Article
Endocrinology & Metabolism
Nikolaus Hommer, Martin Kallab, Andreas Schlatter, Kinga Howorka, Rene M. Werkmeister, Doreen Schmidl, Leopold Schmetterer, Gerhard Garhoefer
Summary: The aim of this study is to assess the retinal oxygen metabolism in patients with type 2 diabetes and different stages of nonproliferative diabetic retinopathy. The results indicate that retinal oxygen metabolism is altered in patients with type 2 diabetes and retinal oxygen extraction decreases with increasing severity of DR.
Article
Ophthalmology
Stuart K. Gardiner, Grant Cull, Brad Fortune
Summary: Higher retinal vascular resistance, indicating stiffer retinal vessels, is associated with faster functional loss in glaucoma. This finding suggests that tissue stiffening plays a role in glaucomatous damage.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Chih-Yu Chen, Kuo-meng Liao, Sheng-Hung Wang, Su-Chiu Chen, Chen-Jung Chang, Tien-Chung Wang, Gin-Chung Wang
Summary: This study aimed to investigate whether radial pressure wave analysis can non-invasively screen for women's risk of type 2 diabetes. The results showed that the first five harmonic components of the radial pressure wave were significantly different between women with and without type 2 diabetes. Logistic regression analysis revealed associations between type 2 diabetes and C1, C2, and C3. ROC analysis demonstrated that pulse spectrum analysis can accurately predict women's risk of type 2 diabetes.
Article
Ophthalmology
Sangeetha Srinivasan, Sobha Sivaprasad, Ramachandran Rajalakshmi, Ranjit Mohan Anjana, Rayaz A. Malik, Vaitheeswaran Kulothungan, Rajiv Raman, Muna Bhende
Summary: This study revealed that retinal and visual functional changes are present in diabetic patients even without DR, and these changes are correlated with subclinical retinal structural alterations detectable through multimodal imaging.
Article
Nutrition & Dietetics
Allison M. Hodge, Md Nazmul Karim, James R. Hebert, Nitin Shivappa, Barbora de Courten
Summary: The study found that dietary inflammatory index and Alternative Healthy Eating Index-2010 were positively associated with diabetes incidence, while Mediterranean Diet Score was not. Mediation analysis indicated that body size played a moderate to large mediating role in the association between AHEI and DII and incident diabetes.
Review
Physiology
Ann-Katrin Grotle, Jasdeep Kaur, Audrey J. Stone, Paul J. Fadel
Summary: Type 2 diabetes may impair circulation adjustment during exercise, leading to amplified blood pressure, reduced skeletal muscle blood flow, and an overactive sympathetic nervous system. This could result in neurovascular dysregulation during exercise.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Robert Arnar Karlsson, Olof Birna Olafsdottir, Vedis Helgadottir, Soumaya Belhadj, Thorunn Scheving Eliasdottir, Einar Stefansson, Sveinn Hakon Hardarson
Summary: Automated measurements of retinal oximetry values are more repeatable compared to measurements where vessels are selected manually, with higher ICC values for the automated version than the semiautomatic version.
Article
Endocrinology & Metabolism
Frederik Pagh Bredahl Kristensen, Diana Hedevang Christensen, Brian Christopher Callaghan, Jacob Volmer Stidsen, Jens Steen Nielsen, Kurt Hojlund, Henning Beck-Nielsen, Troels Staehelin Jensen, Henning Andersen, Peter Vestergaard, Niels Jessen, Michael Hecht Olsen, Torben Hansen, Charlotte Brons, Allan Vaag, Henrik Toft Sorensen, Reimar Wernich Thomsen
Summary: This study investigated the prevalence of diabetic polyneuropathy (DPN) in three subgroups of type 2 diabetes mellitus (T2DM) patients based on β-cell function and insulin sensitivity. The results showed that patients with hyperinsulinemia had the highest prevalence of DPN (23%), while patients with low insulin sensitivity had the lowest prevalence (14%). Therefore, hyperinsulinemia may be an important risk factor for DPN.
Article
Biology
Madhuri Rudraraju, S. Priya Narayanan, Payaningal R. Somanath
Summary: High blood sugar and infection mediators have different effects on the blood-retinal barrier, which may lead to ocular diseases.
Article
Multidisciplinary Sciences
Harumasa Yokota, Taiji Nagaoka, Hidetaka Noma, Akemi Ofusa, Tomoe Kanemaki, Hiroshi Aso, Hirotsugu Hanazaki, Satoru Yamagami, Masahiko Shimura
Summary: In this study, it was found that total retinal blood flow did not significantly differ between eyes with macula-on and macula-off rhegmatogenous retinal detachment (RRD) at 3 and 6 months postoperatively. However, in macula-off RRD cases, there was a continued significant decrease in retinal blood flow 6 months after surgery. Additionally, levels of soluble intercellular adhesion molecule-1 (sICAM-1) were negatively correlated with relative retinal blood flow in macula-on RRD before surgery and significantly correlated with retinal blood flow in macula-off RRD 6 months postoperatively. This suggests that ICAM-1 may play a role in the worsening of retinal circulation caused by RRD.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Serra Ucer Ozgurel, Elizabeth A. Swallow, Corinne E. Metzger, Matthew R. Allen
Summary: This study investigates the changes in bone perfusion and its relationship with changes in bone mass in a mouse model of type 1 diabetes. The results show that femoral blood flow and VEGF-A expression in the cortical bone shafts are lower in type 1 diabetic mice compared to healthy controls, consistent with changes in bone mass. These findings suggest a possible association between reduced skeletal perfusion and reduced bone mass in the context of type 1 diabetes.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Spectroscopy
Mohammad Ezati, Fahimeh Ghavamipour, Hadi Adibi, Khadijeh Pouraghajan, Seyed Shahriar Arab, Reza H. Sajedi, Reza Khodarahmi
Summary: Curcumin has an important role in preventing various diseases, including diabetes. In this study, curcumin-fused aldohexose derivatives were synthesized and found to inhibit two enzymes related to hyperglycemia. Spectral analysis confirmed the formation of the target compounds. In vivo studies showed that one of the compounds could lower blood glucose levels in rats.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Cardiac & Cardiovascular Systems
Doyeon Hwang, Jinlong Zhang, Joo Myung Lee, Joon-Hyung Doh, Chang-Wook Nam, Eun-Seok Shin, Masahiro Hoshino, Tadashi Murai, Taishi Yonetsu, Hernan Mejia-Renteria, Tsunekazu Kakuta, Javier Escaned, Bon-Kwon Koo
Summary: This study found that in patients with deferred coronary revascularization, those with diabetes mellitus had a higher risk of patient-oriented composite outcome (POCO) compared to those without diabetes. Among diabetic patients, the low coronary flow reserve (CFR) group had a higher risk of POCO, while CFR values could not differentiate POCO risk in non-diabetic patients. Independent predictors of POCO in diabetic patients were low CFR and family history of coronary artery disease, while in non-diabetic patients were percent diameter stenosis and multivessel disease.
REVISTA ESPANOLA DE CARDIOLOGIA
(2021)
Article
Endocrinology & Metabolism
Alisa D. Kjaergaard, Jesse Krakauer, Nir Krakauer, Alexander Teumer, Thomas W. Winkler, Christina Ellervik
Summary: This study used two-sample Mendelian randomization analysis to examine the association between BMI-independent allometric body shape indices and kidney function. The results showed that genetically high ABSI and WHI levels were associated with higher urinary albumin-to-creatinine ratio (UACR) in women, while genetically high HI levels were associated with lower UACR in both men and women. The risk of type 2 diabetes (T2D) was also affected by these body shape indices. A score of 8 out of 10 is given for the importance of this study.
DIABETES OBESITY & METABOLISM
(2023)
Article
Biochemical Research Methods
Kaiyuan Liu, Tiepei Zhu, Mengqin Gao, Xiaoting Yin, Rong Zheng, Yan Yan, Lei Gao, Zhihua Ding, Juan Ye, Peng Li
Summary: Altered retinal neurovascular coupling may contribute to the development and progression of diabetic retinopathy (DR) but is challenging to measure. This study presents a novel modality of functional OCT angiography (fOCTA) for 3D imaging of retinal functional hyperemia with high resolution. The results show that retinal capillary functional hyperemia could serve as sensitive biomarkers for early DR, and the fOCTA technique provides new insights into the pathophysiology, screening, and treatment of early DR.
BIOMEDICAL OPTICS EXPRESS
(2023)
