Article
Biochemistry & Molecular Biology
Jordan K. Vance, Travis W. Rawson, Jessica M. Povroznik, Kathleen M. Brundage, Cory M. Robinson
Summary: Neonates have an increased risk of infectious diseases, partly due to the abundance and dynamic activity of myeloid-derived suppressor cells (MDSCs) during an infection. These MDSCs modulate gene expression and exhibit variable effector responses to pathogen-associated molecular patterns (PAMPS) on bacteria like E. coli, ultimately leading to enhanced immune suppression and inhibition of protective immunity in early life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Defne Bayik, Cynthia F. Bartels, Katreya Lovrenert, Dionysios C. Watson, Duo Zhang, Kristen Kay, Juyeun Lee, Adam Lauko, Sadie Johnson, Alice Lo, Daniel J. Silver, Mary McGraw, Matthew Grabowski, Alireza M. Mohammadi, Filippo Veglia, Yi Fan, Michael A. Vogelbaum, Peter Scacheri, Justin D. Lathia
Summary: The study revealed that the enhanced cell adhesion ability of mMDSC in the GBM microenvironment is linked to tumor promotion, and targeting Integrin (31) and DPP-4 to interfere with mMDSC may be an effective way to alleviate immune suppression driven by myeloid cells in GBM.
Article
Critical Care Medicine
Dijoia B. Darden, Rhonda Bacher, Maigan A. Brusko, Parker Knight, Russell B. Hawkins, Michael C. Cox, Marvin L. Dirain, Ricardo Ungaro, Dina C. Nacionales, Jaimar C. Rincon, Marie-Pierre L. Gauthier, Michael Kladde, Azra Bihorac, Todd M. Brusko, Frederick A. Moore, Scott C. Brakenridge, Alicia M. Mohr, Lyle L. Moldawer, Philip A. Efron
Summary: This pilot study successfully identified MDSC subsets in septic patients and found a relative expansion of G-MDSCs at 21 days. Genomic analysis revealed cell-specific and common differential expression of genes in MDSC subsets between septic patients and control subjects.
Review
Immunology
Claudia Giannotta, Federica Autino, Massimo Massaia
Summary: Myeloid derived suppressor cells (MDSC) have significant roles in regulating immune homeostasis and immune responses, especially in cancer. MDSC interact with cancer cells in the tumor microenvironment through various mechanisms such as producing soluble factors, expressing inhibitory molecules, rewiring metabolism, and releasing exosomes. The relationship between MDSC and tumor cells leads to immune evasion and cancer growth. In multiple myeloma (MM), MDSC play a major role in creating a tumor-promoting microenvironment. This minireview discusses the interplay between MDSC and MM microenvironment, as well as potential strategies to target MDSC.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Julian Swatler, Laura Turos-Korgul, Ewa Kozlowska, Katarzyna Piwocka
Summary: Effector immune system cells have the ability to kill tumor cells, but they are inhibited and evaded as myeloid leukemias develop. Factors such as inhibitory receptors, enzymes and suppressive immune cells contribute to the immunosuppressive microenvironment. Changes in immunosuppressive features during therapy include modulation of cytotoxic cells, promotion of regulatory T cells and suppressive myeloid cells, and spreading of leukemic blasts. Treatment modalities such as tyrosine kinase inhibitors and chemotherapy aim to restore effector immunity in myeloid leukemias.
Article
Immunology
Bo Li, Min Lian, Yikang Li, Qiwei Qian, Jun Zhang, Qiaoyan Liu, Ruqi Tang, Xiong Ma
Summary: The study found that upregulation of LXR alpha in patients with autoimmune hepatitis can promote the expansion of MDSCs and alleviate hepatic injury. By downregulating IRF-8, LXR alpha plays an important role in MDSCs, providing a new approach to treating AIH.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Zhaonian Hao, Ruyuan Li, Yuanyuan Wang, Shuangying Li, Zhenya Hong, Zhiqiang Han
Summary: MDSC play vital roles in cancer microenvironment, influencing the responses to immunotherapies and prognosis of cancer patients. Therefore, proposing MDSC-inhibiting strategies becomes crucial in the field of cancer immunotherapies.
BIOMARKER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Kevin Alicea-Torres, Emilio Sanseviero, Jun Gui, Jinyun Chen, Filippo Veglia, Qiujin Yu, Laxminarasimha Donthireddy, Andrew Kossenkov, Cindy Lin, Shuyu Fu, Charles Mulligan, Brian Nam, Gregory Masters, Fred Denstman, Joseph Bennett, Neil Hockstein, Agnieszka Rynda-Apple, Yulia Nefedova, Serge Y. Fuchs, Dmitry Gabrilovich
Summary: Type I interferon receptor signaling serves as a universal mechanism restricting MDSC suppressive activity, with downregulation of IFNAR1 required for activation of immune suppressive properties in MDSC. Modulating IFNAR1 undermines MDSC suppressive activity and has potent anti-tumor effects.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Ellis Tibbs, Xuefang Cao
Summary: This paper addresses the controversy surrounding the expression of GzmB by murine MDSCs. The authors conducted experiments to investigate this question and found that MDSCs under stringent developmental processes do not express GzmB. Additionally, the GzmB protein detected in the MDSC culture was attributed to T cells or natural killer cells present in the bone marrow culture. The authors further strengthened their findings by genetically deleting GzmB from the myeloid lineage and assessing tumor burden, finding no significant difference compared to the control group. Therefore, this paper proposes alternative theories that align with the known understanding of GzmB expression and secretion.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Review
Immunology
Ioana Plesca, Luise Mueller, Jan P. Boettcher, Hind Medyouf, Rebekka Wehner, Marc Schmitz
Summary: Dendritic cells (DCs) are crucial in orchestrating anti-tumor immunity, capable of producing proinflammatory cytokines, initiating T-cell responses, and exhibiting direct cytotoxicity against tumor cells. The functionality of DCs depends on intrinsic properties and the tumor microenvironment, with immunogenic DCs promoting tumor elimination and tolerogenic DCs fostering tumor progression.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Clinical Neurology
Claudia Cantoni, Laura Ghezzi, Jasmine Choi, Anne H. Cross, Laura Piccio
Summary: MiR-223 may be a therapeutic target for enhancing the immunosuppressive activities of MDSCs in MS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Immunology
Tianju Liu, Francina Gonzalez De Los Santos, Andrew E. Rinke, Chuling Fang, Kevin R. Flaherty, Sem H. Phan
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease without effective therapy. This study investigated the role of myeloid-derived suppressor cells (MDSCs) expressing B7H3 in IPF. The expansion of MDSCs correlated with disease severity in IPF patients. B7H3-mediated MDSCs activated lung fibroblasts and myofibroblast differentiation, and also suppressed T-cell proliferation. Inhibition of MDSC recruitment with anti-B7H3 antibodies reduced inflammation and fibrosis in a mouse model of pulmonary fibrosis. These findings suggest that MDSCs and B7H3 may play a significant role in the progression of IPF and could be potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yoshiaki Nagatani, Yohei Funakoshi, Hirotaka Suto, Yoshinori Imamura, Masanori Toyoda, Naomi Kiyota, Kimihiro Yamashita, Hironobu Minami
Summary: MDSC are divided into M-MDSC, G-MDSC, and I-MDSC subsets, with M-MDSC and G-MDSC suppressing T cell activation while I-MDSC has no suppressive effect. High levels of IL-1RA and arginase were detected in M-MDSC and G-MDSC cultures, with no inhibitory molecules found in I-MDSC cultures. The population of functional MDSC was significantly increased in cancer patients compared to healthy donors.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Article
Immunology
Giuseppe Bronte, Alberto Verlicchi, Serena De Matteis, Alice Rossi, Alessandra Affatato, Francesco Giulio Sullo, Caterina Gianni, Matteo Canale, Marco Angelo Burgio, Angelo Delmonte, Michele Milella, Lucio Crino
Summary: Immune checkpoint inhibition has shown significant progress in treating non-small cell lung cancer patients, though resistance mechanisms like myeloid-derived suppressor cells and exhausted immune cells may limit effectiveness. Analyzing changes in immune cell subsets and disease progression during treatment could offer insights for developing new targets or biomarkers for cancer immunotherapy resistance.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Galina Gabriely, Duanduan Ma, Shafiuddin Siddiqui, Linqing Sun, Nathaniel P. Skillin, Hadi Abou-El-Hassan, Thais G. Moreira, Dustin Donnelly, Andre P. da Cunha, Mai Fujiwara, Lena R. Walton, Amee Patel, Rajesh Krishnan, Stuart S. Levine, Brian C. Healy, Rafael M. Rezende, Gopal Murugaiyan, Howard L. Weiner
Summary: Myeloid suppressor cells expressing LAP on their surface promote tumor growth by stimulating Tregs and inhibiting effector T cells. Blocking TGF-beta can reduce the tolerogenic ability of these cells, leading to slower cancer progression. Additionally, single-cell RNA-Seq analysis reveals distinct immunosuppressive cell subsets with high levels of MHCII and PD-L1 genes. This study provides new insights into the role of LAP(Hi) MCs in tumor growth and potential therapeutic targets for cancer treatment.
Article
Multidisciplinary Sciences
Anna Wrobeln, Tristan Leu, Jadwiga Jablonska, Urban Geisthoff, Stephan Lang, Joachim Fandrey, Freya Droege
Summary: Patients with hereditary haemorrhagic telangiectasia (HHT) suffer from abnormal vessel structures, leading to vessel hemorrhage and shunt effects. This study found significantly decreased expression of HIF-1 alpha in HHT patients, with no effect on the known upstream regulators of HIF-1 alpha. The results highlight the importance of HIF in HHT and suggest an interaction between the known HHT mutation and HIF-1 alpha dysregulation in HHT patients.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Johannes Doescher, Moritz Meyer, Christoph Arolt, Alexander Quaas, Jens Peter Klussmann, Philipp Wolber, Agnes Bankfalvi, Hans-Ulrich Schildhaus, Tobias Bastian, Stephan Lang, Simon Laban, Patrick J. Schuler, Cornelia Brunner, Thomas K. Hoffmann, Stephanie E. Weissinger
Summary: Adenoid cystic carcinoma (ACC) is a rare tumor with late occurring metastases and recurrences. The lack of effective treatment in the palliative situation and unsuccessful trials on immunotherapeutic drugs show the need for prognostic markers and understanding the reasons for the lack of response to immunotherapy. The study found that ACC is not recognized by infiltrating immune cells, suggesting the need for other methods to induce recognition of ACC by the immune system. The low immunogenicity of ACC and the abundance of lymphocytes have no influence on prognosis, explaining the observed lack of response towards immunotherapy.
Article
Cell Biology
Jadwiga Jablonska, Malwina Rist, Ilona Spyra, Luisa Tengler, Maksim Domnich, Benjamin Kansy, Bernd Giebel, Basant Kumar Thakur, Nicole Rotter, Stephan Lang, Sonja Ludwig
Summary: Head and Neck Cancers (HNCs) exhibit highly immunosuppressive properties, and small extracellular vesicles (sEVs) play a role in intercellular communication by carrying immunosuppressive proteins and inhibiting anti-tumor immune responses. This study evaluates immunosuppressive markers on sEVs from HNC patients at different disease stages and follow-up periods. The findings suggest that a combination of immunoregulatory markers should be used to monitor disease progression and therapy response in HNC.
Article
Otorhinolaryngology
L. C. Holtmann, E. Deuss, M. Meyer, F. Kaster, T. Bastian, M. C. Schleupner, E. Hagedorn, S. Lang, D. Arweiler-Harbeck
Summary: This study evaluated the accuracy of using photographs taken by patients to detect skin irritations or complications after cochlear implantation. The results showed that digital evaluators could reliably detect treatment-requiring conditions, indicating that digital photographic assessment could reduce in-person consultations.
COCHLEAR IMPLANTS INTERNATIONAL
(2022)
Article
Otorhinolaryngology
Timon Hussain, Kruthika Thangavelu, Cornelius Kurten, Lisa Galland, Benedikt Hoing, Eric Deuss, Stefan Mattheis, Stephan Lang, Cornelius Deuschl, Michael Forsting, Nils Doerner
Summary: The results show a considerable inaccuracy of clinical neck staging in all OPSCC patients, and these findings need to be taken into consideration during therapy planning. For p16-positive patients, these findings warrant attention in the context of therapy deintensification.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Cell Biology
Ekaterina Pylaeva, Georg Korschunow, Ilona Spyra, Sharareh Bordbari, Elena Siakaeva, Irem Ozel, Maksim Domnich, Anthony Squire, Anja Hasenberg, Kruthika Thangavelu, Timon Hussain, Moritz Goetz, Karl S. Lang, Matthias Gunzer, Wiebke Hansen, Jan Buer, Agnes Bankfalvi, Stephan Lang, Jadwiga Jablonska
Summary: In this study, researchers found that tumor-associated neutrophils migrate to lymph nodes during head and neck cancer progression and play a dual role in shaping anti-tumor responses. In metastasis-free stages, neutrophils stimulate T cells, while in metastatic stages, they suppress T cell responses. The accumulation of neutrophils in lymph nodes can predict the survival rate of head and neck cancer patients.
Article
Immunology
Timon Hussain, Maksim Domnich, Sharareh Bordbari, Ekaterina Pylaeva, Elena Siakaeva, Ilona Spyra, Irem Ozel, Freya Droege, Anthony Squire, Stefan Lienenklaus, Kathrin Sutter, Anja Hasenberg, Matthias Gunzer, Stephan Lang, Jadwiga Jablonska
Summary: Tumor-draining lymph nodes (TDLNs) are the first organs where metastatic spread of cancer occurs, and myeloid cells such as neutrophils play a crucial role in the activation of effector lymphocytes. The availability of type I interferon (IFN) influences the tumor-supportive or tumor-inhibiting activity of neutrophils. Defective type I IFN signaling leads to an impaired immunoregulatory capacity of neutrophils, resulting in enhanced tumor growth. Stimulation of IFN signaling may provide a therapeutic opportunity in head and neck cancer patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Bara Barakat, Ulrich Gauger, Christian Rehme, Boris Hadaschik, Ingmar Wolff, Sameh Hijazi
Summary: This study evaluated the sensitivity and specificity of pelvic floor ultrasound (PFUS) in the diagnosis of female urethral diverticulum (UD) and compared it with voiding cystourethrogram (VCUG). The results showed that PFUS had higher sensitivity and specificity compared to VCUG, suggesting the use of PFUS as part of a non-invasive diagnostic work-up.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Article
Oncology
YaoYao Pollock, Matthew R. Smith, Fred Saad, Simon Chowdhury, Stephane Oudard, Boris Hadaschik, David Olmos, Ji Youl Lee, Hiroji Uemura, Amitabha Bhaumik, Anil Londhe, Brendan Rooney, Sabine D. Brookman-May, Peter De Porre, Suneel D. Mundle, Eric J. Small
Summary: This study analyzed the risk factors for falls in patients with non-metastatic castration-resistant prostate cancer treated with apalutamide and suggested that clinical management can minimize these risks and improve patient outcomes.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Audiology & Speech-Language Pathology
Laura Christine Holtmann, Amadea Strahlenbach, Stefan Hans, Stephan Lang, Diana Arweiler-Harbeck
Summary: The medial olivocochlear reflex (MOCR) may affect bimodal hearing in some individuals, but it is not observable in all cases. Threshold changes observed in acoustic brainstem response (ABR) measurements were reproducible in a specific subgroup, potentially due to a reactivated MOCR.
AUDIOLOGY AND NEURO-OTOLOGY
(2023)
Review
Oncology
Adam Szeles, Tamas Fazekas, Szilard Vancsa, Melinda Varadi, Petra Terezia Kovacs, Ulrich Krafft, Viktor Gruenwald, Boris Hadaschik, Anita Csizmarik, Peter Hegyi, Alex Varadi, Peter Nyirady, Tibor Szarvas
Summary: Elevated levels of soluble PD-L1 (sPD-L1) are associated with poorer prognosis in cancer patients receiving immune checkpoint inhibitor (ICI) therapy, although this association appears to be tumor type dependent. Additionally, sPD-L1 levels may increase during anti-PD-L1 therapy, but this is therapy specific.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Otorhinolaryngology
Benedikt Hoeing, L. Wittig, L. Weber, B. A. Stuck, S. Mattheis, T. Hussain, S. Lang, J. M. Theysohn, Y. Li, S. Hansen
Summary: This retrospective study aimed to investigate the use of abdominal ultrasound as a staging procedure in head and neck squamous cell carcinoma (HNSCC). Out of 426 patients who received abdominal ultrasound, 7% were suspected of metastasis, with the majority being liver masses. The study found that abdominal ultrasound had a negative predictive value of 99.03% and a positive predictive value of 5.88% in HNSCC patients with N2/N3 cervical lymph node status.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Eric Deuss, Saskia Schieder, Stephan Lang, Stefan Mattheis, Orlando Guntinas-Lichius, Moritz Friedo Meyer
Summary: This survey aimed to assess the diagnostic workup and therapeutic strategies for salivary gland diseases in German otorhinolaryngology departments. The results showed diversity in the diagnosis and treatment methods, with variations in different locations.
Article
Public, Environmental & Occupational Health
Daniel Maier, Joerg Janne Vehreschild, Barbara Uhl, Sandra Meyer, Karin Berger-Thuermel, Melanie Boerries, Rickmer Braren, Viktor Gruenwald, Boris Hadaschik, Stefan Palm, Susanne Singer, Martin Stuschke, David Juarez, Pierre Delpy, Mohamed Lambarki, Michael Hummel, Caecilia Engels, Stefanie Andreas, Nicola Goekbuget, Kristina Ihrig, Susen Burock, Dietmar Keune, Angelika Eggert, Ulrich Keilholz, Hagen Schulz, Daniel Buettner, Steffen Loeck, Mechthild Krause, Mirko Esins, Frank Ressing, Martin Schuler, Christian Brandts, Daniel P. Brucker, Gabriele Husmann, Thomas Oellerich, Patrick Metzger, Frederik Voigt, Anna L. Illert, Matthias Theobald, Thomas Kindler, Ursula Sudhof, Achim Reckmann, Felix Schwinghammer, Daniel Nasseh, Wilko Weichert, Michael von Bergwelt-Baildon, Michael Bitzer, Nisar Malek, Oeznur Oener, Klaus Schulze-Osthoff, Stefan Bartels, Joerg Haier, Raimund Ammann, Anja Franziska Schmidt, Bernd Guenther, Melanie Janning, Bernd Kasper, Sonja Loges, Stephan Stilgenbauer, Peter Kuhn, Eugen Tausch, Silvana Runow, Alexander Kerscher, Michael Neumann, Martin Breu, Martin Lablans, Hubert Serve
Summary: The Clinical Communication Platform of the German Cancer Consortium is a potential catalyst for translational cancer research, providing comprehensive patient groups and improving understanding of the clinical course of various malignancies. It serves as a decision-making tool for clinical trial design and contributes to the evaluation of scientific findings in real-world conditions.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrei Gafita, Loic Djaileb, Isabel Rauscher, Wolfgang P. Fendler, Boris Hadaschik, Steven P. Rowe, Ken Herrmann, Jeremie Calais, Matthew Rettig, Matthias Eiber, Manuel Weber, Matthias R. Benz, Andrea Farolfi
Summary: This study assessed the agreement between RECIP determined quantitatively using tumor segmentation software and qualitatively by nuclear medicine physicians. The results showed excellent agreement and reliability between the two methods, indicating that qualitatively assessed RECIP can be readily implemented in clinical practice for response evaluation in men with metastatic castration-resistant prostate cancer.