Article
Rheumatology
Ashish J. Mathew, Bente Glintborg, Niels Steen Krogh, Merete L. Hetland, Mikkel Ostergaard
Summary: This study explored the registration, pattern, and burden of clinical enthesitis among routine-care patients with psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) in the Danish nationwide DANBIO registry. The results showed that enthesitis was frequent, particularly in women, and associated with a higher disease burden reported by both physicians and patients.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Medicine, General & Internal
Fan Yang, Chaofan Lu, Huilan Liu, Lei Dou, Yanhong Wang, Hongbin Li, Xinwang Duan, Lijun Wu, Yongfu Wang, Xiuying Zhang, Jian Xu, Jinmei Su, Dong Xu, Jiuliang Zhao, Qingjun Wu, Mengtao Li, Xiaomei Leng, Xiaofeng Zeng
Summary: Enthesitis is common in Chinese patients with PsA, and it is important to evaluate both peripheral and axial sites. Compared with other cohorts, Chinese patients with enthesitis tend to be younger, have a lower body mass index, a higher rate of positive HLA-B27, more frequent dactylitis, and a higher proportion of csDMARDs use.
CHINESE MEDICAL JOURNAL
(2023)
Review
Genetics & Heredity
Alberto Floris, Mattia Congia, Elisabetta Chessa, Maria Maddalena Angioni, Matteo Piga, Alberto Cauli
Summary: Specific and high-quality evidence on the efficacy of current targeted therapies for axial disease in psoriatic arthritis (axPsA) is lacking. More studies specifically designed for axPsA and based on validated definition and outcome measures are urgently needed to provide reliable evidence.
FRONTIERS IN GENETICS
(2021)
Article
Rheumatology
Juan Molina Collada, Cristina Macia-Villa, Chamaida Plasencia, Jose Maria Alvaro-Gracia, Eugenio de Miguel
Summary: Most patients with active axSpA and PsA were found to have PD enthesitis, regardless of axial or peripheral involvement. Both MASEI and OMERACT PD definitions were useful in detecting active enthesitis, supporting the usefulness of PD ultrasound evaluation of entheses in axSpA and PsA assessment.
CLINICAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Emilio Filippucci, Gianluca Smerilli, Andrea Di Matteo, Walter Grassi
Summary: Enthesitis plays a crucial role in the diagnosis and management of patients with spondyloarthritis and psoriatic arthritis, but clinical assessment is often inaccurate due to poor specificity. Ultrasound has the potential to improve the evaluation of enthesitis and enhance patient management in this context. Reviewing the OMERACT definitions for ultrasound enthesitis can help identify current limitations and their potential implications for rheumatology research and clinical practice.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Dermatology
Alice B. Gottlieb, Joseph F. Merola
Summary: Psoriasis is a chronic inflammatory disorder that can lead to psoriatic arthritis, a heterogeneous musculoskeletal disease causing joint damage. Early detection and intervention by dermatologists is crucial in preventing permanent joint damage from psoriatic arthritis, which often manifests after skin symptoms.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Rheumatology
Raquel Ena Maria Granados, M. Lourdes Ladehesa-Pineda, M. Angeles Puche-Larrubia, Alejandro Escudero-Contreras, Maxime Dougados, Eduardo Collantes-Estevez, Clementina Lopez-Medina
Summary: The aim of this study was to evaluate whether the proportion of patients with enthesitis differs across different subtypes of spondyloarthritis and psoriatic arthritis, and to evaluate the level of agreement among different indices in detecting patients with enthesitis. The results showed that the prevalence of enthesitis varies depending on the disease and the index used, with MEI and MASES performing best in assessing enthesis in spondyloarthritis and axial spondyloarthritis, while MEI and SPARCC performed best in assessing enthesitis in peripheral spondyloarthritis and psoriatic arthritis patients.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Rheumatology
Michaela Koehm, Tanja Rossmanith, Ann C. Foldenauer, Eva Herrmann, Jan Brandt-Juergens, Gerd R. Burmester, Herbert Kellner, Uta Kiltz, David M. Kofler, Juergen Rech, Sorwe Mojtahed-Poor, Christin Jonetzko, Harald Burkhardt, Frank Behrens
Summary: The study aimed to compare the efficacy of ustekinumab plus placebo with ustekinumab plus methotrexate in patients with active psoriatic arthritis. The results showed that the addition of methotrexate did not increase the efficacy of ustekinumab. Therefore, there is no evidence to support the addition or maintainance of methotrexate when initiating ustekinumab in patients with active psoriatic arthritis.
LANCET RHEUMATOLOGY
(2023)
Article
Rheumatology
Jean-Guillaume Letarouilly, Benoit Flachaire, Celine Labadie, Maeva Kyheng, Nicolas Cohen, Jeremie Sellam, Pascal Richette, Philippe Dieude, Pascal Claudepierre, Bruno Fautrel, Eric Houvenagel, Chi Duc Nguyen, Marie-Helene Guyot, Nicolas Segaud, Laurent Marguerie, Xavier Deprez, Jean-Hugues Salmon, Guy Baudens, Corinne Miceli-Richard, Elisabeth Gervais, Isabelle Chary-Valckenaere, Pierre Lafforgue, Peggy Philippe, Damien Loeuille, Christophe Richez, Florence Tubach, Thao Pham, Rene-Marc Flipo
Summary: This study evaluated the real-world persistence of ustekinumab (UST) and secukinumab (SEK) in patients with Psoriatic Arthritis (PsA) and found that SEK had a higher persistence rate compared to UST, especially when used in combination with MTX. Discontinuation due to inefficacy was the most common reason for discontinuation in both UST and SEK groups.
Review
Medicine, General & Internal
Loredana Sabina Pascu, Nicolae Sarbu, Andrei Vlad Bradeanu, Daniela Jicman (Stan), Madalina Nicoleta Matei, Mihaela Ionela Sarbu, Doina Carina Voinescu, Aurel Nechita, Alin Laurentiu Tatu
Summary: Psoriatic arthritis is a clinically significant disease with a high prevalence and overlapping symptoms with other spondylarthritis disorders. Understanding the MRI manifestations and implementing a multidisciplinary strategy is crucial for effective management.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jerney de Jongh, Robert Hemke, Gerben J. C. Zwezerijnen, Maqsood Yaqub, Irene E. Van der Horst-Bruinsma, Marleen G. H. van de Sande, Arno W. R. van Kuijk, Alexandre E. Voskuyl, Conny J. van der Laken
Summary: This study demonstrates that F-18-sodium fluoride PET-CT scans can detect new bone formation in patients with psoriatic arthritis, with a majority of these findings being asymptomatic.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Medicine, General & Internal
Ivan Giovannini, Alen Zabotti, Carmelo Ciccio, Matteo Salgarello, Lorenzo Cereser, Salvatore De Vita, Ilaria Tinazzi
Summary: The frequent involvement of the spine and sacroiliac joint in Psoriatic Arthritis (PsA) has led to its classification within the Spondyloarthritis group, although a clear distinction between PsA and Spondyloarthritis remains challenging. Axial involvement, ranging from 25 to 70% in PsA patients, must be taken into consideration alongside peripheral involvement for disease management. The lack of consensus in defining axial involvement in PsA has led to varying interpretations over the years, highlighting a need for improved clinical and radiological assessment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Victoria Furer, Jonathan Wollman, David Levartovsky, Valerie Aloush, Ofir Elalouf, Hagit Sarbagil-Maman, Liran Mendel, Sara Borok, Daphna Paran, Ori Elkayam, Ari Polachek
Summary: This study found that male patients with psoriatic arthritis (PsA) had more severe enthesitis based on ultrasound evaluation. These sex-based differences in enthesitis were not reflected in disease activity scores derived from clinical assessment.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Beatrice Andreea Chisalau, Andreea Lili Barbulescu, Cristina Dorina Parvanescu, Sineta Cristina Firulescu, Stefan Cristian Dinescu, Roxana Mihaela Dumitrascu, Adina Turcu-Stiolica, Razvan Adrian Ionescu, Horatiu Valeriu Popoviciu, Simona Banicioiu Covei, Mihail Virgil Boldeanu, Alina Maria Vilcea, Paulina Lucia Ciurea, Florentin Ananu Vreju
Summary: Psoriatic arthritis is an inflammatory disease with potential destructive effects, where enthesitis is considered the main pathogenic event. Ultrasonography has emerged as an essential imaging tool for evaluating structural and inflammatory changes in the enthesis. This study analyzed entheseal involvement in PsA patients using US examination, finding a high prevalence of ultrasonographically confirmed enthesitis, particularly in the Achilles enthesis. The presence of tendon abnormalities and enthesophytes underscores the importance of chronic inflammation in enthesial sites.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Immunology
Zikang Guo, Boya Li, Yimeng Zhang, Chunyu Kong, Yang Liu, Jin Qu, Ying Zhan, Zhiwei Shen, Xinwei Lei
Summary: The distribution and diagnostic value of peripheral enthesitis in axial spondyloarthritis (axSpA) diagnosis can be determined through whole-body MRI. The enthesitis score may provide a more accurate assessment and diagnostic tool in axSpA compared with enthesitis site counting.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Brigitte Michelsen, Stylianos Georgiadis, Daniela Di Giuseppe, Anne G. Loft, Michael J. Nissen, Florenzo Iannone, Manuel Pombo-Suarez, Herman Mann, Ziga Rotar, Kari K. Eklund, Tore K. Kvien, Maria J. Santos, Bjorn Gudbjornsson, Catalin Codreanu, Sema Yilmaz, Johan K. Wallman, Cecilie H. Brahe, Burkhard Moeller, Ennio G. Favalli, Carlos Sanchez-Piedra, Lucie Nekvindova, Matija Tomsic, Nina Trokovic, Eirik K. Kristianslund, Helena Santos, Thorvardur J. Love, Ruxandra Ionescu, Yavuz Pehlivan, Gareth T. Jones, Irene Van der Horst-Bruinsma, Lykke M. Ornbjerg, Mikkel Ostergaard, Merete L. Hetland
Summary: This study assessed the real-life effectiveness of secukinumab in psoriatic arthritis patients. The results showed that the drug had good retention, remission, and low disease activity rates after 6 and 12 months of treatment. The effectiveness was significantly better for patients who had not used biologic/targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) before.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Delphine Sophie Courvoisier, Kim Lauper, Joanna Kedra, Maarten de Wit, Bruno Fautrel, Thomas Frisell, Kimme L. Hyrich, Florenzo Iannone, Pedro M. Machado, Lykke Midtboll Ornbjerg, Ziga Rotar, Maria Jose Santos, Tanja A. Stamm, Simon R. Stones, Anja Strangfeld, Sytske Anne Bergstra, Robert B. M. Landewe, Axel Finckh
Summary: The European Alliance of Associations for Rheumatology (EULAR) has developed a set of points to consider (PtC) for analyzing and reporting comparative effectiveness research using observational data in rheumatology, aiming to reduce biases and improve the trustworthiness of the research results.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Letter
Rheumatology
Marco Fornaro, Vincenzo Venerito, Florenzo Iannone, Fabio Cacciapaglia
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Sara Nysom Christiansen, Lykke Midtboll Ornbjerg, Simon Horskjaer Rasmussen, Anne Gitte Loft, Johan Askling, Florenzo Iannone, Jakub Zavada, Brigitte Michelsen, Michael Nissen, Fatos Onen, Maria Jose Santos, Manuel Pombo-Suarez, Heikki Relas, Gary J. Macfarlane, Matija Tomsic, Catalin Codreanu, Bjorn Gudbjornsson, Irene Van der Horst-Bruinsma, Daniela Di Giuseppe, Bente Glintborg, Elisa Gremese, Karel Pavelka, Eirik Klami Kristianslund, Adrian Ciurea, Nurullah Akkoc, Anabela Barcelos, Carlos Sanchez-Piedra, Ritva Peltomaa, Gareth T. Jones, Ziga Rotar, Ruxandra Ionescu, Gerdur Grondal, Marleen G. H. Van de Sande, Karin Laas, Mikkel Ostergaard, Merete L. Hetland
Summary: This study investigated the time trends in baseline characteristics and treatment outcomes of TNF inhibitor (TNFi) treatment in bio-naive axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) patients. The results showed that over the past decades, clinicians have implemented more aggressive treatment strategies in spondyloarthritis, leading to shorter disease duration at treatment initiation, decreased retention rates, and higher remission rates.
Review
Medicine, General & Internal
Gabriele Mandarelli, Florenzo Iannone, Stefano Ferracuti, Ignazio Grattagliano, Marcello Benevento, Biagio Solarino, Davide Ferorelli, Roberto Catanesi
Summary: The study reviewed the literature on biological agents and found that there were no specific studies addressing the issue of informed consent in patients receiving biological agents. However, the association between biological agents and serious infections or malignancies needs to be disclosed in the informed consent process, and ethical and clinical issues related to experimenting with new agents with potential serious adverse effects deserve attention.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Rheumatology
Manuel Pombo-Suarez, Carlos Sanchez-Piedra, Juan Gomez-Reino, Kim Lauper, Denis Mongin, Florenzo Iannone, Karel Pavelka, Dan C. Nordstrom, Nevsun Inanc, Catalin Codreanu, Kimme L. Hyrich, Denis Choquette, Anja Strangfeld, Burkhard F. Leeb, Ziga Rotar, Ana Rodrigues, Eirik Klami Kristianslund, Tore K. Kvien, Ori Elkayam, Galina Lukina, Sytske Anne Bergstra, Axel Finckh, Delphine Sophie Courvoisier
Summary: The objective of this study was to compare the effectiveness of cycling Janus kinase inhibitors (JAKi) with switching to biologic disease-modifying antirheumatic drug (bDMARD) in patients with rheumatoid arthritis (RA). The results showed that both strategies had similar observed drug retention rates after 2 years, but cycling JAKi was associated with higher retention after adjusting for confounders. It was also found that if the first JAKi was discontinued due to an adverse event (AE), it was more likely that the second JAKi would also be stopped due to an AE. Improvement in Clinical Disease Activity Index (CDAI) over time was similar in both strategies.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Simone Parisi, Anna Zanetti, Greta Carrara, Carlo Alberto Scire, Annamaria Iagnocco, Georgios Filippou
Summary: This study aimed to evaluate the differences in joint and tendon involvement between patients receiving combination therapy and monotherapy. The results showed that combination therapy was more effective in controlling tenosynovitis and synovitis compared to monotherapy.
Review
Rheumatology
Fabio Cacciapaglia, Stefano Stano, Marco Fornaro, Florenzo Iannone
Summary: The use of immunoglobulin has shown efficacy in the treatment of different rheumatologic autoimmune systemic diseases. A study on immunoglobulin therapy for systemic sclerosis showed encouraging results in improving skin symptoms. We present a case of a young woman with rapidly progressive diffuse cutaneous systemic sclerosis who had significant skin improvement after one year of subcutaneous immunoglobulin treatment. A narrative literature review on alternative treatments for systemic sclerosis skin involvement, focusing on immunoglobulin use, was also carried out.
JOURNAL OF SCLERODERMA AND RELATED DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Roberta Zerlotin, Marco Fornaro, Mariella Errede, Patrizia Pignataro, Clelia Suriano, Maddalena Ruggieri, Silvia Colucci, Florenzo Iannone, Maria Grano, Graziana Colaianni
Summary: In this cohort study, 41 patients with DM and IMNM were examined. The results showed lower expression of FNDC5 in the muscle biopsies of these patients compared to the control group, while serum irisin levels were higher. The authors hypothesize that increased expression of ADAM10 in the skeletal muscle of DM and IMNM patients may be responsible for the discrepancy between irisin levels and FNDC5 expression. Further research is needed to understand the mechanisms underlying exacerbated FNDC5 cleavage and muscle irisin resistance in these inflammatory myopathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Vincenzo Venerito, Andreina Manfredi, Antonio Carletto, Stefano Gentileschi, Fabiola Atzeni, Serena Guiducci, Marlea Lavista, Laura La Corte, Elisa Pedrollo, Arnaldo Scardapane, Caterina Tomassini, Bruno Frediani, Carlo Salvarani, Florenzo Iannone, Marco Sebastiani
Summary: The aim of this multicenter retrospective study was to investigate the effectiveness and safety of JAK-inhibitors (JAKi) in patients with rheumatoid arthritis (RA) and interstitial lung disease (ILD). The study suggests that JAKi therapy might be a safe therapeutic option for patients with RA-ILD in a short-term follow-up.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Vincenzo Venerito, Pasquale Stefanizzi, Luca Cantarini, Marlea Lavista, Maria Grazia Galeone, Antonio Di Lorenzo, Florenzo Iannone, Silvio Tafuri, Giuseppe Lopalco
Summary: RA patients treated with JAK inhibitors or anti-cellular bDMARDS have an increased risk of herpes zoster (HZ). This prospective study assessed the immunogenicity and safety of the Adjuvanted Recombinant Zoster Vaccine (RZV) in RA patients on JAK inhibitors or anti-cellular bDMARDS. The results showed that RZV vaccination induced a similar immune response in RA patients compared to healthy controls, regardless of the treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Rheumatology
Vincenzo Venerito, Emre Bilgin, Florenzo Iannone, Sedat Kiraz
Summary: Natural Language Processing (NLP) and Large Language Models (LLMs) such as GPT, ChatGPT, or LLAMA have gained significant attention recently. They have impacted finance, economics, and healthcare in terms of diagnostic/scoring systems. Additionally, academic life, particularly in the field of rheumatology, is also experiencing the opportunities and challenges brought by NLP and LLMs.
Review
Medicine, General & Internal
Simone Perniola, Maria Sole Chimenti, Francesca Romana Spinelli, Bruno Frediani, Rosario Foti, Sara Ferrigno, Cristina Garufi, Giulia Cassone, Vincenzo Venerito, Fabiola Atzeni, Roberto Caporali, Fabrizio Conti, Ennio Giulio Favalli, Florenzo Iannone, Marco Sebastiani, Gian Franco Ferraccioli, Giovanni Lapadula, Elisa Gremese
Summary: Rheumatoid Arthritis (RA) is a complex disease with various clinical phenotypes, categorized by disease duration, seropositivity for rheumatoid factor (RF) and/or anti-citrullinated protein antibodies (ACPA), joint subtype, clinical behavior, and other subgroups. This review provides a summary of the multifaceted aspects of RA, specifically focusing on the association between autoimmune status and clinical outcomes, achievement of remission, and treatment response, as discussed in the 2022 International GISEA/OEG Symposium.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Florenzo Iannone, Giuseppe Lopalco, Fabio Cacciapaglia, Vincenzo Venerito, Simone Perniola, Marco Fornaro
Summary: This study aimed to evaluate the effectiveness of bDMARDs in RA patients negative for RF and ACPA. The results showed that tocilizumab had a higher survival rate compared to abatacept in RF/ACPA negative RA patients.