Article
Immunology
Maria K. Borszewska-Kornacka, Agnieszka Mastalerz-Migas, Aneta Nitsch-Osuch, Teresa Jackowska, Iwona Paradowska-Stankiewicz, Ernest Kuchar, Jan Mazela, Ewa Helwich, Marcin Czech, Ryszard Lauterbach, Jaroslaw Pinkas, Miroslaw Wielgos, Jacek Wysocki
Summary: Respiratory syncytial virus (RSV) is a common pathogen causing respiratory tract infections in infants, with a significant healthcare burden in Poland. However, data on RSV disease in Poland is scarce and may be underestimated. In recent years, the infection seasonality has changed due to preventive measures for coronavirus disease. The surveillance system in Poland has limitations but may be improved.
Article
Immunology
Hangjie Zhang, Aiqing Zhu, George F. Gao, Zhongjie Li
Summary: Respiratory syncytial virus (RSV) is a common virus that causes acute respiratory tract infections in children. A study analyzing data from 2014 to 2018 in China found an overall infection rate of 17.3% among children under 5 years old, with the majority being hospitalized. Infants under 6 months old were at higher risk of infection, especially during the winter season. Cough was the most common symptom of RSV infection, and infants under 6 months old were more likely to develop bronchopneumonia.
Review
Microbiology
Rogier W. Sanders, John P. Moore
Summary: Most viral vaccines work by inducing neutralizing antibodies against the virus envelope or spike glycoproteins, which are engineered for stability and presentation of key epitopes to optimize vaccine performance. This technique emerged during HIV-1 Env vaccine development and has been widely applied to other viral vaccines, including SARS-CoV-2.
CELL HOST & MICROBE
(2021)
Article
Immunology
Meghana Nadiger, Prithvi Sendi, Paul A. Martinez, Balagangadhar R. Totapally
Summary: In hospitalized children in the United States, HMPV infection is less common than RSV infection. Complex chronic conditions are more prevalent in children hospitalized with HMPV infection. Hospitalization with HMPV is associated with longer length of stay and higher hospital charges. The adjusted mortality is similar with both infections.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Infectious Diseases
Yuki Furuse, Raita Tamaki, Akira Suzuki, Taro Kamigaki, Michiko Okamoto, Mariko Saito-Obata, Emiko Nakagawa, Mayuko Saito, Edelwisa Segubre-Mercado, Veronica Tallo, Socorro Lupisan, Hitoshi Oshitani
Summary: This study examined the prevalence of respiratory viruses among children with acute respiratory infections in the Philippines. The research found that the prevalence of respiratory viruses in healthcare facilities was significantly higher than in households, with respiratory syncytial virus and rhinovirus being the most common.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Agriculture, Dairy & Animal Science
Sherri A. Powledge, Taylor B. McAtee, Amelia R. Woolums, T. Robin Falkner, John T. Groves, Merilee Thoresen, Robert Valeris-Chacin, John T. Richeson
Summary: Vaccination with modified-live virus (MLV) did not have a clear impact on the health or growth of high-risk calves, but intranasal MLV vaccination was associated with increased carriage of Histophilus somni (Hs) in the naris and reduced culture of Mannheimia haemolytica (Mh) from lung tissue samples. This suggests that intranasal MLV vaccination can alter the microbial community in the respiratory tract of cattle.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Medicine, General & Internal
Michal Rzad, Krzysztof Kanecki, Katarzyna Lewtak, Piotr Tyszko, Martyna Szwejkowska, Pawel Gorynski, Aneta Nitsch-Osuch
Summary: This study provides up-to-date information on RSV hospitalization cases in children under 5 years old in Poland, revealing an increasing hospitalization rate for RSV patients. The study also found that patients from urban areas had significantly higher hospitalization rates compared to those from rural areas, and there was a seasonal pattern with the highest hospitalization rates observed from January to March.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Virology
Manika Suryadevara, Joseph B. Domachowske
Summary: RSV infections in young children are a major global health concern, with seasonal patterns of activity playing a crucial role in guiding resource allocation for treatment and prevention strategies. Surveillance data from developed countries have been instrumental in advancing public health initiatives, while surveillance in tropical regions still needs improvement.
Article
Immunology
Ann R. Falsey, Andrew Cameron, Angela R. Branche, Edward E. Walsh
Summary: The COVID-19 pandemic has had an impact on the activity of RSV. After initial suppression, there was a seasonal surge of RSV in 2021, but without proportional increases in infections in older adults, likely due to differences in adherence to public health measures.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Public, Environmental & Occupational Health
Karla Cantu-Flores, Gerardo Rivera-Alfaro, Juan Carlos Munoz-Escalante, Daniel E. Noyola
Summary: This study provides a systematic review of global and continental patterns of respiratory syncytial virus (RSV) circulation, shedding light on the distribution and changes of RSV A and B genotypes. The study identifies two circulation patterns for RSV and reveals a decrease in genotype diversity after 2000.
PATHOGENS AND GLOBAL HEALTH
(2022)
Article
Virology
Guohong Zhu, Dan Xu, Yuanyuan Zhang, Tianlin Wang, Lingyan Zhang, Weizhong Gu, Meiping Shen
Summary: The study found that the rates of viral infection in children vary by different ages and seasons, with the highest positivity rate of adenovirus appearing in the preschool period, respiratory syncytial virus being highest in infants, and influenza virus increasing with age. The total positive rate of viral infection in different seasons is highest in winter, with influenza positivity rate also being highest in winter.
Article
Microbiology
Takashi Ono, Koichi Hashimoto, Yohei Kume, Mina Chishiki, Hisao Okabe, Masatoki Sato, Sakurako Norito, Jumpei Aso, Mitsuru Sada, Izumi Mochizuki, Fumi Mashiyama, Naohisa Ishibashi, Shigeo Suzuki, Hiroko Sakuma, Reiko Suwa, Miyuki Kawase, Makoto Takeda, Kazuya Shirato, Hirokazu Kimura, Mitsuaki Hosoya
Summary: Understanding the molecular diversity of human respiratory syncytial viruses during pandemics caused by different viruses can provide insights that can guide public health decisions and vaccine development.
MICROBIOLOGY SPECTRUM
(2023)
Review
Immunology
Camila Covian, Mariana Rios, Roslye Berrios-Rojas, Susan M. Bueno, Alexis M. Kalergis
Summary: Vaccines play a crucial role in protecting humans from various pathogens and can induce trained immunity, providing non-specific memory against a wide range of pathogens. Recombinant BCG vaccines have shown potential in combating respiratory syncytial virus and metapneumovirus by simultaneously inducing specific adaptive immunity and non-specific trained immunity, offering broader protection against pathogenic viruses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Patricia Niekler, David Goettler, Johannes G. Liese, Andrea Streng
Summary: This study analyzed RSV-coded hospitalization data in Germany, revealing a significant economic burden of RSV-related hospitalizations, particularly among adults and seniors. Although children represent the majority of RSV hospitalizations, adults and seniors have an increasing hospitalization incidence and are more prone to severe complications.
Article
Medicine, Research & Experimental
Alessandra Pierangeli, Antonio Piralla, Sara Uceda Renteria, Giovanni Giacomel, Giovanna Lunghi, Elisabetta Pagani, Elisabetta Giacobazzi, Elisa Vian, Valeria Biscaro, Giulia Piccirilli, Tiziana Lazzarotto, Stefano Menzo, Monica Lucia Ferreri, Federica Novazzi, Laura Petrarca, Amelia Licari, Guglielmo Ferrari, Giuseppe Oliveto, Guido Antonelli, Sandro Binda, Cristina Galli, Laura Pellegrinelli, Elena Pariani, Fausto Baldanti
Summary: This study provides insights into the burden, seasonality, and clinical presentation of respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) infections in Italy. RSV and HMPV were found to cause a high burden of disease in both children and the elderly, with different seasonality patterns. RSV was more prevalent in infants, while HMPV affected more elderly adults, but their clinical course was similar. RSV-A ON1 variants were the most common. These findings can serve as the basis for establishing a national respiratory virus surveillance network.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Ravneet Kaur, Timothy Callaghan, Annette K. Regan
Summary: This study evaluated disparities in urban-rural immunization rates among pregnant women by indicators of access to health care. The findings suggested that pregnant women residing in rural areas relied more on Medicaid for prenatal care, but had less access to Medicaid coverage, leading to disparities in vaccine uptake and increased rates of vaccine-preventable diseases.
JOURNAL OF RURAL HEALTH
(2023)
Article
Obstetrics & Gynecology
Lisa Mchugh, Paul Van Buynder, Mohinder Sarna, Ross M. Andrews, Hannah C. Moore, Michael J. Binks, Gavin Pereira, Christopher C. Blyth, Karin Lust, Damien Foo, Annette K. Regan
Summary: This study aims to investigate the gaps and predictors of influenza and pertussis vaccinations during pregnancy in Australia. The study found inequity in vaccine uptake between First Nations and non-Indigenous pregnancies, as well as low overall vaccination rates. If the pertussis vaccine is driving the uptake of influenza vaccine, changes in antenatal healthcare practices are needed to protect against infection.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Pediatrics
Damien Foo, Mohinder Sarna, Gavin Pereira, Hannah C. Moore, Annette K. Regan
Summary: This retrospective cohort study examined the association between in utero exposure to seasonal inactivated influenza vaccine (IIV) and the risk of a diagnosis of a neurodevelopmental disorder in early childhood. The results showed that there was no increased risk of neurodevelopmental disorders following in utero exposure to seasonal IIV. However, there was some evidence suggesting that exposure during the first trimester may reduce the risk of seizure disorders, and exposure in preterm children may reduce the risk of sleep disorders.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Infectious Diseases
Cara A. Minney-Smith, David A. Foley, Chisha T. Sikazwe, Avram Levy, David W. Smith
Summary: The seasonality of respiratory syncytial virus (RSV) in Western Australia (WA) is influenced by local climate. Before the SARS-CoV-2 pandemic, RSV seasons in the Metropolitan and Southern regions of WA were consistent in timing and intensity, while the Northern region did not experience a distinct seasonality.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2023)
Article
Pediatrics
David A. Foley, Daniel K. Yeoh, Cara A. Minney-Smith, Christine Shin, Briony Hazelton, Tobias Hoeppner, Hannah C. Moore, Mark Nicol, Chisha Sikazwe, Meredith L. Borland, Avram Levy, Chris C. Blyth
Summary: The study examines the impact of a surge in hMPV cases on pediatric hospital admissions and the influence of changes in testing. Results show that hMPV-positive admissions in 2021 were significantly higher than the baseline period, particularly in children aged 1-4 years and those with other acute lower respiratory infection. The increase in testing contributed to the higher number of hMPV-positive cases, suggesting a genuine rise in hMPV infections.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2023)
Editorial Material
Public, Environmental & Occupational Health
Annette K. Regan, Gavin Pereira
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Immunology
Amelia K. Wesselink, Sharonda M. Lovett, Janice Weinberg, Ruth J. Geller, Tanran R. Wang, Annette K. Regan, Mary D. Willis, Rebecca B. Perkins, Jennifer J. Yland, Martha R. Koenig, Kenneth J. Rothman, Elizabeth E. Hatch, Lauren A. Wise
Summary: We conducted a prospective cohort study to examine the association between COVID-19 vaccination and menstrual cycle characteristics. Our findings suggest that COVID-19 vaccination is associated with a temporary increase in menstrual cycle length by 1 day, but not with other menstrual cycle characteristics.
Article
Economics
Annette K. Regan, Pallavi Aytha Swathi, Marcianna Nosek, Ning Yan Gu
Summary: This study used EQ-5D-5L to assess health-related quality of life (HRQoL) during pregnancy and postpartum. The results showed a gradual increase in the use of EQ-5D-5L and a decline in its utility values until the ninth month of pregnancy. The values increased during the first postpartum month and then stabilized. The study indicates a decline in HRQoL during pregnancy and a recovery postpartum.
APPLIED HEALTH ECONOMICS AND HEALTH POLICY
(2023)
Article
Obstetrics & Gynecology
Jennifer J. Yland, Amelia K. Wesselink, Annette K. Regan, Elizabeth E. Hatch, Kenneth J. Rothman, David A. Savitz, Tanran R. Wang, Krista F. Huybrechts, Sonia Hernandez-Diaz, Michael L. Eisenberg, Lauren A. Wise
Summary: COVID-19 vaccination in either partner at any time before conception is not associated with an increased rate of miscarriage.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Annette K. Regan, Amelia K. Wesselink, Tanran R. Wang, David A. Savitz, Jennifer J. Yland, Kenneth J. Rothman, Elizabeth E. Hatch, Lauren A. Wise
Summary: This study evaluated the association between seasonal influenza vaccination and miscarriage. The results showed that there was no significant association between receiving influenza vaccination before or during pregnancy and the risk of miscarriage.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Immunology
Mohinder Sarna, Amanuel Gebremedhin, Peter Richmond, Avram Levy, Kathryn Glass, Hannah C. Moore
Summary: Respiratory syncytial virus is a major cause of illness and death in infants worldwide. By analyzing pre-pandemic RSV testing data and hospital admission data, a statistical prediction model was used to estimate RSV-hospitalizations in infants under 1 year old. The highest incidence rate of RSV-hospitalization in infants under 6 months was found in those born in April/May.
Editorial Material
Immunology
Annette K. Regan, Deshayne B. Fell, Lauren A. Wise, Gabriela Vazquez-Benitez, Siri E. Haberg, Comfort Ogar, Jennifer J. Yland, Amelia K. Wesselink, Ousseny Zerbo
Article
Immunology
Mohinder Sarna, Amanuel Gebremedhin, Peter C. Richmond, Kathryn Glass, Avram Levy, Hannah C. Moore
Summary: This study examined the association between sociodemographic and perinatal factors and childhood respiratory morbidity following early-life respiratory syncytial virus (RSV) infection. The results showed that in addition to preterm and young infants, children aged 12-<24 months could also be potential target groups for RSV prevention.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Anna N. Chard, Francisco Nogareda, Annette K. Regan, Marta Fernanda Olivares Barraza, Rodrigo A. Fasce, Natalia Vergara, Marcela Avendano, Elena Penayo, Cynthia Vazquez, Marta Von Horoch, Fabiana Michel, Adriana Alfonso, Cristina Mogdasy, Hector Chiparelli, Natalia Goni, Miguel Alegretti, Sergio Loayza, Paula Couto, Angel Rodriguez, Daniel Salas, Ashley L. Fowlkes, Eduardo Azziz-Baumgartner
Summary: This study estimated the vaccine effectiveness (VE) against severe acute respiratory illness (SARI) hospitalization in Chile, Paraguay, and Uruguay during the 2022 influenza season. The results showed that the VE against any influenza-associated SARI hospitalization was 33.8%, and the VE against influenza A(H3N2)-associated SARI hospitalization was 30.4%. VE estimates were similar across target populations.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Ashley L. Fowlkes, Francisco Nogareda, Annette Regan, Sergio Loayza, Jose Mendez Mancio, Lindsey M. Duca, Paula Couto, Juliana Leite, Angel Rodriguez, Daniel Salas, REVELAC i Network
Summary: Evaluations of vaccine effectiveness in the Southern Hemisphere influenza season indicate that vaccines substantially reduce the risk of severe influenza illnesses. In preparation for the Northern Hemisphere influenza season, it is recommended to encourage eligible individuals, especially those at increased risk for severe outcomes, to receive influenza vaccination.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2023)
