4.2 Editorial Material

The changing aetiology of head and neck squamous cell cancer: A tale of three cancers?

期刊

CLINICAL OTOLARYNGOLOGY
卷 43, 期 4, 页码 999-1003

出版社

WILEY
DOI: 10.1111/coa.13144

关键词

-

资金

  1. National Institute for Health Research (NIHR) under its Programme Grants [RP-PG-0707-10034]

向作者/读者索取更多资源

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.2
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Dentistry, Oral Surgery & Medicine

Surgical sequence, timing and volume, and variation in dento-facial outcome, speech and secondary surgery in children with unilateral cleft lip and palate: The Cleft Care UK Study

Rona Slator, Lydia Perisanidou, Debbie Sell, Jonathan Sandy, Andrew R. Ness, Andrew K. Wills

Summary: This study found associations between surgical variables and speech outcomes at 5 years of age, but not between surgical variables and dento-facial outcome, nor between surgical variables and secondary speech surgery.

ORTHODONTICS & CRANIOFACIAL RESEARCH (2023)

Article Oncology

A risk prediction model for head and neck cancers incorporating lifestyle factors, HPV serology and genetic markers

Sanjeev Budhathoki, Brenda Diergaarde, Geoffrey Liu, Andrew Olshan, Andrew Ness, Tim Waterboer, Shama Virani, Patricia Basta, Noemi Bender, Nicole Brenner, Tom Dudding, Neil Hayes, Andrew Hope, Shao Hui Huang, Katrina Hueniken, Beatriz Kanterewicz, James D. McKay, Miranda Pring, Steve Thomas, Kathy Wisniewski, Sera Thomas, Yonathan Brhane, Antonio Agudo, Laia Alemany, Areti Lagiou, Luigi Barzan, Cristina Canova, David I. Conway, Claire M. Healy, Ivana Holcatova, Pagona Lagiou, Gary J. Macfarlane, Tatiana V. Macfarlane, Jerry Polesel, Lorenzo Richiardi, Max Robinson, Ariana Znaor, Paul Brennan, Rayjean J. Hung

Summary: To aid early detection of head and neck cancer, a risk prediction model based on demographic and lifestyle factors, HPV serological markers, and genetic markers has been developed. The risk models showed reasonable predictive accuracy for overall head and neck cancer, and substantially improved accuracy for oropharyngeal cancer when including HPV serology. These models may be helpful for identifying high-risk individuals.

INTERNATIONAL JOURNAL OF CANCER (2023)

Editorial Material Oncology

Depth of invasion in oral squamous carcinoma-More to this than meets the eye!

Yash P. Merchant, Sameep Shetty, Rama Jayaraj, D. Gopalkrishnan

ORAL ONCOLOGY (2023)

Article Medicine, General & Internal

Impact of pausing elective hip and knee replacement surgery during winter 2017 on subsequent service provision at a major NHS Trust: a descriptive observational study using interrupted time series

Tim Jones, Chris Penfold, Maria Theresa Redaniel, Emily Eyles, Tim Keen, Andrew Elliott, Ashley W. Blom, Andrew Judge

Summary: This study aims to investigate the impact of temporarily cancelling elective surgery in winter 2017 on the trends in primary hip and knee replacement at a major NHS Trust. The study also explores whether there are lessons to be learned about efficient surgery provision. The results showed a sustained reduction in knee replacements, a decrease in the proportion of deprived people having knee replacements, and an increase in average age and comorbidity for both types of surgery.

BMJ OPEN (2023)

Article Biology

Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization

Mark Gormley, Tom Dudding, Steven J. Thomas, Jessica Tyrrell, Andrew R. Ness, Miranda Pring, Danny Legge, George Davey Smith, Rebecca C. Richmond, Emma E. Vincent, Caroline Bull, Belinda Nicolau

Summary: A recent study suggests that smoking, alcohol consumption, and obesity are important modifiable lifestyle factors contributing to cancer. However, further investigation is needed to identify other potential risk factors for head and neck cancer, especially in light of the declining smoking rates. The study conducted Mendelian randomization using genetic variants associated with adiposity, diabetes, and hypertension to explore their causal effects on oral and oropharyngeal cancer risk. The findings suggested limited evidence of a causal relationship between body mass index, diabetes, hypertension, and the risk of head and neck cancer.
Article Oncology

Development of a Duplex Serological Multiplex Assay for the Simultaneous Detection of Epstein-Barr Virus IgA and IgG Antibodies in Nasopharyngeal Carcinoma Patients

Jennifer Schieber, Miranda Pring, Andy Ness, Zhiwei Liu, Wan-Lun Hsu, Nicole Brenner, Julia Butt, Tim Waterboer, Julia Simon

Summary: A novel duplex multiplex serology assay was developed to simultaneously analyze IgA and IgG antibodies against multiple antigens. The assay was validated using serum samples from 98 nasopharyngeal carcinoma (NPC) patients and 142 controls, and compared to separate IgA and IgG multiplex assays. The duplex serological multiplex assay showed similar sensitivities to the separate assays and was able to accurately identify EBV-positive NPC cases.

CANCERS (2023)

Review Microbiology

Onco-Pathogen Mediated Cancer Progression and Associated Signaling Pathways in Cancer Development

Sandra Kannampuzha, Abilash Valsala Gopalakrishnan, Hafiza Padinharayil, Reema Rose Alappat, Kavya V. V. Anilkumar, Alex George, Abhijit Dey, Balachandar Vellingiri, Harishkumar Madhyastha, Raja Ganesan, Thiyagarajan Ramesh, Rama Jayaraj, D. S. Prabakaran

Summary: Infection with viruses, bacteria, and parasites is responsible for about 8-17% of global cancer burden, with one in every five malignancies being caused by an infectious pathogen. Eleven major pathogens are believed to aid in oncogenesis. It is important to identify potential human carcinogens and understand the pathways they induce to effectively prevent and control pathogen-driven cancers. This review focuses on major onco-pathogens, the types of cancer they cause, and the altered pathways leading to cancer progression.

PATHOGENS (2023)

Article Biochemistry & Molecular Biology

Cytotoxic Effects of Nanoliposomal Cisplatin and Diallyl Disulfide on Breast Cancer and Lung Cancer Cell Lines

Kaavya Gunasekaran, Bala Murali Krishna Vasamsetti, Priyadharshini Thangavelu, Karthi Natesan, Bonaventure Mujyambere, Viswanathan Sundaram, Rama Jayaraj, Yeon-Jun Kim, Suja Samiappan, Jae-Won Choi

Summary: Dual drug delivery using nanoliposomes loaded with cisplatin and diallyl disulfide shows improved therapeutic efficacy and physical characteristics, making it a promising formulation for cancer treatment.

BIOMEDICINES (2023)

Article Psychiatry

Associations between physical activity and mental health and behaviour in early adolescence

Josephine N. Booth, Andy R. Ness, Carol Joinson, Phillip D. Tomporowski, James M. E. Boyle, Sam D. Leary, John J. Reilly

Summary: This study examines the relationship between physical activity, depressive symptoms, and emotional and behavioral difficulties in adolescents. The results show that higher levels of physical activity are associated with reduced depressive symptoms and improved emotional and behavioral well-being. Specifically, higher physical activity levels at age 11 are related to decreased depressive symptoms in females, while positive changes in physical activity levels between ages 11 and 13 are associated with reduced depressive symptoms in males. Additionally, higher physical activity predicts decreased emotional symptoms and hyperactivity in both genders. However, the effect sizes are small.

MENTAL HEALTH AND PHYSICAL ACTIVITY (2023)

Article Oncology

Poor oral health influences head and neck cancer patient survival: an International Head and Neck Cancer Epidemiology Consortium pooled analysis

Jason Tasoulas, Douglas R. Farquhar, Siddharth Sheth, Trevor Hackman, Wendell G. Yarbrough, Chris B. Agala, Alzina Koric, Luca Giraldi, Eleonora Fabianova, Jolanta Lissowska, Beata Swiatkowska, Marta Vilensky, Victor Wunsch-Filho, Marcos Brasilino de Carvalho, Rossana Veronica Mendoza Lopez, Ivana Holcatova, Diego Serraino, Jerry Polesel, Cristina Canova, Lorenzo Richiardi, Jose P. Zevallos, Andy Ness, Miranda Pring, Steve J. Thomas, Tom Dudding, Yuan-Chin Amy Lee, Mia Hashibe, Paolo Boffetta, Andrew F. Olshan, Kimon Divaris, Antonio L. Amelio

Summary: Good oral health, as defined by maintaining natural teeth and frequent dental visits, appears to be associated with improved overall survival among head and neck squamous cell carcinoma patients.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2023)

Review Medicine, Research & Experimental

Epicardial adipose tissue and cardiac lipotoxicity: A review

Anirban Goutam Mukherjee, Kaviyarasi Renu, Abilash Valsala Gopalakrishnan, Rama Jayaraj, Abhijit Dey, Balachandar Vellingiri, Raja Ganesan

Summary: Epicardial adipose tissue (EAT) is a visceral fat deposit that is morphologically and physiologically connected to the myocardium and coronary arteries. It has cardioprotective characteristics, but under clinical processes, it can impact the heart and coronary arteries by secreting proinflammatory cytokines. The factors affecting this equilibrium are still not fully understood. This review focuses on the physiological and pathophysiological dimensions of EAT and its various clinical utilities.

LIFE SCIENCES (2023)

Article Oncology

Large-scale meta-genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types

Elnaz Naderi, Miguel E. Aguado-Barrera, Line M. H. Schack, Leila Dorling, Tim Rattay, Laura Fachal, Holly Summersgill, Laura Martinez-Calvo, Ceilidh Welsh, Tom Dudding, Yasmin Odding, Ana Varela-Pazos, Rajesh Jena, David J. Thomson, Roel J. H. M. Steenbakkers, Joe Dennis, Ramon Lobato-Busto, Jan Alsner, Andy Ness, Chris Nutting, Antonio Gomez-Caamano, Jesper G. Eriksen, Steve J. Thomas, Amy M. Bates, Adam J. Webb, Ananya Choudhury, Barry S. Rosenstein, Begona Taboada-Valladares, Carsten Herskind, David Azria, David P. Dearnaley, Dirk de Ruysscher, Elena Sperk, Emma Hall, Hilary Stobart, Jenny Chang-Claude, Kim De Ruyck, Liv Veldeman, Manuel Altabas, Maria Carmen De Santis, Marie-Pierre Farcy-Jacquet, Marlon R. Veldwijk, Matthew R. Sydes, Matthew Parliament, Nawaid Usmani, Neil G. Burnet, Petra Seibold, R. Paul Symonds, Rebecca M. Elliott, Renee Bultijnck, Sara Gutierrez-Enriquez, Meritxell Molla, Sarah L. Gulliford, Sheryl Green, Tiziana Rancati, Victoria Reyes, Ana Carballo, Paula Peleteiro, Paloma Sosa-Fajardo, Chris Parker, Valerie Fonteyne, Kerstie Johnson, Maarten Lambrecht, Ben Vanneste, Riccardo Valdagni, Alexandra Giraldo, Monica Ramos, Brenda Diergaarde, Geoffrey Liu, Suzanne M. Leal, Melvin L. K. Chua, Miranda Pring, Jens Overgaard, Luis M. Cascallar-Caneda, Frederic Duprez, Christopher J. Talbot, Gillian C. Barnett, Alison M. Dunning, Ana Vega, Christian Nicolaj Andreassen, Johannes A. Langendijk, Catharine M. L. West, Behrooz Z. Alizadeh, Sarah L. Kerns

Summary: This study identified shared genetic susceptibility for acute radiation-induced toxicity across different cancer types, with a shared SNV-based heritability estimated at around 10%. Higher heritability rates were found for prostate, head and neck, and breast cancers. Additionally, several potentially associated SNVs and gene sets related to acute toxicity were discovered.

JNCI CANCER SPECTRUM (2023)

Letter Oncology

HPV DNA and p16INK4a positivity in vulvar cancer and vulvar intraepithelial neoplasia

Rama Jayaraj, Sameep Shetty, Kodiveri Muthukaliannan Gothandam, Samiappan Suja, Yash Merchant

LANCET ONCOLOGY (2023)

Review Oncology

Recent advances in understanding brain cancer metabolomics: a review

Anirban Goutam Mukherjee, Abilash Valsala Gopalakrishnan, Rama Jayaraj, Raja Ganesan, Kaviyarasi Renu, Balachandar Vellingiri, Abhijit Dey, Mohamudha Parveen

Summary: Despite medical advancements in surgery and adjuvant therapies, brain tumors continue to be a leading cause of cancer-related death and illness in both children and adults. Metabolomics, the comprehensive analysis of small molecules, has emerged as a promising area for personalized medicine and drug discovery, offering insights into cellular activity and cancer biology. Advanced analytical techniques like nuclear magnetic resonance spectroscopy (MRS) and mass spectrometry (MS) allow for high-throughput analysis, enabling the study of human brain tumor metabolomics.

MEDICAL ONCOLOGY (2023)

Review Oncology

HPV-associated cancers: insights into the mechanistic scenario and latest updates

Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Abilash Valsala Gopalakrishnan, Rama Jayaraj, Ramkumar Katturajan, Sandra Kannampuzha, Reshma Murali, Arunraj Namachivayam, Sabina Evan Prince, Balachandar Vellingiri, Abhijit Dey, Kaviyarasi Renu

Summary: Cancer and related diseases rank second in global causes of death. Human papillomavirus (HPV) is an infectious agent primarily transmitted through sexual contact and is associated with various malignancies in both sexes. HPV is strongly linked to cervical cancer and also plays a role in head and neck cancer, particularly oropharyngeal cancer. Additionally, certain HPV-related cancers such as vaginal, vulvar, penile, and anal cancers are associated with the anogenital region. Extensive research has focused on HPV16 and HPV18 due to their significant carcinogenic potential, with the viral genes E6 and E7 identified as key players in cellular transformation and cancer progression. This review highlights the different types of cancers caused by HPV and discusses the signaling cascades involved.

MEDICAL ONCOLOGY (2023)

暂无数据