Article
Infectious Diseases
Lauren Freeman, Ashley Milkovits, Lauren McDaniel, Nathan Everson
Summary: This study compared the rates of treatment modifications and failures between A + C therapy and A + G therapy for Enterococcus faecalis infective endocarditis (EFIE). The results showed that A + C therapy had lower rates of treatment modifications and adverse events, with the most common adverse event being nephrotoxicity, while the A + G therapy had a higher incidence of acute kidney injury.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Medicine, General & Internal
Laura Herrera-Hidalgo, Jose Manuel Lomas-Cabezas, Luis Eduardo Lopez-Cortes, Rafael Luque-Marquez, Luis Fernando Lopez-Cortes, Francisco J. Martinez-Marcos, Javier de la Torre-Lima, Antonio Plata-Ciezar, Carmen Hidalgo-Tenorio, Maria Victoria Garcia-Lopez, David Vinuesa, Alicia Gutierrez-Valencia, Maria Victoria Gil-Navarro, Aristides De Alarcon
Summary: This study aimed to evaluate the clinical effectiveness and safety of three AC regimens for the treatment of Enterococcus faecalis infective endocarditis. The results suggest that ACjoined may be a feasible and effective alternative in outpatient parenteral antibiotic treatment programs, while AC24 regimen showed an unexpected failure rate.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Infectious Diseases
Karl Oldberg, Rebecca Thoren, Bo Nilson, Patrik Gilje, Malin Inghammar, Magnus Rasmussen
Summary: Time to blood culture positivity (TTP) is an indirect measure of bacterial concentration in blood. A short TTP has been linked to infective endocarditis (IE) and poor prognosis in Staphylococcus aureus bacteremia. Factors associated with IE were investigated, and TTP remained associated with IE when adjusted for age, gender, comorbidity, and nosocomial acquisition, with no association between TTP and mortality.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Review
Health Care Sciences & Services
Raluca Ecaterina Haliga, Victorita Sorodoc, Bianca Codrina Morarasu, Adorata Elena Coman, Alexandr Ceasovschih, Oana Sirbu, Catalina Lionte, Cristina Bologa, Alexandra Stoica, Mihai Constantin, Gabriela Puha, Ovidiu Rusalim Petris, Minerva Codruta Badescu, Daniela Crisu, Andreea Nicoleta Catana, Ioana Bianca Haliga, Laurentiu Sorodoc
Summary: The article presents a case-based narrative review of Enterococcus faecalis double valve endocarditis involving both the aortic native and prosthetic mitral valve, discussing its clinical characteristics, treatment, and complications. It highlights the rarity of simultaneous double valve or multivalvular involvement in infective endocarditis.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Microbiology
Laura Herrera-Hidalgo, Aristides de Alarcon, Luis Eduardo Lopez-Cortes, Rafael Luque-Marquez, Luis Fernando Lopez-Cortes, Alicia Gutierrez-Valencia, Maria Victoria Gil-Navarro
Summary: This pharmacokinetic study aimed to investigate the efficacy of ceftriaxone in the treatment of Enterococcus faecalis infective endocarditis in OPAT programs. The results showed a low proportion of patients maintaining the recommended drug concentration under the current regimen.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Mustapha Abdeljalil Brai, Nadji Hannachi, Nabila El Gueddari, Jean-Pierre Baudoin, Abderrhamane Dahmani, Hubert Lepidi, Gilbert Habib, Laurence Camoin-Jau
Summary: The incidence of infective endocarditis (IE) has increased in the past decade, with changes in the causative bacteria. The role of bacterial interaction with human platelets in the pathogenesis of IE is crucial but not yet fully understood. This review explores the involvement of platelets in endocarditis, their role in vegetation formation depending on bacterial species, and investigates platelet therapy advancements and future research avenues to understand the mechanistic enigma of bacteria-platelet interaction for preventive and curative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
G. Royer, L. Roisin, V. Demontant, S. Lo, L. Coutte, P. Lim, J. M. Pawlotsky, H. Jacquier, R. Lepeule, C. Rodriguez, P. L. Woerther
Summary: The study found considerable genomic microdiversity in Enterococcus faecalis isolates from patients with infective endocarditis (IE), with deletions of virulence factors and other key genes. Mutations in genes related to cell cycle and metabolism suggest an evolutionary convergence in these isolates. These modifications impact phenotypic heterogeneity, growth, and early biofilm production, potentially allowing adaptation to antibiotic and immune pressures and promoting relapses.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Immunology
Pierre Danneels, Jean Francois Hamel, Lea Picard, Scheherazade Rezig, Pauline Martinet, Aurelien Lorleac'h, Jean Philippe Talarmin, Rodolphe Buzele, Thomas Guimard, Gwenael Le Moal, Julia Brochard-Libois, Aurelie Beaudron, Julien Letheulle, Cyrielle Codde, Rachel Chenouard, David Boutoille, Adrien Lemaignen, Louis Bernard, Vincent Cattoir, Vincent Dubee
Summary: This study investigates the impact of antibiotic regimen on the risk of relapse in Enterococcus faecalis infective endocarditis (EFIE). The results show that cardiac surgery and antibiotic combination are crucial for preventing relapse. The retrospective multicenter study of 279 EFIE patients reveals a relapse rate of 9.3%, with relapses occurring more than 1 year after the initial episode.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Niyati H. Shah, Kathleen A. Shutt, Yohei Doi
Summary: This study compared the efficacy of AC and AG in treating EIE patients, finding no significant difference in 90-day mortality between the two groups. However, adverse events were more common in the AG group, and more patients in the AG cohort needed to switch antibiotic regimens.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Laura Escola-Verge, Nuria Fernandez-Hidalgo, Maria Nieves Larrosa, Ruben Fernandez-Galera, Benito Almirante
Summary: The study showed an increasing prevalence of E. faecalis as a causative agent of infective endocarditis (EFIE) over the past decade, along with clinical changes including older patient age, fewer surgical indications, and a slightly decreased in-hospital mortality rate. Additionally, there was an increase in the percentage of echocardiograms performed in patients with EFMB and EFIE diagnoses. Further investigations into the factors driving these clinical changes in EFIE are warranted.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Medicine, Research & Experimental
Robert Seby, Christine Kim, Mahmoud Khreis, Khaldoun Khreis
Summary: This case report describes a 69-year-old female patient who presented with myocardial infarction symptoms and was diagnosed with infective endocarditis and rectal perforation. Despite treatment, the patient did not survive.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Review
Medicine, General & Internal
Andrea Marino, Antonio Munafo, Aldo Zagami, Manuela Ceccarelli, Rosaria Di Mauro, Giuseppina Cantarella, Renato Bernardini, Giuseppe Nunnari, Bruno Cacopardo
Summary: EFIE is a potentially fatal infectious disease with limited progress in antibiotic therapy, high prevalence of multi-drug resistant strains, and double beta-lactam therapy is considered as a potentially effective treatment method.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Anders Dahl, Vance G. Fowler, Jose M. Miro, Niels E. Bruun
Summary: By including Enterococcus faecalis as a typical endocarditis bacterium regardless of the place of acquisition or the portal of entry, the sensitivity to correctly identify definite endocarditis can be improved from 70% (modified Duke criteria) to 96% (enterococcal adjusted Duke criteria) based on data from a prospective study of 344 patients with E. faecalis bacteremia evaluated with echocardiography.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Chemistry, Medicinal
Salim Manoharadas, Naushad Ahmad, Mohammad Altaf, Abdulwahed Fahad Alrefaei, Basel F. Al-Rayes
Summary: This study evaluated the activity of two engineered enzybiotics against a dual biofilm formed by Staphylococcus aureus and Enterococcus faecalis. The cocktail of proteins showed an additive effect in rapidly disrupting the preformed dual biofilm, resulting in over 90% dispersion within 3 hours of treatment. Furthermore, it effectively reduced bacterial cells embedded in the biofilm matrix by over 90% within the same time frame. This is the first successful use of an engineered enzybiotic cocktail to impede the structural integrity of a dual biofilm.
Review
Microbiology
Jennifer L. L. Adema, Aileen Ahiskali, Madiha Fida, Krutika Mediwala Hornback, Ryan W. W. Stevens, Christina G. G. Rivera
Summary: Infective endocarditis (IE) is a rare but increasingly prevalent disease with high morbidity and mortality. The management of IE has been complicated by dogmas and uncertainties, as well as the introduction of new antimicrobials and novel combinations. This review evaluates contemporary debates in IE treatment pharmacotherapy, including beta-lactam choice in MSSA IE, combination therapies, the use of oral antimicrobials, rifamycins, and long-acting lipoglycopeptides.
Review
Immunology
Theresa M. Fiorito, Megan K. Luther, Penelope H. Dennehy, Kerry L. LaPlante, Kelly L. Matson
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2018)
Letter
Pediatrics
Kerry LaPlante, Marc L. Hutchison, Amy B. St Amand
Article
Pharmacology & Pharmacy
Tristan T. Timbrook, Aisling R. Caffrey, Megan K. Luther, Vrishali Lopes, Kerry L. LaPlante
Article
Immunology
Haley J. Appaneal, Aisling R. Caffrey, Maya Beganovic, Sanja Avramovic, Kerry L. LaPlante
OPEN FORUM INFECTIOUS DISEASES
(2018)
Editorial Material
Infectious Diseases
Kerry LaPlante, Jaclyn Cusumano, Glenn Tillotson
LANCET INFECTIOUS DISEASES
(2018)
Article
Microbiology
Matthew Geriak, Fadi Haddad, Khulood Rizvi, Warren Rose, Ravina Kullar, Kerry LaPlante, Marie Yu, Logan Vasina, Krista Ouellette, Marcus Zervos, Victor Nizet, George Sakoulas
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Letter
Immunology
Maya Beganovic, Megan K. Luther, Louis B. Rice, Cesar A. Arias, Michael J. Rybak, Kerry L. LaPlante
CLINICAL INFECTIOUS DISEASES
(2019)
Article
Infectious Diseases
Maya Beganovic, Megan K. Luther, Kathryn E. Daffinee, Kerry L. LaPlante
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2019)
Article
Public, Environmental & Occupational Health
Aisling R. Caffrey, Zachary R. Babcock, Vrishali V. Lopes, Tristan T. Timbrook, Kerry L. LaPlante
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2019)
Article
Pharmacology & Pharmacy
Haley J. Appaneal, Aisling R. Caffrey, Maya Beganovic, Sanja Avramovic, Kerry L. LaPlante
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2019)
Article
Infectious Diseases
Jaclyn A. Cusumano, Aisling R. Caffrey, Kathryn E. Daffinee, Megan K. Luther, Vrishali Lopes, Kerry L. LaPlante
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2019)
Review
Geriatrics & Gerontology
Christian M. Gill, Maria-Stephanie A. Hughes, Kerry L. LaPlante
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2020)
Article
Geriatrics & Gerontology
Maria-Stephanie A. Hughes, David M. Dosa, Aisling R. Caffrey, Haley J. Appaneal, Robin L. P. Jump, Vrishali Lopes, Kerry L. LaPlante
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2020)
Article
Geriatrics & Gerontology
Haley J. Appaneal, Aisling R. Caffrey, Maria-Stephanie A. Hughes, Vrishali V. Lopes, Robin L. P. Jump, Kerry L. LaPlante, David M. Dosa
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2020)
Article
Pharmacology & Pharmacy
Haley J. Appaneal, Megan K. Luther, Tristan T. Timbrook, Kerry L. LaPlante, David M. Dosa