Review
Biochemistry & Molecular Biology
Wiebke Kallenborn-Gerhardt, Katrin Schroeder, Achim Schmidtko
Summary: This article investigates the impact of oxidative stress on chronic pain, finding that reactive oxygen species (ROS) play a specific role in signaling during chronic inflammatory and neuropathic pain. The Nox family members Nox1, Nox2, and Nox4 have been found to contribute to distinct signaling pathways in the nociceptive system. Thus, targeting Nox1, Nox2, and/or Nox4 could be a novel strategy for treating chronic pain.
Article
Biochemistry & Molecular Biology
Gregory E. Conner
Summary: The redox status of cells is crucial for cellular activities; H2O2 metabolism regulates the redox status by modifying protein cysteine oxidation; Calcium-stimulated epithelial Duox H2O2 synthesis is transient and prevents harmful changes in redox tone following continuous stimulation.
Review
Cell Biology
Timothy Fabisiak, Manisha Patel
Summary: Neuroinflammation and oxidative stress play important roles in the pathophysiology of epilepsy. They have significant crosstalk and influence each other through various mechanisms, affecting epileptic processes and disease outcomes. Treatment strategies targeting oxidative stress and redox regulation may help control neuroinflammation and improve patient outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hannah Mason, Ganesha Rai, Arina Kozyr, Nathaniel De Jonge, Emily Gliniewicz, Lars J. Berg, Gal Wald, Cayce Dorrier, Mark J. Henderson, Alexey Zakharov, Tristan Dyson, John Audley, Anthony M. Pettinato, Elias Carvalho Padilha, Pranav Shah, Xin Xu, Thomas L. Leto, Anton Simeonov, Kol A. Zarember, Dorian B. McGavern, John I. Gallin
Summary: NADPH oxidases (NOX's) and the reactive oxygen species (ROS) they produce are involved in various physiological processes, but excessive ROS production is associated with several diseases. In this study, a small molecule inhibitor, NCATS-SM7270, was developed and shown to specifically inhibit NOX2 activity in human and mouse granulocytes. The role of different NOX isoforms in mild traumatic brain injury (mTBI) was investigated, and it was found that NOX2 deficiency provided protection against mTBI pathology, while NOX4 deficiency exacerbated the injury. Treatment of mice with NCATS-SM7270 after mTBI reduced cortical cell death in a dose-dependent manner, and also partially reversed cortical damage in NOX4-deficient mice. These findings highlight the potential of NCATS-SM7270 as a specific inhibitor of NOX2 in protecting against NOX2-dependent cell death in mTBI.
Article
Biochemistry & Molecular Biology
Renato Simoes Gaspar, Plinio M. Ferreira, Joanne L. Mitchell, Giordano Pula, Jonathan M. Gibbins
Summary: The study shows that PDEVs contain Nox-1 and can induce platelet activation through Nox1-mediated superoxide generation. Inhibition of Nox-1 eliminates PDEV-mediated platelet activation.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Jeeshan Singh, Michael Boettcher, Maximilian Doelling, Annika Heuer, Bettina Hohberger, Moritz Leppkes, Elisabeth Naschberger, Mirco Schapher, Christine Schauer, Janina Schoen, Michael Stuerzl, Ljubomir Vitkov, Han Wang, Leticija Zlatar, Georg A. Schett, David S. Pisetsky, Ming-Lin Liu, Martin Herrmann, Jasmin Knopf
Summary: Extracellular chromatin, particularly in the form of NETs, plays a crucial role in the progression of various diseases. It functions as a driver of the interferon system, autoantigen, and scaffold for innate immune system proteins. Insufficient clearance of extruded chromatin can contribute to immune-inflammatory and occlusive disorders. This article discusses the cellular events involved in extracellular chromatin release and NET formation, the negative consequences of dysregulated NET formation, and the imbalance between NET formation and clearance. It also explores the role of NET formation in various diseases and injuries, highlighting the importance of targeting chromatin decondensation pathways and promoting extracellular chromatin clearance for effective therapies.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Stephenson B. Owusu, Elodie Hudik, Celine Ferard, Sophie Dupre-Crochet, Eric C. D. K. Addison, Kwasi Preko, Tania Bizouarn, Chantal Houee-Levin, Laura Baciou
Summary: Simulating oxidative stress with gamma irradiation leads to shortened half-lives of neutrophils but pre-activates surviving cells to produce superoxide anions. Incomplete assembly of the NADPH oxidase complex after irradiation significantly enhances neutrophil reactivity.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Immunology
Yafei Yuan, Wei Wang, Yue Zhang, Qiaohui Hong, Wenhui Huang, Lijuan Li, Zhanzhan Xie, Yixin Chen, Xu Li, Ying Meng
Summary: Apelin-13 protects against LPS-induced inflammatory responses and ALI by regulating PFKFB3-driven glycolysis induced by NOX4-dependent ROS.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Rana M. Nassif, Elias Chalhoub, Pia Chedid, Margarita Hurtado-Nedelec, Elia Raya, Pham My-Chan Dang, Jean-Claude Marie, Jamel El-Benna
Summary: Metformin exhibits anti-inflammatory effects by inhibiting the differentiation of human monocytes into proinflammatory macrophages and by limiting ROS production by macrophages via the activation of AMPK.
Review
Pharmacology & Pharmacy
Huamei Forsman, Claes Dahlgren, Jonas Martensson, Lena Bjorkman, Martina Sundqvist
Summary: Human neutrophils, as professional phagocytes, express several G protein-coupled receptors (GPCRs) that are essential for their functions. Recently, the FFA receptors, GPR84 and FFA2, have attracted attention for their involvement in neutrophil activation. This review summarizes the current understanding of how GPR84 affects human neutrophil functions and discusses the regulatory mechanisms, comparing them to the two FPRs and FFA2.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yilong Hao, Tao Ren, Xiaoke Huang, Mi Li, Jong-Ho Lee, Qianming Chen, Rui Liu, Qingfeng Tang
Summary: Exposure to ionizing radiation leads to oxidative damages in living cells. The pentose phosphate pathway (PPP) is the major route to produce NADPH in mammalian cells, and G6PD is the rate-limiting step of PPP. However, whether G6PD is timely co-opted under ionizing radiation to cope with oxidative stress remains elusive.
Article
Biochemistry & Molecular Biology
Renato Simoes Gaspar, Tanya Sage, Gemma Little, Neline Kriek, Giordano Pula, Jonathan M. Gibbins
Summary: This study demonstrates that PDI and Nox-1 cooperate to control platelet function and are associated with cardiometabolic risk factors.
Review
Biochemistry & Molecular Biology
Caspar Schiffers, Niki L. Reynaert, Emiel F. M. Wouters, Albert van der Vliet
Summary: With the aging population, the incidence of age-related lung diseases like COPD is increasing, although antioxidant supplementation strategies have had limited success in mitigating disease progression. Reactive oxygen species are believed to play a crucial role in aging, and the role of NADPH oxidase enzymes in age-related lung diseases remains largely unexplored.
Article
Biochemistry & Molecular Biology
Giulia K. Buchmann, Christoph Schuermann, Manuela Spaeth, Wesley Abplanalp, Lukas Tombor, David John, Timothy Warwick, Flavia Rezende, Andreas Weigert, Ajay M. Shah, Martin-Leo Hansmann, Norbert Weissmann, Stefanie Dimmeler, Katrin Schroeder, Ralf P. Brandes
Summary: Genetic deletion of Nox4 did not affect neointima formation in the mouse carotid artery injury model, likely due to the low expression of Nox4 in proliferating de-differentiated smooth muscle cells within the neointima.
Article
Biochemistry & Molecular Biology
Honghong Zhan, Qingxiu Pu, Xiaoliang Long, Wei Lu, Guowei Wang, Fancheng Meng, Zhihua Liao, Xiaozhong Lan, Min Chen
Summary: The extract of Oxybaphus himalaicus showed significant anti-inflammatory activity by inhibiting the formation of Toll-like receptor 4/myeloid differentiation factor 2 (TLR4/MD2) complex. It alleviated lipopolysaccharide (LPS)-induced acute kidney injury (AKI) in mice. The study also identified 41 components in the extract using UPLC-MS/MS analysis.
Review
Biochemistry & Molecular Biology
Masoud Najafi, Shima Tavakol, Ali Zarrabi, Milad Ashrafizadeh
Summary: Chemotherapy is an important treatment for cancer, but the resistance of cancer cells reduces its effectiveness. Quercetin, a flavonoid compound with high anti-tumour activity, can be used with cisplatin to enhance the efficacy of chemotherapy and reduce its side effects.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Clinical Neurology
Abolhasan Rezaeyan, Somayeh Asadi, S. Kamran Kamrava, Samideh Khoei, Arash Zare-Sadeghi
Summary: This study investigates the effects of olfactory training on olfactory function and brain structure in patients with post-traumatic olfactory dysfunction (PTOD). The results show that both classical olfactory training and modified olfactory training can improve olfactory function, and the improvement is associated with changes in the structure of olfactory processing areas in the brain.
JOURNAL OF NEURORADIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hossein Moutabian, Ruhollah Ghahramani-Asl, Tohid Mortezazadeh, Reza Laripour, Asghar Narmani, Hamed Zamani, Gholamreza Ataei, Hamed Bagheri, Bagher Farhood, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: Nano-curcumin can alleviate doxorubicin-induced cardiotoxicity and improve treatment efficacy.
Review
Immunology
Run Yang, Changming Tan, Masoud Najafi
Summary: Cardiovascular disorders are a major concern among individuals undergoing cancer therapy, with heart diseases being a common cause of mortality in these patients. Inflammatory changes and fibrosis are key mechanisms of cardiac diseases following chemotherapy and radiotherapy. Chronic oxidative stress, cell death, and overproduction of pro-inflammatory and pro-fibrosis cytokines are the underlying mechanisms of cardiovascular diseases following cancer therapy.
INFLAMMOPHARMACOLOGY
(2022)
Review
Cell Biology
Zihong Wu, Caidie Zhang, Masoud Najafi
Summary: This article discusses the interaction between anti-tumor immune cells and immunosuppressive cells in the tumor microenvironment, as well as the modulating effects of metformin on various cells and secretions in TME.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2022)
Review
Biochemistry & Molecular Biology
Jun Huang, Zaoshang Chang, Quzhe Lu, Xuedong Chen, Masoud Najafi
Summary: Cancer resistance to therapy is a significant challenge in cancer treatment, involving reduced induction of cell death and decreased response to anti-tumor immunity. Nobiletin can induce endogenous ROS generation, leading to damage to critical macromolecules and ultimately cell death. Additionally, NOB can induce cancer cell killing by modulating multiple mechanisms of cell death.
Article
Immunology
Ding-Li Yu, Zhi-Ping Lou, Feng-Yun Ma, Masoud Najafi
Summary: Interactions within the tumour microenvironment (TME) play a crucial role in cancer therapy. Paclitaxel, a commonly used chemotherapy drug, not only inhibits cell cycle but also modulates interactions in TME to suppress tumour growth. This review discusses the effects of paclitaxel on anti-tumour immunity, immunosuppressive cells, hypoxia, and angiogenesis, and suggests targeting these interactions to improve therapy efficiency.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Peyman Amini, Saeedeh Jafari Nodooshan, Milad Ashrafizadeh, Akbar Aliasgharzadeh, Zarichehr Vakili, Saeed Tavakoli, Tayebeh Aryafar, Ahmed Eleojo Musa, Masoud Najafi, Shahram Taeb, Bagher Farhood
Summary: In this study, imperatorin (IMP) was found to enhance the effectiveness of external radiotherapy (ERT) and hyperthermia (HT) in breast cancer cells by increasing the expression of pro-apoptotic genes and reducing the levels of the anti-apoptotic protein Bcl-2, leading to a decrease in cell viability.
CURRENT RADIOPHARMACEUTICALS
(2022)
Review
Biochemistry & Molecular Biology
Shuang Zhao, Yufei Tang, Ruohan Wang, Masoud Najafi
Summary: This article focuses on the cell death mechanisms induced by paclitaxel, a chemotherapy drug, in cancer treatment and the resistance of cancer cells to paclitaxel. The study found that paclitaxel can induce apoptosis and mitotic catastrophe, as well as other cell death mechanisms, and it can also lead to drug resistance. The article also discusses the use of combination therapies to overcome drug resistance.
Article
Immunology
Masoud Moslehi, Reza Moazamiyanfar, Mohammad Sedigh Dakkali, Sepideh Rezaei, Nima Rastegar-Pouyani, Emad Jafarzadeh, Kave Mouludi, Ehsan Khodamoradi, Shahram Taeb, Masoud Najafi
Summary: The immune system plays a crucial role in the response of cancer cells to anti-cancer agents, as well as the side effects on normal tissues. Modulating immune responses can enhance the effectiveness of anti-tumor therapy and reduce normal tissue toxicity. Melatonin has shown promise in modulating tumor response and alleviating normal tissue toxicity. This review focuses on the immunomodulatory effects of melatonin in both tumor and normal tissues.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Cell Biology
Xiao-yu Wu, Wen-Wen Xu, Xiang-kun Huan, Guan-nan Wu, Gang Li, Yu-Hong Zhou, Masoud Najafi
Summary: Resistance of cancer cells to anti-tumour agents is a major challenge in cancer treatment. Metformin, an antidiabetic drug, can enhance cell death mechanisms and play a key role in inducing cell death, thereby increasing the therapeutic efficiency of anti-cancer therapy.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Masoud Moslehi, Sepideh Rezaei, Pourya Talebzadeh, Mohammad Javed Ansari, Mohammed Abed Jawad, Abduladheem Turki Jalil, Nima Rastegar-Pouyani, Emad Jafarzadeh, Shahram Taeb, Masoud Najafi
Summary: The incidence of cancer is increasing globally. The long-term adverse effects of cancer therapy and tumor resistance to anticancer agents are major concerns. Apigenin, a plant-derived molecule, has potential as an adjuvant for chemoprevention and overcoming malignancy resistance to cancer therapy. It has promising anti-tumor effects and may reduce genomic instability and risks of second malignancies in normal tissues, as well as improve the efficacy of anticancer modalities.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)
Article
Clinical Neurology
Abolhasan Rezaeyan, Somayeh Asadi, S. Kamran Kamrava, Arash Zare-Sadeghi
Summary: This study examines the characteristics of gray matter in post-traumatic anosmia (PTA) patients using surfaced-based morphometry (SBM) and voxel-based morphometry (VBM). The results show that PTA patients have reduced olfactory bulb (OB) volume and olfactory sulcus (OS) depth, and there are overlapping changes in the VBM and SBM findings in specific brain regions. Furthermore, correlations are found between the orbitofrontal cortex and odor threshold score, as well as the middle frontal gyrus and smell loss duration.
JOURNAL OF NEURORADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ehsan Khodamoradi, Shima Afrashi, Karim Khoshgard, Farshid Fathi, Soodeh Shahasavari, Rasool Azmoonfar, Masoud Najafi
Summary: This study aimed to evaluate the effects of simultaneous exposure to Wi-Fi waves and gamma-ray on DNA in peripheral blood lymphocytes. The results showed that simultaneous exposure to Wi-Fi waves and gamma-ray can increase the number of double-strand breaks in DNA in peripheral blood lymphocytes within 72 hours after technetium injection.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daryoush Khoramian, Soroush Sistani, Bagher Farhood
Summary: The study measured systematic and random set-up errors in prostate cancer radiotherapy using EPID and proposed the optimum CTV-to-PTV margin. Results showed population systematic and random errors in different directions, leading to calculated margins based on different formulas, with overall margins averaging at 2.73, 4.98 and 5.86 mm.
JOURNAL OF RADIOTHERAPY IN PRACTICE
(2022)