Divalproex sodium modulates nuclear localization of ataxin-3 and prevents cellular toxicity caused by expanded ataxin-3

Safety and efficacy of valproic acid treatment in SCA3/MJD patients

(2016) Li-Fang Lei et al.   PARKINSONISM & RELATED DISORDERS

Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease

(2015) Andreia Teixeira-Castro et al.   BRAIN

Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease

(2015) Sofia Esteves et al.   PLoS One

Polyglutamine-expanded ataxin-3 impairs long-term depression in Purkinje neurons of SCA3 transgenic mouse by inhibiting HAT and impairing histone acetylation

(2014) An-Hsun Chou et al.   BRAIN RESEARCH

Valproic acid attenuates the suppression of acetyl histone H3 and CREB activity in an inducible cell model of Machado–Joseph disease

(2014) X.P. Lin et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling

(2013) Bwarenaba B. Kautu et al.   NEUROSCIENCE LETTERS

Sodium Valproate Alleviates Neurodegeneration in SCA3/MJD via Suppressing Apoptosis and Rescuing the Hypoacetylation Levels of Histone H3 and H4

(2013) Jiping Yi et al.   PLoS One

Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1

(2011) Wing Man Chan et al.   HUMAN MOLECULAR GENETICS

SAHA Decreases HDAC 2 and 4 Levels In Vivo and Improves Molecular Phenotypes in the R6/2 Mouse Model of Huntington's Disease

(2011) Michal Mielcarek et al.   PLoS One

HDAC inhibitor sodium butyrate reverses transcriptional downregulation and ameliorates ataxic symptoms in a transgenic mouse model of SCA3

(2010) An-Hsun Chou et al.   NEUROBIOLOGY OF DISEASE

Proteotoxic stress increases nuclear localization of ataxin-3

(2009) Christopher P. Reina et al.   HUMAN MOLECULAR GENETICS

Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation

(2009) Zoya Marinova et al.   JOURNAL OF NEUROCHEMISTRY

Identification and functional dissection of localization signals within ataxin-3

(2009) Paul Michel Aloyse Antony et al.   NEUROBIOLOGY OF DISEASE

Nucleocytoplasmic Shuttling Activity of Ataxin-3

(2009) Sandra Macedo-Ribeiro et al.   PLoS One

Valproic acid extends Caenorhabditis elegans lifespan

(2008) Kimberley Evason et al.   AGING CELL

Histone deacetylase inhibitors: possible implications for neurodegenerative disorders

(2008) Eric Hahnen et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Study of subcellular localization and proteolysis of ataxin-3

(2008) Chiara Pozzi et al.   NEUROBIOLOGY OF DISEASE