure, hybrid PLGA-phospholipid nanoparticles were produced with specific properties dependent on the mass ratio. The formulation with R=4 resulted in a uniform and easily workable material in thin sheets.
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)