Article
Chemistry, Applied
Maher Fathalla, Lutfan Sinatra
Summary: Ionic self-assembly (ISA) is used to create functional nanomaterials through electrostatic interactions. This study introduces a pH responsive hybrid material formed by benzoic acid functionalized silica nanoparticles (MSNs-Bn) and meso-tetrakis(N-methylpyridinium-4-yl)porphyrin (TMPyP). The hybrid material shows potential as a drug delivery system that is responsive to changing pH values and can deliver both chemotherapeutic drugs and PDT agents.
JOURNAL OF POROUS MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Yanhong Liu, Linjiao Chen, Qingyang Shi, Qing Zhao, Hongshuang Ma
Summary: Tumor microenvironment-responsive polypeptide nanogels have excellent biocompatibility and degradability, and can be used for selective delivery of antitumor drugs. These nanogels can release drugs in response to stimuli from tumor tissues or cells, reducing side effects and improving efficacy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Polymer Science
Nour M. AlSawaftah, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Summary: Stimuli-responsive nanoparticles have shown promising potential in overcoming the limitations of conventional chemotherapy. pH-sensitive nanoparticles, in particular, have proven to be highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review summarizes the different strategies used to develop pH-sensitive nanoparticles for cancer therapy.
Article
Biophysics
Priyanka Ray, Narendra Kale, Mohiuddin Quadir
Summary: Novel molecular motifs act as pH-regulating triggers for amphiphilic, pH-sensitive block copolymers, enhancing their self-assembling properties and potential for drug delivery systems.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Hien Phan, Robert Cavanagh, Damien Destouches, Francis Vacherot, Blandine Brissault, Vincenzo Taresco, Jacques Penelle, Benoit Couturaud
Summary: H2O2-sensitive block copolymer nanoparticles were prepared using the polymerization-induced self-assembly (PISA) approach, which can be used for controlled drug release.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yun Liu, Yanfang Wang, Yuejun Yao, Juan Zhang, Wei Liu, Kangfan Ji, Xinwei Wei, Yuanwu Wang, Xiangsheng Liu, Shiming Zhang, Jinqiang Wang, Zhen Gu
Summary: Lipid nanoparticle-based drug delivery systems have a significant impact on nucleic acid-based therapy and vaccination. We designed phenylboronic acid-based quaternary amine-type cationic lipids that can self-assemble into spherical lipid nanoparticles. Mixing insulin with the lipid nanoparticles immediately forms a heterostructured insulin complex, and in a hyperglycemia-relevant glucose solution, the lipid nanoparticles gradually become less positively charged, leading to insulin release.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Zhiqiang Lin, Junfeng Ding, Xuesi Chen, Chaoliang He
Summary: pH- and temperature-responsive hydrogels based on mPEG-polypeptide block copolymers were developed in this study. The hydrogels exhibited an alpha-helix-to-beta-sheet transition at increased pH and underwent thermo-induced sol-gel phase transitions at elevated polymer concentrations, dependent on the pH. They demonstrated good histocompatibility and almost complete degradation in the subcutaneous layer of mice. The doxorubicin-loaded hydrogels showed pH-responsive drug release profiles with rapid release at acidic pH and sustained release at neutral pH, suggesting their potential as environment-responsive depots for drug delivery.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Polymer Science
Wanda Celentano, Stefania Ordanini, Riccardo Bruni, Luca Marocco, Pietro Medaglia, Andrea Rossi, Stefano Buzzaccaro, Francesco Cellesi
Summary: Well-defined amphiphilic PCL-PEG copolymers with complex molecular architectures were synthesized using ROP and ATRP. These copolymers were used to produce self-assembled nanoparticles for drug encapsulation, with the ability to tune self-assembly, particle size, and drug loading by designing specific macromolecular architectures.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Lei Zou, Christopher J. Addonizio, Bo Su, Matthew J. Sis, Adam S. Braegelman, Dongping Liu, Matthew J. Webber
Summary: This study utilized host-guest physical cross-linking to prepare supramolecular hydrogels, with the introduction of asymmetric azobenzene into copolymers enabling temperature and light responsiveness control. UV light was used to disrupt the supramolecular motif leading to a gel-to-sol transition, with rapid hydrogel recovery achieved through thermal relaxation of azobenzene.
Article
Chemistry, Physical
Matthew C. Urquhart, Francesca Ercole, Andrew J. Clulow, Thomas P. Davis, Michael R. Whittaker, Ben J. Boyd, John F. Quinn
Summary: This study discovers that an amphiphilic trisulfide can alter the behavior of lipid particles and enable triggered release of H2S, providing potential applications in stimuli-responsive drug delivery systems.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Daniel A. Paterson, Wye-Khay Fong, Sarah Hook, Allan B. Gamble
Summary: This study utilized a robust activator to synthesize BCPs, investigated self-assembly conditions and particle properties, and found that different solvents resulted in different structural morphologies. Triggering by hydrogen sulfide caused disruption or cross-linking of particles containing unsubstituted aryl azides, but was less sensitive for particles with substituents.
Review
Chemistry, Physical
Krystal A. A. Hughes, Bishal Misra, Maryam Maghareh, Sharan Bobbala
Summary: Drug delivery has seen significant progress in the past decade, particularly in the development of targeted therapies and intracellular delivery. However, the imprecise and non-targeted release profiles of intracellular drug delivery systems pose limitations. Stimuli-responsive soft nanoparticles, containing organic materials such as lipids and polymers, offer a solution to this problem. The choice of biomaterial is crucial for these soft nanoparticles to respond to internal or external stimuli, while maintaining integrity in non-targeted physiological conditions and releasing drugs in specific intracellular environments.
Article
Biophysics
Qiang Li, Dongsheng Fu, Jie Zhang, Hong Yan, Huifang Wang, Baolong Niu, Ruijie Guo, Yiming Liu
Summary: A new type of polypeptide-based dual-sensitive drug delivery system was synthesized for efficient chemotherapy. The nanoparticles showed enhanced drug release in acidic and hypoxic environments, leading to higher cytotoxicity against lung cancer cells. This system has the potential to be a promising platform for stimuli-responsive controlled drug release in cancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Tobias A. A. Bauer, Irina Alberg, Lydia A. A. Zengerling, Pol Besenius, Kaloian Koynov, Bram Slutter, Rudolf Zentel, Ivo Que, Heyang Zhang, Matthias Barz
Summary: Core cross-linked polymeric micelles (CCPMs) are designed to improve the therapeutic profile of hydrophobic drugs, reduce or completely avoid protein corona formation, and offer prolonged circulation times. CCPM stability was tuned by using bifunctional or trifunctional cross-linkers and varying the cross-linkable polymer block length. The circulation time and biodistribution of CCPMs can be enhanced by using trivalent peptide cross-linkers.
Article
Chemistry, Multidisciplinary
Shengcai Yang, Jiayu Leong, Yanming Wang, Rachel Sim, Ko Hui Tan, Yau Hong Chua, Nathanael Tan, Ashlynn L. Z. Lee, Joyce Tay, Yi Yan Yang
Summary: By neutralizing the positive charges of cationic anticancer polymers/peptides and self-assembling into nanoparticles, we have successfully developed a nanoparticulate delivery system with improved stability and reduced toxicity. The system exhibits excellent anticancer activity, can enter cancer cells, and bypass drug resistance mechanisms. In vivo experiments demonstrate that the system effectively inhibits tumor growth with minimal side effects.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Yu-Fon Chen, Chien-Hsiang Chang, Ming-Wei Hsu, Ho-Min Chang, Yi-Cheng Chen, Yi-Sheng Go, Jeng-Shiung Jan
Article
Cell & Tissue Engineering
Hsiu-Chu Chou, Chien-Hsiang Chang, Chien-Han Chen, Willie Lin, Chung-Ming Chen
Summary: The consecutive intratracheal administration of surfactant and hUC-MSCs for two days effectively attenuated hyperoxia-induced lung injury in neonatal rats, demonstrating a potential therapeutic regimen for this condition.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Agricultural Engineering
Ya-Yun Chiang, Dillirani Nagarajan, Yung-Chung Lo, Chun-Yen Chen, I-Son Ng, Chien-Hsiang Chang, Duu-Jong Lee, Jo-Shu Chang
Summary: This study demonstrates the efficiency of polyvinyl-alcohol-immobilized Actinobacillus succinogenes ATCC55618 for succinic acid (SA) production, especially when using sugars derived from microalgae. The highest productivity for SA fermentation using microalgae-derived sugars was achieved in this study.
BIORESOURCE TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Martina Havlikova, Adam Jugl, Jitka Krouska, Jana Szabova, Ludmila Mravcova, Tereza Venerova, Chien-Hsiang Chang, Miloslav Pekar, Filip Mravec
Summary: High-resolution ultrasound spectroscopy, size and zeta-potential titrations, and isothermal titration calorimetry were used to characterize the interactions between hyaluronan and catanionic ion pair amphiphile vesicles. The interactions showed a correlation between data from size titration, HR-US, and visual observation. Intensity of interactions and the disaggregation were dependent on the molecular weight of hyaluronan.
Article
Multidisciplinary Sciences
Manas Barai, Emili Manna, Habiba Sultana, Manas Mandal, Kartik Guchhait, Tuhin Manna, Anuttam Patra, Chien-Hsiang Chang, Parikshit Moitra, Chandradipa Ghosh, Anna-Carin Larsson, Santanu Bhattacharya, Amiya Panda
Summary: The study found that surfactants based on dicarboxylic amino acids combined with HTAB form various aggregates with composition and concentration-dependent phase behaviors. These aggregates show minimal toxicity and irritation to cells and skin in vitro, while exhibiting significant antibacterial effects against Staphylococcus aureus.
SCIENTIFIC REPORTS
(2021)
Article
Polymer Science
Yu-Fon Chen, Wei-Chen Lin, Cheng-Ju Wu, Chien-Hsiang Chang, Jeng-Shiung Jan
Summary: In this study, we investigated the effects of emulsion process and DNA sequence on the morphology and surface property of gel particles. The results showed that the oil-water interface and payload-DNA interactions play crucial roles in determining the size, surface property, and payload encapsulation of the nanogels.
JOURNAL OF POLYMER RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Yuan-Pin Hung, Yu-Fon Chen, Pei-Jane Tsai, I-Hsiu Huang, Wen-Chien Ko, Jeng-Shiung Jan
Summary: Bacteria-targeting nanomaterials have been widely used for diagnosis and treatment of bacterial infectious diseases, showing great potential as antimicrobial agents. These materials prevent bacterial colonization and spreading, benefiting biomaterial implants. Tailoring nanomaterials for wound repair and incorporating immune activating adjuvants can improve function and prevent bacterial infections.
Article
Materials Science, Multidisciplinary
Chun-Yen Liu, Chien-Hsiang Chang, Thanh Tran Thi, Guan-Yi Wu, Chia-Ming Tu, Hung-Yi Chen
Summary: In this study, a series of cross-linked and interpenetrated poly(NIPAM-co-AM) hydrogel networks were synthesized to enhance the biocompatibility of artificial iris. The N3A1-N3A1 interpenetrated network hydrogel showed the best performance and was selected for the fabrication of thermally and light tunable iris-like actuators. The results demonstrated the feasibility of using poly(NIPAM-co-AM) IPN hydrogels for the design of thermal and light-responsive actuators.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Environmental Sciences
Jia-Yi Lin, Shih- Tan, Ying-Chen Yi, Chuan-Chieh Hsiang, Chien-Hsiang Chang, Chun-Yen Chen, Jo-Shu Chang, I-Son Ng
Summary: In this study, it was found that the Cyanobacterium Synechococcus sp. PCC7002 can efficiently absorb carbon dioxide, and the produced Cphycocyanin (C-PC) can reduce CO2 emissions and exhibit antioxidant and antibacterial activities.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Petra Holinkova, Filip Mravec, Tereza Venerova, Chien-Hsiang Chang, Miloslav Pekar
Summary: This study investigated the interactions between hyaluronan and micelles formed by cationic surfactants using fluorescence resonance energy transfer (FRET). The results showed that the addition of hyaluronan led to the formation of a pearl necklace structure with smaller micelles compared to pure surfactant. This research is of significance for the formulation of drug delivery systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Yi-Sheng Jiang, Ming-Hsien Hu, Jeng-Shiung Jan, Jin-Jia Hu
Summary: This study aimed to retard the degradation rate of Poly(glycerol sebacate) (PGS) by incorporating L-glutamic acid into its network. The results showed that the introduction of L-glutamic acid formed peptide bonds which led to altered mechanical properties and retarded degradation kinetics of the elastomer. It was found that PGSE displayed a lower degradation rate and different mechanical properties compared to PGS, making it a potential scaffold material for tissues with a low healing rate.
Article
Medicine, Research & Experimental
Yu-Fon Chen, Zih-Hua Wang, Yi-Cheng Chen, Chien-Hsiang Chang, Hui-Zhong Zhuang, Fang-Yu Chung, Jeng-Shiung Jan
Summary: Developing gene vectors with high efficiency and low cytotoxicity is crucial for gene therapy. This study investigated the use of cationic polypeptide bilayer assemblies as gene vectors and found that they showed improved transfection efficiency and biocompatibility compared to traditional vectors. The study also demonstrated that the gene vectors combined with low-dose chemotherapy drugs can effectively treat genetically resistant cancers while reducing side effects.
MOLECULAR PHARMACEUTICS
(2023)
Article
Cell Biology
Maria Meszaros, Thi Ha My Phan, Judit P. Vigh, Gergo Porkolab, Anna Kocsis, Emese K. Pali, Tamas F. Polgar, Fruzsina R. Walter, Silvia Bolognin, Jens C. Schwamborn, Jeng-Shiung Jan, Maria A. Deli, Szilvia Veszelka
Summary: Research has found that nanoparticles targeting cerebral endothelial cells can enhance drug delivery to the brain. By combining alanine and glutathione, these polypeptide nanocarriers showed increased permeability and cellular uptake in a co-culture model of human endothelial cells and brain pericytes. These findings suggest that poly(l-glutamic acid) nanoparticles can be effective nanocarriers for drug delivery to the nervous system.
Article
Polymer Science
Thi Ha My Phan, Yu-Hsun Yang, Yi-Jen Tsai, Fang-Yu Chung, Tooru Ooya, Shiho Kawasaki, Jeng-Shiung Jan
Summary: The packing of the grafting moiety via non-covalent interactions can facilitate the polypeptide segments to adopt more ordered conformations and trigger spontaneous hydrogelation. The hydrogelation ability is correlated with polypeptide composition and topology, with star-shaped polypeptides of asymmetric topology showing poorer hydrogelation ability. Star-shaped polypeptides grafted with indole group on the side chain exhibit better hydrogelation ability than those grafted with phenyl group.
Article
Chemistry, Applied
Chun-Wei Wang, Ming-Chen Chuang, Chieh-Yi Chang, Chien-Hsiang Chang, Yu-Min Yang
Summary: Novel vesicles composed of lipid-like pseudo-double-chained catanionic surfactants have been successfully prepared for potential drug delivery applications, with high encapsulation efficiencies for water-soluble drugs. The use of suitable amounts of ethanol and cholesterol in the preparation process resulted in stable vesicles with uniform size distribution and predictable drug loading efficiencies, providing important guidelines for controlling drug delivery. The linear correlations between trap volume ratio and vesicle size/concentration of additional cholesterol further support the successful development of these vesicles for transdermal drug delivery.
JOURNAL OF OLEO SCIENCE
(2021)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
