Use of composite outcomes to assess risk–benefit in clinical trials

Defining Study Outcomes That Better Reflect Individual Response to Treatment

(2018) Konstantia Angelidou et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Safety and efficacy of ozanezumab in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled, phase 2 trial

(2017) Vincent Meininger et al.   LANCET NEUROLOGY

Weighted win loss approach for analyzing prioritized outcomes

(2017) Xiaodong Luo et al.   STATISTICS IN MEDICINE

On the win-ratio statistic in clinical trials with multiple types of event

(2016) D. Oakes   BIOMETRIKA

A rank test for bivariate time-to-event outcomes when one event is a surrogate

(2016) Pamela A. Shaw et al.   STATISTICS IN MEDICINE

Using Outcomes to Analyze Patients Rather than Patients to Analyze Outcomes: A Step Toward Pragmatism in Benefit:Risk Evaluation

(2016) Scott R. Evans et al.   Statistics in Biopharmaceutical Research

Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR)

(2015) Scott R. Evans et al.   CLINICAL INFECTIOUS DISEASES

Treatment selections using risk-benefit profiles based on data from comparative randomized clinical trials with multiple endpoints

(2014) B. Claggett et al.   BIOSTATISTICS

A joint test for progression and survival with interval-censored data from a cancer clinical trial

(2014) Dianne M. Finkelstein et al.   STATISTICS IN MEDICINE

Opportunities and challenges of combined effect measures based on prioritized outcomes

(2013) Geraldine Rauch et al.   STATISTICS IN MEDICINE

Evaluation of early percutaneous coronary intervention vs. standard therapy after fibrinolysis for ST-segment elevation myocardial infarction: contribution of weighting the composite endpoint

(2012) J. A. Bakal et al.   EUROPEAN HEART JOURNAL

Impact of weighted composite compared to traditional composite endpoints for the design of randomized controlled trials

(2012) Jeffrey A Bakal et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

The win ratio: a new approach to the analysis of composite endpoints in clinical trials based on clinical priorities

(2011) S. J. Pocock et al.   EUROPEAN HEART JOURNAL

A Rank-Based Test for Comparison of Multidimensional Outcomes

(2010) Aiyi Liu et al.   JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION

Generalized pairwise comparisons of prioritized outcomes in the two-sample problem

(2010) Marc Buyse   STATISTICS IN MEDICINE