Article
Surgery
K. R. Amin, J. P. Stone, J. Kerr, A. Geraghty, L. Joseph, A. Montero-Fernandez, J. K. Wong, J. E. Fildes
Summary: Efforts to improve limb preservation for transplantation using ex vivo perfusion have shown promising results, with normothermic machine perfusion being superior to static cold storage in terms of tissue integrity and reperfusion injury.
BRITISH JOURNAL OF SURGERY
(2021)
Review
Medicine, Research & Experimental
Carolyn Ton, Sara Salehi, Sara Abasi, John R. Aggas, Renee Liu, Gerald Brandacher, Anthony Guiseppi-Elie, Warren L. Grayson
Summary: Vascularized composite allotransplantation plays a crucial role in improving quality of life and restoring functionality. However, the complex tissue composition of VCAs presents unique clinical challenges, increasing the risk of transplant rejection. The development of methods to evaluate VCAs is crucial for mitigating rejection.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Surgery
Sachiko Tobiume, Yoshio Kaji, Osamu Nakamura, Konosuke Yamaguchi, Kunihiko Oka, Tetsuji Yamamoto
Summary: The study demonstrated that adding VEGF-containing HAp/Col effectively stimulates angiogenesis and bone formation in prefabricated vascularized bone allografts, without causing bone resorption.
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2021)
Article
Surgery
Guoxuan Dong, Huanhuan Wu, JunLong Hu, Li Teng
Summary: The study found that SVF can reduce skin flap necrosis and activate neovascularization in rats by facilitating intercellular adhesion, cell migration, and regulating positive immune response.
AESTHETIC PLASTIC SURGERY
(2022)
Review
Oncology
Remo Accorona, Luca Gazzini, Roberto Grigolato, Enrico Fazio, Letizia Nitro, Monir Abousiam, Giovanni Giorgetti, Lorenzo Pignataro, Pasquale Capaccio, Luca Calabrese
Summary: Reconstruction of head and neck bones using revascularized free periosteal flaps and scaffold is a feasible alternative for patients unable to undergo bone free flap complex reconstruction, with a relatively high success rate. This technique opens new possibilities in reconstructive surgery for head and neck, offering lower donor site morbidity and potential for tailored complex 3D defect reconstruction.
Article
Multidisciplinary Sciences
Mubarak Ahmed Mashrah, Taghrid Aldhohrah, Ahmed Abdelrehem, Karim Ahmed Sakran, Hyat Ahmad, Hamada Mahran, Faisal Abu-lohom, Hanfu Su, Ying Fang, Liping Wang
Summary: This network meta-analysis compared four osseous flaps for mandibular reconstruction and found that fibula free flap (FFF), deep circumferential iliac artery flap (DCIA), scapula flap, and osteocutaneous radial forearm flap (ORFF) showed comparable survival rates. The selection of osseous flap should be based on multiple factors rather than simply flap survival rate.
Article
Orthopedics
Matthew M. Florczynski, Kevin C. Chung
Summary: Lunate revascularization has emerged as a promising treatment for Kienbock disease, with various bone flap options providing reliable early-stage treatment and free vascularized flaps being suitable for more advanced cases. Further research is needed to determine the optimal surgical treatments for different stages of the disease.
Article
Chemistry, Multidisciplinary
Idan Redenski, Shaowei Guo, Majd Machour, Ariel Szklanny, Shira Landau, Ben Kaplan, Roberta Lock, Yankel Gabet, Dana Egozi, Gordana Vunjak-Novakovic, Shulamit Levenberg
Summary: Functional regeneration of complex large-scaled defects requires both soft- and hard-tissue grafts. Soft-tissue pedicles are often used to vascularize bony constructs. Pre-vascularization of the soft-tissue matrix using dental pulp stem cells and human adipose microvascular endothelial cells enhances vascular development within decellularized bones.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Menghong Li, Gang Wu, Mingjie Wang, Ernst B. Hunziker, Yuelian Liu
Summary: This study investigated the use of a biomimetic calcium phosphate coating on mini-pin implants to promote early osseointegration. The results demonstrated that the crystalline BioCaP coating served as a drug carrier with sustained release properties. Additionally, the crystalline coating significantly increased the bone to implant contact percentage at week 1. These findings suggest that the crystalline BioCaP coating may be a promising surface modification to improve the success rate of miniscrew implants in orthodontic clinics.
Article
Multidisciplinary Sciences
Christian Heiliger, Lucas M. Ritschl, Andreas M. Fichter, Lukas K. Postl, Anastasios Kanatas, Klaus Dietrich Wolff, Thomas Muecke
Summary: This study aimed to assess the survival rates associated with a pure venous perfusion flap and investigate whether the timing of the vascular conditioning can affect free flap survival. The results showed that suitable vascular conditioning can provide adequate perfusion in the rat epigastric flap model, and the timing of vascular conditioning appears to be critical for flap survival.
SCIENTIFIC REPORTS
(2023)
Article
Surgery
Laura C. Burlage, Alexandre G. Lellouch, Corentin B. Taveau, Philipp Tratnig-Frankl, Casie A. Pendexter, Mark A. Randolph, Robert J. Porte, Laurent A. Lantieri, Shannon N. Tessier, Curtis L. Cetrulo, Korkut Uygun
Summary: This study developed a protocol for ex vivo subnormothermic oxygenated machine perfusion of rodent hindlimbs and validated its efficacy in a heterotopic hindlimb transplant model. The results showed that perfusion with the acellular oxygen carrier HBOC-201 resulted in superior tissue preservation compared to conventional SCS.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Michael S. Xu, Golnaz Karoubi, Thomas K. Waddell, Siba Haykal
Summary: Large volume soft tissue defects can greatly impact a patient's quality of life. Current surgical reconstruction methods have limitations, and the use of engineered tissues using decellularization/recellularization methods may provide a solution. This protocol provides a detailed procedure for generating decellularized soft tissue scaffolds and a description of the perfusion bioreactor design and setup.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Cell Biology
Hongping Deng, Alexander Zhang, Dillon Ren Rong Pang, Yinsheng Xi, Zhihong Yang, Rudy Matheson, Guoping Li, Hao Luo, Kang M. Lee, Qiang Fu, Zhongliang Zou, Tao Chen, Zhenjuan Wang, Ivy A. Rosales, Cole W. Peters, Jibing Yang, Maria M. Coronel, Esma S. Yolcu, Haval Shirwan, Andres J. Garcia, James F. Markmann, Ji Lei
Summary: Transplanting allogeneic islets onto the omentum can effectively treat diabetes and provide insights for the development of strategies for b cell replacement.
CELL REPORTS MEDICINE
(2023)
Article
Immunology
Biao Lei, M. Mahdi Sleiman, Qi Cheng, Zhenxiao Tu, Peng Zhu, Martin Goddard, Paulo N. Martins, Logan Langerude, Satish Nadig, Stephen Tomlinson, Carl Atkinson
Summary: This study found that donor brain death exacerbates ischemia-reperfusion injury in vascularized composite allograft transplantation and leads to earlier rejection of the graft. Treatment of donor VCAs with CR2-Crry significantly reduced complement deposition, inflammation, and injury, providing localized protection without significant immunosuppression effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Orthopedics
Sergi Barrera-Ochoa, Rita Sapage, Sergi Alabau-Rodriguez, Tryno Munoz-Perdomo, Jorge Knorr, Francisco Soldado
Summary: The use of a vascularized ulnar periosteal pedicled flap in treating forearm nonunion in children shows significant postoperative pain improvement, high union rate, and low complication rate.
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2022)
Article
Dentistry, Oral Surgery & Medicine
Julia R. Davies, James Field, Jonathan Dixon, Maria-Cristina Manzanares-Cespedes, Sibylle Vital, Corrado Paganelli, Ilze Akota, Barry Quinn, Valerie Roger-Leroi, Denis Murphy, Gabor Gerber, Stephanie Tubert-Jeannin
Summary: The Erasmus+O-Health-EDU project aims to gain a comprehensive view of oral health professional education in Europe, and ARTICULATE is a glossary created as a shared language for terms and concepts used in the field. It is a resource for OHP educators and promotes accurate communication and collaboration among academic teams.
EUROPEAN JOURNAL OF DENTAL EDUCATION
(2023)
Article
Orthopedics
Matias Vicente, Inca Vilar, Rosa Fraile Soriano, Irina Capo, Pablo S. Corona
Summary: Industrially custom-made spacers are an effective and safe option for performing two-stage exchange arthroplasty in cases of end-stage hip periprosthetic joint infection (HPJI) with extensive bone defects.
Article
Dentistry, Oral Surgery & Medicine
Sebastiana Arroyo-Bote, Carolina Martinez-Arroyo, Ma Angeles Gallego-Alvarez, Chelo Arroyo-Bote, Ma Cristina Manzanares-Cespedes
Summary: This study aims to understand the academic preparation of Spanish dentistry students in learning outcomes related to interpersonal violence during their undergraduate training. The survey results indicate that most Spanish universities provide training on violence, but the current training hours are insufficient. In the future, there will be an increase in training hours and areas related to interpersonal violence.
EUROPEAN JOURNAL OF DENTAL EDUCATION
(2023)
Editorial Material
Dentistry, Oral Surgery & Medicine
James Field, Jonathan Dixon, Julia Davies, Barry Quinn, Denis Murphy, Sibylle Vital, Corrado Paganelli, Ilze Akota, Gabor Gerber, Valerie Roger-Leroi, Maria Cristina Manzanares-Cespedes, Stephanie Tubert-Jeannin
Summary: This consensus paper presents a renewed vision for Oral Health Professional (OHP) education in Europe, which aligns with international and regional health objectives and aims to benefit students, patients, and overall health.
EUROPEAN JOURNAL OF DENTAL EDUCATION
(2023)
Article
Surgery
Francisco Soldado, Maria Cristina Garcia-Martinez, Sergi Barrera-Ochoa, Jorge Knorr, Jose Couceiro, Michael W. Aversano
Summary: A novel technique using an intermetacarpal palmar flap for syndactyly release is described. Anatomical study and clinical application confirmed its effectiveness. The technique provides good outcomes for simple syndactylies with no complications.
Letter
Surgery
Francisco Soldado, Chantal L. Sallaberry, Trong-Quynh Nguyen, Juliana Rojas-Neira, Paula Diaz-Gallardo, Jorge Knorr
Article
Biotechnology & Applied Microbiology
Lluis Martorell, Alba Lopez-Fernandez, Andrea Garcia-Lizarribar, Roger Sabata, Patricia Galvez-Martin, Josep Samitier, Joaquim Vives
Summary: Three dimensional (3D) bioprinting is an emerging technology with vast therapeutic potential in regenerative medicine. The success of 3D bioprinting relies on defining a bioprintable zone specific to each combination of hydrogels and scaffolds, which matches the mechanical and biological characteristics of the target tissue. This study investigates the advantages of natural hydrogel-based bioinks in preserving critical quality attributes (CQA) in bone tissue regeneration applications, particularly focusing on cell viability and osteogenic potential of multipotent mesenchymal stromal cells (MSCs) in vitro. The use of hyaluronic acid, fibrin, and gelatin as bioinks allows for optimal recovery of viable cells while maintaining MSC's proliferation capacity and osteogenic potency.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Orthopedics
Unai Jambrina-Abasolo, Dragos Hutanu, Diego Gonzalez-Morgado, Ferran Blasco-Casado, Juliana Rojas-Neira, Francisco Soldado
Summary: Impairment of shoulder extension and behind-the-back function is common in patients with residual neonatal brachial plexus injury. This study found that both passive glenohumeral extension (PGE) and active shoulder extension (ASE) angles can be reliably measured with a clinical exam, and at least 10 degrees of extension is necessary to perform the hand-to-spine Mallet task.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Surgery
Francisco Soldado, Trong-Quynh Nguyen, Diego Gonzalez-Morgado, Juliana Rojas-Neira, Dinh-Hung Nguyen, Paula Diaz-Gallardo
Summary: We report a case of successful transfer of the extensor carpi radialis brevis motor branch to the deep branch of the ulnar nerve to repair intrinsic hand palsy. By 18 months post-operatively, all the digits showed complete active IP extension. Thirty-six months after surgery, no signs of first dorsal interosseous nerve or thenar muscle reinnervation were present, thus an extensor carpi ulnaris opponensplasty was performed.
Article
Surgery
Francisco Soldado, Felipe Moreira Borim, Jorge Knorr
Summary: Although no surgical procedure has received unanimous support for treating Freiberg's disease, several surgical treatment options have been described. A novel technique using a reverse pedicled metatarsal bone flap from the first metatarsal to treat one case of Freiberg's disease in a 13-year-old female has been reported. Based on the powerful vasculogenic and osteogenic properties of bone flaps, this technique could effectively induce bone revascularization and prevent further collapse of the metatarsal's head.
Article
Chemistry, Multidisciplinary
Maria Florencia Lezcano, Fernando Dias, Nicole Farfan-Beltran, Maria Cristina Manzanares-Cespedes, Camila Cerda, Ramon Fuentes
Summary: This study proposed and established a method to synchronize 3D Electromagnetic Articulography (3D-EMA) with Surface Electromyography (SEMG) based on the standard components of this equipment. The results showed that this method can effectively analyze mandibular movements and electromyographic activity, providing insights for the analysis of masticatory activity and its complexity in different clinical situations.
APPLIED SCIENCES-BASEL
(2023)
Article
Surgery
Sergi Barrera-Ochoa, Jose Antonio Prieto Mere
Summary: Locked volar plate fixation is the gold-standard treatment for distal radius fractures, but complications can occur, such as median nerve injury. We present a case of an 84-year-old male who developed a late postoperative complication of complete median nerve axonotmesis due to screw migration of a locked volar plate for a left distal radius fracture. Electromyography confirmed the injury, and a Martin-Gruber anastomosis was discovered with proximal stimulation.
JOURNAL OF SURGICAL CASE REPORTS
(2023)
Article
Anatomy & Morphology
M. Dalmau-Pastor, N. Alvarez Toledo, I. Valdivia-Gandur, R. S. Tubbs, T. Vazquez-Osorio, J. M. de Anta, C. Simon de Blas, A. Prats-Galino, M. Loukas, M. C. Manzanares-Cespedes
Summary: This study aimed to develop a global quality management system (DRQS) for Dissection Rooms (DRs) used for teaching and research on human anatomy. A Delphi panel of 20 anatomy professors from 20 different countries was used to achieve consensus on the items that should be included in the DRQS. After two rounds of revisions, 150 standards were considered essential and important, and were incorporated into the DRQS for improving the functioning of DRs globally.
Article
Orthopedics
Pablo S. Corona, Marta Perez, Matias Vicente, Oriol Pujol, Carles Amat, Lluis Carrera
Summary: A retrospective cohort study suggests that incorporating a tibial tubercle osteotomy (TTO) during a two-stage exchange protocol for knee periprosthetic joint infection (PJI) can lead to higher treatment success and lower reinfection rate, with a decrease in complications.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2023)