Article
Pharmacology & Pharmacy
Elnaz Z. Fallahasghari, Marie Hojgaard Lynge, Emma Espholin Gudnason, Kristin Munkerup, Ana C. Mendes, Ioannis S. Chronakis
Summary: This study evaluated the encapsulation of vitamin A palmitate within a core-shell carbohydrate matrix by co-axial electrospray and its oxidative stability. The core-shell microcapsules showed enhanced oxidative stability of vitamin A, with the most effective protection achieved by adding casein protein hydrolysate to the core. The use of ethanol as a solvent increased the hydrophobicity of the proteins and contributed to their antioxidant ability.
Article
Pharmacology & Pharmacy
Man Li, Guoqiang Wang, Yinyin Yan, Mengyuan Jiang, Zhirong Wang, Zhenqiang Zhang, Xiangxiang Wu, Huahui Zeng
Summary: In this study, a novel nanoparticle platform was developed to deliver TP for synergistic treatment of rheumatoid arthritis and inhibition of oxidative stress. Compared to traditional triptolide, TP-VP NPs effectively improved arthritis symptoms and significantly reduced multi-organ toxicity.
Article
Pharmacology & Pharmacy
Manisha Prajapati, Thorsteinn Loftsson
Summary: This study investigates the degradation kinetics, stability, and solubility of difluprednate in aqueous CD solutions for the development of an aqueous eye drop vehicle for ophthalmic delivery. The results show that difluprednate has maximum stability at pH 5 in aqueous CD solution. HP gamma CD was found to be the best solubilizer and stabilizer among all the CDs tested. The stability was further improved with the combination of HP gamma CD and different polymers.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Silvia Navarro-Orcajada, Francisco Jose Vidal-Sanchez, Irene Conesa, Adrian Matencio, Jose Manuel Lopez-Nicolas
Summary: This study analyzed and compared the growth inhibition of colorectal cancer cells by methoxylated stilbene rhapontigenin and some analogues, and overcame potential issues in fortified product development by designing inclusion complexes. The results showed that the solubility and stability of rhapontigenin were significantly improved, achieving a sevenfold increase in water solubility and maintaining over 73% of stilbene content. These findings are of great importance for industries aiming to deliver novel bioactive compounds with higher solubility and lower degradation.
Article
Food Science & Technology
Bo Zhang, Luyao Zheng, Siyuan Liang, Yifan Lu, Jianmei Zheng, Guoquan Zhang, Wenhao Li, Hao Jiang
Summary: Spray-dried capsaicin microcapsules were fabricated using whey protein and modified starch as wall materials. The study investigated the impact of protein/starch ratio on the physicochemical characteristics and stability of the microcapsules. The research showed that microencapsulation significantly improved the stability and water-solubility of capsaicin.
Article
Biochemistry & Molecular Biology
Silvia Navarro-Orcajada, Francisco Jose Vidal-Sanchez, Irene Conesa, Francisco Escribano-Naharro, Adrian Matencio, Jose Manuel Lopez-Nicolas
Summary: In this study, the antiproliferative activity of isorhapontigenin against colorectal cancer was investigated. It was found to have similar cytotoxic activity to resveratrol and piceatannol, suggesting it as a viable alternative. Encapsulation of isorhapontigenin in cyclodextrins improved its solubility and stability, with HP-beta-CD being the most suitable. These findings provide insights for the development of novel formulations for delivering isorhapontigenin.
Article
Chemistry, Physical
Liyuan Chen, Waixiang Yang, Chuanzhu Gao, Xiali Liao, Jing Yang, Bo Yang
Summary: In this study, two bridged cyclodextrin dimers were designed and synthesized for the encapsulation of CBD, leading to significantly improved water solubility and antioxidant activity without compromising its anti-tumor activity.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Review
Pharmacology & Pharmacy
Kleyton Santos Veras, Flavia Nathiely Silveira Fachel, Valquiria Linck Bassani, Helder Ferreira Teixeira, Leticia Scherer Koester
Summary: This review focuses on CD-based delivery systems containing HCAs, discussing their effects on crucial parameters that affect the oral bioavailability of HCAs.
Article
Food Science & Technology
Do Hee Kim, Eun Woo Jeong, Youjin Baek, Hyeon Gyu Lee
Summary: To overcome the limitations of low solubility and instability, researchers encapsulated propolis extract in nanoparticles using chitosan and hyaluronic acid as wall materials. The optimal ratio for the formulation of these nanoparticles was found to be 4:7 for chitosan and hyaluronic acid, and 1:2 for the core to wall material. These nanoparticles significantly increased the solubility and stability of the propolis extract, as well as maintained higher levels of total flavonoid content and DPPH radical scavenging effects after heat treatment and storage.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Ye-Rim Lee, Hyun-Mo Jeong, Ji-Soo Kim, Eun-A Kim, Eun-Hyeong Lee, Jae-Hoon Shim
Summary: In order to improve the applicability of quercetin (QCT), we created an inclusion complex of QCT and cyclodextrin glucanotransferase (CGTase; EC 2.4.1.19) called cycloamylose (CA-QCT). The solubility of CA-QCT in water was 55,000 times higher than that of QCT. CA-QCT showed higher stability and antioxidant activity compared to QCT, and it also exhibited greater inhibitory effects on inflammatory mediators.
CARBOHYDRATE POLYMERS
(2023)
Article
Agricultural Engineering
K. O. Sodeinde, A. M. Ojo, S. O. Olusanya, O. S. Ayanda, A. O. Adeoye, T. M. Dada, O. S. Lawal
Summary: In this study, native cellulose was extracted from flamboyant fruit pods and subsequently modified to obtain carboxyl methyl cellulose and cellulose acetate under acidic conditions. The modified cellulose showed reduced structural crystallinity, altered surface morphology, and improved thermal stability.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Food Science & Technology
Shahin Banasaz, Ksenia Morozova, Giovanna Ferrentino, Matteo Scampicchio
Summary: This study investigated the oxidative stability of vitamin A encapsulated in oil-in-water emulsions prepared by a microfluidizer. Results showed that the highest stability was achieved with the highest content of alpha-tocopherol and pressure between 100 and 200 MPa, due to the smaller particle size of the resulting oil droplets. However, high pressure (200 MPa) had a negative effect on vitamin A retention, which could be important for future retinoid formulations.
Article
Food Science & Technology
Zahra Toutou, Sofiane Fatmi, Nacera Chibani, Lamia Taouzinet, Imene Harrate, Ahlam Inouri-Iskounen, Mohamed Skiba, Mokrane Iguerouada
Summary: This study aims to investigate the solubility diagrams of propolis extract and improve its stability, absorption, and solubility by adding cyclodextrins. A D-optimal experimental design with three factors (ratio, solvent, and temperature) is used to formulate an optimized inclusion complex. The results show that PM-beta CD is more efficient, with an optimal formulation obtained using 40 mL solvent, a temperature of 40 degrees C, and a 1:1 stoichiometry. Cytotoxicity tests demonstrate that both propolis extract and its inclusion complex are non-toxic to red blood cells and can preserve sperm viability.
Article
Food Science & Technology
Zahra Toutou, Sofiane Fatmi, Nacera Chibani, Lamia Taouzinet, Imene Harrate, Ahlam Inouri-Iskounen, Mohamed Skiba, Mokrane Iguerouada
Summary: This study aims to investigate the solubility of propolis extract of Melbou region (PEM) in the presence of α-CD, β-CD, and PM-β CD, and to formulate an optimized inclusion complex. The optimal formulation, characterized by FTIR, XRD, and SEM, shows that PM-β CD is more efficient. Cytotoxicity tests reveal that both PEM and its inclusion complex are non-toxic to RBCs and can maintain sperm conservation.
Article
Biochemistry & Molecular Biology
Shima Saffarionpour, Levente L. Diosady
Summary: β-cyclodextrin is a potential carrier for the delivery of highly bioavailable and hydrophilic iron salt, with improved stability and thermal resistance.
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.