A77 1726 (leflunomide) blocks and reverses cardiac hypertrophy and fibrosis in mice

CTRP3 protected against doxorubicin-induced cardiac dysfunction, inflammation and cell death via activation of Sirt1

(2018) Yu-Pei Yuan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKα/Smad3 signaling

(2018) Xin Zhang et al.   Cell Death & Disease

Leflunomide prevents ROS-induced systemic fibrosis in mice

(2017) Florence Morin et al.   FREE RADICAL BIOLOGY AND MEDICINE

The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1

(2017) Su-Jin Moon et al.   Journal of Translational Medicine

The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis

(2017) Peng Zhang et al.   NATURE MEDICINE

Bezafibrate Attenuates Pressure Overload-Induced Cardiac Hypertrophy and Fibrosis

(2017) Si-Chi Xu et al.   PPAR Research

Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-γ/AKT Pathways

(2017) Zhen-Guo Ma et al.   EBioMedicine

Protection against cardiac hypertrophy by geniposide involves the GLP-1 receptor / AMPKα signalling pathway

(2016) Zhen-Guo Ma et al.   BRITISH JOURNAL OF PHARMACOLOGY

OX40 regulates pressure overload-induced cardiac hypertrophy and remodelling via CD4+ T-cells

(2016) Q.-Q. Wu et al.   CLINICAL SCIENCE

Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKα Signalling Pathway

(2016) Zhen-Guo Ma et al.   International Journal of Biological Sciences

Pioglitazone Protected against Cardiac Hypertrophy via Inhibiting AKT/GSK3βand MAPK Signaling Pathways

(2016) Wen-Ying Wei et al.   PPAR Research

Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy

(2016) Ke-Qiong Deng et al.   Nature Communications

Immune Cell and Other Noncardiomyocyte Regulation of Cardiac Hypertrophy and Remodeling

(2015) R. A. Frieler et al.   CIRCULATION

Inflammation, Immunity, and Hypertensive End-Organ Damage

(2015) W. G. McMaster et al.   CIRCULATION RESEARCH

Left Ventricular T-Cell Recruitment Contributes to the Pathogenesis of Heart FailureCLINICAL PERSPECTIVE

(2015) Tania Nevers et al.   Circulation-Heart Failure

A77 1726, the active metabolite of leflunomide, attenuates lupus nephritis by promoting the development of regulatory T cells and inhibiting IL-17-producing double negative T cells

(2015) Guilin Qiao et al.   CLINICAL IMMUNOLOGY

Leflunomide biodegradable microspheres intended for intra-articular administration: Development, anti-inflammatory activity and histopathological studies

(2015) Doaa Ahmed El-Setouhy et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

CD4 + T Cells Promote the Transition From Hypertrophy to Heart Failure During Chronic Pressure Overload

(2014) Fanny Laroumanie et al.   CIRCULATION

Cardiac Fibroblast Glycogen Synthase Kinase-3β Regulates Ventricular Remodeling and Dysfunction in Ischemic Heart

(2014) Hind Lal et al.   CIRCULATION

Myocardial Extracellular Matrix

(2014) Marieke Rienks et al.   CIRCULATION RESEARCH

The Global Health and Economic Burden of Hospitalizations for Heart Failure

(2014) Andrew P. Ambrosy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas

(2014) Teresa Palomero et al.   NATURE GENETICS

The pathogenesis of cardiac fibrosis

(2013) Ping Kong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Quantification of Cardiomyocyte Hypertrophy by Cardiac Magnetic Resonance

(2013) Otavio R. Coelho-Filho et al.   CIRCULATION

A Novel Disease-Modifying Antirheumatic Drug, Iguratimod, Ameliorates Murine Arthritis by Blocking IL-17 Signaling, Distinct from Methotrexate and Leflunomide

(2013) Q. Luo et al.   JOURNAL OF IMMUNOLOGY

Mechanically activated fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells

(2013) William R. Thompson et al.   STEM CELLS

Selective PDE5A inhibition with sildenafil rescues left ventricular dysfunction, inflammatory immune response and cardiac remodeling in angiotensin II-induced heart failure in vivo

(2012) Dirk Westermann et al.   BASIC RESEARCH IN CARDIOLOGY

Interferon-γ Signaling Inhibition Ameliorates Angiotensin II–Induced Cardiac Damage

(2012) Lajos Markó et al.   HYPERTENSION

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1–Smad signalling

(2011) Ling Yan et al.   CARDIOVASCULAR RESEARCH

Lentivirus mediated IL-17R blockade improves diastolic cardiac function in spontaneously hypertensive rats

(2011) Wei Liu et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

New Targets to Treat the Structural Remodeling of the Myocardium

(2011) Arantxa González et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Fyn

(2010) Yoshihito D. Saito et al.   CANCER

Intracellular or extracellular heat shock protein 70 differentially regulates cardiac remodelling in pressure overload mice

(2010) Wen-Feng Cai et al.   CARDIOVASCULAR RESEARCH

Innate immunity and remodelling

(2010) Guro Valen   HEART FAILURE REVIEWS

Protein kinase inhibitors can control the progression of endometriosis in vitro and in vivo

(2010) Charlotte Ngô et al.   JOURNAL OF PATHOLOGY

Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells

(2009) P. Baumann et al.   MOLECULAR CANCER THERAPEUTICS

Suppressive effect of leflunomide on rat hepatic stellate cell proliferation involves on PDGF-BB-elicited activation of three mitogen-activated protein kinases

(2008) H.F. Si et al.   CYTOKINE

The active metabolite of leflunomide, A77 1726, protects rat hepatocytes against bile acid-induced apoptosis

(2008) Titia E. Vrenken et al.   JOURNAL OF HEPATOLOGY